AR012217A1 - A TOPICAL COMPOSITION TO IMPROVE THE PENETRATION OF PHARMACEUTICAL COMPOUNDS - Google Patents
A TOPICAL COMPOSITION TO IMPROVE THE PENETRATION OF PHARMACEUTICAL COMPOUNDSInfo
- Publication number
- AR012217A1 AR012217A1 ARP980101461A ARP980101461A AR012217A1 AR 012217 A1 AR012217 A1 AR 012217A1 AR P980101461 A ARP980101461 A AR P980101461A AR P980101461 A ARP980101461 A AR P980101461A AR 012217 A1 AR012217 A1 AR 012217A1
- Authority
- AR
- Argentina
- Prior art keywords
- penetration
- topical composition
- improve
- composition
- pharmaceutical compounds
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 5
- 239000000203 mixture Substances 0.000 title abstract 4
- 230000035515 penetration Effects 0.000 title abstract 2
- 230000000699 topical effect Effects 0.000 title abstract 2
- 239000002904 solvent Substances 0.000 abstract 4
- 239000007853 buffer solution Substances 0.000 abstract 2
- 239000003814 drug Substances 0.000 abstract 2
- 229940079593 drug Drugs 0.000 abstract 2
- 239000000872 buffer Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Dermatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oncology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Dispersion Chemistry (AREA)
- Communicable Diseases (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Una composicion topica que comprende: a) un compuesto o droga farmacéutica topicamente activa; y b) un sistema solvente buffer que comprende: 1) uncomponente solvente volátil; ii) un componente solvente no volátil; y iii) un componente buffer quefunciona para mantener el pH de la composicion tal queel compuesto farmacéutico permanezca mayormente en su estado ionizado capaz de mejorar la penetracion de dicha droga. El sistema solvente buffer permite a unacantidad reducida del compuesto farmacéutico de la composicion no alterar significativamente la eficacia de dicho compuesto.A topical composition comprising: a) a topically active pharmaceutical compound or drug; and b) a solvent buffer system comprising: 1) a volatile solvent component; ii) a non-volatile solvent component; and iii) a buffer component that works to maintain the pH of the composition such that the pharmaceutical compound remains mostly in its ionized state capable of improving the penetration of said drug. The solvent buffer system allows a reduced amount of the pharmaceutical compound in the composition not to significantly alter the efficacy of said compound.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US82909197A | 1997-03-31 | 1997-03-31 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR012217A1 true AR012217A1 (en) | 2000-09-27 |
Family
ID=25253504
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP980101461A AR012217A1 (en) | 1997-03-31 | 1998-03-31 | A TOPICAL COMPOSITION TO IMPROVE THE PENETRATION OF PHARMACEUTICAL COMPOUNDS |
Country Status (14)
Country | Link |
---|---|
EP (1) | EP0971746A1 (en) |
JP (1) | JP2001518879A (en) |
KR (1) | KR19980081207A (en) |
CN (1) | CN1252003A (en) |
AR (1) | AR012217A1 (en) |
AU (1) | AU6677698A (en) |
BR (1) | BR9811458A (en) |
CA (1) | CA2285368A1 (en) |
CO (1) | CO5050328A1 (en) |
HU (1) | HUP0001739A3 (en) |
IL (1) | IL132096A0 (en) |
PL (1) | PL335934A1 (en) |
WO (1) | WO1998043673A1 (en) |
ZA (1) | ZA982662B (en) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2232855C (en) * | 1997-04-10 | 2007-10-09 | Roche Consumer Health (Worldwide) Sa | Pharmaceutical formulation |
AU5146600A (en) * | 1999-05-27 | 2000-12-18 | Procter & Gamble Company, The | Topical compositions providing improved treatment of skin or scalp fungal infections |
GB0103046D0 (en) | 2001-02-07 | 2001-03-21 | Novartis Ag | Organic Compounds |
IL142037A0 (en) * | 2001-03-15 | 2002-03-10 | Agis Ind 1983 Ltd | Pharmaceutical compositions containing a non-steroidal anti-inflammatory drug |
MY129350A (en) * | 2001-04-25 | 2007-03-30 | Bristol Myers Squibb Co | Aripiprazole oral solution |
JP5435836B2 (en) * | 2003-07-03 | 2014-03-05 | 大正製薬株式会社 | Antifungal composition for external use |
JP4784051B2 (en) * | 2003-07-03 | 2011-09-28 | 大正製薬株式会社 | Antifungal composition for external use that prevents adsorption to the container |
DE102005059742A1 (en) | 2005-12-13 | 2007-06-14 | Beiersdorf Ag | Transparent sunscreen |
US20080032994A1 (en) | 2006-08-03 | 2008-02-07 | Marcel Borgers | Modified azole compounds as antifungal and antibacterial agents |
ES2349906T3 (en) * | 2007-07-25 | 2011-01-12 | Ixodes Gmbh | TOPICAL ANTIBIOTIC COMPOSITION TO PREVENT LYME DISEASE. |
CN101820877B (en) * | 2007-08-27 | 2013-09-11 | 日本农药株式会社 | Agent for fungal dermatitis |
US20090175810A1 (en) | 2008-01-03 | 2009-07-09 | Gareth Winckle | Compositions and methods for treating diseases of the nail |
US8039494B1 (en) | 2010-07-08 | 2011-10-18 | Dow Pharmaceutical Sciences, Inc. | Compositions and methods for treating diseases of the nail |
US9839611B2 (en) * | 2013-09-10 | 2017-12-12 | Insys Development Company, Inc. | Sublingual buprenorphine spray |
AU2014329421B2 (en) | 2013-10-03 | 2018-08-02 | Dow Pharmaceutical Sciences, Inc. | Stabilized efinaconazole compositions |
WO2015077729A2 (en) | 2013-11-22 | 2015-05-28 | Dow Pharmaceutical Sciences, Inc. | Anti-infective methods, compositions, and devices |
CN115745757B (en) * | 2022-11-07 | 2024-04-26 | 中国人民解放军军事科学院军事医学研究院 | Synthesis of liquid-state polyglycol column arene derivative and application of liquid-state polyglycol column arene derivative in transdermal pharmacodynamic molecule slow release |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA1331137C (en) * | 1988-02-29 | 1994-08-02 | Pfizer, Inc. | Transdermal flux enhancing compositions |
GB8827822D0 (en) * | 1988-11-29 | 1988-12-29 | Janssen Pharmaceutica Nv | (1h-azol-1-ylmethyl)substituted quinoline derivatives |
CN1106259A (en) * | 1994-02-05 | 1995-08-09 | 日东制药株式会社 | Antiphlogistic and analgesic gel agent for external use containing propanoic acid non steroid pharmaceutical as effective composition |
-
1998
- 1998-03-03 WO PCT/US1998/004033 patent/WO1998043673A1/en not_active Application Discontinuation
- 1998-03-03 AU AU66776/98A patent/AU6677698A/en not_active Abandoned
- 1998-03-03 PL PL98335934A patent/PL335934A1/en unknown
- 1998-03-03 IL IL13209698A patent/IL132096A0/en unknown
- 1998-03-03 BR BR9811458-1A patent/BR9811458A/en not_active Application Discontinuation
- 1998-03-03 HU HU0001739A patent/HUP0001739A3/en unknown
- 1998-03-03 JP JP54163598A patent/JP2001518879A/en active Pending
- 1998-03-03 CN CN98803908A patent/CN1252003A/en active Pending
- 1998-03-03 CA CA002285368A patent/CA2285368A1/en not_active Abandoned
- 1998-03-03 EP EP98908843A patent/EP0971746A1/en not_active Withdrawn
- 1998-03-30 ZA ZA9802662A patent/ZA982662B/en unknown
- 1998-03-31 AR ARP980101461A patent/AR012217A1/en unknown
- 1998-03-31 CO CO98017937A patent/CO5050328A1/en unknown
- 1998-03-31 KR KR1019980012493A patent/KR19980081207A/en not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
HUP0001739A2 (en) | 2000-12-28 |
KR19980081207A (en) | 1998-11-25 |
CN1252003A (en) | 2000-05-03 |
AU6677698A (en) | 1998-10-22 |
EP0971746A1 (en) | 2000-01-19 |
WO1998043673A1 (en) | 1998-10-08 |
PL335934A1 (en) | 2000-05-22 |
BR9811458A (en) | 2000-09-19 |
CO5050328A1 (en) | 2001-06-27 |
CA2285368A1 (en) | 1998-10-08 |
JP2001518879A (en) | 2001-10-16 |
ZA982662B (en) | 1999-09-30 |
HUP0001739A3 (en) | 2001-04-28 |
IL132096A0 (en) | 2001-03-19 |
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