EP1060243A4 - EMBRYONIC OR STEM-LIKE CELL LINES PRODUCED BY NUCLEAR TRANSPLANTATION OF CROSS-SPECIES - Google Patents

EMBRYONIC OR STEM-LIKE CELL LINES PRODUCED BY NUCLEAR TRANSPLANTATION OF CROSS-SPECIES

Info

Publication number
EP1060243A4
EP1060243A4 EP99911062A EP99911062A EP1060243A4 EP 1060243 A4 EP1060243 A4 EP 1060243A4 EP 99911062 A EP99911062 A EP 99911062A EP 99911062 A EP99911062 A EP 99911062A EP 1060243 A4 EP1060243 A4 EP 1060243A4
Authority
EP
European Patent Office
Prior art keywords
cell lines
transplant
core
different species
embryonic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP99911062A
Other languages
German (de)
English (en)
French (fr)
Other versions
EP1060243A1 (en
Inventor
James Robl
Jose Cibelli
Steven L Stice
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Massachusetts Boston
University of Massachusetts Amherst
Original Assignee
University of Massachusetts Boston
University of Massachusetts Amherst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Massachusetts Boston, University of Massachusetts Amherst filed Critical University of Massachusetts Boston
Publication of EP1060243A1 publication Critical patent/EP1060243A1/en
Publication of EP1060243A4 publication Critical patent/EP1060243A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/873—Techniques for producing new embryos, e.g. nuclear transfer, manipulation of totipotent cells or production of chimeric embryos
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2517/00—Cells related to new breeds of animals
    • C12N2517/04—Cells produced using nuclear transfer

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
EP99911062A 1998-03-02 1999-03-02 EMBRYONIC OR STEM-LIKE CELL LINES PRODUCED BY NUCLEAR TRANSPLANTATION OF CROSS-SPECIES Withdrawn EP1060243A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US3294598A 1998-03-02 1998-03-02
US32945 1998-03-02
PCT/US1999/004608 WO1999045100A1 (en) 1998-03-02 1999-03-02 Embryonic or stem-like cell lines produced by cross-species nuclear transplantation

Publications (2)

Publication Number Publication Date
EP1060243A1 EP1060243A1 (en) 2000-12-20
EP1060243A4 true EP1060243A4 (en) 2005-03-09

Family

ID=21867727

Family Applications (1)

Application Number Title Priority Date Filing Date
EP99911062A Withdrawn EP1060243A4 (en) 1998-03-02 1999-03-02 EMBRYONIC OR STEM-LIKE CELL LINES PRODUCED BY NUCLEAR TRANSPLANTATION OF CROSS-SPECIES

Country Status (9)

Country Link
EP (1) EP1060243A4 (https=)
JP (1) JP2002505100A (https=)
CN (1) CN1299408A (https=)
AU (1) AU759322B2 (https=)
BR (1) BR9908499A (https=)
CA (1) CA2323094A1 (https=)
IL (1) IL138201A0 (https=)
NZ (1) NZ506808A (https=)
WO (1) WO1999045100A1 (https=)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ517609A (en) * 1999-09-14 2004-02-27 Univ Massachusetts Embryonic or stem-like cell lines produced by cross species nuclear transplantation and methods for enhancing embryonic development by genetic alteration of donor cells or by tissue culture conditions
WO2001029206A1 (en) 1999-10-15 2001-04-26 Advanced Cell Technology, Inc. Methods of producing differentiated progenitor cells and lineage-defective embryonic stem cells
AU784731B2 (en) * 1999-12-20 2006-06-08 University Of Massachusetts Embryonic or stem-like cells produced by cross species nuclear transplantation
US6921665B2 (en) 2000-11-27 2005-07-26 Roslin Institute (Edinburgh) Selective antibody targeting of undifferentiated stem cells
US6576464B2 (en) * 2000-11-27 2003-06-10 Geron Corporation Methods for providing differentiated stem cells
AU2002250020A1 (en) * 2001-02-02 2002-08-19 Erik Forsberg Method of cloning transgenic mammalian animals using pseudonuclei
CA2466198A1 (en) 2001-11-06 2003-05-15 Shanghai Second Medical University Somatic cell derived embryonic stem cells and their differentiated progenies
JP2005508185A (ja) * 2001-11-06 2005-03-31 上海第二医科大学 ウサギの卵母細胞を用いる異種間体細胞核移植
US20030204860A1 (en) * 2002-04-01 2003-10-30 David Melican Method for selecting cell lines to be used for nuclear transfer in mammalian species
ES2705683T3 (es) * 2002-12-16 2019-03-26 Technion Res & Dev Foundation Medio de cultivo de células madre pluripotentes
US9719068B2 (en) 2010-05-06 2017-08-01 Children's Hospital Medical Center Methods and systems for converting precursor cells into intestinal tissues through directed differentiation
WO2013010045A1 (en) 2011-07-12 2013-01-17 Biotime Inc. Novel methods and formulations for orthopedic cell therapy
WO2013177228A1 (en) 2012-05-22 2013-11-28 Loma Linda University Generation of integration/transgene-free stem cells
CN106661548B (zh) 2014-05-28 2020-12-11 儿童医院医疗中心 用于经由定向分化将前体细胞转化为胃组织的方法和系统
KR102729404B1 (ko) 2016-11-04 2024-11-14 칠드런즈 호스피탈 메디칼 센터 간 유사 장기 조성물 및 이를 제조 및 사용하는 방법
US12281334B2 (en) 2017-04-14 2025-04-22 Children's Hospital Medical Center Multi donor stem cell compositions and methods of making same
EP3694603B1 (en) 2017-10-10 2026-04-08 Children's Hospital Medical Center Esophageal tissue and/or organoid compositions and methods of making same
US12379372B2 (en) 2017-12-21 2025-08-05 Children's Hospital Medical Center Digitalized human organoids and methods of using same
KR102887406B1 (ko) 2018-07-26 2025-11-19 칠드런즈 호스피탈 메디칼 센터 간-담도-췌장 조직 및 이를 제조하는 방법
AU2019339410A1 (en) 2018-09-12 2021-04-15 Children's Hospital Medical Center Organoid compositions for the production of hematopoietic stem cells and derivatives thereof
WO2020160371A1 (en) 2019-02-01 2020-08-06 The University Of Hong Kong Innervated organoid compositions and methods of making same
WO2020243633A1 (en) 2019-05-31 2020-12-03 Children's Hospital Medical Center Shaped organoid compositions and methods of making same
WO2020243613A1 (en) 2019-05-31 2020-12-03 Children's Hospital Medical Center Methods of generating and expanding hematopoietic stem cells

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997037009A1 (en) * 1996-04-01 1997-10-09 University Of Massachusetts, A Public Institution Of Higher Education Of The Commonwealth Of Massachusetts, Represented By Its Amherst Campus Cultured inner cell mass cell lines derived from ungulate embryos
WO1998007841A1 (en) * 1996-08-19 1998-02-26 University Of Massachusetts Embryonic or stem-like cell lines produced by cross species nuclear transplantation

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ337495A (en) * 1997-03-06 2001-06-29 Infigen Inc Bovine primordial germ cells and their use in cloning
AU8587598A (en) * 1997-07-26 1999-02-16 Wisconsin Alumni Research Foundation Trans-species nuclear transfer

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997037009A1 (en) * 1996-04-01 1997-10-09 University Of Massachusetts, A Public Institution Of Higher Education Of The Commonwealth Of Massachusetts, Represented By Its Amherst Campus Cultured inner cell mass cell lines derived from ungulate embryos
WO1998007841A1 (en) * 1996-08-19 1998-02-26 University Of Massachusetts Embryonic or stem-like cell lines produced by cross species nuclear transplantation

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
ARSENIAN S ET AL: "SERUM RESPONSE FACTOR IS ESSENTIAL FOR MESODERM FORMATION DURING MOUSE EMBRYOGENESIS", EMBO JOURNAL, OXFORD UNIVERSITY PRESS, SURREY, GB, vol. 17, no. 21, 2 November 1998 (1998-11-02), pages 6289 - 6299, XP002149683, ISSN: 0261-4189 *
BAGUTTI C, WOBUS AM, FASSLER R, WATT FM.: "Differentiation of embryonal stem cells into keratinocytes: comparison of wild-type and beta 1 integrin-deficient cells.", DEV BIOL., vol. 179, no. 1, 10 October 1996 (1996-10-10), pages 184 - 196, XP002298856 *
ROHWEDEL J ET AL: "Loss of beta-1 integrin function results in a retardation of myogenic, but an acceleration of neuronal, differentiation of embryonic stem cells in vitro", DEVELOPMENTAL BIOLOGY, ACADEMIC PRESS, NEW YORK, NY, US, vol. 201, 1998, pages 167 - 184, XP002963055, ISSN: 0012-1606 *
See also references of WO9945100A1 *

Also Published As

Publication number Publication date
CA2323094A1 (en) 1999-09-10
WO1999045100A1 (en) 1999-09-10
AU759322B2 (en) 2003-04-10
CN1299408A (zh) 2001-06-13
BR9908499A (pt) 2001-12-26
NZ506808A (en) 2003-12-19
IL138201A0 (en) 2001-10-31
EP1060243A1 (en) 2000-12-20
AU2979599A (en) 1999-09-20
JP2002505100A (ja) 2002-02-19

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Inventor name: STICE, STEVEN, L.

Inventor name: CIBELLI, JOSE

Inventor name: ROBL, JAMES

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Inventor name: STICE, STEVEN, L.

Inventor name: CIBELLI, JOSE

Inventor name: ROBL, JAMES

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Inventor name: STICE, STEVEN, L.

Inventor name: CIBELLI, JOSE

Inventor name: ROBL, JAMES

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