EP1121150A4 - Desaturase d'acide gras delta 6 - Google Patents

Desaturase d'acide gras delta 6

Info

Publication number
EP1121150A4
EP1121150A4 EP99953068A EP99953068A EP1121150A4 EP 1121150 A4 EP1121150 A4 EP 1121150A4 EP 99953068 A EP99953068 A EP 99953068A EP 99953068 A EP99953068 A EP 99953068A EP 1121150 A4 EP1121150 A4 EP 1121150A4
Authority
EP
European Patent Office
Prior art keywords
delta
fatty acid
acid desaturase
desaturase
fatty
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP99953068A
Other languages
German (de)
English (en)
Other versions
EP1121150A1 (fr
Inventor
Konstantin Petrukhin
C Thomas Caskey
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of EP1121150A1 publication Critical patent/EP1121150A1/fr
Publication of EP1121150A4 publication Critical patent/EP1121150A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
    • C12N9/0083—Miscellaneous (1.14.99)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Obesity (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Communicable Diseases (AREA)
  • Transplantation (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Oncology (AREA)
  • Microbiology (AREA)
  • Emergency Medicine (AREA)
  • Virology (AREA)
  • Biochemistry (AREA)
EP99953068A 1998-10-09 1999-10-05 Desaturase d'acide gras delta 6 Withdrawn EP1121150A4 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US10376098P 1998-10-09 1998-10-09
US103760P 1998-10-09
PCT/US1999/023253 WO2000021557A1 (fr) 1998-10-09 1999-10-05 Desaturase d'acide gras delta 6

Publications (2)

Publication Number Publication Date
EP1121150A1 EP1121150A1 (fr) 2001-08-08
EP1121150A4 true EP1121150A4 (fr) 2003-06-04

Family

ID=22296902

Family Applications (1)

Application Number Title Priority Date Filing Date
EP99953068A Withdrawn EP1121150A4 (fr) 1998-10-09 1999-10-05 Desaturase d'acide gras delta 6

Country Status (4)

Country Link
EP (1) EP1121150A4 (fr)
JP (1) JP2002527051A (fr)
CA (1) CA2346006A1 (fr)
WO (1) WO2000021557A1 (fr)

Families Citing this family (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1035207A1 (fr) * 1999-03-09 2000-09-13 MultiGene Biotech GmbH Molécules d'ADNc des membres de la famille de gènes codant des désaturases d'acides gras humaines, et leur utilisation dans le diagnostic et la thérapie
DE10030976A1 (de) 2000-06-30 2002-01-10 Basf Ag DELTA6-Desaturasegene exprimierende Pflanzen und PUFAS enthaltende Öle aus diesen Pflanzen und ein Verfahren zur Herstellung ungesättigter Fettsäuren
PT1911837E (pt) 2000-09-28 2011-06-07 Bioriginal Food & Science Corp Membro da família de desaturases dos ácidos gordos fad5-2 e suas utilizações
GB2385852A (en) 2002-02-27 2003-09-03 Rothamsted Ex Station Delta 6-desaturases from Primulaceae
DE10219203A1 (de) 2002-04-29 2003-11-13 Basf Plant Science Gmbh Verfahren zur Herstellung mehrfach ungesättigter Fettsäuren in Pflanzen
WO2004057001A2 (fr) 2002-12-19 2004-07-08 University Of Bristol Nouveau procede de production d'acides gras polyinsatures
WO2004076617A2 (fr) 2003-02-27 2004-09-10 Basf Plant Science Gmbh Procede de production d'acides gras polyinsatures
CA2868312A1 (fr) 2003-03-31 2004-10-14 University Of Bristol Nouvelles acyltransferases vegetales specifiques pour acides gras a longue chaine polyinsatures
US7629503B2 (en) 2003-04-08 2009-12-08 Basf Plant Science Gmbh Δ-4 desaturases from Euglena gracilis, expressing plants, and oils containing PUFA
US11952581B2 (en) 2003-08-01 2024-04-09 Basf Plant Science Gmbh Process for the production of polyunsaturated fatty acids in transgenic organisms
BRPI0413073A (pt) 2003-08-01 2006-10-03 Basf Plant Science Gmbh processo para a produção de compostos, óleo, lipìdeo ou ácido graxo, ou uma fração dos mesmos, composição de óleo, lipìdeo ou ácido graxo, processo para a produção de óleos, lipìdeos ou composições de ácido graxo, uso de óleo, lipìdeo ou ácidos graxos ou de composições de óleo, lipìdeo ou ácido graxo ou de óleos, lipìdeos ou composições de ácido graxo, seqüência de ácido nucleico isolado, seqüência de aminoácidos, construção de gene, vetor, e, organismo não humano transgênico
ATE528403T1 (de) 2004-02-27 2011-10-15 Basf Plant Science Gmbh Verfahren zur herstellung von ungesättigten omega-3-fettsäuren in transgenen organismen
JP4567047B2 (ja) 2004-02-27 2010-10-20 ビーエーエスエフ プラント サイエンス ゲーエムベーハー トランスジェニック植物における多価不飽和脂肪酸の製造方法
CA2563875C (fr) 2004-04-22 2015-06-30 Commonwealth Scientific And Industrial Research Organisation Synthese d'acides gras polyinsatures a chaine longue par des cellules de recombinaison
US7807849B2 (en) 2004-04-22 2010-10-05 Commonwealth Scientific And Industrial Research Organisation Synthesis of long-chain polyunsaturated fatty acids by recombinant cells
DE102005013779A1 (de) 2005-03-22 2006-09-28 Basf Plant Science Gmbh Verfahren zur Herstellung von mehrfach ungesättigten C20- und C22-Fettsäuren mit mindestens vier Doppelbindungen in transgenen Pflanzen
DE102005038036A1 (de) 2005-08-09 2007-02-15 Basf Plant Science Gmbh Verfahren zur Herstellung von Arachidonsäure und/oder Eicosapentaensäure in transgenen Nutzpflanzen
GB2431158A (en) 2005-10-13 2007-04-18 Rothamsted Res Ltd Process for the production of arachidonic and/or eicosapentaenoic acid
DE102005052551A1 (de) 2005-11-02 2007-05-16 Rothamsted Res Harpenden Verfahren zur Herstellung von y-Linolensäure und/oder Stearidonsäure in transgenen Brassicaceae und Linaceae
GB0603160D0 (en) 2006-02-16 2006-03-29 Rothamsted Res Ltd Nucleic acid
AR059376A1 (es) 2006-02-21 2008-03-26 Basf Plant Science Gmbh Procedimiento para la produccion de acidos grasos poliinsaturados
US8629195B2 (en) 2006-04-08 2014-01-14 Bayer Materialscience Ag Production of polyurethane foams
WO2008022963A2 (fr) 2006-08-24 2008-02-28 Basf Plant Science Gmbh Isolation et caractérisation d'une nouvelle oméga-3 désaturase de pythium ayant une spécificité vis-à-vis de tous les acides gras oméga-6 ayant une chaîne plus longue que 18 atomes de carbone
WO2008025068A1 (fr) 2006-08-29 2008-03-06 Commonwealth Scientific And Industrial Research Organisation synthèse d'acides gras
EP2054509A2 (fr) 2006-10-06 2009-05-06 BASF Plant Science GmbH Procédé de production d'acides gras polyinsaturés dans des organismes transgéniques
CN101353661B (zh) * 2007-07-25 2012-05-09 中国科学院遗传与发育生物学研究所 具有△6脂肪酸脱氢酶功能的基因及其应用
EP2176416B1 (fr) 2007-07-31 2016-03-16 BASF Plant Science GmbH Élongases et procédés de production d'acides gras polyinsaturés dans des organismes transgéniques
DE112008003237T5 (de) 2007-12-14 2011-03-17 Basf Plant Science Gmbh Promotoren von Brassica napus für samenspezifische Genexpression
EP2281051B1 (fr) 2008-04-30 2015-03-11 Rothamsted Research Limited Désaturase et procédé pour la production d'acides gras polyinsaturés dans des organismes transgéniques
CA2989798C (fr) 2008-07-01 2019-11-05 Basf Plant Science Gmbh Promoteurs de brassica napus pour l'expression de genes specifique de graines
JP5757870B2 (ja) 2008-08-26 2015-08-05 ビーエーエスエフ プラント サイエンス ゲーエムベーハー デサチュラーゼをコードする核酸および改変植物油
BR122021003835B1 (pt) 2008-11-18 2022-02-08 Grains Research And Development Corporation Polinucleotídeo isolado e/ou exógeno que não ocorre de forma natural, vetor compreendendo o referido polinucleotídeo e método de produção de óleo contendo ácidos graxos insaturados
ES2435572T3 (es) 2008-12-12 2013-12-20 Basf Plant Science Gmbh Desaturasas y proceso para la producción de ácidos grasos poliinsaturados en organismos transgénicos
US9212371B2 (en) 2009-05-13 2015-12-15 Basf Plant Science Company Gmbh Acyltransferases and uses thereof in fatty acid production
CA2804925A1 (fr) 2010-06-25 2011-12-29 Basf Plant Science Company Gmbh Acyltransferases d'especes de thraustochytrium et utilisations associees dans la production d'acide gras
WO2013113030A2 (fr) * 2012-01-26 2013-08-01 Cornell University Régulation des désaturases d'acides gras (fads)
CA2869738C (fr) 2012-04-12 2022-04-05 Rothamsted Research Ltd Production d'acides gras polyinsatures omega-3 a longue chaine
US9333202B2 (en) 2012-05-01 2016-05-10 The Trustees Of Columbia University In The City Of New York Non-retinoid antagonists for treatment of age-related macular degeneration and stargardt disease
SG11201408362SA (en) 2012-06-15 2015-01-29 Commw Scient Ind Res Org Production of long chain polyunsaturated fatty acids in plant cells
EP2968304B1 (fr) 2013-03-14 2018-10-10 The Trustees of Columbia University in the City of New York 4-phénylpipéridines, leur préparation et leur utilisation
US9944644B2 (en) 2013-03-14 2018-04-17 The Trustees Of Columbia University In The City Of New York Octahydropyrrolopyrroles their preparation and use
ES2700541T3 (es) 2013-03-14 2019-02-18 Univ Columbia Octahidrociclopentapirroles, su preparación y uso
US9938291B2 (en) 2013-03-14 2018-04-10 The Trustess Of Columbia University In The City Of New York N-alkyl-2-phenoxyethanamines, their preparation and use
WO2015196250A1 (fr) 2014-06-27 2015-12-30 Commonwealth Scientific And Industrial Research Organisation Lipide comprenant de l'acide docosapentaénoïque
CN111154724B (zh) 2013-12-18 2024-02-06 联邦科学技术研究组织 包含二十二碳六烯酸的提取的植物脂质
ES2909793T3 (es) 2014-04-30 2022-05-10 Univ Columbia 4-fenilpiperidinas sustituidas, su preparación y uso
CN107236679A (zh) * 2017-04-27 2017-10-10 广州弘宝元生物科技有限公司 一种高产不饱和脂肪酸重组工程菌株及其构建方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996021022A2 (fr) * 1994-12-30 1996-07-11 Rhone-Poulenc Agrochimie Production d'acide linoleique gamma au moyen d'une δ6-desaturase

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998039446A2 (fr) * 1997-03-07 1998-09-11 Human Genome Sciences, Inc. 70 proteines humaines secretees

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996021022A2 (fr) * 1994-12-30 1996-07-11 Rhone-Poulenc Agrochimie Production d'acide linoleique gamma au moyen d'une δ6-desaturase

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
"AC O60426", TREMBL PROTEIN SEQUENCE, XP002111714 *
CHO H P ET AL: "Cloning, expression, and nutritional regulation of the mammalian Delta-6 desaturase", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOGICAL CHEMISTS, BALTIMORE, MD, US, vol. 274, no. 1, 1999, pages 471 - 477, XP002111713, ISSN: 0021-9258 *
DATABASE EMBL [online] XP002237473, retrieved from EBI Database accession no. AC004228 *
DATABASE EMBL [online] XP002237474, retrieved from EBI Database accession no. AF134404 *
GIRKE T ET AL: "IDENTIFICATION OF A NOVEL DELTA6-ACYL-GROUP DESATURASE BY TARGETED GENE DISRUPTION IN PHYSCOMITRELLA PATENS", PLANT JOURNAL, BLACKWELL SCIENTIFIC PUBLICATIONS, OXFORD, GB, vol. 15, no. 1, 1998, pages 39 - 48, XP000881712, ISSN: 0960-7412 *
NAPIER ET AL: "Identification of a Caenorhabditis elegans delta6-fatty-acid-desatur ase by heterologos expression in Saccharomyces cerevisiae", BIOCHEMICAL JOURNAL, PORTLAND PRESS, LONDON, GB, vol. 330, no. 2, March 1998 (1998-03-01), pages 611 - 614, XP002099453, ISSN: 0264-6021 *
SAYANOVA ET AL: "Expression of a borage desaturase cDNA containing an N-terminal cytochrome b5 domain results in the accumulation of high levels of delta-6-desaturated fatty acids in transgenic tobacco", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE. WASHINGTON, US, vol. 94, April 1997 (1997-04-01), pages 4211 - 4216, XP002099447, ISSN: 0027-8424 *
See also references of WO0021557A1 *

Also Published As

Publication number Publication date
CA2346006A1 (fr) 2000-04-20
JP2002527051A (ja) 2002-08-27
EP1121150A1 (fr) 2001-08-08
WO2000021557A1 (fr) 2000-04-20

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