EP1027054A4 - Lokale anwendung von phosphodiesterase inhibitoren zur behandlung der erektilen dysfunktion - Google Patents

Lokale anwendung von phosphodiesterase inhibitoren zur behandlung der erektilen dysfunktion

Info

Publication number
EP1027054A4
EP1027054A4 EP19980954032 EP98954032A EP1027054A4 EP 1027054 A4 EP1027054 A4 EP 1027054A4 EP 19980954032 EP19980954032 EP 19980954032 EP 98954032 A EP98954032 A EP 98954032A EP 1027054 A4 EP1027054 A4 EP 1027054A4
Authority
EP
European Patent Office
Prior art keywords
treatment
erectile dysfunction
local administration
phosphodiesterase inhibitors
phosphodiesterase
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
EP19980954032
Other languages
English (en)
French (fr)
Other versions
EP1027054A1 (de
Inventor
Paul C Doherty Jr
Virgil A Place
William L Smith
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Vivus LLC
Original Assignee
Vivus LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/181,070 external-priority patent/US6037346A/en
Application filed by Vivus LLC filed Critical Vivus LLC
Publication of EP1027054A1 publication Critical patent/EP1027054A1/de
Publication of EP1027054A4 publication Critical patent/EP1027054A4/de
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
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    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
    • A—HUMAN NECESSITIES
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4015—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
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    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
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  • Health & Medical Sciences (AREA)
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  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Reproductive Health (AREA)
  • Urology & Nephrology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
EP19980954032 1997-10-28 1998-10-28 Lokale anwendung von phosphodiesterase inhibitoren zur behandlung der erektilen dysfunktion Ceased EP1027054A4 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US958816 1992-10-09
US95881697A 1997-10-28 1997-10-28
US181070 1998-10-27
US09/181,070 US6037346A (en) 1997-10-28 1998-10-27 Local administration of phosphodiesterase inhibitors for the treatment of erectile dysfunction
PCT/US1998/022928 WO1999021558A2 (en) 1997-10-28 1998-10-28 Local administration of phosphodiesterase inhibitors for the treatment of erectile dysfunction

Publications (2)

Publication Number Publication Date
EP1027054A1 EP1027054A1 (de) 2000-08-16
EP1027054A4 true EP1027054A4 (de) 2002-11-04

Family

ID=25501340

Family Applications (1)

Application Number Title Priority Date Filing Date
EP19980954032 Ceased EP1027054A4 (de) 1997-10-28 1998-10-28 Lokale anwendung von phosphodiesterase inhibitoren zur behandlung der erektilen dysfunktion

Country Status (5)

Country Link
EP (1) EP1027054A4 (de)
JP (1) JP2003525845A (de)
AU (1) AU734734B2 (de)
CA (1) CA2305394C (de)
WO (1) WO1999021558A2 (de)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6331543B1 (en) 1996-11-01 2001-12-18 Nitromed, Inc. Nitrosated and nitrosylated phosphodiesterase inhibitors, compositions and methods of use
CA2295595A1 (en) 1997-07-09 1999-01-21 Androsolutions, Inc. Improved methods and compositions for treating male erectile dysfunction
US6103765A (en) 1997-07-09 2000-08-15 Androsolutions, Inc. Methods for treating male erectile dysfunction
US6403597B1 (en) 1997-10-28 2002-06-11 Vivus, Inc. Administration of phosphodiesterase inhibitors for the treatment of premature ejaculation
US6548490B1 (en) 1997-10-28 2003-04-15 Vivus, Inc. Transmucosal administration of phosphodiesterase inhibitors for the treatment of erectile dysfunction
US6472425B1 (en) 1997-10-31 2002-10-29 Nitromed, Inc. Methods for treating female sexual dysfunctions
US6541487B1 (en) * 1998-05-01 2003-04-01 R.T. Alamo Ventures I, Llc PDE III inhibitors for treating sexual dysfunction
DE19834506A1 (de) * 1998-07-31 2000-02-03 Hexal Ag Transmucosales therapeutisches System zur Anwendung von Sildenafil
CZ20012020A3 (cs) * 1998-12-07 2001-10-17 Nissan Chemical Industries, Ltd. Činidlo pro léčbu erektilní dysfunkce
IT1312310B1 (it) * 1999-05-07 2002-04-15 Recordati Ind Chimica E Farma Uso di antagonisti selettivi del recettore adrenergico a 1b per ilmiglioramento della disfunzione sessuale
IL130968A (en) 1999-07-15 2002-12-01 Shmuel Simon Pharmaceutical composition comprising sildenafil or its analogs, useful for the treatment of tinnitus and hearing loss
US6323241B1 (en) * 2000-01-10 2001-11-27 Nexmed (Holdings) Inc. Prostaglandin compositions and methods of treatment for male erectile dysfunction
CA2417552C (en) 2000-06-27 2014-05-13 Qualilife Pharmaceuticals Inc. Compositions and methods for treating females sexual response
US6503894B1 (en) 2000-08-30 2003-01-07 Unimed Pharmaceuticals, Inc. Pharmaceutical composition and method for treating hypogonadism
US6821978B2 (en) 2000-09-19 2004-11-23 Schering Corporation Xanthine phosphodiesterase V inhibitors
FI20002755A0 (fi) 2000-12-15 2000-12-15 Orion Yhtymae Oyj Menetelmä erektiilin dysfunktion hoitamiseen
HUP0401368A2 (hu) * 2000-12-19 2004-10-28 Merck Patent Gmbh Tienopirimidineket és trombózisellenes szereket, kalcium antagonistákat, prosztaglandinokat vagy prosztaglandin származékokat tartalmazó gyógyszerkészítmények
KR20030059349A (ko) * 2000-12-19 2003-07-07 메르크 파텐트 게엠베하 피라졸로[４,３-ｄ]피리미딘 및 항혈전제, 칼슘 길항제,프로스타글란딘 또는 프로스타글란딘 유도체를 포함하여이루어지는 약제학적 조성물
KR20030059351A (ko) * 2000-12-19 2003-07-07 메르크 파텐트 게엠베하 티에노피리미딘 및 항혈전제, 칼슘 길항제,프로스타글란딘 또는 프로스타글란딘 유도체를 포함하여이루어지는 약제학적 조성물
EP1224933A1 (de) * 2001-01-19 2002-07-24 Sanofi-Synthelabo Neue Kombination mit Alfuzosin und Apomorphin als Aktiva
WO2003042216A1 (en) 2001-11-09 2003-05-22 Schering Corporation Polycyclic guanine derivative phosphodiesterase v inhibitors
ATE477020T1 (de) 2002-06-07 2010-08-15 Dyax Corp Prevention und verringerung von ischemia
WO2004071533A1 (ja) * 2003-02-14 2004-08-26 Takeda Pharmaceutical Company Limited 局所投与用製剤
CA2536873C (en) * 2003-08-29 2019-09-10 Dyax Corp. Poly-pegylated protease inhibitors
US7235530B2 (en) 2004-09-27 2007-06-26 Dyax Corporation Kallikrein inhibitors and anti-thrombolytic agents and uses thereof
EP1802277B1 (de) * 2004-10-18 2010-01-13 Polymun Scientific Immunbiologische Forschung GmbH Liposomale zusammensetzung einen wirkstoff zur relaxierung glatter muskulatur enthaltend, die herstellung dieser zusammensetzung und deren therapeutische verwendung
KR20140054312A (ko) * 2007-02-12 2014-05-08 디엠아이 바이오사이언시스 인코포레이티드 조루 및 발기부전을 동시에 치료하는 방법
CA2690294A1 (en) * 2007-06-26 2008-12-31 Solvay Pharmaceuticals B.V. Sildenafil n-oxide as prodrug
US10428158B2 (en) 2014-03-27 2019-10-01 Dyax Corp. Compositions and methods for treatment of diabetic macular edema
CN114174298B (zh) * 2019-08-14 2023-08-01 正大天晴药业集团南京顺欣制药有限公司 哒嗪酮并嘧啶类衍生物及其医药用途

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994028902A1 (en) * 1993-06-09 1994-12-22 Pfizer Limited Pyrazolopyrimidinones for the treatment of impotence
WO1996016644A1 (en) * 1994-11-26 1996-06-06 Pfizer Limited cGMP-PDE INHIBITORS FOR THE TREATMENT OF ERECTILE DYSFUNCTION
WO1998019672A1 (en) * 1996-11-01 1998-05-14 Nitromed Inc. Nitrosated and nitrosylated phosphodiesterase inhibitor compounds, compositions and their uses
WO1998022453A1 (en) * 1996-11-20 1998-05-28 Byk Gulden Lomberg Chemische Fabrik Gmbh Substituted dihydrobenzofurans as pde inhibitors
WO1999021562A1 (en) * 1997-10-28 1999-05-06 Asivi, Llc Treatment of female sexual dysfunction

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4801587A (en) * 1987-03-02 1989-01-31 Gene Voss Impotence ointment
FR2649613B1 (fr) * 1989-07-11 1991-09-27 Virag Ronald Medicament vaso-actif
US5242391A (en) * 1990-04-25 1993-09-07 Alza Corporation Urethral insert for treatment of erectile dysfunction
US5250534A (en) * 1990-06-20 1993-10-05 Pfizer Inc. Pyrazolopyrimidinone antianginal agents
GB9114760D0 (en) * 1991-07-09 1991-08-28 Pfizer Ltd Therapeutic agents

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994028902A1 (en) * 1993-06-09 1994-12-22 Pfizer Limited Pyrazolopyrimidinones for the treatment of impotence
WO1996016644A1 (en) * 1994-11-26 1996-06-06 Pfizer Limited cGMP-PDE INHIBITORS FOR THE TREATMENT OF ERECTILE DYSFUNCTION
WO1998019672A1 (en) * 1996-11-01 1998-05-14 Nitromed Inc. Nitrosated and nitrosylated phosphodiesterase inhibitor compounds, compositions and their uses
WO1998022453A1 (en) * 1996-11-20 1998-05-28 Byk Gulden Lomberg Chemische Fabrik Gmbh Substituted dihydrobenzofurans as pde inhibitors
WO1999021562A1 (en) * 1997-10-28 1999-05-06 Asivi, Llc Treatment of female sexual dysfunction

Non-Patent Citations (9)

* Cited by examiner, † Cited by third party
Title
BOOLELL, M., ET AL.: "Sildenafil, a novel effective oral therapy for male erectile dysfunction", BRITISH JOURNAL OF UROLOGY, vol. 78, no. 2, 1996, pages 257 - 261, XP000853934 *
DERRY F ET AL: "SILDENAFIL (VIAGRA TM): A DOUBLE-BLIND, PLACEBO-CONTROLLED, SINGLE-DOSE, TWO-WAY CROSSOVER STUDY IN MEN WITH ERECTILE DYSFUNCTION CAUSED BY TRAUMATIC SPINAL CORD INJURY", JOURNAL OF UROLOGY, BALTIMORE, MD, US, vol. 157, no. SUPPL 4, 1997, pages 181, XP000921337, ISSN: 0022-5347 *
JEREMY J Y ET AL: "Effects of sildenafil, a type-5 cGMP phosphodiesterase inhibitor, and papaverine on cyclic GMP and cyclic AMP levels in the rabbit corpus cavernosum in vitro", BJU. BRITISH JOURNAL OF UROLOGY, J & C EDICIONES MEDICAS, ESPLUGUES DE LLOBREGAT, ES, vol. 79, 1997, pages 958 - 963, XP002090615, ISSN: 1139-4757 *
See also references of WO9921558A3 *
SPARWASSER C ET AL: "Smooth muscle tone regulation in rabbit cavernosal and spongiosal tissue by cyclic AMP- and cyclic GMP-dependent mechanisms.", JOURNAL OF UROLOGY, vol. 152, no. 6 PART 1, 1994, pages 2159 - 2163, XP000604575, ISSN: 0022-5347 *
STIEF C G (REPRINT) ET AL: "PHOSPHODIESTERASE ISOENZYMES OF THE HUMAN CAVERNOUS TISSUE AND ITS FUNCTIONAL-SIGNIFICANCE", AKTUELLE UROLOGIE, ( SEP 1995 ) VOL. 26, SP. ISS. 1, PP. 22-24. ISSN: 0001-7868., HANNOVER MED SCH, UROL KLIN, D-30623 HANNOVER, GERMANY (Reprint), XP008004657 *
STIEF C G (REPRINT) ET AL: "Selective pharmacological manipulation of the smooth muscle tissues of th genitourinary tract: Experimental and clinical studies", AKTUELLE UROLOGIE, ( MAR 1997 ) VOL. 28, NO. 2, PP. 76-87. PUBLISHER: GEORG THIEME VERLAG, P O BOX 30 11 20, D-70451 STUTTGART, GERMANY. ISSN: 0001-7868., HANNOVER MED SCH, UROL KLIN, D-30623 HANNOVER, GERMANY (Reprint), XP008004658 *
TAHER A ET AL: "Cyclic nucleotide phosphodiesterase in human cavernous smooth muscle.", WORLD JOURNAL OF UROLOGY, vol. 15, no. 1, 1997, pages 32 - 35, XP001021795, ISSN: 0724-4983 *
TRUSS MICHAEL C ET AL: "Phosphodiesterase inhibitors in the treatment of erectile dysfunction.", DRUGS OF TODAY, vol. 34, no. 9, 1998, pages 805 - 812, XP000885894, ISSN: 0025-7656 *

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WO1999021558A3 (en) 2000-10-26
AU734734B2 (en) 2001-06-21
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