CA2346006A1 - Desaturase d'acide gras delta 6 - Google Patents

Desaturase d'acide gras delta 6 Download PDF

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Publication number
CA2346006A1
CA2346006A1 CA002346006A CA2346006A CA2346006A1 CA 2346006 A1 CA2346006 A1 CA 2346006A1 CA 002346006 A CA002346006 A CA 002346006A CA 2346006 A CA2346006 A CA 2346006A CA 2346006 A1 CA2346006 A1 CA 2346006A1
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CA
Canada
Prior art keywords
cyb5rp
protein
cybsrp
seq
delta
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
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CA002346006A
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English (en)
Inventor
Konstantin Petrukhin
C. Thomas Caskey
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Merck and Co Inc
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Individual
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Publication of CA2346006A1 publication Critical patent/CA2346006A1/fr
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
    • C12N9/0083—Miscellaneous (1.14.99)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Wood Science & Technology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Virology (AREA)
  • Vascular Medicine (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Microbiology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Transplantation (AREA)
  • Dermatology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Communicable Diseases (AREA)
  • Emergency Medicine (AREA)
  • Ophthalmology & Optometry (AREA)
  • Oncology (AREA)

Abstract

L'invention porte sur de nouvelles séquences d'ADN humain qui codent le gène CYB5RP et sur une désaturase d'acide gras delta 6. L'invention porte également sur l'ADN génomique CYB5RP, ainsi que sur l'ADNc qui code la protéine CYB5RP. L'invention porte, de plus, sur une protéine CYB5RP codée par les nouvelles séquences d'ADN, sur des procédés d'expression de la protéine CYB5RP dans des systèmes de recombinaison, ainsi que sur des procédés CYB5RP qui identifient les activateurs et les inhibiteurs de la protéine CYB5RP.
CA002346006A 1998-10-09 1999-10-05 Desaturase d'acide gras delta 6 Abandoned CA2346006A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US10376098P 1998-10-09 1998-10-09
US60/103,760 1998-10-09
PCT/US1999/023253 WO2000021557A1 (fr) 1998-10-09 1999-10-05 Desaturase d'acide gras delta 6

Publications (1)

Publication Number Publication Date
CA2346006A1 true CA2346006A1 (fr) 2000-04-20

Family

ID=22296902

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002346006A Abandoned CA2346006A1 (fr) 1998-10-09 1999-10-05 Desaturase d'acide gras delta 6

Country Status (4)

Country Link
EP (1) EP1121150A4 (fr)
JP (1) JP2002527051A (fr)
CA (1) CA2346006A1 (fr)
WO (1) WO2000021557A1 (fr)

Families Citing this family (47)

* Cited by examiner, † Cited by third party
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EP1035207A1 (fr) * 1999-03-09 2000-09-13 MultiGene Biotech GmbH Molécules d'ADNc des membres de la famille de gènes codant des désaturases d'acides gras humaines, et leur utilisation dans le diagnostic et la thérapie
DE10030976A1 (de) 2000-06-30 2002-01-10 Basf Ag DELTA6-Desaturasegene exprimierende Pflanzen und PUFAS enthaltende Öle aus diesen Pflanzen und ein Verfahren zur Herstellung ungesättigter Fettsäuren
ES2343106T3 (es) 2000-09-28 2010-07-23 BIORIGINAL FOOD & SCIENCE CORP. Fad4, fad5, fad5-2 y fad6, miembros de la familia de desaturasas de acidos grasos y usos de los mismos.
GB2385852A (en) 2002-02-27 2003-09-03 Rothamsted Ex Station Delta 6-desaturases from Primulaceae
DE10219203A1 (de) 2002-04-29 2003-11-13 Basf Plant Science Gmbh Verfahren zur Herstellung mehrfach ungesättigter Fettsäuren in Pflanzen
CA2510462A1 (fr) 2002-12-19 2004-07-08 University Of Bristol Methode de production d'acides gras polyinsatures dans une plante transgenique ou un micro-organisme comprenant une delta-9-elongase et une delta-8-desaturase introduites
AU2004215705B2 (en) 2003-02-27 2009-11-12 Basf Plant Science Gmbh Method for the production of polyunsaturated fatty acids
WO2004087902A2 (fr) 2003-03-31 2004-10-14 University Of Bristol Nouvelles acyltransferases vegetales specifiques pour acides gras a longue chaine polyinsatures
MXPA05010571A (es) 2003-04-08 2005-11-23 Basf Plant Science Gmbh Delta-4-desaturasas a partir de euglena gracilis, que expresan plantas y aceites que comprenden pufa
CA3037924A1 (fr) 2003-08-01 2005-02-10 Basf Plant Science Gmbh Methode pour la production d'acides gras polyinsatures dans les organismes transgeniques
US11952581B2 (en) 2003-08-01 2024-04-09 Basf Plant Science Gmbh Process for the production of polyunsaturated fatty acids in transgenic organisms
CN1930277B (zh) 2004-02-27 2011-02-02 巴斯福植物科学有限公司 在转基因植物中产生多不饱和脂肪酸的方法
WO2005083053A2 (fr) 2004-02-27 2005-09-09 Basf Plant Science Gmbh Procede pour produire des acides gras $g(v)-3 insatures dans des organismes transgeniques
CN103451246B (zh) 2004-04-22 2018-02-16 联邦科学技术研究组织 用重组细胞合成长链多不饱和脂肪酸
BR122019013200B1 (pt) 2004-04-22 2022-04-12 Commonwealth Scientific And Industrial Research Organisation Polinucleotídeo isolado, vetor, célula microbiana recombinante capaz de sintetizar ácido (s) graxo(s) poliinsaturado(s) de cadeia longa, método para produção da referida célula microbiana recombinante, método para produção de ácido(s) graxo(s) poliinsaturado(s) de cadeia longa, método para produção de óleo, método para produção de semente oleaginosa, extrato de semente transgênica, composição, ração e uso da referida célula recombinante, vetor ou extrato
DE102005013779A1 (de) 2005-03-22 2006-09-28 Basf Plant Science Gmbh Verfahren zur Herstellung von mehrfach ungesättigten C20- und C22-Fettsäuren mit mindestens vier Doppelbindungen in transgenen Pflanzen
DE102005038036A1 (de) 2005-08-09 2007-02-15 Basf Plant Science Gmbh Verfahren zur Herstellung von Arachidonsäure und/oder Eicosapentaensäure in transgenen Nutzpflanzen
GB2431158A (en) 2005-10-13 2007-04-18 Rothamsted Res Ltd Process for the production of arachidonic and/or eicosapentaenoic acid
DE102005052551A1 (de) 2005-11-02 2007-05-16 Rothamsted Res Harpenden Verfahren zur Herstellung von y-Linolensäure und/oder Stearidonsäure in transgenen Brassicaceae und Linaceae
GB0603160D0 (en) 2006-02-16 2006-03-29 Rothamsted Res Ltd Nucleic acid
AR059376A1 (es) 2006-02-21 2008-03-26 Basf Plant Science Gmbh Procedimiento para la produccion de acidos grasos poliinsaturados
US8629195B2 (en) 2006-04-08 2014-01-14 Bayer Materialscience Ag Production of polyurethane foams
EP2500420B1 (fr) 2006-08-24 2016-06-22 BASF Plant Science GmbH Désaturase à pythium oméga 3 ayant une spécificité pour tous les acides gras oméga 6 chaînes de carbone supérieure à 18
RU2009111266A (ru) 2006-08-29 2010-10-10 Коммонвелт Сайентифик энд Индастриал Рисерч Организейшн (AU) Синтез жирных кислот
AU2007304229B2 (en) 2006-10-06 2013-09-19 Basf Plant Science Gmbh Processes for producing polyunsaturated fatty acids in transgenic organisms
CN101353661B (zh) * 2007-07-25 2012-05-09 中国科学院遗传与发育生物学研究所 具有△6脂肪酸脱氢酶功能的基因及其应用
CA2695112A1 (fr) 2007-07-31 2009-02-05 Basf Plant Science Gmbh Elongases et procedes de production d'acides gras polyinsatures dans des organismes transgeniques
EP2222856A2 (fr) 2007-12-14 2010-09-01 BASF Plant Science GmbH Promoteurs dérivés de brassica napus pour l'expression génétique spécifique de graines
WO2009133145A1 (fr) 2008-04-30 2009-11-05 Basf Plant Science Gmbh Désaturase et procédé pour la production d’acides gras polyinsaturés dans des organismes transgéniques
WO2010000708A2 (fr) 2008-07-01 2010-01-07 Basf Plant Science Gmbh Promoteurs de brassica napus pour l'expression de gènes spécifique de graines
CA2734810C (fr) 2008-08-26 2018-06-19 Basf Plant Science Gmbh Acides nucleiques codant des desaturases et huile vegetale modifiee
CN107858204B (zh) 2008-11-18 2021-10-29 联邦科学技术研究组织 产生ω-3脂肪酸的酶和方法
EP2376638B1 (fr) 2008-12-12 2013-08-14 BASF Plant Science GmbH Désaturases et procédé pour la production d'acides gras polyinsaturés dans des organismes transgéniques
EP2821492A3 (fr) 2009-05-13 2015-04-08 BASF Plant Science Company GmbH Acyltransférases et leurs utilisations dans la production d'acide gras
NO2585603T3 (fr) 2010-06-25 2018-05-19
CN104203288A (zh) * 2012-01-26 2014-12-10 康奈尔大学 Fads调节
EP2836599B1 (fr) 2012-04-12 2019-11-06 Rothamsted Research Limited Production d'acides gras polyinsaturés oméga-3 à longue chaîne
US9333202B2 (en) 2012-05-01 2016-05-10 The Trustees Of Columbia University In The City Of New York Non-retinoid antagonists for treatment of age-related macular degeneration and stargardt disease
NZ631702A (en) 2012-06-15 2017-01-27 Grains Res & Dev Corp Production of long chain polyunsaturated fatty acids in plant cells
US9938291B2 (en) 2013-03-14 2018-04-10 The Trustess Of Columbia University In The City Of New York N-alkyl-2-phenoxyethanamines, their preparation and use
DK2968304T3 (en) 2013-03-14 2019-01-28 Univ Columbia 4-PHENYLPIPERIDINES, THEIR PREPARATION AND USE.
EP2968303B1 (fr) 2013-03-14 2018-07-04 The Trustees of Columbia University in the City of New York Octahydrocyclopentapyrroles, leur préparation et leur utilisation
US9944644B2 (en) 2013-03-14 2018-04-17 The Trustees Of Columbia University In The City Of New York Octahydropyrrolopyrroles their preparation and use
CA3241340A1 (fr) 2013-12-18 2015-06-25 Grains Research And Development Corporation Lipides comprenant des acides gras polyinsatures a longue chaine
ES2909793T3 (es) 2014-04-30 2022-05-10 Univ Columbia 4-fenilpiperidinas sustituidas, su preparación y uso
CA2953008C (fr) 2014-06-27 2024-03-19 Nuseed Pty Ltd Lipide comprenant de l'acide docosapentaenoique
CN107236679A (zh) * 2017-04-27 2017-10-10 广州弘宝元生物科技有限公司 一种高产不饱和脂肪酸重组工程菌株及其构建方法

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US5614393A (en) * 1991-10-10 1997-03-25 Rhone-Poulenc Agrochimie Production of γ-linolenic acid by a Δ6-desaturase
WO1998039446A2 (fr) * 1997-03-07 1998-09-11 Human Genome Sciences, Inc. 70 proteines humaines secretees

Also Published As

Publication number Publication date
JP2002527051A (ja) 2002-08-27
WO2000021557A1 (fr) 2000-04-20
EP1121150A1 (fr) 2001-08-08
EP1121150A4 (fr) 2003-06-04

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