CA2291608C - Recepteurs du facteur neurotrope - Google Patents

Recepteurs du facteur neurotrope Download PDF

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Publication number
CA2291608C
CA2291608C CA002291608A CA2291608A CA2291608C CA 2291608 C CA2291608 C CA 2291608C CA 002291608 A CA002291608 A CA 002291608A CA 2291608 A CA2291608 A CA 2291608A CA 2291608 C CA2291608 C CA 2291608C
Authority
CA
Canada
Prior art keywords
gdnfr
amino acid
gdnf
acid sequence
cells
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CA002291608A
Other languages
English (en)
Other versions
CA2291608A1 (fr
Inventor
Gary M. Fox
Shuqian Jing
Duanzhi Wen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Amgen Inc
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/866,354 external-priority patent/US7138251B1/en
Application filed by Amgen Inc filed Critical Amgen Inc
Publication of CA2291608A1 publication Critical patent/CA2291608A1/fr
Application granted granted Critical
Publication of CA2291608C publication Critical patent/CA2291608C/fr
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Psychiatry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Cell Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hospice & Palliative Care (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

L'invention porte sur le facteur GDNF, puissante neurotrophine présentant un large spectre d'activités biologiques influant sur de nombreux types de cellules des systèmes nerveux central et périphérique. Elle consiste à cloner et caractériser les récepteurs du GDNF et décrit es séquences d'acides nucléiques et d'acides aminés de produits protéiques du récepteur du GDNF. Un domaine hydrophobe présentant les caractéristiques d'un peptide signal se trouve à l'extrémité N-terminale tandis qu'un deuxième domaine hydrophobe se trouvant à l'extrémité C-terminale intervient dans la fixation du récepteur sur la membrane cellulaire. L'absence de domaine transmembranaire et de zone cytoplasmique indique que le récepteur du GDNF nécessite une ou plusieurs molécules accessoires pour pouvoir intervenir sur la signalisation transmembranaire. L'ARNm du récepteur du GDNF est largement distribué à la fois dans le système nerveux et dans les tissus non nerveux ce qui est en accord avec la distribution similaire trouvée pour le GDNF.
CA002291608A 1997-05-30 1998-04-27 Recepteurs du facteur neurotrope Expired - Lifetime CA2291608C (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/866,354 1997-05-30
US08/866,354 US7138251B1 (en) 1996-04-22 1997-05-30 Polynucleotides encoding a neurotrophic factor receptor
PCT/US1998/008486 WO1998054213A2 (fr) 1997-05-30 1998-04-27 Recepteurs du facteur neurotrope

Publications (2)

Publication Number Publication Date
CA2291608A1 CA2291608A1 (fr) 1998-12-03
CA2291608C true CA2291608C (fr) 2004-04-13

Family

ID=25347430

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002291608A Expired - Lifetime CA2291608C (fr) 1997-05-30 1998-04-27 Recepteurs du facteur neurotrope

Country Status (6)

Country Link
EP (1) EP0983354A2 (fr)
JP (1) JP2002505576A (fr)
AU (1) AU7165998A (fr)
CA (1) CA2291608C (fr)
WO (1) WO1998054213A2 (fr)
ZA (1) ZA984404B (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6696259B1 (en) 1995-11-13 2004-02-24 Licentia Ltd. Assays using glial cell line-derived neurotrophic factor receptors
US6677135B1 (en) 1996-05-08 2004-01-13 Biogen, Inc. Ret ligand (RetL) for stimulating neutral and renal growth
NZ501199A (en) * 1997-05-22 2001-12-21 Carlos F Glial cell line-derived neurotrophic factor receptors (BDNFR-beta)
AU765070B2 (en) * 1998-03-23 2003-09-11 Genentech Inc. GFRalpha3 and its uses
US7026138B1 (en) 1998-03-23 2006-04-11 Genentech, Inc. Polynucleotides encoding GFRα3
DE19816186A1 (de) * 1998-04-14 1999-10-21 Univ Muenchen L Maximilians GDNF-kodierende DNA, Teile davon und GDNF-Varianten
JP2019535267A (ja) 2016-11-10 2019-12-12 ケロス セラピューティクス インコーポレイテッドＫｅｒｏｓ Ｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ． Ｇｄｎｆ融合ポリペプチド及びその使用方法
KR20220079857A (ko) * 2019-09-13 2022-06-14 루트거스, 더 스테이트 유니버시티 오브 뉴 저지 Aav-상용성 라미닌-링커 중합 단백질

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4006054A1 (de) * 1990-02-26 1991-08-29 Boehringer Mannheim Gmbh Verfahren zur immunologischen bestimmung von liganden
DK0802800T3 (da) * 1993-08-12 2002-10-07 Neurotech Sa Biokompatible immunoisolatoriske kapsler indeholdende genetisk ændrede celler for levering af biologisk aktive molekyler
US6455277B1 (en) * 1996-04-22 2002-09-24 Amgen Inc. Polynucleotides encoding human glial cell line-derived neurotrophic factor receptor polypeptides
EE9800377A (et) * 1996-05-08 1999-04-15 Biogen, Incorporated Ret-i ligand (RetL) närvi- ja neerukasvu stimuleerimiseks
EP0846764A3 (fr) * 1996-11-27 1998-09-30 Smithkline Beecham Plc Famille de facteurs alpha neurotrophiques des cellules gliales
WO1998036072A1 (fr) * 1997-02-18 1998-08-20 Genentech, Inc. Recepteur de la neurturine

Also Published As

Publication number Publication date
AU7165998A (en) 1998-12-30
WO1998054213A3 (fr) 1999-01-07
CA2291608A1 (fr) 1998-12-03
EP0983354A2 (fr) 2000-03-08
JP2002505576A (ja) 2002-02-19
WO1998054213A2 (fr) 1998-12-03
ZA984404B (en) 1998-12-01

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