CA2277965A1 - Derives de dihydropyrimidone comme antagonistes du neuropeptide y (npy) - Google Patents
Derives de dihydropyrimidone comme antagonistes du neuropeptide y (npy) Download PDFInfo
- Publication number
- CA2277965A1 CA2277965A1 CA002277965A CA2277965A CA2277965A1 CA 2277965 A1 CA2277965 A1 CA 2277965A1 CA 002277965 A CA002277965 A CA 002277965A CA 2277965 A CA2277965 A CA 2277965A CA 2277965 A1 CA2277965 A1 CA 2277965A1
- Authority
- CA
- Canada
- Prior art keywords
- compound
- formula
- compounds
- acid
- npy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Child & Adolescent Psychology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Saccharide Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Cette invention a trait à une série d'antagonistes non peptidergiques du neuropeptide Y (NPY) comprenant des dérivés de pipéridine de 4-phényl-1,4-dihydropyrimidones de la formule I, dans laquelle R, R?1¿ et R?2¿ sont tels que définis dans le descriptif. Agissant en tant qu'antagonistes du comportement alimentaire induit par NPY, ces composés sont censés agir comme agents anorexigènes efficaces en favorisant la perte de poids ainsi qu'en traitant des troubles de l'alimentation.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US3718397P | 1997-02-04 | 1997-02-04 | |
US60/037,183 | 1997-02-04 | ||
US5089397P | 1997-06-26 | 1997-06-26 | |
US60/050,893 | 1997-06-26 | ||
PCT/US1998/001429 WO1998033791A1 (fr) | 1997-02-04 | 1998-01-26 | Derives de dihydropyrimidone comme antagonistes du neuropeptide y (npy) |
Publications (1)
Publication Number | Publication Date |
---|---|
CA2277965A1 true CA2277965A1 (fr) | 1998-08-06 |
Family
ID=26713884
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002277965A Abandoned CA2277965A1 (fr) | 1997-02-04 | 1998-01-26 | Derives de dihydropyrimidone comme antagonistes du neuropeptide y (npy) |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP0986553A4 (fr) |
JP (1) | JP2002514199A (fr) |
AU (1) | AU733883B2 (fr) |
CA (1) | CA2277965A1 (fr) |
WO (1) | WO1998033791A1 (fr) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE9703414D0 (sv) * | 1997-09-23 | 1997-09-23 | Astra Ab | New compounds |
US6657104B1 (en) | 1997-10-16 | 2003-12-02 | Texas Systems, University Of The Board Of The Regents | Transgenic mouse model for cardiac hypertrophy and methods of use thereof |
AU783403B2 (en) * | 2000-07-05 | 2005-10-20 | H. Lundbeck A/S | Selective melanin concentrating hormone-1 (MCH1) receptor antagonists and uses thereof |
US7166603B2 (en) | 2003-07-23 | 2007-01-23 | Bristol-Myers Squibb Co. | Dihydropyrimidone inhibitors of calcium channel function |
US7157461B2 (en) | 2003-07-23 | 2007-01-02 | Bristol-Myers Squibb Co. | Substituted dihydropyrimidine inhibitors of calcium channel function |
EP1685107B1 (fr) | 2003-11-03 | 2008-09-10 | Myogen, Inc. | Composes de 1,4-dihydropyridine, compositions pharmaceutiques et methodes destinees au traitement de maladies cardiovasculaires |
WO2007101213A2 (fr) * | 2006-02-28 | 2007-09-07 | Kalypsys, Inc. | Nouvelles 2-oxo-1,2,3,4-tétrahydropyrimidines, pyrimidine diones bicycliques et imidazolidine-2,4-diones utiles comme inhibiteurs de l'oxyde nitrique synthase inductible |
PL2056882T3 (pl) | 2006-08-01 | 2013-03-29 | Univ Texas | Identyfikacja mikro-RNA, który aktywuje ekspresję łańcucha ciężkiego beta-miozyny |
WO2012064743A2 (fr) | 2010-11-08 | 2012-05-18 | The Johns Hopkins University | Procédés d'amélioration de la fonction cardiaque |
CN103193715A (zh) * | 2013-03-28 | 2013-07-10 | 浙江大学 | 一种5,6-二氢嘧啶酮衍生物的制备方法 |
US9856232B1 (en) | 2017-06-20 | 2018-01-02 | King Saud University | Dihydropyrimidinone derivatives |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4609494A (en) * | 1985-02-21 | 1986-09-02 | Merck & Co., Inc. | 5-acetyl-3,4,5,6-tetrahydro-4-oxo-2,6-methano-2H-1,3,5-benzothiazocine(benzodiazocine)-11-carboxylates useful as calcium channel blockers |
JPS6287574A (ja) * | 1985-10-14 | 1987-04-22 | Suntory Ltd | 新規なn置換3,4−ジヒドロピリミジン−2−オン誘導体、その製造法及び循環器系疾患治療剤 |
US4675321A (en) * | 1986-02-07 | 1987-06-23 | Merck & Co., Inc. | Substituted pyrimidines useful as calcium channel blockers |
US4684656A (en) * | 1986-03-14 | 1987-08-04 | E. R. Squibb & Sons, Inc. | 1,2,3,4-tetrahydro-6-substituted-4-aryl-3-(substituted sulfonyl)-2-thioxo(or oxo)-5-pyrimidinecarboxylic acids and esters and method of using them to lower blood pressure |
US4684655A (en) * | 1986-03-14 | 1987-08-04 | E. R. Squibb & Sons, Inc. | 1,2,3,4-tetrahydro-6-substituted-4-aryl-3-substituted-2-thioxo(or oxo)-5-pyrimidinecarboxylic acids and esters and use thereof to lower blood pressure |
IL81800A0 (en) * | 1986-03-14 | 1987-10-20 | Squibb & Sons Inc | 1,2,3,4-tetrahydro-6-substituted-4-aryl(or heterocyclo)-3-((substituted amino)carbonyl)-2-thioxo(or oxo)-5-pyrimidine-carboxylic acids and esters and pharmaceutical compositions containing the same |
US4738965A (en) * | 1987-02-03 | 1988-04-19 | Institut Organischskogo Sinteza Akademii Nauk Ssr | 2-oxo-4-(2'-difluoromethylthiophenyl)-5-methoxycarbonyl-6-methyl-1,2,3,4-tetrahydropyrimidine |
US4847379A (en) * | 1987-11-30 | 1989-07-11 | E. R. Squibb & Sons, Inc. | 3,6-dihydro-1,5(2H)-pyrimidinecarboxylic acid esters |
WO1990006118A1 (fr) * | 1988-12-05 | 1990-06-14 | Houston Biotechnology Incorporated | Utilisation therapeutique de dihydropyrimidones et de derives de benzazepine et de benzothiazepine dans le disfonctionnement du nerf optique ou retinien |
-
1998
- 1998-01-26 CA CA002277965A patent/CA2277965A1/fr not_active Abandoned
- 1998-01-26 EP EP98902841A patent/EP0986553A4/fr not_active Ceased
- 1998-01-26 AU AU59639/98A patent/AU733883B2/en not_active Ceased
- 1998-01-26 JP JP53298398A patent/JP2002514199A/ja active Pending
- 1998-01-26 WO PCT/US1998/001429 patent/WO1998033791A1/fr not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
AU5963998A (en) | 1998-08-25 |
JP2002514199A (ja) | 2002-05-14 |
WO1998033791A1 (fr) | 1998-08-06 |
AU733883B2 (en) | 2001-05-31 |
EP0986553A4 (fr) | 2000-12-27 |
EP0986553A1 (fr) | 2000-03-22 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FZDE | Dead |