EP0983354A2 - Recepteurs du facteur neurotrope - Google Patents
Recepteurs du facteur neurotropeInfo
- Publication number
- EP0983354A2 EP0983354A2 EP98918805A EP98918805A EP0983354A2 EP 0983354 A2 EP0983354 A2 EP 0983354A2 EP 98918805 A EP98918805 A EP 98918805A EP 98918805 A EP98918805 A EP 98918805A EP 0983354 A2 EP0983354 A2 EP 0983354A2
- Authority
- EP
- European Patent Office
- Prior art keywords
- gdnfr
- protein
- gdnf
- neurotrophic factor
- acid sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
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- 230000015883 synaptic transmission, dopaminergic Effects 0.000 description 1
- 230000002194 synthesizing effect Effects 0.000 description 1
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- 235000012222 talc Nutrition 0.000 description 1
- 230000002381 testicular Effects 0.000 description 1
- 210000001103 thalamus Anatomy 0.000 description 1
- RTKIYNMVFMVABJ-UHFFFAOYSA-L thimerosal Chemical compound [Na+].CC[Hg]SC1=CC=CC=C1C([O-])=O RTKIYNMVFMVABJ-UHFFFAOYSA-L 0.000 description 1
- 229940033663 thimerosal Drugs 0.000 description 1
- 229940104230 thymidine Drugs 0.000 description 1
- 239000012443 tonicity enhancing agent Substances 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
- 108700012359 toxins Proteins 0.000 description 1
- 235000013619 trace mineral Nutrition 0.000 description 1
- 239000011573 trace mineral Substances 0.000 description 1
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- ODLHGICHYURWBS-LKONHMLTSA-N trappsol cyclo Chemical compound CC(O)COC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)COCC(O)C)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1COCC(C)O ODLHGICHYURWBS-LKONHMLTSA-N 0.000 description 1
- 210000000427 trigeminal ganglion Anatomy 0.000 description 1
- IHIXIJGXTJIKRB-UHFFFAOYSA-N trisodium vanadate Chemical compound [Na+].[Na+].[Na+].[O-][V]([O-])([O-])=O IHIXIJGXTJIKRB-UHFFFAOYSA-N 0.000 description 1
- 238000001665 trituration Methods 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Psychiatry (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Toxicology (AREA)
- Cell Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Hospice & Palliative Care (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
L'invention porte sur le facteur GDNF, puissante neurotrophine présentant un large spectre d'activités biologiques influant sur de nombreux types de cellules des systèmes nerveux central et périphérique. Elle consiste à cloner et caractériser les récepteurs du GDNF et décrit es séquences d'acides nucléiques et d'acides aminés de produits protéiques du récepteur du GDNF. Un domaine hydrophobe présentant les caractéristiques d'un peptide signal se trouve à l'extrémité N-terminale tandis qu'un deuxième domaine hydrophobe se trouvant à l'extrémité C-terminale intervient dans la fixation du récepteur sur la membrane cellulaire. L'absence de domaine transmembranaire et de zone cytoplasmique indique que le récepteur du GDNF nécessite une ou plusieurs molécules accessoires pour pouvoir intervenir sur la signalisation transmembranaire. L'ARNm du récepteur du GDNF est largement distribué à la fois dans le système nerveux et dans les tissus non nerveux ce qui est en accord avec la distribution similaire trouvée pour le GDNF.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/866,354 US7138251B1 (en) | 1996-04-22 | 1997-05-30 | Polynucleotides encoding a neurotrophic factor receptor |
| US866354 | 1997-05-30 | ||
| PCT/US1998/008486 WO1998054213A2 (fr) | 1997-05-30 | 1998-04-27 | Recepteurs du facteur neurotrope |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| EP0983354A2 true EP0983354A2 (fr) | 2000-03-08 |
Family
ID=25347430
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EP98918805A Withdrawn EP0983354A2 (fr) | 1997-05-30 | 1998-04-27 | Recepteurs du facteur neurotrope |
Country Status (6)
| Country | Link |
|---|---|
| EP (1) | EP0983354A2 (fr) |
| JP (1) | JP2002505576A (fr) |
| AU (1) | AU7165998A (fr) |
| CA (1) | CA2291608C (fr) |
| WO (1) | WO1998054213A2 (fr) |
| ZA (1) | ZA984404B (fr) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6696259B1 (en) | 1995-11-13 | 2004-02-24 | Licentia Ltd. | Assays using glial cell line-derived neurotrophic factor receptors |
| US6677135B1 (en) | 1996-05-08 | 2004-01-13 | Biogen, Inc. | Ret ligand (RetL) for stimulating neutral and renal growth |
| KR20010012826A (ko) * | 1997-05-22 | 2001-02-26 | 세파론, 인코포레이티드 | 신경교 세포주-유래 향신경성 인자 수용체 |
| NZ506748A (en) * | 1998-03-23 | 2002-10-25 | Genentech Inc | Nucleic acids encoding a GFR alpha 3 polypeptide; host cell and vectors for production of the GRF alpha 3 protein and an assay for detecting GRFalpha 3 production |
| US7026138B1 (en) | 1998-03-23 | 2006-04-11 | Genentech, Inc. | Polynucleotides encoding GFRα3 |
| DE19816186A1 (de) * | 1998-04-14 | 1999-10-21 | Univ Muenchen L Maximilians | GDNF-kodierende DNA, Teile davon und GDNF-Varianten |
| CN110461880A (zh) | 2016-11-10 | 2019-11-15 | 科乐斯疗法公司 | Gdnf融合多肽及其使用方法 |
| CN114555814A (zh) * | 2019-09-13 | 2022-05-27 | 罗特格斯新泽西州立大学 | Aav相容的层粘连蛋白-连接子聚合蛋白 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4006054A1 (de) * | 1990-02-26 | 1991-08-29 | Boehringer Mannheim Gmbh | Verfahren zur immunologischen bestimmung von liganden |
| AU7568094A (en) * | 1993-08-12 | 1995-03-14 | Cytotherapeutics, Inc. | Improved compositions and methods for the delivery of biologically active molecules using genetically altered cells contained in biocompatible immunoisolatory capsules |
| US6455277B1 (en) * | 1996-04-22 | 2002-09-24 | Amgen Inc. | Polynucleotides encoding human glial cell line-derived neurotrophic factor receptor polypeptides |
| EP0914339B1 (fr) * | 1996-05-08 | 2006-08-02 | Biogen Idec MA Inc. | RET LIGAND 3 (RetL3) POUR STIMULER LA CROISSANCE NEUTRALE ET RENALE |
| EP0846764A3 (fr) * | 1996-11-27 | 1998-09-30 | Smithkline Beecham Plc | Famille de facteurs alpha neurotrophiques des cellules gliales |
| AU730430B2 (en) * | 1997-02-18 | 2001-03-08 | Genentech Inc. | Neurturin receptor |
-
1998
- 1998-04-27 AU AU71659/98A patent/AU7165998A/en not_active Abandoned
- 1998-04-27 EP EP98918805A patent/EP0983354A2/fr not_active Withdrawn
- 1998-04-27 JP JP50067499A patent/JP2002505576A/ja not_active Ceased
- 1998-04-27 WO PCT/US1998/008486 patent/WO1998054213A2/fr active Application Filing
- 1998-04-27 CA CA002291608A patent/CA2291608C/fr not_active Expired - Lifetime
- 1998-05-25 ZA ZA984404A patent/ZA984404B/xx unknown
Non-Patent Citations (1)
| Title |
|---|
| See references of WO9854213A2 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CA2291608C (fr) | 2004-04-13 |
| WO1998054213A2 (fr) | 1998-12-03 |
| JP2002505576A (ja) | 2002-02-19 |
| CA2291608A1 (fr) | 1998-12-03 |
| AU7165998A (en) | 1998-12-30 |
| WO1998054213A3 (fr) | 1999-01-07 |
| ZA984404B (en) | 1998-12-01 |
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