EP0986553A4 - Dihydropyrimidon-derivate als npy-antagonisten - Google Patents

Dihydropyrimidon-derivate als npy-antagonisten

Info

Publication number
EP0986553A4
EP0986553A4 EP98902841A EP98902841A EP0986553A4 EP 0986553 A4 EP0986553 A4 EP 0986553A4 EP 98902841 A EP98902841 A EP 98902841A EP 98902841 A EP98902841 A EP 98902841A EP 0986553 A4 EP0986553 A4 EP 0986553A4
Authority
EP
European Patent Office
Prior art keywords
dihydropyrimidone
derivatives
npy antagonists
npy
antagonists
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
EP98902841A
Other languages
English (en)
French (fr)
Other versions
EP0986553A1 (de
Inventor
Marc A Bruce
Graham S Poindexter
Graham Johnson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Squibb Co
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of EP0986553A1 publication Critical patent/EP0986553A1/de
Publication of EP0986553A4 publication Critical patent/EP0986553A4/de
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
EP98902841A 1997-02-04 1998-01-26 Dihydropyrimidon-derivate als npy-antagonisten Ceased EP0986553A4 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US3718397P 1997-02-04 1997-02-04
US37183P 1997-02-04
US5089397P 1997-06-26 1997-06-26
US50893P 1997-06-26
PCT/US1998/001429 WO1998033791A1 (en) 1997-02-04 1998-01-26 Dihydropyrimidone derivatives as npy antagonists

Publications (2)

Publication Number Publication Date
EP0986553A1 EP0986553A1 (de) 2000-03-22
EP0986553A4 true EP0986553A4 (de) 2000-12-27

Family

ID=26713884

Family Applications (1)

Application Number Title Priority Date Filing Date
EP98902841A Ceased EP0986553A4 (de) 1997-02-04 1998-01-26 Dihydropyrimidon-derivate als npy-antagonisten

Country Status (5)

Country Link
EP (1) EP0986553A4 (de)
JP (1) JP2002514199A (de)
AU (1) AU733883B2 (de)
CA (1) CA2277965A1 (de)
WO (1) WO1998033791A1 (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9703414D0 (sv) * 1997-09-23 1997-09-23 Astra Ab New compounds
AU748334B2 (en) 1997-10-16 2002-05-30 Board Of Regents, The University Of Texas System Models and treatments for cardiac hypertrophy in relation with NF-AT3 function
EP1299362A4 (de) * 2000-07-05 2004-11-03 Synaptic Pharma Corp Selektive rezeptorantagonisten des melaninkonzentrierenden hormons-1 (mch1) und ihre anwendung
US7157461B2 (en) 2003-07-23 2007-01-02 Bristol-Myers Squibb Co. Substituted dihydropyrimidine inhibitors of calcium channel function
US7166603B2 (en) 2003-07-23 2007-01-23 Bristol-Myers Squibb Co. Dihydropyrimidone inhibitors of calcium channel function
CA2544763A1 (en) 2003-11-03 2005-05-12 Myogen, Inc. 1,4-dihydropyridine compounds, pharmaceutical compositions, and methods for the treatment of cardiovascular disease
WO2007101213A2 (en) * 2006-02-28 2007-09-07 Kalypsys, Inc. Novel 2-oxo-1,2,3,4-tetrahydropyrimidines, bicyclic pyrimidine diones and imidazolidine-2,4-diones useful as inducible nitric oxide synthase inhibitors
AU2007281261B2 (en) 2006-08-01 2013-03-21 Board Of Regents Of The University Of Texas System Identification of a micro-RNA that activates expression of beta-myosin heavy chain
WO2012064743A2 (en) 2010-11-08 2012-05-18 The Johns Hopkins University Methods for improving heart function
CN103193715A (zh) * 2013-03-28 2013-07-10 浙江大学 一种5,6-二氢嘧啶酮衍生物的制备方法
US9856232B1 (en) 2017-06-20 2018-01-02 King Saud University Dihydropyrimidinone derivatives

Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4609494A (en) * 1985-02-21 1986-09-02 Merck & Co., Inc. 5-acetyl-3,4,5,6-tetrahydro-4-oxo-2,6-methano-2H-1,3,5-benzothiazocine(benzodiazocine)-11-carboxylates useful as calcium channel blockers
JPS6287574A (ja) * 1985-10-14 1987-04-22 Suntory Ltd 新規なｎ置換３，４−ジヒドロピリミジン−２−オン誘導体、その製造法及び循環器系疾患治療剤
US4675321A (en) * 1986-02-07 1987-06-23 Merck & Co., Inc. Substituted pyrimidines useful as calcium channel blockers
US4684656A (en) * 1986-03-14 1987-08-04 E. R. Squibb & Sons, Inc. 1,2,3,4-tetrahydro-6-substituted-4-aryl-3-(substituted sulfonyl)-2-thioxo(or oxo)-5-pyrimidinecarboxylic acids and esters and method of using them to lower blood pressure
US4684655A (en) * 1986-03-14 1987-08-04 E. R. Squibb & Sons, Inc. 1,2,3,4-tetrahydro-6-substituted-4-aryl-3-substituted-2-thioxo(or oxo)-5-pyrimidinecarboxylic acids and esters and use thereof to lower blood pressure
EP0237347A2 (de) * 1986-03-14 1987-09-16 E.R. Squibb & Sons, Inc. 1,2,3,4-Tetrahydro-6-substituierte-4-aryl(oder heterozyklo)3-[(substituierte amino)carbonyl]-2-thioxo(oder oxo)-5-pyrimidinkarbonsäuren und -ester
US4738965A (en) * 1987-02-03 1988-04-19 Institut Organischskogo Sinteza Akademii Nauk Ssr 2-oxo-4-(2'-difluoromethylthiophenyl)-5-methoxycarbonyl-6-methyl-1,2,3,4-tetrahydropyrimidine
US4847379A (en) * 1987-11-30 1989-07-11 E. R. Squibb & Sons, Inc. 3,6-dihydro-1,5(2H)-pyrimidinecarboxylic acid esters
WO1990006118A1 (en) * 1988-12-05 1990-06-14 Houston Biotechnology Incorporated Therapeutic use of dihydropyrimidones and benzazepine and benzothiazepine derivatives in retinal or optic nerve dysfunction

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4609494A (en) * 1985-02-21 1986-09-02 Merck & Co., Inc. 5-acetyl-3,4,5,6-tetrahydro-4-oxo-2,6-methano-2H-1,3,5-benzothiazocine(benzodiazocine)-11-carboxylates useful as calcium channel blockers
JPS6287574A (ja) * 1985-10-14 1987-04-22 Suntory Ltd 新規なｎ置換３，４−ジヒドロピリミジン−２−オン誘導体、その製造法及び循環器系疾患治療剤
US4675321A (en) * 1986-02-07 1987-06-23 Merck & Co., Inc. Substituted pyrimidines useful as calcium channel blockers
US4684656A (en) * 1986-03-14 1987-08-04 E. R. Squibb & Sons, Inc. 1,2,3,4-tetrahydro-6-substituted-4-aryl-3-(substituted sulfonyl)-2-thioxo(or oxo)-5-pyrimidinecarboxylic acids and esters and method of using them to lower blood pressure
US4684655A (en) * 1986-03-14 1987-08-04 E. R. Squibb & Sons, Inc. 1,2,3,4-tetrahydro-6-substituted-4-aryl-3-substituted-2-thioxo(or oxo)-5-pyrimidinecarboxylic acids and esters and use thereof to lower blood pressure
EP0237347A2 (de) * 1986-03-14 1987-09-16 E.R. Squibb & Sons, Inc. 1,2,3,4-Tetrahydro-6-substituierte-4-aryl(oder heterozyklo)3-[(substituierte amino)carbonyl]-2-thioxo(oder oxo)-5-pyrimidinkarbonsäuren und -ester
US4738965A (en) * 1987-02-03 1988-04-19 Institut Organischskogo Sinteza Akademii Nauk Ssr 2-oxo-4-(2'-difluoromethylthiophenyl)-5-methoxycarbonyl-6-methyl-1,2,3,4-tetrahydropyrimidine
US4847379A (en) * 1987-11-30 1989-07-11 E. R. Squibb & Sons, Inc. 3,6-dihydro-1,5(2H)-pyrimidinecarboxylic acid esters
WO1990006118A1 (en) * 1988-12-05 1990-06-14 Houston Biotechnology Incorporated Therapeutic use of dihydropyrimidones and benzazepine and benzothiazepine derivatives in retinal or optic nerve dysfunction

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
PATENT ABSTRACTS OF JAPAN vol. 011, no. 297 25 September 1987 (1987-09-25) *
See also references of WO9833791A1 *

Also Published As

Publication number Publication date
WO1998033791A1 (en) 1998-08-06
CA2277965A1 (en) 1998-08-06
AU733883B2 (en) 2001-05-31
JP2002514199A (ja) 2002-05-14
AU5963998A (en) 1998-08-25
EP0986553A1 (de) 2000-03-22

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