CO4370014A1 - STABLE DIRECTROMYCIN INJECTABLE SOLUTIONS - Google Patents

STABLE DIRECTROMYCIN INJECTABLE SOLUTIONS

Info

Publication number
CO4370014A1
CO4370014A1 CO95011794A CO95011794A CO4370014A1 CO 4370014 A1 CO4370014 A1 CO 4370014A1 CO 95011794 A CO95011794 A CO 95011794A CO 95011794 A CO95011794 A CO 95011794A CO 4370014 A1 CO4370014 A1 CO 4370014A1
Authority
CO
Colombia
Prior art keywords
lipophyl
directromycin
stable
injectable solutions
injectable solution
Prior art date
Application number
CO95011794A
Other languages
Spanish (es)
Inventor
Stefan Leiner
Bernhard Hassel
Original Assignee
Boehringer Ingelheim Vetmed
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Vetmed filed Critical Boehringer Ingelheim Vetmed
Publication of CO4370014A1 publication Critical patent/CO4370014A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Dermatology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

1. SOLUCION INYECTABLE QUE CONTIENE DIRITROMICINA COMO SUSTANCIA ACTIVA EN UNA MEZCLA DE DISOLVENTES FARMACOLOGICAMENTE COMPATIBLE, UNIFASICA, QUE CONTIENE AGUA Y LIPOFILA. 2. SOLUCION INYECTABLE SEGUN LA REIVINDICACION 1, CARACTERIZADA PORQUE LA MEZCLA DE DISOLVENTES LIPOFILA CONSTA DE UN COMPONENTE LIPOFILO Y UN DISOLVENTE ORGANICO ANFIFILO O HIDROFILO. 6. SOLUCION INYECTABLE SEGUN UNA DE LAS PRECEDEN- TES REIVINDICACIONES, CARACTERIZADA PORQUE CONTIE- NE MIRISTATO DE ISOPROPILO COMO COMPONENTE LIPO- FILO Y ETANOL COMO DISOLVENTE HIDROFILO.1. INJECTABLE SOLUTION CONTAINING DIRITHROMYCIN AS AN ACTIVE SUBSTANCE IN A PHARMACOLOGICALLY COMPATIBLE, SINGLE-PHASE SOLVENT MIXTURE, WHICH CONTAINS WATER AND LIPOPHYL. 2. INJECTABLE SOLUTION ACCORDING TO CLAIM 1, CHARACTERIZED BECAUSE THE MIXTURE OF LIPOPHYL SOLVENTS CONSISTS OF A LIPOPHYL COMPONENT AND AN ANPHYPHILIC OR HYDROPHILIC SOLVENT. 6. INJECTABLE SOLUTION ACCORDING TO ONE OF THE ABOVE CLAIMS, CHARACTERIZED BECAUSE IT CONTAINS ISOPROPYL MYRISTATE AS A LIPOPHYL COMPONENT AND ETHANOL AS A HYDROPHILIC SOLVENT.

CO95011794A 1994-03-26 1995-03-23 STABLE DIRECTROMYCIN INJECTABLE SOLUTIONS CO4370014A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4410637A DE4410637C1 (en) 1994-03-26 1994-03-26 Injectable solutions of dirithromycin

Publications (1)

Publication Number Publication Date
CO4370014A1 true CO4370014A1 (en) 1996-10-07

Family

ID=6514000

Family Applications (1)

Application Number Title Priority Date Filing Date
CO95011794A CO4370014A1 (en) 1994-03-26 1995-03-23 STABLE DIRECTROMYCIN INJECTABLE SOLUTIONS

Country Status (7)

Country Link
EP (1) EP0754047A1 (en)
JP (1) JPH09510722A (en)
AU (1) AU2214195A (en)
CO (1) CO4370014A1 (en)
DE (1) DE4410637C1 (en)
WO (1) WO1995026191A1 (en)
ZA (1) ZA952405B (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19518917A1 (en) * 1995-05-23 1996-11-28 Boehringer Ingelheim Vetmed Stable, concentrated, locally tolerated erythromycylamine solutions
DE19701949A1 (en) * 1997-01-13 1998-07-16 Jenapharm Gmbh Transdermal therapeutic system
KR101805087B1 (en) * 2010-09-16 2017-12-05 주식회사 엘지화학 Non-aqueous Oily Injectable Formulation Exhibiting Preservative Efficacy

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT342770B (en) * 1975-04-07 1978-04-25 Thomae Gmbh Dr K PROCESS FOR PRODUCING NEW ERYTHROMYCINE DERIVATIVES
DE3209429A1 (en) * 1982-03-16 1983-10-06 Boehringer Ingelheim Vetmed AGENT FOR IMPROVING THE RESORPTION OF INJECTED ANTIBACTERIAL EFFECTIVE SUBSTANCES AND COMBINATIONS CONTAINING A BENZYAMINE DERIVATIVE
US4918108A (en) * 1982-03-16 1990-04-17 Boehringer Ingelheim Vetmedica Gmbh Method of improving the absorption of injected antibacterial substances
EP0473707A4 (en) * 1989-05-26 1992-12-09 Abbott Laboratories Injectable clarithromycin composition

Also Published As

Publication number Publication date
EP0754047A1 (en) 1997-01-22
ZA952405B (en) 1995-09-26
WO1995026191A1 (en) 1995-10-05
DE4410637C1 (en) 1995-09-21
AU2214195A (en) 1995-10-17
JPH09510722A (en) 1997-10-28

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