EP0999432A2 - Procédé d' opération d' un système de dosage électronique et système de dosage pour la mise en oeuvre du procédé - Google Patents

Procédé d' opération d' un système de dosage électronique et système de dosage pour la mise en oeuvre du procédé Download PDF

Info

Publication number
EP0999432A2
EP0999432A2 EP99120656A EP99120656A EP0999432A2 EP 0999432 A2 EP0999432 A2 EP 0999432A2 EP 99120656 A EP99120656 A EP 99120656A EP 99120656 A EP99120656 A EP 99120656A EP 0999432 A2 EP0999432 A2 EP 0999432A2
Authority
EP
European Patent Office
Prior art keywords
dosing
data
charging
dosing system
data transfer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP99120656A
Other languages
German (de)
English (en)
Other versions
EP0999432B2 (fr
EP0999432B1 (fr
EP0999432A3 (fr
Inventor
Dirk Jansen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eppendorf SE
Original Assignee
Eppendorf SE
Eppendorf Netheler Hinz GmbH
Eppendorf Geraetebau Netheler and Hinz GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=7886673&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EP0999432(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Eppendorf SE, Eppendorf Netheler Hinz GmbH, Eppendorf Geraetebau Netheler and Hinz GmbH filed Critical Eppendorf SE
Publication of EP0999432A2 publication Critical patent/EP0999432A2/fr
Publication of EP0999432A3 publication Critical patent/EP0999432A3/fr
Application granted granted Critical
Publication of EP0999432B1 publication Critical patent/EP0999432B1/fr
Publication of EP0999432B2 publication Critical patent/EP0999432B2/fr
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Images

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02—Burettes; Pipettes
    • B01L3/021—Pipettes, i.e. with only one conduit for withdrawing and redistributing liquids
    • B01L3/0217—Pipettes, i.e. with only one conduit for withdrawing and redistributing liquids of the plunger pump type
    • B01L3/0227—Details of motor drive means
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/02—Identification, exchange or storage of information
    • B01L2300/025—Displaying results or values with integrated means
    • B01L2300/027—Digital display, e.g. LCD, LED

Definitions

  • the invention relates to a method for operating an electronic Dosing system with an electronic hand dosing device and on a dosing system to carry out the method.
  • Electronic dosing devices are used in dosing laboratories of liquids. They are in different designs known. Have dosing devices working according to the air cushion principle an integrated piston-cylinder unit, by means of which an air column can be moved is to suck in and out of sample liquid in a dosing tip to expel this.
  • the piston-cylinder unit does not come into play here Contact with the liquid. Only the dosing tip, which is usually made up Plastic is contaminated and can be replaced after use become.
  • a syringe With direct displacement dosing devices, however, a syringe becomes direct filled with sample liquid. So the pistons and cylinders of the syringe contaminated by the liquid so that the syringe before changing the Liquid is usually replaced or cleaned with a new syringe got to.
  • the syringe is also usually made of plastic.
  • Pistonless metering devices can be a metering tip with a balloon-like Have end portion that for sucking liquid is expanded and compressed to eject. Such dosing tips are has also been designed as an exchange part.
  • Microdosing devices can be a micromembrane pump and / or have a free jet dispenser, at least one of these components microsystem technology, especially in silicon, glass, Plastic injection molding and / or plastic stamping technology.
  • the dosage will achieved by deforming a wall of a chamber with liquid is filled.
  • the electrical drive for deforming the wall can be piezoelectric, thermoelectric, electromagnetic, electrostatic, electromechanical, be magneto-restrictive etc.
  • Air cushion, direct displacement, pistonless and microdosing devices can have an unchangeable or a variable dosing volume.
  • a change in the dosing volume is done by adjusting the displacement reached the displacement device, d. H. of the displacement path the piston or the degree of deformation of the balloon-like end section or the chamber wall.
  • Dispensers are dosing devices that contain an absorbed volume of liquid can deliver repetitively in small portions.
  • All dosing devices can be designed as hand-held devices.
  • All of the aforementioned metering devices can be electronic metering devices an electronic dosing system in the sense of this application. They have a drive device with an electric drive to drive the displacement device. They also have one electronic control and / or regulating device, in particular for the Drive, which is an electric drive motor, an electric linear drive or one of those mentioned in connection with microdosing devices Can be drives. They also have an electrical voltage source to supply control and / or regulating device and drive, the can be rechargeable. Electronic dosing devices have the advantage the high reproducibility of doses. Especially through preset ones Dosing speeds ( ⁇ l / s) can achieve more precise results are considered to be with manually powered devices. You can also use the The advantage of multifunctionality is that they have pipetting, dispensing, titration, Can perform mixed etc. functions.
  • the well-known Response® electronic handheld dispensers Applicants work according to the air cushion principle and are available in single-channel or multi-channel versions. Four models cover the Dosing range from 0.5 ⁇ l to 5 ml. This metering device can be in different Operating modes, including pipette and dispense. The Dispensing is possible in up to 25 steps. The user can choose between three different dosing speeds. The dosing device can be used to charge the battery cells in a charging station.
  • the previously known electronic manual dosing devices have the Disadvantage that the specific operating parameters (e.g. step sizes of the Piston feeds, dosing speeds, state of charge criteria, display outputs) and the program are fixed.
  • the electronic Control device namely comprises a microcomputer which is fixed after one stored program works in which these parameters are contained. Special software is therefore required for each model and one Subsequent changes to the parameters are hardly possible. It is also disadvantageous that the programming of the hands-free operation is laborious over the Keyboard of the hand dosing device must be done and that in free-hand operation the programmed steps are rigidly processed and the The operational sequence cannot be influenced.
  • Dosing devices are test equipment in the sense of the GLP (Good Laboratory Practice) guidelines and comparable QS standards (ISO 9000 ff, EN 45000 ff). According to the GLP guidelines, the published by the manufacturer Error limits are checked at regular intervals. The applicant has disclosed a system with which the Calibration of dosing devices quickly, conveniently and inexpensively accomplish.
  • This system is based on a PICASO® calibration software that works on a PC is running.
  • the software all relevant data of the testing dosing devices. Deviations from these target values are immediately after transfer of the weighing values to the computer determined.
  • a series of measurements comprises up to 15 individual weighings. From that become Average, inaccuracy, imprecision and standard deviation determined and compared with predetermined target values. All measurement and reference data can be logged in accordance with GLP-DIN.
  • the control panel of the electronic hand-held dosing device entered the dosing data and controlled their operation.
  • the weighing values are typed into the PC. This is tedious and can be too Make mistakes.
  • the object of the invention is a method to operate an electronic dosing system in which the Influenceability of operating parameters, operating procedures, program parts or entire programs is improved.
  • advantageous Dosing systems provided for performing the method become.
  • the external data processing system can therefore be used access to the read-write memory of the manual dosing device become. This opens up the possibility of changing operating parameters, to which the program-controlled electronic control and / or regulating device falls back on when carrying out operations.
  • Other device-specific parameters can relate in particular to the monitoring of operating states (e.g.
  • evaluation criteria for the state of charge of an accumulator, for the actuation of a limit switch or for the duration of a break for the purpose of switching off in one Device-specific parameters can in particular be an identification of the device, an identification code for a parameter set stored in each case, etc.
  • User parameters are data that the user can manually enter via a Keyboard of the handheld dosing device can be entered. For this include in particular the dosing volume, dosing speeds etc. Further application parameters concern the calibration of the hand dosing device. In a simple case, this can be a correction factor to convert the set dosing quantities to the actual act dispensed quantities. In particular, this can also Coefficients of a function, which is the deviation of the set from the actual dispensed quantities with different quantity settings includes.
  • routines for carrying out operational processes in the read / write memory of the hand-held metering device so that the program-controlled electronic control and / or regulating device accesses them.
  • routines can be created by the user and are used to control operational sequences composed of several operating processes, especially if these have to be repeated.
  • Short programs "control the intake, mixing and dispensing of certain quantities of liquid or a dilution series in which the dispensed volume is halved from dilution step to dilution step. This simplifies the use of routines for the user.
  • routines stored in the data processing system Hand over metering device There is also the possibility of storing routines stored in the data processing system Hand over metering device.
  • the program can be done by means of the external data processing system the program-controlled electronic control and / or regulating device or at least a part of it is written into the read-write memory and / or read from it. That's what memory is for preferably a flash memory of a processor.
  • a processor with flash memory has implemented a program provided by the manufacturer that initiate communication for data exchange via an interface can. This makes it possible to partially in each hand dosing device or completely different program from the outside via the data interfaces import or change the program in whole or in part.
  • a remote control is possible using the external data processing system the manual dosing device possible.
  • This favors in particular the calibration by the respective dosing data by means of the data processing system transferred to the hand dosing device and if necessary even their operation entirely by means of the data processing system is controlled.
  • the data processing system can each Log dosing data. If necessary, this can be done together with the respective measured values happen, if these are recorded and in the data processing system be imported.
  • a wired or wireless remote control of the Hand dosing device This favors automation in particular the dosing processes, the use of the hand dosing device in a higher-level automation process or safe dosing in a contaminated environment.
  • the invention thus enables the specific parameters of the metering device to be determined only after the device has been installed, even if this is the Includes installation of a module with permanently programmed software. This makes it possible to use the same for different device models Use software and electronics hardware.
  • the respective Parameters can be set or even changed as needed.
  • favors the Invention an automation of calibration and final inspection in manufacturing.
  • the service will receive an easy update to new operating parameters enables.
  • the OEM customer can in turn set parameters for Carry out special OEM dosing parts.
  • the GLP parameter documentation is available to the user facilitated and a simplified calibration with PC software. He will also be involved in automation processes facilitated and enables remote control.
  • the data interfaces of the hand dosing device and the data transfer device can be connected to each other temporarily or permanently. It can be data interfaces that are only connected to each other can be when the hand dosing device in the data transfer device is inserted. The data interfaces can also be independent of which are connected to one another, whether the manual dosing device in the Data transfer device is used.
  • the data interfaces of the hand dosing device and the data transfer device can communicate with each other through radio transmitters and Radio receiver must be connected.
  • the data interfaces can also be used together have communicating IR transmitters and IR receivers. Hereby a permanent connection of the data interfaces or a wireless remote control favors.
  • the Data interfaces have interconnectable electrical contacts, by inserting the hand dosing device into the data transfer device can be connectable.
  • the electronic control device preferably has a microcomputer, especially a microcontroller.
  • the data transfer device can be connected to a separate data processing system, for example with a PC, or an integrated data processing system have, in particular a microcomputer or microcontroller.
  • the electronic control and / or regulating device and / or the data processing system can conventional input and output and storage facilities have, including a removable storage medium.
  • a program for the Remote control and / or calibration of the hand dosing device available his. This favors the equipment of the dosing system with software as required and updated.
  • the hand dosing device can work independently of the mains.
  • it can be provided with a chargeable voltage source, for example one or more batteries.
  • the data transfer device is a charging part for charging the voltage source and a charging interface connected to the charging part for connection with the charging interface of the hand dosing device.
  • the Loading interfaces of the hand dosing device and the data transfer device can have interacting electrical charging contacts. This can coincide with the contacts of the data interfaces.
  • the Data transmission can in particular be based on the charging voltage or the charging current of the charging unit. By modulating the charging voltage or the Charge currents can transmit data on the same physical channel will be realized.
  • the data transfer device can be designed as a stationary device.
  • the hand dosing device can also be used as a stationary device Device or used as an automatic dosing device when it is in the data transfer device is inserted. Then the power supply to the Manual dosing device must be ensured via the charging unit.
  • the electronic hand-held dosing device consists essentially from six functional areas, namely a drive device 1, a displacement device 2, an electronic control and / or Control device 3, an electrical voltage source 4, an operating device 5 and a display device 6.
  • the drive device 1 has an electric drive motor that is designed as a stepper motor 7.
  • An axis 8 is formed by means of the stepping motor 7 can be moved linearly back and forth. It also belongs to the drive device an engine stage in the form of two H-bridges 9, the control the stepper motor 7 is used.
  • the displacement device 2 has a piston 11 on the axis 8 is fixed.
  • the piston 11 is displaceable in a cylinder 12. This is connected via a channel 13 to a metering tip 14 by the device is separable.
  • a microcontroller belongs to the electronic control and / or regulating device 3 15, in particular a timer, a working memory and a integrated non-volatile memory.
  • the microcontroller controls the H-bridges via control lines 16.
  • a bidirectional device belongs to the electronic control and / or regulating device 3 serial interface 17, which has electrical sliding contacts 18 and is connected to the microcontroller 115 via data lines 19. Further This includes an EEPROM 20, which is connected to the microcontroller via data lines 21 15 is connected.
  • the electronic control and / or regulating device 3 a step-up converter 22 for generating the supply voltage of the Stepper motor 7, which feeds the H-bridges 9 via supply lines 23.
  • Control lines 24 connect the microcontroller 15 to the step-up converter 22.
  • Step-up converter 25 Another component of the control and / or regulating device 3 is another Step-up converter 25, which connects the microcontroller 15 via additional supply lines 26 supplied.
  • the axis 8 of the stepping motor 7 is assigned a limit switch 27 which is monitored by a microcontroller 15 via a control line 28 in order to to enable zero adjustment.
  • the electrical voltage source 4 comprises two NiMH batteries 29, the Supply voltage via feed lines 30, the step-up converter 22 and the further step-up converter 25 is supplied.
  • the supply voltage of the two Batteries 29 are supplied to the microcontroller 15 via control lines 31.
  • a charging current control is also part of the electrical voltage source 4 32, on the one hand via charging contacts 33, which act as sliding contacts are executed, can be connected to an external power source and on the other hand is connected to the batteries 29 via charging lines 34.
  • the charging current control 32 is also via control lines 35 for the charging voltage and via charging current control lines 36 each with the microcontroller 15 connected.
  • the operating device 5 comprises an input keyboard 37 which is connected via lines 38 is connected to the microcontroller 15. It also includes release buttons 39, which is connected to the microcontroller 15 via lines 40.
  • the display device 6 is an LCD display which is connected via lines 41 is connected to the microcontroller 15, which contains a display control.
  • the control software is stored in the microcontroller 15. Dosing data can entered before a dosing process using the input keyboard 37 become. Individual dosing processes can be triggered by means of the trigger buttons 39.
  • the display 6 shows entered data, control commands and operating states the hand dosing device 42.
  • the total supply voltage of the two battery cells 29 is 2.4 volts. This is further converter 25 to 3.3 volts supply voltage regulated for the microcontroller 15.
  • the step-up converter switches 22 the supply voltage of the batteries 29 as the supply voltage the supply lines 23 through or increases this to 6 or 8 volts.
  • the microcontroller 15 the operation of the stepper motor 7 via the control lines 16 controls, he knows their respective voltage requirements and controls the step-up converter 22 accordingly.
  • the supply voltage is from the microcontroller 15 via the control lines 31 checked. If it jumps below a permissible value, the display shows 6 a corresponding information is output.
  • the charging current is via the charging current control lines 36 corresponding to the state of charge determined via the control lines 31 the batteries 29 controlled.
  • Hand dosing devices 42 of the above type come - in part somewhat modified - used in the dosing systems discussed below.
  • a hand dosing device 42 ' works with a charging station 43 'together.
  • the charging contacts 33 of the manual dosing device 42 ' corresponding charging contacts 44 assigned to the charging station 43.
  • the serial interface 17 comprises one RF transmitter and receiver coupled to an antenna 45.
  • the Charging station 43 ' has a corresponding RF transmitter and receiver 46 and an antenna 47 connected thereto for radio communication with the Hand dosing device 42 '.
  • the RF transmitter and receiver 46 is via a serial interface 48 Charging station 43 connected to an external PC 49.
  • This configuration enables the batteries 29 to be charged Inserting the manual dosing device 42 'into the charging station 43'.
  • About the Radio connection between the antennas 45, 47 can data between the PC 49 and the hand dosing device 42 'are exchanged, both when the hand dosing device 42 'is inserted into the charging station 43' as even if it is spatially separated from it.
  • Using the PC 49 can Operating parameters, routines, programs or program parts in the EEPROM 20 of the hand dosing device 42 is written in or out of this be read out. Remote control of the PC 49 is also possible Manual dosing device 42 'possible.
  • the hand dosing device 42 ′′ and the charging station 43 ′′ in turn connectable charging contacts 43, 44.
  • the data interface 17 differs from the previous example an IR transmitter 49 and an IR receiver 50.
  • the data interface 46 of the charging station 43 ′′ includes an IR receiver 51 and an IR transmitter 52.
  • the PC 49 and the hand dosing device 42 ′′ in turn exchange data, in principle both when the hand dosing device 42 ′′ is inserted into the charging station 43 ′′ as if it is outside of it.
  • a hand dosing device 42 according to FIG. 1 is used.
  • the charging contacts 43 of the same are in turn charging contacts 44 of the Charging station 43 assigned.
  • the electrical contacts 18 of the data interface 17 are electrical contacts 53 of the data interface 46 of the charging station 43 assigned.
  • the charging station 43 '' ' has an integrated microcontroller system 54 with a non-volatile memory 55 and a keyboard 56, a display 57, a serial interface 58 and an exchangeable storage medium 59 having.
  • the removable storage medium 59 can be an EEPROM card, a SMART card, a FLASH card, a disc, etc.
  • the microcontroller system 54 can take over the functions of the PC 49. In particular, he can control the data traffic to the manual dosing device 42, the triggering of metering functions of the manual metering device 42, the storage of data in internal and external memories 55, 59, 20 of the charging station 43 '' 'and the manual dosing device 42, the data input and triggering the hand dosing device 42 via the keyboard 56, the Display of data on the display 57 and communication with a serve external control (PC) via the serial interface 58.
  • PC serve external control
EP99120656A 1998-11-04 1999-10-19 Procédé d' opération d' un système de dosage électronique et système de dosage pour la mise en oeuvre du procédé Expired - Lifetime EP0999432B2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19850841A DE19850841A1 (de) 1998-11-04 1998-11-04 Verfahren zum Betreiben eines elektronischen Dosiersystems und Dosiersystem zur Durchführung des Verfahrens
DE19850841 1998-11-04

Publications (4)

Publication Number Publication Date
EP0999432A2 true EP0999432A2 (fr) 2000-05-10
EP0999432A3 EP0999432A3 (fr) 2001-02-28
EP0999432B1 EP0999432B1 (fr) 2004-07-07
EP0999432B2 EP0999432B2 (fr) 2008-09-24

Family

ID=7886673

Family Applications (1)

Application Number Title Priority Date Filing Date
EP99120656A Expired - Lifetime EP0999432B2 (fr) 1998-11-04 1999-10-19 Procédé d' opération d' un système de dosage électronique et système de dosage pour la mise en oeuvre du procédé

Country Status (4)

Country Link
US (1) US6778917B1 (fr)
EP (1) EP0999432B2 (fr)
JP (1) JP2000234948A (fr)
DE (2) DE19850841A1 (fr)

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1398604A1 (fr) * 2002-08-30 2004-03-17 Eppendorf Ag Procédé de gestion de données d'un dispositif de dosage et dispositif de dosage pour la mise en oeuvre du procédé
EP1449586A1 (fr) * 2003-02-20 2004-08-25 Eppendorf Ag Système de dosage avec mémoire et méthode pour l'utilisation
EP1452849A1 (fr) * 2003-02-27 2004-09-01 Mettler-Toledo GmbH Appareil et méthode pour la préparation et/ou la dilution de solutions au laboratoire
WO2005052781A2 (fr) 2003-11-27 2005-06-09 Gilson S.A.S. Pipette electronique
EP1714116A1 (fr) * 2004-02-06 2006-10-25 Seyonic SA Dispositif de verification de pipette et pipette
CN100470455C (zh) * 2003-11-27 2009-03-18 吉尔松有限合伙公司 带显示器的电子吸移管和用于控制吸入及排出的选择器
US8122779B2 (en) 2007-09-17 2012-02-28 Integra Biosciences Corp. Electronic pipettor with improved accuracy
WO2012045416A1 (fr) * 2010-10-04 2012-04-12 Eppendorf Ag Pipette mécanique
DE102012102918A1 (de) * 2012-04-03 2013-10-10 Eppendorf Ag Laborgerätesystem und Laborgerät zum Behandeln von Fluiden und Feststoffen sowie Verfahren zum Betreiben eines Laborgerätes
CN107250736A (zh) * 2014-11-10 2017-10-13 凯米斯彼得技术股份公司 计量装置
WO2019175189A1 (fr) 2018-03-16 2019-09-19 Eppendorf Ag Système électronique de dosage de liquides pour laboratoire et procédé de fonctionnement d'un système électronique de dosage de liquides pour laboratoire
EP3851191A1 (fr) * 2020-01-17 2021-07-21 Eppendorf AG Procédé de fonctionnement d'une pipette à course de piston, pipette à course de piston, appareil et système de traitement des données

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4672935B2 (ja) * 2001-09-28 2011-04-20 アロカ株式会社 分注装置
FR2887982B1 (fr) * 2005-07-01 2009-03-06 Biomerieux Sa Dispositif de pipetage automatique permettant de s'assurer de la tracabilite de l'analyse realisee
DE102006028797A1 (de) * 2006-06-23 2007-12-27 Khs Ag Austauschbares Antriebssystem
DE102006032859A1 (de) * 2006-07-14 2008-01-17 Eppendorf Ag Elektronische Dosiervorrichtung zum Dosieren von Flüssigkeiten
DE102007010299B4 (de) * 2007-03-02 2009-01-29 Eppendorf Ag Handpipettiervorrichtung
DE102009051654B4 (de) 2009-10-30 2013-01-03 Eppendorf Ag Dosiervorrichtung für Flüssigkeiten und Verfahren zum Dosieren von Flüssigkeiten
DE102010047826A1 (de) 2010-10-04 2012-04-05 Eppendorf Ag Elektronische Pipette
DE102010047126A1 (de) 2010-10-04 2012-04-05 Eppendorf Ag Pipette
DE102010047828A1 (de) 2010-10-04 2012-04-05 Eppendorf Ag Laborgerät zum Behandeln von Flüssigkeiten
WO2013126343A2 (fr) 2012-02-22 2013-08-29 King Nutronics Corporation Source de pression d'étalonnage de précision multifuide
EP2698202A3 (fr) 2012-08-15 2017-07-19 Integra Biosciences AG Sample distribution system and process
FR3002466A1 (fr) * 2013-02-27 2014-08-29 Gilson Sas Pipette motorisee
US10532355B2 (en) 2015-06-05 2020-01-14 Mimetas B.V. Microfluidic plate
CH714486A1 (de) 2017-12-21 2019-06-28 Integra Biosciences Ag Probenverteilsystem und Verfahren zum Verteilen von Proben.

Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4333458A (en) * 1981-02-09 1982-06-08 Sterling Drug Inc. Self-aspirating syringe with positively engaged locking collet
US4821586A (en) * 1988-02-25 1989-04-18 Medical Laboratory Automation, Inc. Programmable pipette
US4908017A (en) * 1985-05-14 1990-03-13 Ivion Corporation Failsafe apparatus and method for effecting syringe drive
WO1991016974A1 (fr) * 1990-05-04 1991-11-14 Biohit Oy Procede de remplissage et de vidage d'une pipette, et pipette
US5187990A (en) * 1984-02-16 1993-02-23 Rainin Instrument Co., Inc. Method for dispensing liquids with a pipette with compensation for air pressure and surface tension
US5454268A (en) * 1993-11-15 1995-10-03 Kim; Young S. Double-plunger liquid displacement syringe pipet
US5658250A (en) * 1993-07-13 1997-08-19 Sims Deltec, Inc. Systems and methods for operating ambulatory medical devices such as drug delivery devices
US5662612A (en) * 1993-11-24 1997-09-02 Liebel Flarsheim Company Controlling plunger drives for fluid injections in animals
DE19703854A1 (de) * 1997-02-03 1998-08-06 Lange Gmbh Dr Bruno Multifunktionales Labormeßgerät

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR870001472A (ko) * 1985-07-05 1987-03-14 알버트 피. 할루인 자동 액체 처리 장치 및 그 방법
WO1987006008A2 (fr) * 1986-03-26 1987-10-08 Beckman Instruments, Inc. Centre de traitement automatise multi-usages avec poste de travail en laboratoire pour chimie analytique
US4810348A (en) * 1987-03-16 1989-03-07 Helena Laboratories Corporation Automatic electrophoresis apparatus and method
JPH0351760A (ja) * 1989-07-19 1991-03-06 Hitachi Ltd 自動分析装置
JPH0581034A (ja) * 1991-08-03 1993-04-02 Olympus Optical Co Ltd 自動分析装置
JPH05126690A (ja) * 1991-11-05 1993-05-21 Tabai Espec Corp 液体分注装置
EP0810026B1 (fr) * 1994-08-01 2003-10-29 Abbott Laboratories Méthode et appareil de préparation d'un fluide
US5602744A (en) * 1994-09-29 1997-02-11 Meek; Jean L. Universal send/receive utility usage data gathering system
CA2269499C (fr) * 1996-10-22 2006-03-28 Abb Power T & D Company Inc. Dispositif de mesure d'energie comportant des systemes de diagnostic et de controle de qualite d'energie
US6090348A (en) * 1997-03-14 2000-07-18 Becton, Dickinson And Company Method for programming an electronic pipetter

Patent Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4333458A (en) * 1981-02-09 1982-06-08 Sterling Drug Inc. Self-aspirating syringe with positively engaged locking collet
US5187990A (en) * 1984-02-16 1993-02-23 Rainin Instrument Co., Inc. Method for dispensing liquids with a pipette with compensation for air pressure and surface tension
US4908017A (en) * 1985-05-14 1990-03-13 Ivion Corporation Failsafe apparatus and method for effecting syringe drive
US4821586A (en) * 1988-02-25 1989-04-18 Medical Laboratory Automation, Inc. Programmable pipette
WO1991016974A1 (fr) * 1990-05-04 1991-11-14 Biohit Oy Procede de remplissage et de vidage d'une pipette, et pipette
US5343769A (en) * 1990-05-04 1994-09-06 Biohit Oy Procedure for filling and emptying a pipette, and pipette
US5658250A (en) * 1993-07-13 1997-08-19 Sims Deltec, Inc. Systems and methods for operating ambulatory medical devices such as drug delivery devices
US5454268A (en) * 1993-11-15 1995-10-03 Kim; Young S. Double-plunger liquid displacement syringe pipet
US5662612A (en) * 1993-11-24 1997-09-02 Liebel Flarsheim Company Controlling plunger drives for fluid injections in animals
DE19703854A1 (de) * 1997-02-03 1998-08-06 Lange Gmbh Dr Bruno Multifunktionales Labormeßgerät

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
"Anleitung zum Praktikum 'Instrumentelle Analytik'", LMU München, Ausgabe Wintersemester 2000/2001 *
"Trockensäfte: Tipps und Tricks"; ein Service von FORUMpharmazie *
Bedienungsanleitung zum "ECoCHeck H2O2 TM" *
Bedienungsanleitung zum "ECoCheck H2Os TM" *
J.-L. Eiselé, Preparation of Protein Crystallization Buffers with a Computer-Controlled Motorized Pipette: PIPEX, J. Appl. Cryst. 26, 92-96 (1993) mit Broschüre B1. "edp plus motorized microfilter pipette", copyright 1989. *
Praktikum "Biochemische Methoden in der Zellbiologie", 17.-28. September 2001, Giessen *
Produktbeschreibung der Sartorius AG betr. die thermogravimetrische Feuchtmessung durch Infrarottrocknung *
W.Mohr, H.Licht and P. Höller: "Zur Prüfung dünnwandiger Rohre mit geführten Ultraschallwellen", Materialprüfung 17 (1975)Nr.7 Juli, pages 240-241 †

Cited By (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2112479A3 (fr) * 2002-08-30 2011-03-23 Eppendorf Ag Procédé de gestion de données d'un dispositif de dosage et dispositif de dosage pour la mise en oeuvre du procédé
EP1398604A1 (fr) * 2002-08-30 2004-03-17 Eppendorf Ag Procédé de gestion de données d'un dispositif de dosage et dispositif de dosage pour la mise en oeuvre du procédé
EP2112479A2 (fr) 2002-08-30 2009-10-28 Eppendorf AG Procédé de gestion de données d'un dispositif de dosage et dispositif de dosage pour la mise en oeuvre du procédé
EP1449586A1 (fr) * 2003-02-20 2004-08-25 Eppendorf Ag Système de dosage avec mémoire et méthode pour l'utilisation
EP1452849A1 (fr) * 2003-02-27 2004-09-01 Mettler-Toledo GmbH Appareil et méthode pour la préparation et/ou la dilution de solutions au laboratoire
US7651664B2 (en) 2003-02-27 2010-01-26 Mettler-Toledo Gmbh Apparatus and method for preparing solutions and/or dilutions in the laboratory
WO2005052781A2 (fr) 2003-11-27 2005-06-09 Gilson S.A.S. Pipette electronique
WO2005052781A3 (fr) * 2003-11-27 2005-07-21 Gilson Sas Pipette electronique
US7976793B2 (en) 2003-11-27 2011-07-12 Gilson S.A.S. Electronic pipette
CN100470455C (zh) * 2003-11-27 2009-03-18 吉尔松有限合伙公司 带显示器的电子吸移管和用于控制吸入及排出的选择器
EP1714116A1 (fr) * 2004-02-06 2006-10-25 Seyonic SA Dispositif de verification de pipette et pipette
EP1714116A4 (fr) * 2004-02-06 2008-03-26 Seyonic Sa Dispositif de verification de pipette et pipette
US8122779B2 (en) 2007-09-17 2012-02-28 Integra Biosciences Corp. Electronic pipettor with improved accuracy
WO2012045416A1 (fr) * 2010-10-04 2012-04-12 Eppendorf Ag Pipette mécanique
US9415387B2 (en) 2010-10-04 2016-08-16 Eppendorf Ag Mechanical pipette
DE102012102918A1 (de) * 2012-04-03 2013-10-10 Eppendorf Ag Laborgerätesystem und Laborgerät zum Behandeln von Fluiden und Feststoffen sowie Verfahren zum Betreiben eines Laborgerätes
WO2013150064A1 (fr) 2012-04-03 2013-10-10 Eppendorf Ag Système d'appareil de laboratoire et appareil de laboratoire pour traiter des fluides et des matières solides et procédé pour faire fonctionner un appareil de laboratoire
CN107250736A (zh) * 2014-11-10 2017-10-13 凯米斯彼得技术股份公司 计量装置
WO2019175189A1 (fr) 2018-03-16 2019-09-19 Eppendorf Ag Système électronique de dosage de liquides pour laboratoire et procédé de fonctionnement d'un système électronique de dosage de liquides pour laboratoire
EP3851191A1 (fr) * 2020-01-17 2021-07-21 Eppendorf AG Procédé de fonctionnement d'une pipette à course de piston, pipette à course de piston, appareil et système de traitement des données

Also Published As

Publication number Publication date
JP2000234948A (ja) 2000-08-29
US6778917B1 (en) 2004-08-17
DE59909898D1 (de) 2004-08-12
EP0999432B2 (fr) 2008-09-24
EP0999432B1 (fr) 2004-07-07
DE19850841A1 (de) 2000-05-25
EP0999432A3 (fr) 2001-02-28

Similar Documents

Publication Publication Date Title
EP0999432B2 (fr) Procédé d' opération d' un système de dosage électronique et système de dosage pour la mise en oeuvre du procédé
DE102007010299B4 (de) Handpipettiervorrichtung
DE69927137T2 (de) Objektträgerfärbevorrichtung mit wahlfreiem zugriff und unabhängiger objektträgerheizungsregelung
EP2641656B1 (fr) Dispositif de pipetage électrique et procédé de fonctionnement d'un dispositif de pipetage électrique
EP1878500B1 (fr) Utilisation d'un dispositif de dosage électronique destiné au dosage de liquides
WO2013150064A1 (fr) Système d'appareil de laboratoire et appareil de laboratoire pour traiter des fluides et des matières solides et procédé pour faire fonctionner un appareil de laboratoire
DE102008053557B4 (de) Vorrichtung zur Steuerung einer Anlage und Verfahren zur Einrichtung und Bedienung der Steuerung einer Anlage
DE102011117963A1 (de) Fluidtransfervorrichtung
EP1449586B1 (fr) Système de dosage avec mémoire et méthode pour l'utilisation
CH625339A5 (fr)
DE102010047826A1 (de) Elektronische Pipette
EP3370185A1 (fr) Dispositif d'identification d'objets, de collecte de données et de commande de processus de travail, système de commande de processus logistiques, procédé de fonctionnement dudit dispositif et utilisation dudit dispositif
DE10301343B4 (de) Dosiervorrichtung
US20060085162A1 (en) Laboratory sample transfer apparatus with interchangeable tools
EP3043912B1 (fr) Distributeur de substances liquides
US8117928B2 (en) Method for selecting a pipette tip and a device for implementation
CN111604000A (zh) 针筒式定量调配装置
WO2022229384A1 (fr) Système comprenant un dispositif de pipetage portatif
DE102005022978B4 (de) Dentalmischgerät
DD283778A5 (de) Die fluessigkeitsdosiereinrichtung
EP3851191A1 (fr) Procédé de fonctionnement d'une pipette à course de piston, pipette à course de piston, appareil et système de traitement des données
WO2022157364A1 (fr) Dispositif de pipetage à main
EP0998979B1 (fr) Appareil de dosage électronique
US20080093388A1 (en) Attachment for repetitive syringe dispenser

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

AK Designated contracting states

Kind code of ref document: A2

Designated state(s): CH DE FI FR GB LI

AX Request for extension of the european patent

Free format text: AL;LT;LV;MK;RO;SI

RAP1 Party data changed (applicant data changed or rights of an application transferred)

Owner name: EPPENDORF AG

PUAL Search report despatched

Free format text: ORIGINAL CODE: 0009013

AK Designated contracting states

Kind code of ref document: A3

Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

AX Request for extension of the european patent

Free format text: AL;LT;LV;MK;RO;SI

RIC1 Information provided on ipc code assigned before grant

Free format text: 7G 01F 11/02 A, 7B 01L 3/02 B

17P Request for examination filed

Effective date: 20010828

AKX Designation fees paid

Free format text: CH DE FI FR GB LI

17Q First examination report despatched

Effective date: 20031027

GRAP Despatch of communication of intention to grant a patent

Free format text: ORIGINAL CODE: EPIDOSNIGR1

GRAS Grant fee paid

Free format text: ORIGINAL CODE: EPIDOSNIGR3

GRAA (expected) grant

Free format text: ORIGINAL CODE: 0009210

AK Designated contracting states

Kind code of ref document: B1

Designated state(s): CH DE FI FR GB LI

REG Reference to a national code

Ref country code: GB

Ref legal event code: FG4D

Free format text: NOT ENGLISH

REG Reference to a national code

Ref country code: CH

Ref legal event code: NV

Representative=s name: ISLER & PEDRAZZINI AG

Ref country code: CH

Ref legal event code: EP

REF Corresponds to:

Ref document number: 59909898

Country of ref document: DE

Date of ref document: 20040812

Kind code of ref document: P

GBT Gb: translation of ep patent filed (gb section 77(6)(a)/1977)
PLAQ Examination of admissibility of opposition: information related to despatch of communication + time limit deleted

Free format text: ORIGINAL CODE: EPIDOSDOPE2

PLBQ Unpublished change to opponent data

Free format text: ORIGINAL CODE: EPIDOS OPPO

PLBI Opposition filed

Free format text: ORIGINAL CODE: 0009260

PLAQ Examination of admissibility of opposition: information related to despatch of communication + time limit deleted

Free format text: ORIGINAL CODE: EPIDOSDOPE2

PLAR Examination of admissibility of opposition: information related to receipt of reply deleted

Free format text: ORIGINAL CODE: EPIDOSDOPE4

PLBQ Unpublished change to opponent data

Free format text: ORIGINAL CODE: EPIDOS OPPO

PLAQ Examination of admissibility of opposition: information related to despatch of communication + time limit deleted

Free format text: ORIGINAL CODE: EPIDOSDOPE2

PLAR Examination of admissibility of opposition: information related to receipt of reply deleted

Free format text: ORIGINAL CODE: EPIDOSDOPE4

PLBQ Unpublished change to opponent data

Free format text: ORIGINAL CODE: EPIDOS OPPO

PLAB Opposition data, opponent's data or that of the opponent's representative modified

Free format text: ORIGINAL CODE: 0009299OPPO

ET Fr: translation filed
PLAX Notice of opposition and request to file observation + time limit sent

Free format text: ORIGINAL CODE: EPIDOSNOBS2

PLAQ Examination of admissibility of opposition: information related to despatch of communication + time limit deleted

Free format text: ORIGINAL CODE: EPIDOSDOPE2

PLAR Examination of admissibility of opposition: information related to receipt of reply deleted

Free format text: ORIGINAL CODE: EPIDOSDOPE4

PLBQ Unpublished change to opponent data

Free format text: ORIGINAL CODE: EPIDOS OPPO

26 Opposition filed

Opponent name: METTLER-TOLEDO AG

Effective date: 20050407

PLAB Opposition data, opponent's data or that of the opponent's representative modified

Free format text: ORIGINAL CODE: 0009299OPPO

R26 Opposition filed (corrected)

Opponent name: METTLER-TOLEDO AG

Effective date: 20050407

R26 Opposition filed (corrected)

Opponent name: METTLER-TOLEDO GMBH

Effective date: 20050407

PLAF Information modified related to communication of a notice of opposition and request to file observations + time limit

Free format text: ORIGINAL CODE: EPIDOSCOBS2

PLAF Information modified related to communication of a notice of opposition and request to file observations + time limit

Free format text: ORIGINAL CODE: EPIDOSCOBS2

PLAF Information modified related to communication of a notice of opposition and request to file observations + time limit

Free format text: ORIGINAL CODE: EPIDOSCOBS2

PLBB Reply of patent proprietor to notice(s) of opposition received

Free format text: ORIGINAL CODE: EPIDOSNOBS3

PLAB Opposition data, opponent's data or that of the opponent's representative modified

Free format text: ORIGINAL CODE: 0009299OPPO

R26 Opposition filed (corrected)

Opponent name: METTLER-TOLEDO AG

Effective date: 20050407

REG Reference to a national code

Ref country code: CH

Ref legal event code: PCAR

Free format text: ISLER & PEDRAZZINI AG;POSTFACH 1772;8027 ZUERICH (CH)

PUAH Patent maintained in amended form

Free format text: ORIGINAL CODE: 0009272

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: PATENT MAINTAINED AS AMENDED

27A Patent maintained in amended form

Effective date: 20080924

AK Designated contracting states

Kind code of ref document: B2

Designated state(s): CH DE FI FR GB LI

REG Reference to a national code

Ref country code: CH

Ref legal event code: AEN

Free format text: AUFRECHTERHALTUNG DES PATENTES IN GEAENDERTER FORM

REG Reference to a national code

Ref country code: FR

Ref legal event code: PLFP

Year of fee payment: 17

REG Reference to a national code

Ref country code: FR

Ref legal event code: PLFP

Year of fee payment: 18

REG Reference to a national code

Ref country code: FR

Ref legal event code: PLFP

Year of fee payment: 19

REG Reference to a national code

Ref country code: FR

Ref legal event code: PLFP

Year of fee payment: 20

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: DE

Payment date: 20181019

Year of fee payment: 20

Ref country code: FI

Payment date: 20181022

Year of fee payment: 20

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: GB

Payment date: 20181019

Year of fee payment: 20

Ref country code: FR

Payment date: 20181022

Year of fee payment: 20

Ref country code: CH

Payment date: 20181019

Year of fee payment: 20

REG Reference to a national code

Ref country code: DE

Ref legal event code: R071

Ref document number: 59909898

Country of ref document: DE

REG Reference to a national code

Ref country code: CH

Ref legal event code: PL

REG Reference to a national code

Ref country code: GB

Ref legal event code: PE20

Expiry date: 20191018

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: GB

Free format text: LAPSE BECAUSE OF EXPIRATION OF PROTECTION

Effective date: 20191018