EP0986553A4 - Derives de dihydropyrimidone comme antagonistes du neuropeptide y (npy) - Google Patents

Derives de dihydropyrimidone comme antagonistes du neuropeptide y (npy)

Info

Publication number
EP0986553A4
EP0986553A4 EP98902841A EP98902841A EP0986553A4 EP 0986553 A4 EP0986553 A4 EP 0986553A4 EP 98902841 A EP98902841 A EP 98902841A EP 98902841 A EP98902841 A EP 98902841A EP 0986553 A4 EP0986553 A4 EP 0986553A4
Authority
EP
European Patent Office
Prior art keywords
dihydropyrimidone
derivatives
npy antagonists
npy
antagonists
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
EP98902841A
Other languages
German (de)
English (en)
Other versions
EP0986553A1 (fr
Inventor
Marc A Bruce
Graham S Poindexter
Graham Johnson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Squibb Co
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of EP0986553A1 publication Critical patent/EP0986553A1/fr
Publication of EP0986553A4 publication Critical patent/EP0986553A4/fr
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
EP98902841A 1997-02-04 1998-01-26 Derives de dihydropyrimidone comme antagonistes du neuropeptide y (npy) Ceased EP0986553A4 (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US3718397P 1997-02-04 1997-02-04
US37183P 1997-02-04
US5089397P 1997-06-26 1997-06-26
US50893P 1997-06-26
PCT/US1998/001429 WO1998033791A1 (fr) 1997-02-04 1998-01-26 Derives de dihydropyrimidone comme antagonistes du neuropeptide y (npy)

Publications (2)

Publication Number Publication Date
EP0986553A1 EP0986553A1 (fr) 2000-03-22
EP0986553A4 true EP0986553A4 (fr) 2000-12-27

Family

ID=26713884

Family Applications (1)

Application Number Title Priority Date Filing Date
EP98902841A Ceased EP0986553A4 (fr) 1997-02-04 1998-01-26 Derives de dihydropyrimidone comme antagonistes du neuropeptide y (npy)

Country Status (5)

Country Link
EP (1) EP0986553A4 (fr)
JP (1) JP2002514199A (fr)
AU (1) AU733883B2 (fr)
CA (1) CA2277965A1 (fr)
WO (1) WO1998033791A1 (fr)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9703414D0 (sv) * 1997-09-23 1997-09-23 Astra Ab New compounds
US6657104B1 (en) 1997-10-16 2003-12-02 Texas Systems, University Of The Board Of The Regents Transgenic mouse model for cardiac hypertrophy and methods of use thereof
AU783403B2 (en) * 2000-07-05 2005-10-20 H. Lundbeck A/S Selective melanin concentrating hormone-1 (MCH1) receptor antagonists and uses thereof
US7166603B2 (en) 2003-07-23 2007-01-23 Bristol-Myers Squibb Co. Dihydropyrimidone inhibitors of calcium channel function
US7157461B2 (en) 2003-07-23 2007-01-02 Bristol-Myers Squibb Co. Substituted dihydropyrimidine inhibitors of calcium channel function
EP1685107B1 (fr) 2003-11-03 2008-09-10 Myogen, Inc. Composes de 1,4-dihydropyridine, compositions pharmaceutiques et methodes destinees au traitement de maladies cardiovasculaires
WO2007101213A2 (fr) * 2006-02-28 2007-09-07 Kalypsys, Inc. Nouvelles 2-oxo-1,2,3,4-tétrahydropyrimidines, pyrimidine diones bicycliques et imidazolidine-2,4-diones utiles comme inhibiteurs de l'oxyde nitrique synthase inductible
PL2056882T3 (pl) 2006-08-01 2013-03-29 Univ Texas Identyfikacja mikro-RNA, który aktywuje ekspresję łańcucha ciężkiego beta-miozyny
WO2012064743A2 (fr) 2010-11-08 2012-05-18 The Johns Hopkins University Procédés d'amélioration de la fonction cardiaque
CN103193715A (zh) * 2013-03-28 2013-07-10 浙江大学 一种5,6-二氢嘧啶酮衍生物的制备方法
US9856232B1 (en) 2017-06-20 2018-01-02 King Saud University Dihydropyrimidinone derivatives

Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4609494A (en) * 1985-02-21 1986-09-02 Merck & Co., Inc. 5-acetyl-3,4,5,6-tetrahydro-4-oxo-2,6-methano-2H-1,3,5-benzothiazocine(benzodiazocine)-11-carboxylates useful as calcium channel blockers
JPS6287574A (ja) * 1985-10-14 1987-04-22 Suntory Ltd 新規なｎ置換３，４−ジヒドロピリミジン−２−オン誘導体、その製造法及び循環器系疾患治療剤
US4675321A (en) * 1986-02-07 1987-06-23 Merck & Co., Inc. Substituted pyrimidines useful as calcium channel blockers
US4684656A (en) * 1986-03-14 1987-08-04 E. R. Squibb & Sons, Inc. 1,2,3,4-tetrahydro-6-substituted-4-aryl-3-(substituted sulfonyl)-2-thioxo(or oxo)-5-pyrimidinecarboxylic acids and esters and method of using them to lower blood pressure
US4684655A (en) * 1986-03-14 1987-08-04 E. R. Squibb & Sons, Inc. 1,2,3,4-tetrahydro-6-substituted-4-aryl-3-substituted-2-thioxo(or oxo)-5-pyrimidinecarboxylic acids and esters and use thereof to lower blood pressure
EP0237347A2 (fr) * 1986-03-14 1987-09-16 E.R. Squibb & Sons, Inc. Acides et esters 1,2,3,4-tétrahydro-6-substitués-4-aryl(ou hétérocyclo)-3-[(amino substitué)-carbonyl]-2-thioxo(ou oxo)-pyrimidiniques
US4738965A (en) * 1987-02-03 1988-04-19 Institut Organischskogo Sinteza Akademii Nauk Ssr 2-oxo-4-(2'-difluoromethylthiophenyl)-5-methoxycarbonyl-6-methyl-1,2,3,4-tetrahydropyrimidine
US4847379A (en) * 1987-11-30 1989-07-11 E. R. Squibb & Sons, Inc. 3,6-dihydro-1,5(2H)-pyrimidinecarboxylic acid esters
WO1990006118A1 (fr) * 1988-12-05 1990-06-14 Houston Biotechnology Incorporated Utilisation therapeutique de dihydropyrimidones et de derives de benzazepine et de benzothiazepine dans le disfonctionnement du nerf optique ou retinien

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4609494A (en) * 1985-02-21 1986-09-02 Merck & Co., Inc. 5-acetyl-3,4,5,6-tetrahydro-4-oxo-2,6-methano-2H-1,3,5-benzothiazocine(benzodiazocine)-11-carboxylates useful as calcium channel blockers
JPS6287574A (ja) * 1985-10-14 1987-04-22 Suntory Ltd 新規なｎ置換３，４−ジヒドロピリミジン−２−オン誘導体、その製造法及び循環器系疾患治療剤
US4675321A (en) * 1986-02-07 1987-06-23 Merck & Co., Inc. Substituted pyrimidines useful as calcium channel blockers
US4684656A (en) * 1986-03-14 1987-08-04 E. R. Squibb & Sons, Inc. 1,2,3,4-tetrahydro-6-substituted-4-aryl-3-(substituted sulfonyl)-2-thioxo(or oxo)-5-pyrimidinecarboxylic acids and esters and method of using them to lower blood pressure
US4684655A (en) * 1986-03-14 1987-08-04 E. R. Squibb & Sons, Inc. 1,2,3,4-tetrahydro-6-substituted-4-aryl-3-substituted-2-thioxo(or oxo)-5-pyrimidinecarboxylic acids and esters and use thereof to lower blood pressure
EP0237347A2 (fr) * 1986-03-14 1987-09-16 E.R. Squibb & Sons, Inc. Acides et esters 1,2,3,4-tétrahydro-6-substitués-4-aryl(ou hétérocyclo)-3-[(amino substitué)-carbonyl]-2-thioxo(ou oxo)-pyrimidiniques
US4738965A (en) * 1987-02-03 1988-04-19 Institut Organischskogo Sinteza Akademii Nauk Ssr 2-oxo-4-(2'-difluoromethylthiophenyl)-5-methoxycarbonyl-6-methyl-1,2,3,4-tetrahydropyrimidine
US4847379A (en) * 1987-11-30 1989-07-11 E. R. Squibb & Sons, Inc. 3,6-dihydro-1,5(2H)-pyrimidinecarboxylic acid esters
WO1990006118A1 (fr) * 1988-12-05 1990-06-14 Houston Biotechnology Incorporated Utilisation therapeutique de dihydropyrimidones et de derives de benzazepine et de benzothiazepine dans le disfonctionnement du nerf optique ou retinien

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
PATENT ABSTRACTS OF JAPAN vol. 011, no. 297 25 September 1987 (1987-09-25) *
See also references of WO9833791A1 *

Also Published As

Publication number Publication date
CA2277965A1 (fr) 1998-08-06
AU5963998A (en) 1998-08-25
JP2002514199A (ja) 2002-05-14
WO1998033791A1 (fr) 1998-08-06
AU733883B2 (en) 2001-05-31
EP0986553A1 (fr) 2000-03-22

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