EP0967878A4 - TARGETED CYTOTOXIC CELLS - Google Patents

TARGETED CYTOTOXIC CELLS

Info

Publication number
EP0967878A4
EP0967878A4 EP97947273A EP97947273A EP0967878A4 EP 0967878 A4 EP0967878 A4 EP 0967878A4 EP 97947273 A EP97947273 A EP 97947273A EP 97947273 A EP97947273 A EP 97947273A EP 0967878 A4 EP0967878 A4 EP 0967878A4
Authority
EP
European Patent Office
Prior art keywords
cytotoxic cells
targeted cytotoxic
targeted
cells
cytotoxic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP97947273A
Other languages
German (de)
English (en)
French (fr)
Other versions
EP0967878A1 (en
Inventor
Si-Yi Chen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wake Forest University
Original Assignee
Wake Forest University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wake Forest University filed Critical Wake Forest University
Publication of EP0967878A1 publication Critical patent/EP0967878A1/en
Publication of EP0967878A4 publication Critical patent/EP0967878A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
    • C07K16/1036—Retroviridae, e.g. leukemia viruses
    • C07K16/1045—Lentiviridae, e.g. HIV, FIV, SIV
    • C07K16/1063—Lentiviridae, e.g. HIV, FIV, SIV env, e.g. gp41, gp110/120, gp160, V3, PND, CD4 binding site
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2833—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against MHC-molecules, e.g. HLA-molecules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • AIDS & HIV (AREA)
  • Communicable Diseases (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
EP97947273A 1996-10-23 1997-10-23 TARGETED CYTOTOXIC CELLS Withdrawn EP0967878A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US740003 1991-08-02
US74000396A 1996-10-23 1996-10-23
PCT/US1997/019206 WO1998017116A1 (en) 1996-10-23 1997-10-23 Targeted cytotoxic cells

Publications (2)

Publication Number Publication Date
EP0967878A1 EP0967878A1 (en) 2000-01-05
EP0967878A4 true EP0967878A4 (en) 2002-11-27

Family

ID=24974660

Family Applications (1)

Application Number Title Priority Date Filing Date
EP97947273A Withdrawn EP0967878A4 (en) 1996-10-23 1997-10-23 TARGETED CYTOTOXIC CELLS

Country Status (7)

Country Link
EP (1) EP0967878A4 (zh)
JP (1) JP2001503978A (zh)
CN (1) CN1244772A (zh)
AU (1) AU738749B2 (zh)
CA (1) CA2269507A1 (zh)
IL (1) IL129474A0 (zh)
WO (1) WO1998017116A1 (zh)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7101542B1 (en) 1999-05-26 2006-09-05 Vallera Daniel A Cell-mediated targeting of toxins to pathogenic cells
PL366000A1 (en) * 2000-08-08 2005-01-24 M.G.V.S.Ltd. Nucleic acid constructs, vascular cells transformed therewith, pharmaceutical compositions and methods utilizing same for inducing angiogenesis
TW202115245A (zh) * 2019-06-27 2021-04-16 丹麥商諾佛 儂迪克股份有限公司 安全免疫隱形細胞

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995022618A1 (en) * 1994-02-22 1995-08-24 Dana-Farber Cancer Institute Nucleic acid delivery system, method of synthesis and uses thereof

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69027210T2 (de) * 1989-04-21 1997-01-23 Protein Design Labs, Inc., Palo Alto, Calif. Rekombinantes antikörper-toxin-fusion-protein

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995022618A1 (en) * 1994-02-22 1995-08-24 Dana-Farber Cancer Institute Nucleic acid delivery system, method of synthesis and uses thereof

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
CHEN S Y ET AL: "Potent antitumour activity of a new class of tumour-specific killer cells.", NATURE. ENGLAND 2 JAN 1997, vol. 385, no. 6611, 2 January 1997 (1997-01-02), pages 78 - 80, XP001093757, ISSN: 0028-0836 *
CHEN S-Y ET AL: "DESIGN OF A GENETIC IMMUNOTOXIN TO ELIMINATE TOXIN IMMUNOGENICITY", GENE THERAPY, MACMILLAN PRESS LTD., BASINGSTOKE, GB, vol. 2, no. 2, 1 March 1995 (1995-03-01), pages 116 - 123, XP000672862, ISSN: 0969-7128 *
HEIMBROOK D C ET AL: "TRANSFORMING GROWTH FACTOR ALPHA PSEUDOMONAS EXOTOXIN FUSION PROTEIN PROLONGS SURVIVAL OF NUDE MICE BEARING TUMOR XENOGRAFTS", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES, vol. 87, no. 12, 1990, 1990, pages 4697 - 4701, XP002215111, ISSN: 0027-8424 *
See also references of WO9817116A1 *
VITETTA E S ET AL: "Immunotoxins: magic bullets or misguided missiles ?", IMMUNOLOGY TODAY, ELSEVIER PUBLICATIONS, CAMBRIDGE, GB, vol. 14, no. 6, June 1993 (1993-06-01), pages 252 - 259, XP002130421, ISSN: 0167-5699 *
YANG A G ET AL: "A new class of antigen-specific killer cells.", NATURE BIOTECHNOLOGY. UNITED STATES JAN 1997, vol. 15, no. 1, January 1997 (1997-01-01), pages 46 - 51, XP001093758, ISSN: 1087-0156 *

Also Published As

Publication number Publication date
EP0967878A1 (en) 2000-01-05
AU5239498A (en) 1998-05-15
AU738749B2 (en) 2001-09-27
CA2269507A1 (en) 1998-04-30
JP2001503978A (ja) 2001-03-27
WO1998017116A1 (en) 1998-04-30
IL129474A0 (en) 2000-02-29
CN1244772A (zh) 2000-02-16

Similar Documents

Publication Publication Date Title
SG55362A1 (en) Earphone
EP0965597A4 (en) CELL MEMBRANE EFFECTIVE DRUGS
HK1004845A1 (en) Battery
IL122416A0 (en) Battery
GB9710773D0 (en) Cytofunnel arrangement
AU130633S (en) Battery
SG54584A1 (en) Battery
EP1035861A4 (en) PROTEGRINE CONTAINING THREONIN
GB9826682D0 (en) Ridging
AU133676S (en) Battery
PL349315A1 (en) Immunosuppression
AU130634S (en) Battery
IL129474A0 (en) Targeted cytotoxic cells
AU130632S (en) Battery
TW430135U (en) Battery
GB9606421D0 (en) Batteries
HUP9901287A3 (en) Coin-checking arrangement
AU132348S (en) Battery
GB9700448D0 (en) Easy reach
GB9621595D0 (en) Cultivator
PL330823A1 (en) Improved autoradiohraphy
GB9827955D0 (en) Improved weatherbar
GB2309863B (en) Cell aligners
AU1871P (en) Kugotia Clematis serratifolia
CA78992S (en) Battery

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 19990514

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

A4 Supplementary search report drawn up and despatched

Effective date: 20021011

AK Designated contracting states

Kind code of ref document: A4

Designated state(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

17Q First examination report despatched

Effective date: 20030424

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 20031105