CA2291608C - Recepteurs du facteur neurotrope - Google Patents
Recepteurs du facteur neurotrope Download PDFInfo
- Publication number
- CA2291608C CA2291608C CA002291608A CA2291608A CA2291608C CA 2291608 C CA2291608 C CA 2291608C CA 002291608 A CA002291608 A CA 002291608A CA 2291608 A CA2291608 A CA 2291608A CA 2291608 C CA2291608 C CA 2291608C
- Authority
- CA
- Canada
- Prior art keywords
- gdnfr
- amino acid
- gdnf
- acid sequence
- cells
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Psychiatry (AREA)
- Toxicology (AREA)
- Biophysics (AREA)
- Immunology (AREA)
- Hospice & Palliative Care (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Cell Biology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
L'invention porte sur le facteur GDNF, puissante neurotrophine présentant un large spectre d'activités biologiques influant sur de nombreux types de cellules des systèmes nerveux central et périphérique. Elle consiste à cloner et caractériser les récepteurs du GDNF et décrit es séquences d'acides nucléiques et d'acides aminés de produits protéiques du récepteur du GDNF. Un domaine hydrophobe présentant les caractéristiques d'un peptide signal se trouve à l'extrémité N-terminale tandis qu'un deuxième domaine hydrophobe se trouvant à l'extrémité C-terminale intervient dans la fixation du récepteur sur la membrane cellulaire. L'absence de domaine transmembranaire et de zone cytoplasmique indique que le récepteur du GDNF nécessite une ou plusieurs molécules accessoires pour pouvoir intervenir sur la signalisation transmembranaire. L'ARNm du récepteur du GDNF est largement distribué à la fois dans le système nerveux et dans les tissus non nerveux ce qui est en accord avec la distribution similaire trouvée pour le GDNF.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/866,354 US7138251B1 (en) | 1996-04-22 | 1997-05-30 | Polynucleotides encoding a neurotrophic factor receptor |
US08/866,354 | 1997-05-30 | ||
PCT/US1998/008486 WO1998054213A2 (fr) | 1997-05-30 | 1998-04-27 | Recepteurs du facteur neurotrope |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2291608A1 CA2291608A1 (fr) | 1998-12-03 |
CA2291608C true CA2291608C (fr) | 2004-04-13 |
Family
ID=25347430
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002291608A Expired - Lifetime CA2291608C (fr) | 1997-05-30 | 1998-04-27 | Recepteurs du facteur neurotrope |
Country Status (6)
Country | Link |
---|---|
EP (1) | EP0983354A2 (fr) |
JP (1) | JP2002505576A (fr) |
AU (1) | AU7165998A (fr) |
CA (1) | CA2291608C (fr) |
WO (1) | WO1998054213A2 (fr) |
ZA (1) | ZA984404B (fr) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6696259B1 (en) | 1995-11-13 | 2004-02-24 | Licentia Ltd. | Assays using glial cell line-derived neurotrophic factor receptors |
US6677135B1 (en) | 1996-05-08 | 2004-01-13 | Biogen, Inc. | Ret ligand (RetL) for stimulating neutral and renal growth |
KR20010012826A (ko) * | 1997-05-22 | 2001-02-26 | 세파론, 인코포레이티드 | 신경교 세포주-유래 향신경성 인자 수용체 |
US7026138B1 (en) | 1998-03-23 | 2006-04-11 | Genentech, Inc. | Polynucleotides encoding GFRα3 |
IL138593A0 (en) * | 1998-03-23 | 2001-10-31 | Genentech Inc | GFRα3 AND ITS USES |
DE19816186A1 (de) * | 1998-04-14 | 1999-10-21 | Univ Muenchen L Maximilians | GDNF-kodierende DNA, Teile davon und GDNF-Varianten |
JP2019535267A (ja) | 2016-11-10 | 2019-12-12 | ケロス セラピューティクス インコーポレイテッドKeros Therapeutics,Inc. | Gdnf融合ポリペプチド及びその使用方法 |
JP2022547305A (ja) * | 2019-09-13 | 2022-11-11 | ラトガース,ザ ステート ユニバーシティ オブ ニュー ジャージー | Aav適合性ラミニン-リンカー重合タンパク質 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE4006054A1 (de) * | 1990-02-26 | 1991-08-29 | Boehringer Mannheim Gmbh | Verfahren zur immunologischen bestimmung von liganden |
EP1179350A3 (fr) * | 1993-08-12 | 2003-01-02 | Cytotherapeutics, Inc. | Système cellulaire encapsulé pour implantation dans le SNC hunain |
US6455277B1 (en) * | 1996-04-22 | 2002-09-24 | Amgen Inc. | Polynucleotides encoding human glial cell line-derived neurotrophic factor receptor polypeptides |
BR9710665A (pt) * | 1996-05-08 | 1999-08-17 | Biogen Inc | Compostos que promovem o desenvolvimento do tecido |
EP0846764A3 (fr) * | 1996-11-27 | 1998-09-30 | Smithkline Beecham Plc | Famille de facteurs alpha neurotrophiques des cellules gliales |
DK1007666T3 (da) * | 1997-02-18 | 2006-05-08 | Genentech Inc | Neurturinreceptor |
-
1998
- 1998-04-27 EP EP98918805A patent/EP0983354A2/fr not_active Withdrawn
- 1998-04-27 AU AU71659/98A patent/AU7165998A/en not_active Abandoned
- 1998-04-27 CA CA002291608A patent/CA2291608C/fr not_active Expired - Lifetime
- 1998-04-27 WO PCT/US1998/008486 patent/WO1998054213A2/fr active Application Filing
- 1998-04-27 JP JP50067499A patent/JP2002505576A/ja not_active Ceased
- 1998-05-25 ZA ZA984404A patent/ZA984404B/xx unknown
Also Published As
Publication number | Publication date |
---|---|
WO1998054213A2 (fr) | 1998-12-03 |
AU7165998A (en) | 1998-12-30 |
WO1998054213A3 (fr) | 1999-01-07 |
CA2291608A1 (fr) | 1998-12-03 |
ZA984404B (en) | 1998-12-01 |
EP0983354A2 (fr) | 2000-03-08 |
JP2002505576A (ja) | 2002-02-19 |
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WO2000034475A9 (fr) | Facteur de croissance neurotrophique issu des cellules gliales (grnf4), un facteur neurotrophique | |
CA2291608C (fr) | Recepteurs du facteur neurotrope | |
US6413740B1 (en) | Tyrosine kinase receptors and ligands | |
US7138251B1 (en) | Polynucleotides encoding a neurotrophic factor receptor | |
KR100399377B1 (ko) | Gdnf 단백질의 분석방법 및 검정 기구 | |
TW509696B (en) | Glial cell line-derived neurotrophic factor receptor |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request |