EP1025229A4 - CHEMOKINES WITH N-TERMINAL MODIFICATIONS - Google Patents
CHEMOKINES WITH N-TERMINAL MODIFICATIONSInfo
- Publication number
- EP1025229A4 EP1025229A4 EP98953836A EP98953836A EP1025229A4 EP 1025229 A4 EP1025229 A4 EP 1025229A4 EP 98953836 A EP98953836 A EP 98953836A EP 98953836 A EP98953836 A EP 98953836A EP 1025229 A4 EP1025229 A4 EP 1025229A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- chemokines
- amino
- terminal modifications
- terminal
- modifications
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 102000019034 Chemokines Human genes 0.000 title 1
- 108010012236 Chemokines Proteins 0.000 title 1
- 238000011191 terminal modification Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/521—Chemokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Virology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Genetics & Genomics (AREA)
- Heart & Thoracic Surgery (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Cardiology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- AIDS & HIV (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
- Adhesives Or Adhesive Processes (AREA)
Applications Claiming Priority (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US95582697A | 1997-10-22 | 1997-10-22 | |
US955826 | 1997-10-22 | ||
PCT/US1998/004002 WO1998038212A2 (en) | 1997-02-28 | 1998-02-27 | Chimeric polypeptides containing chemokine domains |
WOPCT/US98/04002 | 1998-02-27 | ||
US09/175,713 US6852508B1 (en) | 1997-02-28 | 1998-10-20 | Chemokine with amino-terminal modifications |
US175713 | 1998-10-20 | ||
PCT/US1998/022282 WO1999020759A1 (en) | 1997-10-22 | 1998-10-21 | Chemokines with amino-terminal modifications |
Publications (2)
Publication Number | Publication Date |
---|---|
EP1025229A1 EP1025229A1 (en) | 2000-08-09 |
EP1025229A4 true EP1025229A4 (en) | 2003-06-18 |
Family
ID=56289826
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP98953836A Withdrawn EP1025229A4 (en) | 1997-10-22 | 1998-10-21 | CHEMOKINES WITH N-TERMINAL MODIFICATIONS |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP1025229A4 (ja) |
JP (1) | JP2003526315A (ja) |
AU (1) | AU758576C (ja) |
MX (1) | MXPA00003885A (ja) |
WO (1) | WO1999020759A1 (ja) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL130160A0 (en) * | 1996-12-02 | 2000-06-01 | Univ Wake Forest | Inactivation of HIV co-receptors as therapy for HIV infection |
WO2000046248A1 (en) * | 1999-02-03 | 2000-08-10 | Schering Corporation | Use of agonists or antagonists of mip-3a in therapy |
US6645491B1 (en) | 1999-02-03 | 2003-11-11 | Schering Corporation | Method for treating inflammatory conditions using an antibody to MIP-3α |
MXPA02005199A (es) * | 1999-11-24 | 2002-11-07 | Schering Corp | Metodos para inhibir metastasis. |
US7091310B2 (en) * | 2002-09-13 | 2006-08-15 | Chemokine Therapeutics Corporation | Chemokine analogs for the treatment of human disease |
DE10027383A1 (de) * | 2000-06-02 | 2001-12-20 | Rhein Biotech Proz & Prod Gmbh | Nukleinsäure-Molekül umfassend eine für ein Chemokin, einen Neuropeptid-Präkursor oder mindestens ein Neuropeptid kodierende Nukleinsäuresequenz |
CN1441808A (zh) * | 2000-07-12 | 2003-09-10 | 格莱风治疗公司 | 趋化因子受体调制剂,制备和用途 |
WO2002010138A2 (en) * | 2000-08-01 | 2002-02-07 | Schering Corporation | Uses of mammalian genes and related reagents |
AU2001288985A1 (en) * | 2000-09-13 | 2002-03-26 | Schering Corporation | Uses of mammalian genes and related reagents |
AU2002235168A1 (en) * | 2000-11-05 | 2002-05-15 | University Of Florida | Targeting pluripotent stem cells to tissues |
JP2005502723A (ja) * | 2001-09-20 | 2005-01-27 | シェーリング コーポレイション | 免疫応答のアジュバントとしてのケモカイン |
US20050271639A1 (en) * | 2002-08-22 | 2005-12-08 | Penn Marc S | Genetically engineered cells for therapeutic applications |
WO2004094465A2 (en) * | 2003-04-23 | 2004-11-04 | The Board Of Trustees Of The University Of Illinois Office Of Technology Management University Of Illinois At Urbana-Champaign | Synthetic molecules that mimic chemokines |
CA2682469A1 (en) | 2007-03-30 | 2008-10-09 | The Cleveland Clinic Foundation | Method of treating ischemic disorders |
EP2185719B1 (en) | 2007-08-02 | 2013-11-13 | NovImmune SA | Anti-rantes antibodies and methods of use thereof |
US20100272679A1 (en) | 2007-12-14 | 2010-10-28 | Penn Marc S | Compositions and methods of promoting wound healing |
EP2473196B1 (en) | 2009-08-28 | 2017-05-31 | The Cleveland Clinic Foundation | Sdf-1 delivery for treating ischemic tissue |
US20210388048A1 (en) | 2018-10-22 | 2021-12-16 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Cleavable activators of cxcr3 and methods of use |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1996017935A2 (en) * | 1994-12-08 | 1996-06-13 | Glaxo Group Limited | Rantes peptide and fragments and compositions comprising it for treatment of inflammation |
WO1997037005A1 (en) * | 1996-04-02 | 1997-10-09 | Progenics Pharmaceuticals, Inc. | Method for preventing hiv-1 infection of cd4+ cells |
WO1998004698A1 (fr) * | 1996-07-26 | 1998-02-05 | Institut Pasteur | Utilisation d'une chemokine (sdf-1) ligand pour le recepteur de lestr/fusin/cxcr4 pour prevenir ou traiter l'infection par des virus de type vih |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5656456A (en) * | 1992-07-13 | 1997-08-12 | Bionebraska, Inc. | Chemical method for selective modification of the N- and/or C-terminal amino acid α-carbon reactive group of a recombinant polypeptide or a portion thereof |
CA2117953C (en) * | 1993-10-14 | 2001-12-11 | Tasuku Honjo | Human stromal derived factor 1 alpha and 1 beta and dnas encoding the same |
-
1998
- 1998-02-27 MX MXPA00003885A patent/MXPA00003885A/es unknown
- 1998-10-21 AU AU11105/99A patent/AU758576C/en not_active Ceased
- 1998-10-21 EP EP98953836A patent/EP1025229A4/en not_active Withdrawn
- 1998-10-21 JP JP2000517080A patent/JP2003526315A/ja not_active Withdrawn
- 1998-10-21 WO PCT/US1998/022282 patent/WO1999020759A1/en not_active Application Discontinuation
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1996017935A2 (en) * | 1994-12-08 | 1996-06-13 | Glaxo Group Limited | Rantes peptide and fragments and compositions comprising it for treatment of inflammation |
WO1997037005A1 (en) * | 1996-04-02 | 1997-10-09 | Progenics Pharmaceuticals, Inc. | Method for preventing hiv-1 infection of cd4+ cells |
WO1998004698A1 (fr) * | 1996-07-26 | 1998-02-05 | Institut Pasteur | Utilisation d'une chemokine (sdf-1) ligand pour le recepteur de lestr/fusin/cxcr4 pour prevenir ou traiter l'infection par des virus de type vih |
Non-Patent Citations (3)
Title |
---|
LOCKHART EUAN ET AL: "The cloning, expression and purification of cervine interleukin 2.", CYTOKINE, vol. 8, no. 8, 1996, pages 603 - 612, XP002238542, ISSN: 1043-4666 * |
See also references of WO9920759A1 * |
SIMMONS G ET AL: "POTENT INHIBITION OF HIV-1 INFECTIVITY IN MACROPHAGES AND LYMPHOCYTES BY A NOVEL CCR5 ANTOGONIST", SCIENCE, AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE, US, vol. 276, 1997, pages 276 - 279, XP000887293, ISSN: 0036-8075 * |
Also Published As
Publication number | Publication date |
---|---|
EP1025229A1 (en) | 2000-08-09 |
AU758576B2 (en) | 2003-03-27 |
MXPA00003885A (es) | 2004-04-23 |
WO1999020759A1 (en) | 1999-04-29 |
AU758576C (en) | 2004-04-29 |
JP2003526315A (ja) | 2003-09-09 |
AU1110599A (en) | 1999-05-10 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
17P | Request for examination filed |
Effective date: 20000522 |
|
AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE |
|
RAP1 | Party data changed (applicant data changed or rights of an application transferred) |
Owner name: THE GENERAL HOSPITAL CORPORATION Owner name: GENETICS INSTITUTE, LLC |
|
RIC1 | Information provided on ipc code assigned before grant |
Ipc: 7G 01N 33/68 B Ipc: 7A 61K 38/19 B Ipc: 7C 07K 16/24 B Ipc: 7C 07K 14/52 B Ipc: 7C 12N 15/62 B Ipc: 7C 12N 15/19 A |
|
A4 | Supplementary search report drawn up and despatched |
Effective date: 20030506 |
|
17Q | First examination report despatched |
Effective date: 20041004 |
|
17Q | First examination report despatched |
Effective date: 20041004 |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
|
18D | Application deemed to be withdrawn |
Effective date: 20070328 |