EP0953338A1 - Vorrichtung zum Verpacken eines Produktes - Google Patents

Vorrichtung zum Verpacken eines Produktes Download PDF

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Publication number
EP0953338A1
EP0953338A1 EP98118997A EP98118997A EP0953338A1 EP 0953338 A1 EP0953338 A1 EP 0953338A1 EP 98118997 A EP98118997 A EP 98118997A EP 98118997 A EP98118997 A EP 98118997A EP 0953338 A1 EP0953338 A1 EP 0953338A1
Authority
EP
European Patent Office
Prior art keywords
retinol
emulsion
packaging device
packaging
product
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP98118997A
Other languages
English (en)
French (fr)
Inventor
Nathalie Collin
Eric Quemin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
LOreal SA
Original Assignee
LOreal SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by LOreal SA filed Critical LOreal SA
Publication of EP0953338A1 publication Critical patent/EP0953338A1/de
Withdrawn legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/04—Dispersions; Emulsions
    • A61K8/06—Emulsions
    • A61K8/064—Water-in-oil emulsions, e.g. Water-in-silicone emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67—Vitamins
    • A61K8/671—Vitamin A; Derivatives thereof, e.g. ester of vitamin A acid, ester of retinol, retinol, retinal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/16—Emollients or protectives, e.g. against radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/52—Stabilizers
    • A61K2800/522—Antioxidants; Radical scavengers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
    • A61K2800/87—Application Devices; Containers; Packaging
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/001—Preparations for care of the lips
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/08—Anti-ageing preparations

Definitions

  • the present invention relates to a packaging device perfectly suitable for water-in-oil emulsions stably containing retinol, intended in particular for the cosmetic and / or dermatological fields.
  • Retinol is known for its beneficial effects on the skin, especially in topical application.
  • Retinol has long been used in the treatment of acne. But it's in the field of correction of damage caused either by age or by too intensive sun exposure, as retinol has been shown to be extremely active.
  • retinol on cell differentiation allows us to consider, among other things, its use to effectively fight against the appearance of wrinkles and fine lines, against dry skin, roughness and / or stiffness of the skin. His activity in tissue regeneration makes it an important compound in the healing. Repeated application of cosmetic compositions containing retinol allows, among other things, to erase wrinkles, smooth the skin, repair small tears in the epidermis.
  • Emulsions for use in cosmetics containing retinol are described, in particular in document US-A-4,826,828 and in document WO-A-93/00085.
  • the emulsion of the invention is a water-in-oil emulsion containing retinol, a fatty phase and an aqueous phase, characterized in that the phase fatty contains, at least, an organic solvent of liquid retinol at temperature ambient and the pH of the aqueous phase is basic, so as to stabilize the retinol, at least 2 months.
  • the tests carried out with an emulsion according to the invention have shown significantly improved retinol stability compared to that of art prior.
  • the emulsion according to the invention has the advantage of being able to still contain 82% of active retinol after storage at 45 ° C for 2 months.
  • the subject of the present invention is a suitable packaging for the emulsion described above.
  • This packaging is characterized by the fact that it is provided with a distribution such that the product it contains is not brought into contact with the environment, that it also contains an oxygen capture device and its walls are impermeable to gas and visible ultraviolet light.
  • the dispensing device can be constituted by a valve or a pump without air intake, such as the device described in document FR-A-2,666,308 or in document FR-A-2,658,739.
  • the oxygen capture device is isolated from the product contained in the packaging by a permeable membrane gas and impermeable to liquids, especially those used in the composition of the emulsion according to the invention.
  • the gas permeable membrane can be, for example, that defined in the document FR-A-2,671,055.
  • Any device capable of using oxygen as capture device absorb oxygen without release.
  • the oxygen capture device isolated by the membrane can be, in the packaging device, integral with the walls or not integral with these walls and drowned in the composition.
  • the emulsion used according to the invention is perfectly well suited for use cosmetic and / or dermatological.
  • the emulsion according to the invention is free of any metal ion chelating agent and possibly of agent antioxidant.
  • the fatty phase of the emulsion according to the invention can represent 10% to 50% of the total weight of the emulsion and preferably from 20% to 35%.
  • retinol is present in the emulsion according to the invention in a proportion ranging from 0.001% to 10%, and preferably from 0.01% to 1% of the total weight of the emulsion.
  • the retinol used in the emulsion according to the invention can be retinol in one any of its conformations and in particular that in the all-trans form, such as that sold by the company Fluka under the name "all-trans-retinol".
  • the all-trans retinol has the particularity of exhibiting retinoid activity and safety superior to other retinoids.
  • the organic solvent for retinol can represent from 0.01% to 30% of the total weight of the emulsion according to the invention, and preferably from 0.1% to 10%.
  • the organic solvent which is liquid at room temperature (at 20 ° C. for example) used in the invention is any organic solvent capable of dissolving retinol while retaining good stability therein.
  • this solvent is chosen from the group consisting of C 16 -C 20 branched chain aliphatic fatty alcohols, C 6 -C 14 dicarboxylic acid and isopropyl alcohol diesters, fatty acid triglycerides C 6 -C 18 and mixtures thereof.
  • hexyl-2-decanol such as that sold by the company Condea under the name "Isofol 16”
  • octyldodecanol such as that sold by the company Henkel under the name "Eutanol G”
  • isostearyl alcohol such as that sold by the company Sherex under the name "Adol 66”.
  • di-isopropyl adipate such as that sold by the company ISP under the name "Ceraphyl 230".
  • triglycerides of C 6 -C 18 fatty acids according to the invention, it is preferred to use mixed triglycerides of capric / caprylic acids such as those sold by the company Hüls France under the name "Miglyol 812".
  • the fatty phase of the emulsion according to the invention may contain an emulsifier capable of forming a water-in-oil emulsion and supporting basic pH.
  • This emulsifier is in particular a silicone emulsifier used in a proportion of 0.5% to 10% and preferably from 1% to 6% of the total weight of the emulsion.
  • polyoxyethylenated C 10 -C 22 alkyl dimethicone copolyols such as cetyl dimethicone copolyol or "Abil EM-90" from the company Goldschmidt
  • lauryl dimethicone copolyol polyoxyethylenated and polyoxypropylenated such as Q2-5200 from Dow Corning
  • Polyoxyethylenated dimethicone copolyols such as SP can also be used 1228 from General Electric and also Q2-3225 C from Dow Corning.
  • the fatty phase may also contain a complementary oil which is inert with respect to retinol, different from the emulsifier which is preferably chosen from mineral or silicone oils.
  • the aqueous phase of the emulsion according to the invention has a basic pH greater than 8 and preferably ranging from 8.5 to 9.5.
  • the pH of the aqueous phase is obtained by addition of any base compatible with the stability of retinol in the emulsion according to the invention and in an appropriate amount to obtain the desired pH of the aqueous phase.
  • the base will be used at a proportion ranging from from 0.05% to 0.5% of the total weight of the emulsion.
  • bases used in the invention there may be mentioned for example the triethanolamine, aminomethylpropanol, aminomethylpropanediol, tris or aminomethylpropanetriol, soda, arginine, lysine.
  • the emulsion according to the invention may also contain hydrophilic additives or lipophiles conventionally used in cosmetic compositions or dermatological.
  • moisturizers such as polyols (glycerol) and glycols.
  • lipophilic additives mention may be made of gelling agents such as bentone gel, for example that sold under the name "Simagel SI 345" by the company Biophil, polyethylene waxes, such as the company's polyethylene wax AC 617 Allied Chemical.
  • gelling agents such as bentone gel, for example that sold under the name "Simagel SI 345" by the company Biophil, polyethylene waxes, such as the company's polyethylene wax AC 617 Allied Chemical.
  • the emulsion according to the invention advantageously contains stabilizing salts of non-metallic origin in a proportion, for example, of 0.3% to 2% of the total weight of the emulsion such as sodium chloride (NaCl), chloride of potassium (KCl).
  • stabilizing salts of non-metallic origin in a proportion, for example, of 0.3% to 2% of the total weight of the emulsion such as sodium chloride (NaCl), chloride of potassium (KCl).
  • the preparation of the emulsion of the invention is carried out in an inert atmosphere (nitrogen or rare gas such as Argon) free of all oxygen and in the presence of inactinic light such as that of a sodium vapor lamp.
  • an inert atmosphere nitrogen or rare gas such as Argon
  • inactinic light such as that of a sodium vapor lamp.
  • the fatty (A) and aqueous (B) phases constituting the emulsion are prepared independently, then the aqueous phase (B) is incorporated into the fatty phase (A) with stirring in Moritz, medium speed, at room temperature, under normal conditions of preparation of all water in oil emulsions.
  • the mixture thus formed constitutes the support emulsified in which we will incorporate retinol.
  • compositions of various emulsions produced according to the invention give compositions of various emulsions produced according to the invention.
  • This very soft and nourishing cream is ideal for daily application on the face, in the evening, for a long-term anti-wrinkle effect.
  • This flexible body milk is an excellent anti-aging body care provided use it daily on the whole body. After application, the skin is softened and smoothed.
  • This compact, very slippery cream when applied is a nourishing treatment and repairer of damaged and wrinkled lips.
  • Example 1 a stability test was carried out in which a emulsion according to the invention (example 1) and different formulas derived from those from Example 1, (A, B, C, D, E, F).
  • composition A Composition A
  • Example 1 Fat phase of Example 1 to which we add: ⁇ -tocopherol 0.1% ⁇ -tocopherol acetate 1% ascorbyle palmitate 0.2% + Aqueous phase of Example 1 in which we add: Desquest 2046 0.2% and in which the deionized water has been adjusted accordingly.
  • Example 1 Composition of Example 1 in which is incorporated after manufacture the oxygen absorber isolated from the emulsion.
  • compositions were carried out by measuring the percentage of degradation after storage for 1 month or 2 months, either at 4 ° C., either at ambient temperature, or at 45 ° C. The results are given in the following table: 1 MONTH 2 MONTHS Compositions 4 ° C Temperat. ambient 45 ° C 4 ° C Temperat. ambient 45 ° C 1 0 0 19 6 10 33 AT 2 5 25 4 12 35 B 0 1 27 2 18 37 VS 0 8 44 4 34 72 D 0 1 40 0 14 68 E 0 0 9 0 0 27 F 0 1 6 1 16 18
  • the emulsion according to the invention (e.g. 1, F) has a comparable or even better retinol stability than that containing a or several antioxidants (A, B) as described in the prior art while emulsions produced with either a retinol dissolved in a solvent other than those selected in the invention (D), ie a retinol in the presence of a phase aqueous at an inappropriate pH (C) show poorer stability.
  • This table shows the possibility of stabilizing retinol in emulsions without antioxidant but also shows that choosing a particular antioxidant (Raluquin, E) introduced into the emulsion according to the invention, can improve stability.
  • FIG. 1 Described below, with reference to the appended figure (Fig. 1), an example of packaging compatible with the emulsion according to the invention.
  • the packaging (2) comprises a container (3) whose walls (4) are made of any gas impermeable material that can be made, for example, of a thermoformed material or any other suitable material provided that the internal surface of said walls, in contact with the emulsion (6), either non-metallic and that this material is impermeable to visible ultraviolet rays.
  • the container (3) is surmounted by a distribution device without air intake (8), such as that described in document FR-A-2,666,308, consisting of a outwardly convex dome (10) and at least one slot (12) provided in the top of the dome.
  • a distribution device without air intake (8) such as that described in document FR-A-2,666,308, consisting of a outwardly convex dome (10) and at least one slot (12) provided in the top of the dome.
  • the walls (14, 16) of the slot (12) are suitable for coming into contact with one another the other to achieve a watertight closure at rest.
  • the whole device (8) is surmounted by a hermetic cover (18) ensuring double protection of the emulsion according to the invention contained in the packaging, with respect to the environment.
  • the encapsulated oxygen absorber (24) forms the oxygen capture device embedded in the emulsion according to the invention contained in the packaging device.
  • the membrane surrounding the oxygen capture device can be made by any material capable of allowing oxygen to pass through while remaining impermeable liquids in particular liquids constituting the emulsion according to the invention and for example in one of the materials chosen from polyethylene, propylene and polyethylene terephthalate.
  • the walls (14,16) of the dome (10) are in close contact, thus ensuring the hermeticity of the slot (12).
  • a pressure is transmitted to the emulsion contained in this packaging which will tend to spread the walls (14,16) thus allowing the emulsion to exit conditioning.
  • the pressure being released, the walls (14,16) regain their rest position and occlude the slot (12).

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Birds (AREA)
  • Dermatology (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Dispersion Chemistry (AREA)
  • Toxicology (AREA)
  • Cosmetics (AREA)
  • Colloid Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Emulsifying, Dispersing, Foam-Producing Or Wetting Agents (AREA)
  • Processes Of Treating Macromolecular Substances (AREA)
EP98118997A 1993-12-30 1994-12-15 Vorrichtung zum Verpacken eines Produktes Withdrawn EP0953338A1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR9315862A FR2714595B1 (fr) 1993-12-30 1993-12-30 Emulsion eau dans huile contenant du rétinol, son utilisation et son conditionnement.
FR9315862 1993-12-30
EP94402619A EP0666076B1 (de) 1993-12-30 1994-12-15 Wasser in Öl Emulsion enthaltend Retinol

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
EP94402619A Division EP0666076B1 (de) 1993-12-30 1994-12-15 Wasser in Öl Emulsion enthaltend Retinol

Publications (1)

Publication Number Publication Date
EP0953338A1 true EP0953338A1 (de) 1999-11-03

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ID=9454565

Family Applications (2)

Application Number Title Priority Date Filing Date
EP94402619A Expired - Lifetime EP0666076B1 (de) 1993-12-30 1994-12-15 Wasser in Öl Emulsion enthaltend Retinol
EP98118997A Withdrawn EP0953338A1 (de) 1993-12-30 1994-12-15 Vorrichtung zum Verpacken eines Produktes

Family Applications Before (1)

Application Number Title Priority Date Filing Date
EP94402619A Expired - Lifetime EP0666076B1 (de) 1993-12-30 1994-12-15 Wasser in Öl Emulsion enthaltend Retinol

Country Status (12)

Country Link
US (2) US5656672A (de)
EP (2) EP0666076B1 (de)
JP (1) JP2716387B2 (de)
AT (1) ATE174789T1 (de)
BR (1) BR9405480A (de)
CA (1) CA2138112A1 (de)
DE (1) DE69415491T2 (de)
ES (1) ES2128528T3 (de)
FR (1) FR2714595B1 (de)
HU (1) HU215490B (de)
PL (1) PL177705B1 (de)
RU (1) RU2130302C1 (de)

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FR2714595B1 (fr) 1996-02-02
EP0666076A3 (de) 1997-01-02
EP0666076B1 (de) 1998-12-23
US5656672A (en) 1997-08-12
JP2716387B2 (ja) 1998-02-18
ES2128528T3 (es) 1999-05-16
CA2138112A1 (fr) 1995-07-01
ATE174789T1 (de) 1999-01-15
PL177705B1 (pl) 2000-01-31
US5800596A (en) 1998-09-01
FR2714595A1 (fr) 1995-07-07
HU215490B (hu) 1999-01-28
PL306580A1 (en) 1995-07-10
BR9405480A (pt) 1995-09-19
JPH08986A (ja) 1996-01-09
RU94045128A (ru) 1996-10-20
DE69415491D1 (de) 1999-02-04
DE69415491T2 (de) 1999-05-12
HUT73060A (en) 1996-06-28
EP0666076A2 (de) 1995-08-09
RU2130302C1 (ru) 1999-05-20

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