EP1025229A4 - Chemokines with amino-terminal modifications - Google Patents

Chemokines with amino-terminal modifications

Info

Publication number
EP1025229A4
EP1025229A4 EP98953836A EP98953836A EP1025229A4 EP 1025229 A4 EP1025229 A4 EP 1025229A4 EP 98953836 A EP98953836 A EP 98953836A EP 98953836 A EP98953836 A EP 98953836A EP 1025229 A4 EP1025229 A4 EP 1025229A4
Authority
EP
European Patent Office
Prior art keywords
chemokines
amino
terminal modifications
terminal
modifications
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP98953836A
Other languages
German (de)
French (fr)
Other versions
EP1025229A1 (en
Inventor
Stephen H Herrmann
Zhijian Lu
John M Mccoy
Stephen L Swanberg
Bruce Walker
Otto Yang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
General Hospital Corp
Genetics Institute LLC
Original Assignee
General Hospital Corp
Genetics Institute LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/US1998/004002 external-priority patent/WO1998038212A2/en
Priority claimed from US09/175,713 external-priority patent/US6852508B1/en
Application filed by General Hospital Corp, Genetics Institute LLC filed Critical General Hospital Corp
Publication of EP1025229A1 publication Critical patent/EP1025229A1/en
Publication of EP1025229A4 publication Critical patent/EP1025229A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/521—Chemokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • AIDS & HIV (AREA)
  • Biochemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Adhesives Or Adhesive Processes (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
EP98953836A 1997-10-22 1998-10-21 Chemokines with amino-terminal modifications Withdrawn EP1025229A4 (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US95582697A 1997-10-22 1997-10-22
US955826 1997-10-22
WOPCT/US98/04002 1998-02-27
PCT/US1998/004002 WO1998038212A2 (en) 1997-02-28 1998-02-27 Chimeric polypeptides containing chemokine domains
US09/175,713 US6852508B1 (en) 1997-02-28 1998-10-20 Chemokine with amino-terminal modifications
US175713 1998-10-20
PCT/US1998/022282 WO1999020759A1 (en) 1997-10-22 1998-10-21 Chemokines with amino-terminal modifications

Publications (2)

Publication Number Publication Date
EP1025229A1 EP1025229A1 (en) 2000-08-09
EP1025229A4 true EP1025229A4 (en) 2003-06-18

Family

ID=56289826

Family Applications (1)

Application Number Title Priority Date Filing Date
EP98953836A Withdrawn EP1025229A4 (en) 1997-10-22 1998-10-21 Chemokines with amino-terminal modifications

Country Status (5)

Country Link
EP (1) EP1025229A4 (en)
JP (1) JP2003526315A (en)
AU (1) AU758576C (en)
MX (1) MXPA00003885A (en)
WO (1) WO1999020759A1 (en)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL130160A0 (en) * 1996-12-02 2000-06-01 Univ Wake Forest Inactivation of HIV co-receptors as therapy for HIV infection
EP1149113A1 (en) * 1999-02-03 2001-10-31 Schering Corporation Use of agonists or antagonists of mip-3a in therapy
US6645491B1 (en) 1999-02-03 2003-11-11 Schering Corporation Method for treating inflammatory conditions using an antibody to MIP-3α
CA2389979C (en) * 1999-11-24 2011-08-16 Schering Corporation Methods of inhibiting metastasis
US7091310B2 (en) * 2002-09-13 2006-08-15 Chemokine Therapeutics Corporation Chemokine analogs for the treatment of human disease
DE10027383A1 (en) * 2000-06-02 2001-12-20 Rhein Biotech Proz & Prod Gmbh Nucleic acid molecule comprising a nucleic acid sequence coding for a chemokine, a neuropeptide precursor or at least one neuropeptide
CA2412150A1 (en) * 2000-07-12 2002-01-17 Gryphon Therapeutics, Inc. Polymer-modified bioactive synthetic chemokines, and methods for their manufacture and use
AU2001280891A1 (en) * 2000-08-01 2002-02-13 Schering Corporation Uses of mammalian genes and related reagents
AU2001288985A1 (en) * 2000-09-13 2002-03-26 Schering Corporation Uses of mammalian genes and related reagents
WO2002036078A2 (en) * 2000-11-05 2002-05-10 University Of Florida Targeting pluripotent stem cells to tissues
CA2460321A1 (en) * 2001-09-20 2003-03-27 Schering Corporation Chemokines as adjuvants of immune response
US20140170116A9 (en) 2002-08-22 2014-06-19 Marc S. Penn Method of treating ischemic disorders
US20050271639A1 (en) * 2002-08-22 2005-12-08 Penn Marc S Genetically engineered cells for therapeutic applications
WO2004094465A2 (en) * 2003-04-23 2004-11-04 The Board Of Trustees Of The University Of Illinois Office Of Technology Management University Of Illinois At Urbana-Champaign Synthetic molecules that mimic chemokines
DK2185719T3 (en) 2007-08-02 2014-02-17 Novimmune Sa ANTI-RANTES ANTIBODIES AND PROCEDURES FOR USE THEREOF
WO2009079451A2 (en) 2007-12-14 2009-06-25 The Cleveland Clinic Foundation Compositions and methods of promoting wound healing
CA2772610C (en) 2009-08-28 2018-01-23 The Cleveland Clinic Foundation Sdf-1 delivery for treating ischemic tissue
AU2019365654A1 (en) 2018-10-22 2021-05-13 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Cleavable activators of CXCR3 and methods of use

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996017935A2 (en) * 1994-12-08 1996-06-13 Glaxo Group Limited Rantes peptide and fragments and compositions comprising it for treatment of inflammation
WO1997037005A1 (en) * 1996-04-02 1997-10-09 Progenics Pharmaceuticals, Inc. Method for preventing hiv-1 infection of cd4+ cells
WO1998004698A1 (en) * 1996-07-26 1998-02-05 Institut Pasteur Use of a lestr/fusin/cxcr4 receptor ligand chemokine (sdf-1) for treating or preventing hiv-type viral infection

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5656456A (en) * 1992-07-13 1997-08-12 Bionebraska, Inc. Chemical method for selective modification of the N- and/or C-terminal amino acid α-carbon reactive group of a recombinant polypeptide or a portion thereof
JP3367581B2 (en) * 1993-10-14 2003-01-14 小野薬品工業株式会社 Novel polypeptide, method for producing the same, DNA encoding the polypeptide, vector comprising the DNA, and host cells transformed with the vector

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996017935A2 (en) * 1994-12-08 1996-06-13 Glaxo Group Limited Rantes peptide and fragments and compositions comprising it for treatment of inflammation
WO1997037005A1 (en) * 1996-04-02 1997-10-09 Progenics Pharmaceuticals, Inc. Method for preventing hiv-1 infection of cd4+ cells
WO1998004698A1 (en) * 1996-07-26 1998-02-05 Institut Pasteur Use of a lestr/fusin/cxcr4 receptor ligand chemokine (sdf-1) for treating or preventing hiv-type viral infection

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
LOCKHART EUAN ET AL: "The cloning, expression and purification of cervine interleukin 2.", CYTOKINE, vol. 8, no. 8, 1996, pages 603 - 612, XP002238542, ISSN: 1043-4666 *
See also references of WO9920759A1 *
SIMMONS G ET AL: "POTENT INHIBITION OF HIV-1 INFECTIVITY IN MACROPHAGES AND LYMPHOCYTES BY A NOVEL CCR5 ANTOGONIST", SCIENCE, AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE, US, vol. 276, 1997, pages 276 - 279, XP000887293, ISSN: 0036-8075 *

Also Published As

Publication number Publication date
AU1110599A (en) 1999-05-10
JP2003526315A (en) 2003-09-09
WO1999020759A1 (en) 1999-04-29
EP1025229A1 (en) 2000-08-09
AU758576B2 (en) 2003-03-27
AU758576C (en) 2004-04-29
MXPA00003885A (en) 2004-04-23

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Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

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17P Request for examination filed

Effective date: 20000522

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

RAP1 Party data changed (applicant data changed or rights of an application transferred)

Owner name: THE GENERAL HOSPITAL CORPORATION

Owner name: GENETICS INSTITUTE, LLC

RIC1 Information provided on ipc code assigned before grant

Ipc: 7G 01N 33/68 B

Ipc: 7A 61K 38/19 B

Ipc: 7C 07K 16/24 B

Ipc: 7C 07K 14/52 B

Ipc: 7C 12N 15/62 B

Ipc: 7C 12N 15/19 A

A4 Supplementary search report drawn up and despatched

Effective date: 20030506

17Q First examination report despatched

Effective date: 20041004

17Q First examination report despatched

Effective date: 20041004

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 20070328