EP0999432B2 - Procédé d' opération d' un système de dosage électronique et système de dosage pour la mise en oeuvre du procédé - Google Patents

Procédé d' opération d' un système de dosage électronique et système de dosage pour la mise en oeuvre du procédé Download PDF

Info

Publication number
EP0999432B2
EP0999432B2 EP99120656A EP99120656A EP0999432B2 EP 0999432 B2 EP0999432 B2 EP 0999432B2 EP 99120656 A EP99120656 A EP 99120656A EP 99120656 A EP99120656 A EP 99120656A EP 0999432 B2 EP0999432 B2 EP 0999432B2
Authority
EP
European Patent Office
Prior art keywords
proportioning
data
charging
electronic control
anyone
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
EP99120656A
Other languages
German (de)
English (en)
Other versions
EP0999432B1 (fr
EP0999432A2 (fr
EP0999432A3 (fr
Inventor
Dirk Jansen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eppendorf SE
Original Assignee
Eppendorf SE
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=7886673&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EP0999432(B2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Eppendorf SE filed Critical Eppendorf SE
Publication of EP0999432A2 publication Critical patent/EP0999432A2/fr
Publication of EP0999432A3 publication Critical patent/EP0999432A3/fr
Publication of EP0999432B1 publication Critical patent/EP0999432B1/fr
Application granted granted Critical
Publication of EP0999432B2 publication Critical patent/EP0999432B2/fr
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Images

Classifications

    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02Burettes; Pipettes
    • B01L3/021Pipettes, i.e. with only one conduit for withdrawing and redistributing liquids
    • B01L3/0217Pipettes, i.e. with only one conduit for withdrawing and redistributing liquids of the plunger pump type
    • B01L3/0227Details of motor drive means
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/02Identification, exchange or storage of information
    • B01L2300/025Displaying results or values with integrated means
    • B01L2300/027Digital display, e.g. LCD, LED

Definitions

  • the invention relates to a method for operating an electronic dosing system with an electronic hand dosing device and to a dosing system for carrying out the method.
  • Dosing devices are used in laboratories for dosing liquids. They are known in different versions. Dosing devices operating on the principle of the air cushion have an integrated piston-cylinder unit, by means of which an air column can be displaced in order to suck in and eject sample liquid into a dosing tip. In this case, the piston-cylinder unit does not come into contact with the liquid. Only the dosing tip, which is usually made of plastic, is contaminated and can be replaced after use.
  • a syringe In direct displacement metering, however, a syringe is filled directly with sample liquid. Piston and cylinder of the syringe are so contaminated by the liquid, so that the syringe usually has to be replaced or cleaned by a new syringe before changing the liquid.
  • the syringe is usually made of plastic.
  • Microdosing devices may have a micromembrane pump and / or a free jet dispenser, wherein at least one of these components is designed microsystem technology, in particular in silicon, glass, plastic injection molding and / or plastic embossing technique.
  • the dosage is achieved by deformation of a wall of a chamber which is filled with liquid.
  • the electric drive for deforming the wall may be piezoelectric, thermoelectric, electromagnetic, electrostatic, electromechanical, magneto-restrictive, etc.
  • Air-cushion, direct-displacement, piston-less and micro-metering devices may have a fixed or variable metering volume.
  • a change in the metering volume is achieved by adjusting the displacement of the displacement device, d. H. the displacement of the piston or the degree of deformation of the balloon-like end portion or the chamber wall.
  • Dispensers are dosing devices that can deliver a recorded volume of liquid repetitively in small quantities.
  • All dosing devices can be designed as handsets.
  • All of the aforementioned metering devices may be electronic metering devices of an electronic metering system in the sense of this application.
  • they have a drive device with an electric drive for driving the displacement device.
  • they have an electronic control and / or regulating device, in particular for the drive, which may be an electric drive motor, an electric linear drive or one of the drives mentioned in connection with microdosing devices.
  • they have an electrical voltage source for supplying control and / or regulating device and drive, which can be rechargeable.
  • Electronic metering devices have the advantage of high reproducibility of dosages.
  • pre-set dosing speeds ( ⁇ / s) can achieve more accurate results than with manually driven devices.
  • they can have the benefit of multi-functionality, as they can perform pipetting, dispensing, titration, mixing, etc. functions.
  • Applicants' known electronic hand dispensers Response® operate on the air-cushion principle and are available in single-channel or multi-channel designs. Four models cover the dosing range from 0.5 ⁇ l to 5 ml.
  • This metering device can operate in various modes, i.a. pipette and dispense. Dispensing is possible in up to 25 steps. The user can choose between three different dosing speeds.
  • the metering device can be used for charging the battery cells in a charging station.
  • EP 0 864 364 A2 discloses a similar electronic manual dosing device with rechargeable batteries and a charging station for charging them.
  • the handheld dosing device may be operated in various modes including hands-free operation other than pipetting and dispensing.
  • the manual dosing device is programmed to control the aspiration, dispensing, and time delays to exchange or treat the dosing tip. It executes these program steps over a specified number of cycles.
  • the previously known electronic manual dosing devices have the disadvantage that the specific operating parameters (eg step widths of the piston feed, metering speeds, state of charge criteria, display outputs) and the program are predefined.
  • the electronic control device comprises a microcomputer which operates according to a permanently stored program in which these parameters are contained.
  • a special software is required for each model and a subsequent change of the parameters hardly possible.
  • the programming of the freehand operation must be carried out laboriously on the keyboard of the manual dosing and that in the freehand mode, the programmed steps are executed rigidly and the operation is not influenced.
  • Dosing devices are test equipment within the meaning of the GLP (Good Laboratory Practice) guidelines and comparable QA standards (ISO 9000 ff, EN 45000 ff). According to the GLP guidelines, the error limits published by the manufacturer must be checked at regular intervals. By the applicant, a system has become known, with which the calibration of metering devices can be done quickly, conveniently and inexpensively.
  • This system is based on a calibration software PICASO®, which runs on a PC.
  • a measuring structure is required, which includes weighing containers, adapters and carrier sleeves as well as an evaporation trap and a semi-microbalance. All relevant data of the dosing devices to be tested are stored in the software. Deviations from these nominal values are determined immediately after transfer of the weighing values to the computer. A series of measurements covers up to 15 individual weighings. From this mean value, incorrectness, imprecision and standard deviation are determined and compared with predetermined target values. All measurement and reference data can be logged in accordance with GLP-DIN.
  • the dosing data are entered and their operation is controlled via the control panel of the electronic manual dosing device.
  • the weighing values are typed into the PC. This is troublesome and can lead to mistakes.
  • a method for filling and emptying a pipette with quantitative accuracy in which the distance traveled by a piston path is measured during the movement of the piston and the piston is stopped when a distance corresponding to the desired amount of liquid has been achieved has been achieved.
  • a pipette with elements for measuring the piston stroke and elements for controlling the movements of the piston is known.
  • the pipette has a data input device, such as a keyboard, a display and an interface.
  • the data input device serves to supply the control device with data or commands.
  • the display is used to display the entered data and / or the steps performed.
  • the interface allows the controller to be connected to an external device, for example for data transmission or data processing.
  • the object of the invention is to provide a method for operating an electronic dosing system in which the ability to influence programs is improved.
  • advantageous metering systems are to be provided for carrying out the method.
  • the external data processing system can be used to access the read-write memory of the manual dosing device.
  • routines for the execution of operating sequences in the read-write memory of the manual dosing device by means of the external data processing system so that the program-controlled electronic control and / or regulating device makes use of it.
  • routines can be created by the user and serve to control operations composed of multiple operations, especially if they are to be repeated. For example, by means of such a "short program" it is possible to control the picking, mixing and dispensing of specific quantities of liquid or a series of dilutions in which the dispensing volume dispensed is halved from one dilution step to the next. This facilitates the use of routines for the user.
  • the memory is preferably a flash memory of a processor.
  • a flash memory processor has implemented a proprietary program that can initiate communication for data exchange over an interface. This makes it possible to load a partially or completely different program from the outside via the data interfaces into each hand-dose device or to change the program completely or partially.
  • These may be device-type-specific parameters, in particular those that are intended for carrying out operating procedures.
  • these may be the parameters of the movement of the piston of a displacement device (eg acceleration characteristic, piston speed, driving force, holding torque).
  • these may be, for example, quantity-determining parameters (for example: basic values and limit values of metered quantities, possible numbers of metering steps, overspill volume for discharging residual liquid).
  • other device-type specific parameters may relate to the monitoring of operating conditions (eg, evaluation criteria for the state of charge of an accumulator, for the actuation of a limit switch or for the duration of a rest in order to switch off to a "sleep state").
  • Device-specific parameters can be, in particular, an identification of the device, an identification code for a respectively stored parameter set, etc.
  • User parameters are data that can also be input manually by the user via a keyboard of the manual dosing device. These include, in particular, the metering volume, metering rates, etc. Further application parameters relate to the calibration of the manual metering device. In a simple case, this may be a correction factor for the conversion of the set dosing amounts to the actually dispensed dosing quantities. In particular, these may also be coefficients of a function which includes the deviation of the set metering quantities actually delivered with different quantity settings.
  • a remote control of the manual dosing device is possible.
  • This favors, in particular, the calibration by transferring the respective dosing data to the manual dosing device by means of the data processing system and, if appropriate, by completely controlling the operation by means of the data processing system.
  • the data processing system can log the respective dosing data. Optionally, this can be done together with the respective measured values, if they are detected and recorded in the data processing system.
  • a wired or a wireless remote control of the manual dosing device take place. This favors, in particular, an automation of the dosing operations, the use of the manual dosing device in a higher-level automation process or a safe dosing in a contaminated environment.
  • the invention makes it possible to determine the specific parameters of the metering device only after the device assembly, even if this includes the installation of a block with permanently programmed software. This makes it possible to use the same software and electronic hardware for different device models.
  • the respective parameters can be set as required or even changed.
  • a device-type-specific or device-specific definition or modification of program parts or of the entire program is possible.
  • the storability of user parameters by means of an external data processing system creates an additional, advantageous operating option.
  • the invention favors automation of calibration and final inspection in manufacturing. The service will be able to easily update to new operating parameters.
  • the OEM customer can in turn carry out a parameterization for special OEM metering parts. The user is facilitated the GLP parameter documentation and a simplified calibration with a PC software is made possible. It also facilitates integration into automation processes and enables remote control.
  • the data interfaces of the manual dosing device and the data transfer device may be interconnected temporarily or permanently. It may be data interfaces that can only be connected to each other when the hand-held dosing device is inserted into the data transfer device. However, the data interfaces can also be connected to one another independently of whether the manual dosing device is inserted in the data transfer device.
  • the data interfaces of the manual dosing device and the data transfer device may be connected by radio transmitters and radio receivers communicating with each other. Also, the data interfaces may include communicating IR transmitters and IR receivers. This promotes a permanent connection of the data interfaces or a wireless remote control. In addition or instead, the data interfaces may have interconnectable electrical contacts that may be connectable by inserting the handheld dosing device into the data transfer device.
  • the electronic control device a microcomputer, in particular a microcontroller on.
  • the data transfer device can be connected to a separate data processing system, for example with a PC, or have an integrated data processing system, in particular a microcomputer or Mikrocontoller
  • the electronic control and / or regulating device and / or the data processing system may have conventional input and output and memory devices, including an exchangeable storage medium.
  • a program for the remote control and / or the calibration of the manual dosing device can be present on the exchangeable storage medium. This favors the equipment of the dosing system with software as needed and their update.
  • the manual dosing device can work independently of the mains.
  • it may be provided with a rechargeable voltage source, for example one or more rechargeable batteries.
  • the data transfer device may comprise a charging part for charging the voltage source and a charging interface connected to the charging part for connecting to the charging interface of the hand metering device.
  • the charging interfaces of the hand-held meter and the data transfer device may have cooperating electrical charging contacts. These can coincide with the contacts of the data interfaces.
  • the data transmission can be carried out in particular on the charging voltage or the charging current of the charging part. By modulating the charging voltage or charging current, data transmission can be realized on the same physical channel.
  • the data transfer device can be designed as a stationary device.
  • the manual dosing device can also be used as a stationary device or as a dosing machine when it is inserted into the data transfer device. Then the power supply of the manual dosing device can be ensured via the charging part.
  • the electronic hand-held meter essentially consists of six functional areas, namely a drive device 1, a displacement device 2, an electronic control and / or regulating device 3, an electrical voltage source 4, an operating device 5 and a display device 6.
  • the drive device 1- has an electric drive motor, which is designed as a stepping motor 7. By means of the stepping motor 7, an axis 8 is linearly displaceable back and forth.
  • the drive device includes an engine stage in the form of two H-bridges 9, which serves to control the stepping motor 7. This includes, in a manner known to those skilled in eight H-connected power transistors with which the stepper motor, 7 can be operated via supply lines 10 in the forward and reverse directions.
  • the displacement device 2 has a piston 11 which is fixed to the axis 8.
  • the piston 11 is displaceable in a cylinder 12. This is connected via a channel 13 with a metering tip 14 which is separable from the device.
  • the electronic control and / or regulating device 3 includes a microcontroller 15, which in particular has integrated a timer, a main memory and a nonvolatile memory.
  • the microcontroller controls the H-bridges via control lines 16.
  • the electronic control and / or regulating device 3 includes a bidirectional serial interface 17 which has electrical sliding contacts 18 and is connected to the microcontoller 15 via data lines 19. Furthermore, this includes an EEPROM 20, which is connected via data lines 21 to the microcontroller 15.
  • the electronic control and / or regulating device 3 has an up-converter 22 for generating the supply voltage of the stepping motor 7, which feeds the H-bridges 9 via supply lines 23.
  • Control lines 24 connect the microcontroller 15 to the boost converter 22.
  • boost converter 25 Another component of the control and / or regulating device 3 is another boost converter 25 which supplies the microcontroller 15 via further supply lines 26.
  • the axis 8 of the stepping motor 7 is associated with a limit switch 27 which is monitored by a control line 28 from the microcontroller 15 to allow a zero point adjustment.
  • the electrical voltage source 4 comprises two NiMH batteries 29, whose supply voltage is fed via feed lines 30 to the up-converter 22 and the further boost converter 25.
  • the supply voltage of the two batteries 29 is supplied via control lines 31 to the microcontroller 15.
  • the electrical voltage source 4 includes a charging current control 32 which is connectable to an external power source via charging contacts 33, which are designed as sliding contacts, and is connected to the batteries 29 via charging lines 34.
  • the charge current controller 32 is also connected to the microcontroller 15 via control lines 35 for the charging voltage and via charging current control lines 36, respectively.
  • the operating device 5 comprises an input keyboard 37, which is connected via lines 38 to the microcontroller 15. It also includes release buttons 39, which is connected via lines 40 to the microcontroller 15.
  • the display device 6 is an LCD display, which is connected via lines 41 to the microcontroller 15, which contains a display control
  • the control software is stored in the microcontroller 15. Dosing data can be entered before dosing by means of the input keyboard 37. By means of the release buttons 39 individual dosing operations are triggered.
  • the display 6 displays input data, control commands and operating states of the manual dosing device 42.
  • the total supply voltage of the two battery cells 29 is 2.4 volts. This is regulated by the further boost converter 25 to 3.3 volts supply voltage for the microcontroller 15.
  • the microcontroller 15 controls the operation of the stepper motor 7 via the control lines 16, it knows its respective voltage requirement and controls the boost converter 22 accordingly.
  • the supply voltage is controlled by the microcontroller 15 via the control lines 31. If it jumps below a permissible value, the display 6 outputs a corresponding information.
  • the charging contacts 33 By connecting the charging contacts 33 to an external power supply can be done in case of need, a charge of the battery 29.
  • the charging current is controlled according to the determined via the control lines 31 state of charge of the battery 29.
  • Manual dosing devices 42 of the above type are used - in some cases somewhat modified - in the dosing systems discussed below.
  • a manual dosing device 42 cooperates with a charging station 43'.
  • the charging contacts 33 of the manual dosing device 42 ' are associated with corresponding charging contacts 44 of the charging station 43.
  • the RF transmitter and receiver 46 is connected to an external PC 49 via a serial interface 48 of the charging station 43.
  • This configuration allows the accumulators 29 to be charged by inserting the hand meter 42 'into the charging station 43'.
  • Data can be exchanged between the PC 49 and the manual dosing device 42 'via the radio connection between the antennas 45, 47, both when the manual dosing device 42' is inserted into the charging station 43 'and when it is spatially separated therefrom.
  • the PC 49 operating parameters, routines, programs or program parts can be written into the EEPROM 20 of the manual dosing device 42 and possibly read out from this. Also, by means of the PC 49, a remote control of the manual dosing device 42 'possible.
  • the hand-dose device 42 "and the charging station 43" again have connectable charging contacts 43, 44.
  • the data interface 17 has an IR transmitter 49 and an IR receiver 50.
  • the data interface 46 of the charging station 43 "comprises an IR receiver 51 and an IR transmitter 52.
  • the PC 49 and the manual dosing device 42 can in turn exchange data, in principle both when the manual dosing device 42" is inserted into the charging station 43 °, and when they are outside of the same located.
  • Fig. 4 comes a hand meter 42 according to Fig. 1 for use.
  • Charging contacts 43 of the charging station 43 are in turn associated with the charging contacts 43 of the charging station 43.
  • the electrical contacts 18 of the data interface 17 are associated with electrical contacts 53 of the data interface 46 of the charging station 43.
  • the execution according to Fig. 5 differs from the according to Fig. 4 in that the charging station 43 "'has an integrated micro-controller system 54 with a non-volatile memory 55 and a keyboard 56, a display 57, a serial interface 58 and a removable storage medium 59.
  • the removable storage medium 59 may be an EEPROM card, a SMART Card, a FLASH card, a disk, etc.
  • the handheld dosing device 42 can control the data traffic to the handheld dosing device 42, initiate dosing functions of the hand dosing device 42, store data in internal and external memories 55, 59, 20 of the charging station 43 "'and the hand-held dosing device 42, the data input and release of the Häriddosienrorcardi 42 via the keyboard 56, the display of data on the display 57 and the communication with an external controller (PC) via the serial interface 58 are used.
  • PC external controller

Claims (24)

  1. Procédé pour exploiter un système de dosage électronique avec
    - un dispositif de dosage manuel électronique (42), présentant
    - un dispositif d'entraînement (1) présentant un entraînement électrique (7),
    - au moins un dispositif de refoulement (2) pouvant être entraîné par le dispositif d'entraînement (1) pour le dosage de liquide, dans lequel le dispositif de refoulement présente un piston (11) mobile dans un cylindre (12) pour déplacer une colonne d'air et le cylindre est relié à travers un canal (13) à un cône de dosage (14) pour aspirer un liquide d'échantillonnage dans le cône de dosage et l'expulser hors de celui-ci, ou le dispositif de refoulement est une seringue présentant un piston et un cylindre et étant remplie directement avec un liquide d'échantillonnage,
    - un dispositif de commande et/ou de régulation électronique programmable (3) pour l'entraînement (7),
    - au moins une mémoire d'écriture/lecture non volatile (20),
    - une source de tension électrique (29) en particulier pour l'entraînement électrique (7) et le dispositif de commande et/ou de régulation électronique (3), et
    - une interface de données (17) reliée au dispositif de commande et/ou de régulation électronique,
    avec
    - un équipement informatique externe (49),
    et avec
    - un dispositif de transfert de données (43), présentant
    - une interface de données (46) pour relier l'interface de données (17) du dispositif de dosage (42) à l'équipement informatique (49),
    caractérisé en ce qu'au moyen de l'équipement informatique (49), à travers les interfaces de données (17, 46)
    - des routines pour l'exécution de séquences d'opérations du dispositif de dosage manuel (42), auxquelles le dispositif de commande et/ou de régulation électronique programmable (3) fait appel, sont écrites dans la mémoire d'écriture/lecture (20).
  2. Procédé selon la revendication 1, dans lequel au moyen de l'équipement informatique (49), à travers les interfaces de données (17, 46), en plus des paramètres spécifiques au type d'appareil et/ou des paramètres spécifiques à l'appareil et/ou des paramètres d'application sont écrits dans la mémoire d'écriture/lecture (20) et/ou sont lus à partir de celle-ci et/ou le dispositif de dosage manuel (42) peut être télécommandé.
  3. Procédé selon la revendication 1 ou 2, dans lequel les interfaces de données (17, 46) communiquent ensemble par contact.
  4. Procédé selon l'une quelconque des revendications 1 à 3, dans lequel les interfaces de données (17, 46) communiquent ensemble sans fil.
  5. Procédé selon la revendication 5, dans lequel les interfaces de données (17, 46) communiquent ensemble par radiocommunication, de façon optique, de façon inductive et/ou de façon capacitive.
  6. Système de dosage, adapté pour exécuter le procédé selon l'une quelconque des revendications 1 à 5, avec
    - un dispositif de dosage manuel électronique (42), présentant
    - un dispositif d'entraînement (1) présentant un entraînement électrique (7),
    - au moins un dispositif de refoulement (2) pouvant être entraîné par le dispositif d'entraînement (1) pour le dosage de liquide, dans lequel le dispositif de refoulement présente un piston (11) mobile dans un cylindre (12) pour déplacer une colonne d'air et le cylindre est relié à travers un canal (13) à un cône de dosage (14) pour aspirer un liquide d'échantillonnage dans le cône de dosage et l'expulser hors de celui-ci, ou le dispositif de refoulement est une seringue présentant un piston et un cylindre et étant remplie directement avec un liquide d'échantillonnage,
    - un dispositif de commande et/ou de régulation électronique programmable (3) pour l'entraînement (7),
    - au moins une mémoire d'écriture/lecture non volatile (20),
    - une source de tension électrique (29) en particulier pour l'entraînement électrique (7) et le dispositif de commande et/ou de régulation électronique (3), et
    - une interface de données (17) reliée au dispositif de commande et/ou de régulation électronique,
    avec
    - un équipement informatique externe (49),
    et avec
    - un dispositif de transfert de données (43), présentant une interface de données (46) pour relier l'interface de données (17) du dispositif de dosage (42) à l'équipement informatique (49),
    caractérisé en ce que
    - le dispositif de commande et/ou de régulation électronique programmable (3) est conçu de telle sorte qu'au moyen de l'équipement informatique (49), à travers les interfaces de données (17, 46), des routines pour l'exécution de séquences d'opérations du dispositif de dosage manuel (42), auxquelles le dispositif de commande et/ou de régulation électronique programmable (3) fait appel, peuvent être écrites dans la mémoire d'écriture/lecture (20).
  7. Système de dosage adapté pour exécuter le procédé selon l'une quelconque des revendications 1 à 5 selon le préambule de la revendication 6, dans lequel les interfaces de données (17, 46) du dispositif de dosage (42) et du dispositif de transfert de données (43) comportent des émetteurs radio et des récepteurs radio et/ou des émetteurs IF (49, 52) et des récepteurs IF (50, 51).
  8. Système de dosage adapté pour exécuter le procédé selon l'une quelconque des revendications 1 à 5 selon le préambule de la revendication 6, en particulier selon la revendication 6 ou 7, dans lequel les interfaces de données (17, 46) du dispositif de dosage (42) et du dispositif de transfert de données (43) sont des interfaces de données série.
  9. Système de dosage adapté pour exécuter le procédé selon l'une quelconque des revendications 1 à 5 selon le préambule de la revendication 6, en particulier selon l'une quelconque des revendications 6 à 8, dans lequel le dispositif de commande et/ou de régulation électronique (3) présente un micro-ordinateur ou un microcontrôleur (15).
  10. Système de dosage selon la revendication 9, dans lequel la mémoire d'écriture/lecture non volatile est une mémoire flash du micro-ordinateur ou du microcontrôleur.
  11. Système de dosage adapté pour exécuter le procédé selon l'une quelconque des revendications 1 à 5 selon le préambule de la revendication 6, en particulier selon l'une quelconque des revendications 6 à 10, dans lequel l'équipement informatique (49) relié à l'interface de données (46) du dispositif de transfert de données (43) présente un PC connecté au dispositif de transfert de données (43).
  12. Système de dosage adapté pour exécuter le procédé selon l'une quelconque des revendications 1 à 5 selon le préambule de la revendication 6, en particulier selon l'une quelconque des revendications 6 à 11, dans lequel l'interface de données (46) du dispositif de transfert de données (43) est reliée à un équipement informatique (54) intégré dans le dispositif de transfert de données (43).
  13. Système de dosage selon la revendication 12, dans lequel l'équipement informatique (49, 54) comprend un micro-ordinateur ou un microcontrôleur.
  14. Système de dosage adapté pour exécuter le procédé selon l'une quelconque des revendications 1 à 5 selon le préambule de la revendication 6, en particulier selon l'une quelconque des revendications 6 à 13, dans lequel le dispositif de commande électronique (3) et/ou l'équipement informatique (49, 54) présentent une mémoire non volatile (20, 55) et/ou un clavier (37, 39 ; 56) et/ou un affichage (6, 57) et/ou une interface série (17, 58) et/ou un support de mémoire échangeable (59).
  15. Système de dosage adapté pour exécuter le procédé selon l'une quelconque des revendications 1 à 5 selon le préambule de la revendication 6, en particulier selon l'une quelconque des revendications 6 à 14, dans lequel le dispositif de dosage manuel (42) comporte une interface de charge (33) reliée à une source de tension rechargeable (29) et le dispositif de transfert de données (43) comporte un chargeur pour recharger la source de tension (29) et une interface de charge (44) reliée au chargeur (43) pour la connexion avec l'interface de charge (33) du dispositif de dosage manuel (42).
  16. Système de dosage selon la revendication 15, dans lequel le dispositif de dosage (42) et le dispositif de transfert de données (43) comportent respectivement des interfaces de charge (33, 44) et de données (17, 46) communes.
  17. Système de dosage selon l'une des revendications 15 ou 16, dans lequel le dispositif de commande et/ou de régulation électronique (3) coopère avec une commande de courant de charge (32) du dispositif de dosage (42) pour commander le courant de charge selon l'état de charge de la source de tension (29).
  18. Système de dosage selon la revendication 17, dans lequel le dispositif de commande et/ou de régulation électronique (3) détermine l'état de charge par surveillance de la tension d'alimentation électrique de la source de tension (29).
  19. Système de dosage pour exécuter le procédé selon l'une quelconque des revendications 1 à 5 selon le préambule de la revendication 6, en particulier selon l'une quelconque des revendications 15 à 18, dans lequel le dispositif de transfert de données (43) présente plusieurs interfaces de charge (44) pour recharger simultanément les sources de tension (29) de plusieurs dispositifs de dosage (42) et/ou plusieurs interfaces de données (46) pour communiquer simultanément avec les interfaces de données (17) de plusieurs dispositifs de dosage (42).
  20. Dispositif de dosage selon l'une quelconque des revendications 15 à 19, dans lequel le dispositif de transfert de données (43) présente au moins une interface de charge (44) pour une source de tension électrique (29) rechargeable, extractible du dispositif de dosage (42).
  21. Système de dosage selon l'une quelconque des revendications 15 à 20, dans lequel les interfaces de charge (33, 44) du dispositif de dosage (42) et du dispositif de transfert de données (43) et/ou de la source de tension extractible (29) présentent des contacts de charge électriques pouvant être reliés ensemble.
  22. Système de dosage pour exécuter le procédé selon l'une quelconque des revendications 1 à 5 selon le préambule de la revendication 6, en particulier selon l'une quelconque des revendications 6 à 21, dans lequel le dispositif de dosage manuel (42) est indépendant du secteur.
  23. Système de dosage adapté pour exécuter le procédé selon l'une quelconque des revendications 1 à 5 selon le préambule de la revendication 6, en particulier selon l'une quelconque des revendications 6 à 22, dans lequel le dispositif de transfert de données est un appareil stationnaire.
  24. Système de dosage selon l'une quelconque des revendications 6 à 23, dans lequel, au moyen de l'équipement informatique (49) ou des interfaces de données, des paramètres spécifiques au type d'appareil et/ou des paramètres spécifiques à l'appareil et/ou des paramètres d'utilisateur peuvent être écrits dans la mémoire d'écriture/lecture (20) et/ou peuvent être lus à partir de celle-ci et/ou le dispositif de dosage manuel (42) peut être télécommandé.
EP99120656A 1998-11-04 1999-10-19 Procédé d' opération d' un système de dosage électronique et système de dosage pour la mise en oeuvre du procédé Expired - Lifetime EP0999432B2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19850841 1998-11-04
DE19850841A DE19850841A1 (de) 1998-11-04 1998-11-04 Verfahren zum Betreiben eines elektronischen Dosiersystems und Dosiersystem zur Durchführung des Verfahrens

Publications (4)

Publication Number Publication Date
EP0999432A2 EP0999432A2 (fr) 2000-05-10
EP0999432A3 EP0999432A3 (fr) 2001-02-28
EP0999432B1 EP0999432B1 (fr) 2004-07-07
EP0999432B2 true EP0999432B2 (fr) 2008-09-24

Family

ID=7886673

Family Applications (1)

Application Number Title Priority Date Filing Date
EP99120656A Expired - Lifetime EP0999432B2 (fr) 1998-11-04 1999-10-19 Procédé d' opération d' un système de dosage électronique et système de dosage pour la mise en oeuvre du procédé

Country Status (4)

Country Link
US (1) US6778917B1 (fr)
EP (1) EP0999432B2 (fr)
JP (1) JP2000234948A (fr)
DE (2) DE19850841A1 (fr)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4672935B2 (ja) * 2001-09-28 2011-04-20 アロカ株式会社 分注装置
DE10239901A1 (de) * 2002-08-30 2004-03-25 Eppendorf Ag Verfahren zum Handhaben von Daten einer Dosiervorrichtung und Dosiervorrichtung geeignet zur Durchführung des Verfahrens
DE10307030A1 (de) * 2003-02-20 2004-09-09 Eppendorf Ag Dosiersystem
EP1452849B1 (fr) * 2003-02-27 2016-02-24 Mettler-Toledo GmbH Appareil et méthode pour la préparation et/ou la dilution de solutions au laboratoire
FR2862889B1 (fr) * 2003-11-27 2006-09-22 Gilson Sas Pipette a main pour le prelevement d'un echantillon liquide sans derive de temperature
US7976793B2 (en) 2003-11-27 2011-07-12 Gilson S.A.S. Electronic pipette
JP4719692B2 (ja) * 2004-02-06 2011-07-06 セヨニック エス.アー. ピペット検査装置及びそれを取り付けたピペット
FR2887982B1 (fr) * 2005-07-01 2009-03-06 Biomerieux Sa Dispositif de pipetage automatique permettant de s'assurer de la tracabilite de l'analyse realisee
DE102006028797A1 (de) * 2006-06-23 2007-12-27 Khs Ag Austauschbares Antriebssystem
DE102006032859A1 (de) * 2006-07-14 2008-01-17 Eppendorf Ag Elektronische Dosiervorrichtung zum Dosieren von Flüssigkeiten
DE102007010299B4 (de) 2007-03-02 2009-01-29 Eppendorf Ag Handpipettiervorrichtung
US7540205B2 (en) 2007-09-17 2009-06-02 Viaflo Corp. Electronic pipettor
DE102009051654B4 (de) 2009-10-30 2013-01-03 Eppendorf Ag Dosiervorrichtung für Flüssigkeiten und Verfahren zum Dosieren von Flüssigkeiten
DE102010047126A1 (de) 2010-10-04 2012-04-05 Eppendorf Ag Pipette
DE102010047828A1 (de) 2010-10-04 2012-04-05 Eppendorf Ag Laborgerät zum Behandeln von Flüssigkeiten
DE102010047829A1 (de) 2010-10-04 2012-04-05 Eppendorf Ag Mechanische Pipette
DE102010047826A1 (de) 2010-10-04 2012-04-05 Eppendorf Ag Elektronische Pipette
WO2013126343A2 (fr) 2012-02-22 2013-08-29 King Nutronics Corporation Source de pression d'étalonnage de précision multifuide
DE102012102918A1 (de) 2012-04-03 2013-10-10 Eppendorf Ag Laborgerätesystem und Laborgerät zum Behandeln von Fluiden und Feststoffen sowie Verfahren zum Betreiben eines Laborgerätes
EP2698202A3 (fr) 2012-08-15 2017-07-19 Integra Biosciences AG Sample distribution system and process
FR3002466A1 (fr) * 2013-02-27 2014-08-29 Gilson Sas Pipette motorisee
CH710350A2 (de) 2014-11-10 2016-05-13 Chemspeed Tech Ag Dosiervorrichtung.
US10532355B2 (en) 2015-06-05 2020-01-14 Mimetas B.V. Microfluidic plate
CH714486A1 (de) 2017-12-21 2019-06-28 Integra Biosciences Ag Probenverteilsystem und Verfahren zum Verteilen von Proben.
PL3539665T3 (pl) 2018-03-16 2022-12-12 Eppendorf Se Elektroniczny laboratoryjny system dozowania cieczy oraz sposób działania elektronicznego laboratoryjnego systemu dozowania cieczy
EP3851191A1 (fr) * 2020-01-17 2021-07-21 Eppendorf AG Procédé de fonctionnement d'une pipette à course de piston, pipette à course de piston, appareil et système de traitement des données

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4333458A (en) * 1981-02-09 1982-06-08 Sterling Drug Inc. Self-aspirating syringe with positively engaged locking collet
US5187990A (en) * 1984-02-16 1993-02-23 Rainin Instrument Co., Inc. Method for dispensing liquids with a pipette with compensation for air pressure and surface tension
US4908017A (en) * 1985-05-14 1990-03-13 Ivion Corporation Failsafe apparatus and method for effecting syringe drive
KR870001472A (ko) * 1985-07-05 1987-03-14 알버트 피. 할루인 자동 액체 처리 장치 및 그 방법
WO1987006008A2 (fr) * 1986-03-26 1987-10-08 Beckman Instruments, Inc. Centre de traitement automatise multi-usages avec poste de travail en laboratoire pour chimie analytique
US4810348A (en) * 1987-03-16 1989-03-07 Helena Laboratories Corporation Automatic electrophoresis apparatus and method
US4821586A (en) * 1988-02-25 1989-04-18 Medical Laboratory Automation, Inc. Programmable pipette
JPH0351760A (ja) * 1989-07-19 1991-03-06 Hitachi Ltd 自動分析装置
FI87740C (fi) * 1990-05-04 1994-04-08 Biohit Oy Pipett
JPH0581034A (ja) * 1991-08-03 1993-04-02 Olympus Optical Co Ltd 自動分析装置
JPH05126690A (ja) * 1991-11-05 1993-05-21 Tabai Espec Corp 液体分注装置
WO1995002426A1 (fr) * 1993-07-13 1995-01-26 Sims Deltec, Inc. Pompe medicale et procede de programmation de ladite pompe
US5454268A (en) * 1993-11-15 1995-10-03 Kim; Young S. Double-plunger liquid displacement syringe pipet
CA2129284C (fr) * 1993-11-24 1999-03-09 Kenneth J. Niehoff Regulation de l'entrainement du plongeur pour l'injection de liquides a des animaux
DE69532045T2 (de) * 1994-08-01 2004-07-08 Abbott Laboratories, Abbott Park Verfahren und Vorrichtung zur Vorbereitung einer Flüssigkeit
US5602744A (en) * 1994-09-29 1997-02-11 Meek; Jean L. Universal send/receive utility usage data gathering system
RO120431B1 (ro) * 1996-10-22 2006-01-30 Abb Power T & D Company Inc. Dispozitiv electric de măsurare a energiei electrice
DE19703854A1 (de) * 1997-02-03 1998-08-06 Lange Gmbh Dr Bruno Multifunktionales Labormeßgerät
US6090348A (en) * 1997-03-14 2000-07-18 Becton, Dickinson And Company Method for programming an electronic pipetter

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
W.Mohr, H.Licht and P. Höller: "Zur Prüfung dünnwandiger Rohre mit geführten Ultraschallwellen", Materialprüfung 17 (1975)Nr.7 Juli, pages 240-241

Also Published As

Publication number Publication date
EP0999432B1 (fr) 2004-07-07
EP0999432A2 (fr) 2000-05-10
EP0999432A3 (fr) 2001-02-28
DE59909898D1 (de) 2004-08-12
US6778917B1 (en) 2004-08-17
DE19850841A1 (de) 2000-05-25
JP2000234948A (ja) 2000-08-29

Similar Documents

Publication Publication Date Title
EP0999432B2 (fr) Procédé d' opération d' un système de dosage électronique et système de dosage pour la mise en oeuvre du procédé
EP1878500B1 (fr) Utilisation d'un dispositif de dosage électronique destiné au dosage de liquides
DE102007010299B4 (de) Handpipettiervorrichtung
DE69927137T2 (de) Objektträgerfärbevorrichtung mit wahlfreiem zugriff und unabhängiger objektträgerheizungsregelung
EP2371455B1 (fr) Système et procédé destinés au titrage de liquides
EP1859869B1 (fr) Appareil électrique de dosage pour liquide
EP1508808B1 (fr) Procédé de distribution microscopique a commande électrique
EP1452849B1 (fr) Appareil et méthode pour la préparation et/ou la dilution de solutions au laboratoire
EP2574402B1 (fr) Seringue avec cylindre avec codage et des elements de controles
EP2184590B1 (fr) Dispositif de dosage doté d'un dispositif de changement pour unités de dosage
DE102011117963A1 (de) Fluidtransfervorrichtung
EP1449586B1 (fr) Système de dosage avec mémoire et méthode pour l'utilisation
EP1912741A1 (fr) Systeme de titrage
EP1886728B1 (fr) Dispositif de dosage électronique destiné au dosage de liquides
EP3066431A1 (fr) Dispositif de dosage avec balance et module de climatisation intégrés
DE102012102918A1 (de) Laborgerätesystem und Laborgerät zum Behandeln von Fluiden und Feststoffen sowie Verfahren zum Betreiben eines Laborgerätes
CH625339A5 (fr)
DE10301343B4 (de) Dosiervorrichtung
DE10038569C2 (de) Repetierend manuell zu betätigende Abgabe- und/oder Aufnahmeeinrichtung für Flüssigkeiten
EP1424129B1 (fr) Distributeur et méthode pour l'ajustement automatique de distributeurs à canaux multiples
DE3913632C2 (de) Titriergerät
EP3043912A1 (fr) Distributeur de substances liquides
DD283778A5 (de) Die fluessigkeitsdosiereinrichtung
EP3851191A1 (fr) Procédé de fonctionnement d'une pipette à course de piston, pipette à course de piston, appareil et système de traitement des données
WO2022157364A1 (fr) Dispositif de pipetage à main

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

AK Designated contracting states

Kind code of ref document: A2

Designated state(s): CH DE FI FR GB LI

AX Request for extension of the european patent

Free format text: AL;LT;LV;MK;RO;SI

RAP1 Party data changed (applicant data changed or rights of an application transferred)

Owner name: EPPENDORF AG

PUAL Search report despatched

Free format text: ORIGINAL CODE: 0009013

AK Designated contracting states

Kind code of ref document: A3

Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

AX Request for extension of the european patent

Free format text: AL;LT;LV;MK;RO;SI

RIC1 Information provided on ipc code assigned before grant

Free format text: 7G 01F 11/02 A, 7B 01L 3/02 B

17P Request for examination filed

Effective date: 20010828

AKX Designation fees paid

Free format text: CH DE FI FR GB LI

17Q First examination report despatched

Effective date: 20031027

GRAP Despatch of communication of intention to grant a patent

Free format text: ORIGINAL CODE: EPIDOSNIGR1

GRAS Grant fee paid

Free format text: ORIGINAL CODE: EPIDOSNIGR3

GRAA (expected) grant

Free format text: ORIGINAL CODE: 0009210

AK Designated contracting states

Kind code of ref document: B1

Designated state(s): CH DE FI FR GB LI

REG Reference to a national code

Ref country code: GB

Ref legal event code: FG4D

Free format text: NOT ENGLISH

REG Reference to a national code

Ref country code: CH

Ref legal event code: NV

Representative=s name: ISLER & PEDRAZZINI AG

Ref country code: CH

Ref legal event code: EP

REF Corresponds to:

Ref document number: 59909898

Country of ref document: DE

Date of ref document: 20040812

Kind code of ref document: P

GBT Gb: translation of ep patent filed (gb section 77(6)(a)/1977)
PLAQ Examination of admissibility of opposition: information related to despatch of communication + time limit deleted

Free format text: ORIGINAL CODE: EPIDOSDOPE2

PLBQ Unpublished change to opponent data

Free format text: ORIGINAL CODE: EPIDOS OPPO

PLBI Opposition filed

Free format text: ORIGINAL CODE: 0009260

PLAQ Examination of admissibility of opposition: information related to despatch of communication + time limit deleted

Free format text: ORIGINAL CODE: EPIDOSDOPE2

PLAR Examination of admissibility of opposition: information related to receipt of reply deleted

Free format text: ORIGINAL CODE: EPIDOSDOPE4

PLBQ Unpublished change to opponent data

Free format text: ORIGINAL CODE: EPIDOS OPPO

PLAQ Examination of admissibility of opposition: information related to despatch of communication + time limit deleted

Free format text: ORIGINAL CODE: EPIDOSDOPE2

PLAR Examination of admissibility of opposition: information related to receipt of reply deleted

Free format text: ORIGINAL CODE: EPIDOSDOPE4

PLBQ Unpublished change to opponent data

Free format text: ORIGINAL CODE: EPIDOS OPPO

PLAB Opposition data, opponent's data or that of the opponent's representative modified

Free format text: ORIGINAL CODE: 0009299OPPO

ET Fr: translation filed
PLAX Notice of opposition and request to file observation + time limit sent

Free format text: ORIGINAL CODE: EPIDOSNOBS2

PLAQ Examination of admissibility of opposition: information related to despatch of communication + time limit deleted

Free format text: ORIGINAL CODE: EPIDOSDOPE2

PLAR Examination of admissibility of opposition: information related to receipt of reply deleted

Free format text: ORIGINAL CODE: EPIDOSDOPE4

PLBQ Unpublished change to opponent data

Free format text: ORIGINAL CODE: EPIDOS OPPO

26 Opposition filed

Opponent name: METTLER-TOLEDO AG

Effective date: 20050407

PLAB Opposition data, opponent's data or that of the opponent's representative modified

Free format text: ORIGINAL CODE: 0009299OPPO

R26 Opposition filed (corrected)

Opponent name: METTLER-TOLEDO AG

Effective date: 20050407

R26 Opposition filed (corrected)

Opponent name: METTLER-TOLEDO GMBH

Effective date: 20050407

PLAF Information modified related to communication of a notice of opposition and request to file observations + time limit

Free format text: ORIGINAL CODE: EPIDOSCOBS2

PLAF Information modified related to communication of a notice of opposition and request to file observations + time limit

Free format text: ORIGINAL CODE: EPIDOSCOBS2

PLAF Information modified related to communication of a notice of opposition and request to file observations + time limit

Free format text: ORIGINAL CODE: EPIDOSCOBS2

PLBB Reply of patent proprietor to notice(s) of opposition received

Free format text: ORIGINAL CODE: EPIDOSNOBS3

PLAB Opposition data, opponent's data or that of the opponent's representative modified

Free format text: ORIGINAL CODE: 0009299OPPO

R26 Opposition filed (corrected)

Opponent name: METTLER-TOLEDO AG

Effective date: 20050407

REG Reference to a national code

Ref country code: CH

Ref legal event code: PCAR

Free format text: ISLER & PEDRAZZINI AG;POSTFACH 1772;8027 ZUERICH (CH)

PUAH Patent maintained in amended form

Free format text: ORIGINAL CODE: 0009272

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: PATENT MAINTAINED AS AMENDED

27A Patent maintained in amended form

Effective date: 20080924

AK Designated contracting states

Kind code of ref document: B2

Designated state(s): CH DE FI FR GB LI

REG Reference to a national code

Ref country code: CH

Ref legal event code: AEN

Free format text: AUFRECHTERHALTUNG DES PATENTES IN GEAENDERTER FORM

REG Reference to a national code

Ref country code: FR

Ref legal event code: PLFP

Year of fee payment: 17

REG Reference to a national code

Ref country code: FR

Ref legal event code: PLFP

Year of fee payment: 18

REG Reference to a national code

Ref country code: FR

Ref legal event code: PLFP

Year of fee payment: 19

REG Reference to a national code

Ref country code: FR

Ref legal event code: PLFP

Year of fee payment: 20

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: DE

Payment date: 20181019

Year of fee payment: 20

Ref country code: FI

Payment date: 20181022

Year of fee payment: 20

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: GB

Payment date: 20181019

Year of fee payment: 20

Ref country code: FR

Payment date: 20181022

Year of fee payment: 20

Ref country code: CH

Payment date: 20181019

Year of fee payment: 20

REG Reference to a national code

Ref country code: DE

Ref legal event code: R071

Ref document number: 59909898

Country of ref document: DE

REG Reference to a national code

Ref country code: CH

Ref legal event code: PL

REG Reference to a national code

Ref country code: GB

Ref legal event code: PE20

Expiry date: 20191018

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: GB

Free format text: LAPSE BECAUSE OF EXPIRATION OF PROTECTION

Effective date: 20191018