EP1063988A1 - Hesperidine et hesperitine en tant qu'inhibiteur d'acyle coa-cholesterol-o-acyltransferase, inhibiteur de l'accumulation du complexe macrophages-lipides sur la paroi arterielle et agent prophylactique ou therapeutique de maladies hepatiques - Google Patents

Hesperidine et hesperitine en tant qu'inhibiteur d'acyle coa-cholesterol-o-acyltransferase, inhibiteur de l'accumulation du complexe macrophages-lipides sur la paroi arterielle et agent prophylactique ou therapeutique de maladies hepatiques

Info

Publication number
EP1063988A1
EP1063988A1 EP98951777A EP98951777A EP1063988A1 EP 1063988 A1 EP1063988 A1 EP 1063988A1 EP 98951777 A EP98951777 A EP 98951777A EP 98951777 A EP98951777 A EP 98951777A EP 1063988 A1 EP1063988 A1 EP 1063988A1
Authority
EP
European Patent Office
Prior art keywords
hesperidin
hesperetin
composition
mammal
cholesterol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP98951777A
Other languages
German (de)
English (en)
Inventor
Song Hae Bok
Tae Sook Jeong
Myung Sook Choi
Surk Sik Moon
Yong Kook Kwon
Eun Sook Lee
Byung Hwa Hyun
Yang-Kyu Choi
Chui Ho Lee
Ki Hwan Bae
Yong Bok Park
Jun Sung Lee
Kwang Hee Son
Byoung Mog Kwon
Young Kook Kim
Doil Choi
Sung Uk Kim
Ingyu Hwang
Jung Ah Ahn
Young Bae Park
Hyo Soo Kim
Seong Choon Choe
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Korea Advanced Institute of Science and Technology KAIST
Korea Institute of Science and Technology KIST
Original Assignee
Korea Advanced Institute of Science and Technology KAIST
Korea Institute of Science and Technology KIST
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from KR1019970055578A external-priority patent/KR19990034089A/ko
Priority claimed from KR1019980010888A external-priority patent/KR19990076178A/ko
Priority claimed from KR1019980012411A external-priority patent/KR19990079683A/ko
Priority claimed from KR1019980013283A external-priority patent/KR19990080214A/ko
Application filed by Korea Advanced Institute of Science and Technology KAIST, Korea Institute of Science and Technology KIST filed Critical Korea Advanced Institute of Science and Technology KAIST
Publication of EP1063988A1 publication Critical patent/EP1063988A1/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
    • A23L2/52—Adding ingredients
    • A23L2/56—Flavouring or bittering agents
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105—Plant extracts, their artificial duplicates or their derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

Abstract

L'invention concerne des utilisations d'hespéridine ou d'hespérétine afin d'inhiber l'activité d'acyle CoA-cholestérol-o-acyltransférase, d'inhiber l'accumulation du complexe constitué par des macrophages et des lipides sur l'endothélium artériel et d'exercer une action prophylactique ou thérapeutique sur des maladies hépatiques chez le mammifère.
EP98951777A 1997-10-28 1998-10-20 Hesperidine et hesperitine en tant qu'inhibiteur d'acyle coa-cholesterol-o-acyltransferase, inhibiteur de l'accumulation du complexe macrophages-lipides sur la paroi arterielle et agent prophylactique ou therapeutique de maladies hepatiques Withdrawn EP1063988A1 (fr)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
KR9755578 1997-10-28
KR1019970055578A KR19990034089A (ko) 1997-10-28 1997-10-28 헤스페리딘또는헤스페레틴을포함하는아실코에이:콜레스테롤-오르토-아실트랜스퍼레이즈 저해제조성물
KR9810888 1998-03-28
KR1019980010888A KR19990076178A (ko) 1998-03-28 1998-03-28 헤스페리딘을 포함하는 간 질환의 예방 및 치료용 조성물
KR9812411 1998-04-08
KR1019980012411A KR19990079683A (ko) 1998-04-08 1998-04-08 감귤류의 과피 분말 또는 과피 추출물을 포함하는 기능성 건강식품
KR9813283 1998-04-14
KR1019980013283A KR19990080214A (ko) 1998-04-14 1998-04-14 감귤류의 과피 추출물을 포함하는 건강개선용 기능성 음료
PCT/KR1998/000324 WO1999021549A1 (fr) 1997-10-28 1998-10-20 Hesperidine et hesperetine en tant qu'inhibiteur d'acyle coa-cholesterol-o-acyltransferase, inhibiteur de l'accumulation du complexe macrophages-lipides sur la paroi arterielle et agent prophylactique ou therapeutique de maladies hepatiques

Publications (1)

Publication Number Publication Date
EP1063988A1 true EP1063988A1 (fr) 2001-01-03

Family

ID=27483239

Family Applications (1)

Application Number Title Priority Date Filing Date
EP98951777A Withdrawn EP1063988A1 (fr) 1997-10-28 1998-10-20 Hesperidine et hesperitine en tant qu'inhibiteur d'acyle coa-cholesterol-o-acyltransferase, inhibiteur de l'accumulation du complexe macrophages-lipides sur la paroi arterielle et agent prophylactique ou therapeutique de maladies hepatiques

Country Status (5)

Country Link
EP (1) EP1063988A1 (fr)
JP (1) JP2001520993A (fr)
CN (1) CN1124133C (fr)
CA (1) CA2307890A1 (fr)
WO (1) WO1999021549A1 (fr)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020006953A1 (en) * 1999-11-05 2002-01-17 Carla R. McGill Modification of cholesterol concentrations with citus phytochemicals
FR2841472B1 (fr) * 2002-06-28 2006-02-24 Agronomique Inst Nat Rech Composition nutritionnelle ou therapeutique contenant le compose hesperidine ou l'un de ses derives
TW201418453A (zh) 2004-07-23 2014-05-16 Suntory Holdings Ltd 醇類浸漬物或使用其之食品、飲料及其製造方法
KR101356330B1 (ko) 2004-12-24 2014-01-27 가부시끼가이샤 하야시바라 세이부쓰 가가꾸 겐꾸조 간기능 개선제
EP2368442B1 (fr) 2005-07-27 2014-12-17 Symrise AG Utilisation d'hespérétine pour améliorer le goût sucré
KR101303401B1 (ko) * 2006-01-23 2013-09-05 산토리 홀딩스 가부시키가이샤 식품 또는 음료 및 그 제조 방법
JP2007112806A (ja) * 2006-11-27 2007-05-10 Kao Corp 体脂肪燃焼促進剤
JP2009007256A (ja) * 2007-06-26 2009-01-15 Kao Corp Ｎａｄｈ／ｎａｄｐｈオキシダーゼ抑制剤
CN104688756A (zh) * 2013-12-09 2015-06-10 中国药科大学 一种药物组合物及其在制备治疗酒精性肝损伤药物中的应用
TWI715172B (zh) * 2019-08-28 2021-01-01 健茂生物科技股份有限公司 具有抑制體脂肪形成之組合物
CN114832041A (zh) * 2021-02-01 2022-08-02 健茂生物科技股份有限公司 具有护肝效果的组合物及其制备方法
CN114832007A (zh) * 2021-02-01 2022-08-02 健茂生物科技股份有限公司 降低胆固醇的组合物及其制备方法
CN115607538A (zh) * 2022-09-26 2023-01-17 浙江工商大学 橙皮素在制备抑制和/或治疗小麦过敏的药物中的应用

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4150038A (en) * 1977-05-16 1979-04-17 Dynapol Conversion of hesperidin into hesperetin
JPS54154569A (en) * 1978-05-20 1979-12-05 Lotte Co Ltd Chewing gum for sports
ATE87204T1 (de) * 1987-12-10 1993-04-15 Tsumura & Co Anti-retrovirales arzneimittel.
MC2041A1 (fr) * 1988-06-24 1990-05-30 Johannes Cornelius Str Andries Agents anti-atherogenic
JPH04295428A (ja) * 1991-03-22 1992-10-20 Dai Ichi Seiyaku Co Ltd 抗アレルギー剤
CN1123523A (zh) * 1993-04-20 1996-05-29 普罗克特和甘保尔公司 用橙皮甙元控制皮脂和治疗痤疮的方法
JPH0725761A (ja) * 1993-07-09 1995-01-27 Kureha Chem Ind Co Ltd 軟骨保護剤
JPH08283154A (ja) * 1995-04-12 1996-10-29 Nippon Shinyaku Co Ltd 脂質代謝改善剤
JP3557711B2 (ja) * 1995-04-12 2004-08-25 日本新薬株式会社 脂質代謝改善に有効な食品及び製法

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See references of WO9921549A1 *

Also Published As

Publication number Publication date
CA2307890A1 (fr) 1999-05-06
WO1999021549A1 (fr) 1999-05-06
JP2001520993A (ja) 2001-11-06
CN1278170A (zh) 2000-12-27
CN1124133C (zh) 2003-10-15

Similar Documents

Publication Publication Date Title
US6165984A (en) Naringin and naringenin as inhibitors of acyl CoA-cholesterol-o-acyltransferase
CA2307553C (fr) Extrait d'ecorce d'agrumes en tant qu'inhibiteur d'acyle coa-cholesterol-o-acyltransferase, inhibiteur de l'accumulation du complexe macrophage-lipide sur les parois arterielles et agent de prevention ou de traitement des maladies hepatiques
US6509372B2 (en) Method for preventing or treating elevated blood lipid level-related diseases by administering rutin and quercetin
US6133241A (en) Bioflavonoids as plasma high density lipoprotein level increasing agent
RU2203050C2 (ru) Биофлавоноиды в качестве агента, снижающего уровень глюкозы в крови
US20060040911A1 (en) Method for preventing and/or treating the cardiovascular and hepatic diseases induced by hyperlipidemia which comprises administered an effective amount of bioflavonoids extract derived from fructus crataegus (lipid metabolism and fructus crataegus)
WO1998016221A1 (fr) NARINGINE ET NARINGENINE UTILISEES EN TANT QU'INHIBITEUR DE 3-HYDROXY-3-METHYL-GLUTARYL COENZYME A (HMG CoA) REDUCTASE
EP1063988A1 (fr) Hesperidine et hesperitine en tant qu'inhibiteur d'acyle coa-cholesterol-o-acyltransferase, inhibiteur de l'accumulation du complexe macrophages-lipides sur la paroi arterielle et agent prophylactique ou therapeutique de maladies hepatiques
US20010002264A1 (en) Citrus peel extract as inhibitor of fatty streak formation on the arterial wall
EP1113726B1 (fr) Utilisation de neohesperidine dihydrochalcone dans la preparation d'un medicament pour la prevention ou le traitement de maladies liees a des niveaux eleves de lipide dans le sang
RU2197239C2 (ru) Гесперидин и гесперетин в качестве ингибитора ацил соа-холестерин-о-ацилтрансферазы, ингибиторов накопления комплексов макрофаг-липид на стенках артерий, и в качестве средства для профилактики или лечения заболеваний печени
RU2201228C2 (ru) Нарингин и нарингенин в качестве средства для профилактики или лечения заболеваний печени
EP1123096A1 (fr) Flavonoides utilises comme agents augmentant la teneur en lipoproteines de haute densite du plasma
KR20010015495A (ko) 루틴 및 쿼세틴을 포함하는 고지혈증, 동맥경화증 및 간질환의 예방 및 치료용 조성물

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 20000519

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): DE FR GB IT

17Q First examination report despatched

Effective date: 20030916

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 20040127

RIN1 Information on inventor provided before grant (corrected)

Inventor name: CHOE, SEONG CHOON

Inventor name: KIM, HYO SOO

Inventor name: PARK, YOUNG BAE

Inventor name: AHN, JUNG AH

Inventor name: HWANG, INGYU

Inventor name: KIM, SUNG UK

Inventor name: CHOI, DOIL

Inventor name: KIM, YOUNG KOOK

Inventor name: KWON, BYOUNG MOG

Inventor name: SON, KWANG HEE

Inventor name: LEE, JUN SUNG

Inventor name: PARK, YONG BOK

Inventor name: BAE, KI HWAN

Inventor name: LEE, CHUI HO

Inventor name: CHOI, YANG-KYU

Inventor name: HYUN, BYUNG HWA

Inventor name: LEE, EUN SOOK

Inventor name: KWON, YONG KOOK

Inventor name: MOON, SURK SIK

Inventor name: CHOI, MYUNG SOOK

Inventor name: JEONG, TAE SOOK

Inventor name: BOK, SONG HAE