EP1044461A4 - Nebuliseur a injection directe haute efficacite destine a la spectrometrie analytique - Google Patents

Nebuliseur a injection directe haute efficacite destine a la spectrometrie analytique

Info

Publication number
EP1044461A4
EP1044461A4 EP98965011A EP98965011A EP1044461A4 EP 1044461 A4 EP1044461 A4 EP 1044461A4 EP 98965011 A EP98965011 A EP 98965011A EP 98965011 A EP98965011 A EP 98965011A EP 1044461 A4 EP1044461 A4 EP 1044461A4
Authority
EP
European Patent Office
Prior art keywords
high efficiency
direct injection
efficiency nebulizer
injection high
spectrometry
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP98965011A
Other languages
German (de)
English (en)
Other versions
EP1044461A1 (fr
Inventor
Akbar Montaser
John A Mclean
Jerold M Kacsir
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
George Washington University
Original Assignee
George Washington University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by George Washington University filed Critical George Washington University
Publication of EP1044461A1 publication Critical patent/EP1044461A1/fr
Publication of EP1044461A4 publication Critical patent/EP1044461A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/10—Ion sources; Ion guns
    • H01J49/105—Ion sources; Ion guns using high-frequency excitation, e.g. microwave excitation, Inductively Coupled Plasma [ICP]
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/71—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light thermally excited
    • G01N21/714—Sample nebulisers for flame burners or plasma burners
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/04—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components
    • H01J49/0431—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components for liquid samples
    • H01J49/0445—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components for liquid samples with means for introducing as a spray, a jet or an aerosol
    • H01J49/045—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components for liquid samples with means for introducing as a spray, a jet or an aerosol with means for using a nebulising gas, i.e. pneumatically assisted

Landscapes

  • Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Plasma & Fusion (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Dispersion Chemistry (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
EP98965011A 1997-12-30 1998-12-28 Nebuliseur a injection directe haute efficacite destine a la spectrometrie analytique Withdrawn EP1044461A4 (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US7002497P 1997-12-30 1997-12-30
US70024P 1997-12-30
US57198 1998-04-08
US09/057,198 US6166379A (en) 1997-12-30 1998-04-08 Direct injection high efficiency nebulizer for analytical spectrometry
PCT/US1998/027797 WO1999034400A1 (fr) 1997-12-30 1998-12-28 Nebuliseur a injection directe haute efficacite destine a la spectrometrie analytique

Publications (2)

Publication Number Publication Date
EP1044461A1 EP1044461A1 (fr) 2000-10-18
EP1044461A4 true EP1044461A4 (fr) 2010-09-15

Family

ID=26736184

Family Applications (1)

Application Number Title Priority Date Filing Date
EP98965011A Withdrawn EP1044461A4 (fr) 1997-12-30 1998-12-28 Nebuliseur a injection directe haute efficacite destine a la spectrometrie analytique

Country Status (5)

Country Link
US (1) US6166379A (fr)
EP (1) EP1044461A4 (fr)
AU (1) AU746155B2 (fr)
CA (1) CA2316825C (fr)
WO (1) WO1999034400A1 (fr)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6222186B1 (en) * 1998-06-25 2001-04-24 Agilent Technologies, Inc. Power-modulated inductively coupled plasma spectrometry
US7119342B2 (en) * 1999-02-09 2006-10-10 Syagen Technology Interfaces for a photoionization mass spectrometer
US6586731B1 (en) * 1999-04-12 2003-07-01 Mds Inc. High intensity ion source apparatus for mass spectrometry
US20060169800A1 (en) 1999-06-11 2006-08-03 Aradigm Corporation Aerosol created by directed flow of fluids and devices and methods for producing same
US6478238B1 (en) 1999-11-03 2002-11-12 Cornell Research Foundation Inc. Miniaturized fluid transfer device
DE19963317A1 (de) * 1999-12-22 2001-07-12 Hans Bernhard Linden Verfahren und Vorrichtung zur schonenden Ionisierung von Analysensubstanzen
US6618139B2 (en) * 2000-01-13 2003-09-09 Perkinelmer Instruments Llc Torch glassware for use with inductively coupled plasma-optical emission spectrometer
EP1252930A1 (fr) * 2001-04-27 2002-10-30 Tecan Trading AG Tête de pulvérisation
EP1402762B1 (fr) * 2001-07-03 2013-09-25 Agilent Technologies Australia (M) Pty Ltd Torche a plasma
JP3954361B2 (ja) * 2001-11-13 2007-08-08 株式会社ナノ・ソリューション マイクロスプレーカラムと質量分析計及び質量分析方法
EP1450962B1 (fr) * 2001-12-03 2009-04-29 The Regents of The University of California Procede et appareil permettant d'etancheifier un conduit au moyen d'un injecteur inserable anti-obstruction
US20040014227A1 (en) * 2002-01-04 2004-01-22 Frederick Erik D. Apparatus, method and computer program product for automated high-throughput sampling and data acquisition
US6634572B1 (en) * 2002-05-31 2003-10-21 John A. Burgener Enhanced parallel path nebulizer with a large range of flow rates
JP4232951B2 (ja) * 2002-11-07 2009-03-04 独立行政法人産業技術総合研究所 誘導結合プラズマトーチ
WO2005062883A2 (fr) * 2003-12-23 2005-07-14 The George Washington University Nebuliseur demontable a rendement eleve a injection directe pour spectrometrie de masse a plasma couple par induction
US7317186B2 (en) * 2003-12-23 2008-01-08 The George Washington University Short torch design for direct liquid sample introduction using conventional and micro-nebulizers for plasma spectrometry
US6870154B1 (en) * 2004-02-27 2005-03-22 The University Of Western Ontario Capillary mixer with adjustable reaction chamber volume for mass spectrometry
JP4151592B2 (ja) * 2004-03-10 2008-09-17 株式会社島津製作所 質量分析装置
JP2006038729A (ja) * 2004-07-29 2006-02-09 National Institute Of Advanced Industrial & Technology 誘導結合プラズマトーチ
EP1819639A4 (fr) * 2004-11-30 2012-05-02 Univ Tulane Procede de traitement de nebulisation
US8007742B2 (en) * 2005-09-20 2011-08-30 United States Of America As Represented By The Secretary Of Commerce IRIS digester-evaporator interface
DE102007054949B4 (de) * 2007-11-17 2016-09-29 Airbus Defence and Space GmbH Sprühpistole
US8181544B2 (en) * 2008-11-18 2012-05-22 Picarro, Inc. Liquid sample evaporator for vapor analysis
US8361805B2 (en) * 2009-03-10 2013-01-29 Brennan Ryan G System and method for automated sample introduction
US8598522B2 (en) * 2010-05-21 2013-12-03 Waters Technologies Corporation Techniques for automated parameter adjustment using ion signal intensity feedback
FR2960798A1 (fr) * 2010-06-07 2011-12-09 Commissariat Energie Atomique Dispositif microfluidique et procede de nebulisation d'un liquide d'interet.
US8882085B1 (en) * 2012-07-25 2014-11-11 The United States Of America As Represented By The Secretary Of The Army Micro atomizer
GB2506892B (en) 2012-10-11 2015-06-10 Thermo Fisher Scient Bremen Apparatus and method for improving throughput in spectrometry
US10285255B2 (en) * 2013-02-14 2019-05-07 Elemental Scientific Lasers, Llc Laser ablation cell and injector system for a compositional analysis system
EP2777818A1 (fr) * 2013-03-15 2014-09-17 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Procédé et dispositif de production d'un jet de liquide intermittent
US9821325B2 (en) * 2013-04-30 2017-11-21 Arizona Board Of Regents On Behalf Of Arizona State University Apparatus and methods for lipidic cubic phase (LCP) injection for membrane protein investigations
US10192726B1 (en) 2013-10-18 2019-01-29 Elemental Scientific, Inc. Rapid inline preparation of a diluted sample
CN106255548A (zh) * 2014-03-11 2016-12-21 凸版印刷株式会社 液滴制造器件、液滴的制造方法、脂质体的制造方法、固定工具及液滴制造工具盒
US9165751B1 (en) * 2014-06-06 2015-10-20 Agilent Technologies, Inc. Sample atomization with reduced clogging for analytical instruments
US9673032B1 (en) 2016-03-31 2017-06-06 Agilent Technologies Inc. Sample sprayer with adjustable conduit and related methods
RU2677501C1 (ru) * 2017-12-27 2019-01-17 Объединенный Институт Ядерных Исследований (Оияи) Способ анализа атомного состава органических веществ и устройство для его осуществления
JP6945894B2 (ja) 2018-02-23 2021-10-06 国立研究開発法人産業技術総合研究所 噴霧器、試料導入ユニットおよび分析装置
JP2022547430A (ja) 2019-08-30 2022-11-14 オートモーティブ・コーリション・フォー・トラフィック・セーフティ，インコーポレーテッド 揮発性被分析物を含有する高精度の混合ガス混合物を生成するための方法及び装置
CN111266140B (zh) * 2020-03-09 2021-07-16 厦门大学 无油分选-直接注入-icpms单细胞分析系统
EP4215025A1 (fr) * 2020-09-18 2023-07-26 Fluidigm Canada Inc. Procédés et systèmes d'analyse atomique utilisant un plasma à couplage inductif
CN114965831A (zh) * 2022-05-19 2022-08-30 厦门大学 色谱与质谱联用的零死体积接口装置及其应用
US11944993B1 (en) 2022-11-22 2024-04-02 John A. Burgener Semi concentric enhanced parallel path pneumatic nebulizer

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5212365A (en) * 1991-12-27 1993-05-18 Cetac Technologies, Inc. Direct injection micro nebulizer system and method of use

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1109602A (en) * 1963-10-21 1968-04-10 Albright & Wilson Mfg Ltd Improvements relating to spectroscopic methods and apparatus
US3467471A (en) * 1963-10-21 1969-09-16 Albright & Wilson Mfg Ltd Plasma light source for spectroscopic investigation
US4575609A (en) * 1984-03-06 1986-03-11 The United States Of America As Represented By The United States Department Of Energy Concentric micro-nebulizer for direct sample insertion
DE3818058A1 (de) * 1988-05-27 1989-12-07 Bodenseewerk Perkin Elmer Co Vorrichtung zur zufuhr von fluessigkeit zu einem zerstaeuber bei einem spektrometer
US4990740A (en) * 1989-03-06 1991-02-05 The Dow Chemical Company Intra-microspray ICP torch
JP3786724B2 (ja) * 1994-08-11 2006-06-14 エスアイアイ・ナノテクノロジー株式会社 誘導結合プラズマ分析装置およびその試料導入装置

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5212365A (en) * 1991-12-27 1993-05-18 Cetac Technologies, Inc. Direct injection micro nebulizer system and method of use

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
WIEDERIN D R ET AL: "DIRECT INJECTION NEBULIZATION FOR INDUCTIVELY COUPLED PLASMA MASS SPECTROMETRY", ANALYTICAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US LNKD- DOI:10.1021/AC00003A007, vol. 63, no. 3, 1 February 1991 (1991-02-01), pages 219 - 225, XP000205565, ISSN: 0003-2700 *

Also Published As

Publication number Publication date
AU2021199A (en) 1999-07-19
CA2316825A1 (fr) 1999-07-08
WO1999034400A9 (fr) 1999-09-30
US6166379A (en) 2000-12-26
AU746155B2 (en) 2002-04-18
CA2316825C (fr) 2009-02-03
WO1999034400A1 (fr) 1999-07-08
EP1044461A1 (fr) 2000-10-18

Similar Documents

Publication Publication Date Title
EP1044461A4 (fr) Nebuliseur a injection directe haute efficacite destine a la spectrometrie analytique
AU1360799A (en) Curved introduction for mass spectrometry
GB9612070D0 (en) Plasma mass spectrometer
GB2330450B (en) Chemical ionization source for mass spectrometry
GB9920280D0 (en) Mass spectrometer
GB9916403D0 (en) Compounds for mass spectrometry
GB9802111D0 (en) Time-of-flight mass spectrometer
HU9802612D0 (en) Electrode assembly for luminescent lamps
GB9802115D0 (en) Time-of-flight mass spectrometer
AU2463299A (en) Mass spectrometry from surfaces
EP1166340A4 (fr) Buse d'electronebulisation a base de polymere pour spectrometrie de masse
AU7022298A (en) Rf-only mass spectrometer with auxiliary excitation
EP1012931A4 (fr) Spectrometre multipassages
GB2322473B (en) Electron gun
AU8274798A (en) Novel mass spectrometer
AU3041197A (en) Time-of-flight mass spectrometer
GB2323468B (en) Mass spectrometer total pressure collector
GB2317266B (en) Linear time-of-flight mass spectrometer
AU1239497A (en) Electrothermal atomization means for analytical spectrometry
GB9614071D0 (en) Spectrometer
GB2308491A8 (en) Time-of-flight mass spectrometry
GB9725174D0 (en) Spectrometers
GB9714782D0 (en) High performance mosfet
GB2340237B (en) Compounds for mass spectrometry
GB9727285D0 (en) Spectrometer

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 20000715

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): CH DE FR GB IT LI

A4 Supplementary search report drawn up and despatched

Effective date: 20100818

17Q First examination report despatched

Effective date: 20101126

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 20120703