EP1021462A4 - Essais pour ligands a recepteurs nucleaires reposant sur le transfert d'energie de resonance en fluorescence - Google Patents
Essais pour ligands a recepteurs nucleaires reposant sur le transfert d'energie de resonance en fluorescenceInfo
- Publication number
- EP1021462A4 EP1021462A4 EP98956094A EP98956094A EP1021462A4 EP 1021462 A4 EP1021462 A4 EP 1021462A4 EP 98956094 A EP98956094 A EP 98956094A EP 98956094 A EP98956094 A EP 98956094A EP 1021462 A4 EP1021462 A4 EP 1021462A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- fret
- assays
- nuclear receptor
- receptor ligands
- ligands
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/536—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
- G01N33/542—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with steric inhibition or signal modification, e.g. fluorescent quenching
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/566—Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6875—Nucleoproteins
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
- G01N2333/70567—Nuclear receptors, e.g. retinoic acid receptor [RAR], RXR, nuclear orphan receptors
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Cell Biology (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biotechnology (AREA)
- Analytical Chemistry (AREA)
- Microbiology (AREA)
- Food Science & Technology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Physics & Mathematics (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US6138597P | 1997-10-07 | 1997-10-07 | |
US61385P | 1997-10-07 | ||
PCT/US1998/021049 WO1999018124A1 (fr) | 1997-10-07 | 1998-10-06 | Essais pour ligands a recepteurs nucleaires reposant sur le transfert d'energie de resonance en fluorescence |
Publications (2)
Publication Number | Publication Date |
---|---|
EP1021462A1 EP1021462A1 (fr) | 2000-07-26 |
EP1021462A4 true EP1021462A4 (fr) | 2005-04-13 |
Family
ID=22035450
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP98956094A Withdrawn EP1021462A4 (fr) | 1997-10-07 | 1998-10-06 | Essais pour ligands a recepteurs nucleaires reposant sur le transfert d'energie de resonance en fluorescence |
Country Status (4)
Country | Link |
---|---|
EP (1) | EP1021462A4 (fr) |
JP (1) | JP2001519525A (fr) |
CA (1) | CA2305711A1 (fr) |
WO (1) | WO1999018124A1 (fr) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2002528721A (ja) * | 1998-10-23 | 2002-09-03 | グラクソ グループ リミテッド | 核内受容体のリガンド用のアッセイ |
EP1140079B1 (fr) * | 1998-12-23 | 2009-06-03 | Glaxo Group Limited | Methodes de titrage de ligands de recepteurs nucleaires |
WO2001020326A2 (fr) * | 1999-09-13 | 2001-03-22 | Equitech Laboratories, Inc. | Materiaux et procede de detection et de quantification d'un analysat |
WO2001040805A1 (fr) * | 1999-11-30 | 2001-06-07 | Akzo Nobel N.V. | Composes steroidiques destines a des dosages par liaison de recepteur de steroides |
WO2001071352A2 (fr) * | 2000-03-17 | 2001-09-27 | The Salk Institute For Biological Studies | Compositions associees a la formation de complexes et leurs procedes d'utilisation |
US7198924B2 (en) | 2000-12-11 | 2007-04-03 | Invitrogen Corporation | Methods and compositions for synthesis of nucleic acid molecules using multiple recognition sites |
US6924311B2 (en) | 2001-10-17 | 2005-08-02 | X-Ceptor Therapeutics, Inc. | Methods for affecting various diseases utilizing LXR compounds |
DE60116109T2 (de) | 2001-11-07 | 2006-09-07 | Schering Ag | In vitro Screening nach Liganden des Östrogenrezeptors |
WO2004010107A2 (fr) * | 2002-07-24 | 2004-01-29 | 3-Dimensional Pharmaceuticals, Inc. | Procede permettant de determiner la regulation de l'elimination des xenobiotiques |
WO2004042404A1 (fr) * | 2002-11-07 | 2004-05-21 | Erasmus Universiteit Rotterdam | Sondes fret et procedes de detection de molecules d'interaction |
JP4803976B2 (ja) * | 2003-07-09 | 2011-10-26 | 独立行政法人科学技術振興機構 | 細胞内ip3測定用分子センサー |
WO2005021025A2 (fr) * | 2003-08-28 | 2005-03-10 | Choongwae Pharma Corporation | Modulation de la transcription activee par ?-catenine/tcf |
WO2005054438A2 (fr) | 2003-12-01 | 2005-06-16 | Invitrogen Corporation | Molecule d'acide nucleique contenant des sites de recombinaison et leurs procedes d'utilisation |
US20080286260A1 (en) * | 2004-03-26 | 2008-11-20 | Bayer Healthcare Ag | Diagnostic and Therapeutics for Diseases Associated with Peroxisome Proliferative Activated Receptor Alpha (Ppara) |
KR100704011B1 (ko) | 2005-02-16 | 2007-04-04 | 한국과학기술원 | 금속나노입자와 양자점의 fret에 의한 생체분자특이결합 검출 방법 |
JP4936476B2 (ja) * | 2005-06-28 | 2012-05-23 | 第一三共株式会社 | Lxrリガンドの試験方法 |
JP5264421B2 (ja) | 2007-11-22 | 2013-08-14 | 富士フイルム株式会社 | 被験物測定用担体およびその製造方法 |
WO2009141926A1 (fr) * | 2008-05-23 | 2009-11-26 | 国立大学法人東京大学 | Procédé d'acquisition d'un composé capable d'agir sur le métabolisme du glucose/métabolisme lipidique |
WO2015159292A2 (fr) | 2014-04-14 | 2015-10-22 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Procédé et kit permettant de déterminer l'origine tissulaire ou cellulaire de l'adn |
JP2019521673A (ja) | 2016-06-07 | 2019-08-08 | ザ リージェンツ オブ ザ ユニヴァーシティー オブ カリフォルニア | 疾患および状態の分析のためのセルフリーdnaメチル化パターン |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1998056806A1 (fr) * | 1997-06-12 | 1998-12-17 | The Regents Of The University Of California | Proteine de coactivation de facteur de transcription, p/cip |
WO1999041608A2 (fr) * | 1998-02-12 | 1999-08-19 | Prolifix Limited | Interaction de la cycline d1 et des coactivateurs de recepteur steroidien, et utilisations aux fins d'essais |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9608143D0 (en) * | 1996-04-19 | 1996-06-26 | Ver Nl Kanker Inst | Assay |
-
1998
- 1998-10-06 EP EP98956094A patent/EP1021462A4/fr not_active Withdrawn
- 1998-10-06 JP JP2000514931A patent/JP2001519525A/ja active Pending
- 1998-10-06 WO PCT/US1998/021049 patent/WO1999018124A1/fr active Application Filing
- 1998-10-06 CA CA002305711A patent/CA2305711A1/fr not_active Abandoned
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1998056806A1 (fr) * | 1997-06-12 | 1998-12-17 | The Regents Of The University Of California | Proteine de coactivation de facteur de transcription, p/cip |
WO1999041608A2 (fr) * | 1998-02-12 | 1999-08-19 | Prolifix Limited | Interaction de la cycline d1 et des coactivateurs de recepteur steroidien, et utilisations aux fins d'essais |
Non-Patent Citations (9)
Title |
---|
CLINICAL CHEMISTRY, vol. 43, no. 6 PART 2, 1997, 49TH ANNUAL MEETING OF THE AMERICAN ASSOCIATION FOR CLINICAL CHEMISTRY; ATLANTA, GEORGIA, USA; JULY 20-24, 1997, pages S159, ISSN: 0009-9147 * |
DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; 22 July 1997 (1997-07-22), BELLANGER L ET AL: "Homogeneous time-resolved fluoroimmunoassay for cardiac troponin-I using TRACE technology", XP008042758, Database accession no. PREV199799633726 * |
KOLB A J ET AL: "HOMOGENEOUS, TIME-RESOLVED FLUORESCENCE METHOD FOR DRUG DISCOVERY", 1997, HIGH-THROUGHPUT SCREENING, THE DISCOVERY OF BIOACTIVE SUBSTANCES, XX, XX, PAGE(S) 345-360, XP008042717 * |
KOLB J M ET AL: "USE OF A NOVEL HOMOGENEOUS FLUORESCENT TECHNOLOGY IN HIGH THROUGHPUT SCREENING", JOURNAL OF BIOMOLECULAR SCREENING, LARCHMONT, NY, US, vol. 1, no. 4, 1996, pages 203 - 210, XP008042702, ISSN: 1087-0571 * |
LEE S P ET AL: "CHARACTERIZATION OF ENDONUCLEOLYTIC ACTIVITY OF HIV-1 INTEGRASE USING A FLUOROGENIC SUBSTRATE", ANALYTICAL BIOCHEMISTRY, ACADEMIC PRESS, SAN DIEGO, CA, US, vol. 227, 1995, pages 295 - 301, XP002945389, ISSN: 0003-2697 * |
MATHIS G: "PROBING MOLECULAR INTERACTIONS WITH HOMOGENEOUS TECHNIQUES BASED ONRARE EARTH CRYPTATES AND FLUORESCENCE ENERGY TRANSFER", CLINICAL CHEMISTRY, vol. 41, no. 9, 1995, pages 1391 - 1397, XP001018128, ISSN: 0009-9147 * |
ROGERS M V: "LIGHT ON HIGH-THROUGHPUT SCREENING: FLUORESCENCE-BASED ASSAY TECHNOLOGIES", DRUG DISCOVERY TODAY, ELSEVIER SCIENCE LTD, GB, vol. 2, no. 4, April 1997 (1997-04-01), pages 156 - 160, XP002916138, ISSN: 1359-6446 * |
See also references of WO9918124A1 * |
ZHOU G ET AL: "Use of homogeneous time-resolved fluorescence energy transfer in the measurement of nuclear receptor activation", METHODS : A COMPANION TO METHODS IN ENZYMOLOGY, ACADEMIC PRESS INC., NEW YORK, NY, US, vol. 25, no. 1, September 2001 (2001-09-01), pages 54 - 61, XP002267175, ISSN: 1046-2023 * |
Also Published As
Publication number | Publication date |
---|---|
EP1021462A1 (fr) | 2000-07-26 |
JP2001519525A (ja) | 2001-10-23 |
WO1999018124A1 (fr) | 1999-04-15 |
CA2305711A1 (fr) | 1999-04-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
17P | Request for examination filed |
Effective date: 20000508 |
|
AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE |
|
A4 | Supplementary search report drawn up and despatched |
Effective date: 20050225 |
|
17Q | First examination report despatched |
Effective date: 20060915 |
|
17Q | First examination report despatched |
Effective date: 20060915 |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
|
18D | Application deemed to be withdrawn |
Effective date: 20071204 |