NO20012736L - Pharmaceutical composition comprising cyclosporin in a lipid carrier - Google Patents

Pharmaceutical composition comprising cyclosporin in a lipid carrier

Info

Publication number
NO20012736L
NO20012736L NO20012736A NO20012736A NO20012736L NO 20012736 L NO20012736 L NO 20012736L NO 20012736 A NO20012736 A NO 20012736A NO 20012736 A NO20012736 A NO 20012736A NO 20012736 L NO20012736 L NO 20012736L
Authority
NO
Norway
Prior art keywords
cyclosporin
pharmaceutical composition
lipid carrier
monoglycerides
lipids
Prior art date
Application number
NO20012736A
Other languages
Norwegian (no)
Other versions
NO20012736D0 (en
Inventor
Bengt Hersloef
Peter Kaufmann
Carl-Gunnar Kroon
Original Assignee
Lipocore Holding Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lipocore Holding Ab filed Critical Lipocore Holding Ab
Publication of NO20012736D0 publication Critical patent/NO20012736D0/en
Publication of NO20012736L publication Critical patent/NO20012736L/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1274—Non-vesicle bilayer structures, e.g. liquid crystals, tubules, cubic phases, cochleates; Sponge phases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A61K38/13—Cyclosporins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

Abstract

Farmasøytisk preparat som omfatter et cyklosporin som en aktiv substans i en lipidbærer, hvor bæreren omfatter membranlipider i kombinasjon med monoglycerider og eventuelt ikke-polare lipider, idet preparatet er karakterisert ved at det er flytende ved romtemperatur og inneholder 0,5-25% cyklosporin, 10-45% membranlipider, 10-55% monoglycerider og 0-45% ikke-polare lipider. Et preparat som her beskrevet er bioekvivalent med en kommersiell droge som inneholder, i tilegg til cyklosporin og additiver, også toksiske emulgatorer og etanol.A pharmaceutical composition comprising a cyclosporin as an active substance in a lipid carrier, wherein the carrier comprises membrane lipids in combination with monoglycerides and optionally non-polar lipids, the composition being characterized as being liquid at room temperature and containing 0.5-25% cyclosporin. 10-45% membrane lipids, 10-55% monoglycerides and 0-45% non-polar lipids. A composition described herein is bioequivalent to a commercial drug containing, in addition to cyclosporine and additives, also toxic emulsifiers and ethanol.

NO20012736A 1998-12-03 2001-06-01 Pharmaceutical composition comprising cyclosporin in a lipid carrier NO20012736L (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE9804192A SE9804192D0 (en) 1998-12-03 1998-12-03 New formulation
PCT/SE1999/002259 WO2000032219A1 (en) 1998-12-03 1999-12-03 A pharmaceutical composition comprising cyclosporin in a lipid carrier

Publications (2)

Publication Number Publication Date
NO20012736D0 NO20012736D0 (en) 2001-06-01
NO20012736L true NO20012736L (en) 2001-06-01

Family

ID=20413540

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20012736A NO20012736L (en) 1998-12-03 2001-06-01 Pharmaceutical composition comprising cyclosporin in a lipid carrier

Country Status (10)

Country Link
EP (1) EP1135152A1 (en)
JP (1) JP2002531412A (en)
AU (1) AU764413B2 (en)
CA (1) CA2352388A1 (en)
HU (1) HUP0105399A3 (en)
NO (1) NO20012736L (en)
NZ (1) NZ512194A (en)
PL (1) PL348062A1 (en)
SE (1) SE9804192D0 (en)
WO (1) WO2000032219A1 (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE0200475D0 (en) * 2002-02-15 2002-02-15 Ltp Lipid Technologies Provide Oral pharmaceutical preparation
US20050058671A1 (en) * 2003-05-09 2005-03-17 Bedding Peter M.J. Dietary supplement and method for treating digestive system-related disorders
SE0303135D0 (en) * 2003-11-25 2003-11-25 Lipocore Holding Ab Controlled food effect composition
SE0401942D0 (en) * 2004-07-28 2004-07-28 Lipopeptide Ab New antimicrobial peptide complexes
CN101189029A (en) * 2005-04-28 2008-05-28 盖伦尼卡技术股份公司 Pharmaceutical dosage forms comprising a lipid phase
WO2012144943A1 (en) * 2011-04-18 2012-10-26 Lipidor Ab Liquid carrier for oral delivery of a pharmacologically active agent
WO2014103742A1 (en) * 2012-12-25 2014-07-03 ポーラ化成工業株式会社 Reverse vesicle composition and method for producing same
JP6242582B2 (en) * 2013-04-01 2017-12-06 ポーラ化成工業株式会社 Method for producing reverse vesicle composition
JP6334151B2 (en) * 2012-12-25 2018-05-30 ポーラ化成工業株式会社 Reverse vesicle composition
JP6242581B2 (en) * 2013-04-01 2017-12-06 ポーラ化成工業株式会社 Method for producing reverse vesicle composition

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2222770B (en) * 1988-09-16 1992-07-29 Sandoz Ltd Pharmaceutical compositions containing cyclosporins
US5529785A (en) * 1993-05-12 1996-06-25 Dietl; Hans Pharmaceutical preparation containing cyclosporin(s) for oral administration and process for producing same
CN1091591C (en) * 1994-02-04 2002-10-02 利珀克尔集团公司 Lipophilic carrier preparations
MY129435A (en) * 1994-10-26 2007-04-30 Novartis Ag Pharmaceutical microemulsion preconcentrates
IT1289939B1 (en) * 1997-02-20 1998-10-19 Angelini Ricerche Spa AQUEOUS PHARMACEUTICAL COMPOSITION INCLUDING A HIGHLY WATER INSOLUBLE ACTIVE SUBSTANCE
US6063762A (en) * 1997-12-05 2000-05-16 Chong Kun Dang Corp. Cyclosporin-containing microemulsion preconcentrate composition

Also Published As

Publication number Publication date
EP1135152A1 (en) 2001-09-26
JP2002531412A (en) 2002-09-24
NZ512194A (en) 2002-09-27
NO20012736D0 (en) 2001-06-01
CA2352388A1 (en) 2000-06-08
PL348062A1 (en) 2002-05-06
AU764413B2 (en) 2003-08-21
AU2016700A (en) 2000-06-19
HUP0105399A3 (en) 2005-06-28
WO2000032219A1 (en) 2000-06-08
SE9804192D0 (en) 1998-12-03
HUP0105399A2 (en) 2002-06-29

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Legal Events

Date Code Title Description
FC2A Withdrawal, rejection or dismissal of laid open patent application