EP0953151A1 - Cellule electrochimique a flux continu - Google Patents

Cellule electrochimique a flux continu

Info

Publication number
EP0953151A1
EP0953151A1 EP98905292A EP98905292A EP0953151A1 EP 0953151 A1 EP0953151 A1 EP 0953151A1 EP 98905292 A EP98905292 A EP 98905292A EP 98905292 A EP98905292 A EP 98905292A EP 0953151 A1 EP0953151 A1 EP 0953151A1
Authority
EP
European Patent Office
Prior art keywords
electrodes
thick
cell
flow cell
electrochemical flow
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP98905292A
Other languages
German (de)
English (en)
Inventor
Ursula Bilitewski
Matthias Stiene
Ingrid Rohm
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Helmholtz Zentrum fuer Infektionsforschung HZI GmbH
Original Assignee
Helmholtz Zentrum fuer Infektionsforschung HZI GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE1997101798 external-priority patent/DE19701798C2/de
Priority claimed from DE1997145423 external-priority patent/DE19745423A1/de
Application filed by Helmholtz Zentrum fuer Infektionsforschung HZI GmbH filed Critical Helmholtz Zentrum fuer Infektionsforschung HZI GmbH
Publication of EP0953151A1 publication Critical patent/EP0953151A1/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/403—Cells and electrode assemblies

Definitions

  • the invention relates to an electrochemical flow cell for electrical current / voltage measurement on liquids.
  • Thick film sensors in the classic sense are planar detectors, such as those used for thermal, piezoelectric, potentiometric and amperometric measurements.
  • Flow cells of this type are known, for example, from A. Günter, U. Bilitewski: Analytica Chemica Acta 300 (1975), page 120, in which a recess (flow volume) is provided in a plexiglass block and is connected to an inlet and outlet channel. In the flow cell shown there, the cell volume is rectangular in cross section.
  • a thick film electrode attached to a substrate is attached to the hypotenuse of the cross-sectional rectangle shown.
  • a flow cell from Hewlett Packard is also known, which is also composed of a large number of individual components. Two highly planar parts, into which electrodes are integrated, are separated in a housing by a thin non-conductive film. A flow path for the transport of the liquid sample through the cell is omitted in the film, so that the internal volume of the flow cell is determined by the thickness of the film and the area of the recess in this film. The total height of this cell is approx. 9 cm.
  • the invention is therefore based on the object of providing a flow cell which is simple and inexpensive to produce and has a small dead volume in the range of a few ⁇ -liters and a method for producing such a cell.
  • the present invention relates to an electrochemical flow cell with two electrodes arranged at a distance from one another and a flow path arranged between them, which is connected to an inlet and an outlet, the spacer between the electrodes being formed by an insulator layer produced using thick-film technology and a planar recess in the insulator layer Internal volume of the flow path determined.
  • the electrodes of the electrochemical flow cell according to the invention are preferably formed by planar thick-film electrodes, the cell according to the invention having an upper and a lower substrate, which serves as the basis for the corresponding electrodes.
  • Conductor tracks and solder lugs can be arranged between the electrodes and the corresponding substrates, which can also be implemented using thick-film technology, ie screen printing.
  • the electrochemical flow cell according to the invention can furthermore have heating and / or temperature elements which can also be produced using thick-film technology.
  • heating and / or temperature elements which can also be produced using thick-film technology.
  • individual electrodes it is also possible to use a plurality of electrodes or an electrode array, it being possible for the printed conductive surface to be structured, for example with a laser trimmer, in order to obtain an electrode array.
  • a multi-channel electrochemical flow cell according to the present invention can be manufactured by layering or stacking at least two electrochemical flow cells.
  • the present invention relates to a method for producing an electrochemical flow-through cell, at least one electrode or an electrode array using thick film technology being applied to each substrate, and by connecting the two planar thick film substrates provided with electrodes (electrode arrays) by means of an insulator layer produced using thick film technology, which has a recess area connected to the inlet and outlet, the flow cell being formed.
  • the internal volume of the flow cell is determined by the recess area and the layer thickness of the insulator layer over the electrode area. This volume definition advantageously already takes place during the screen printing process of the electrodes, or by the choice of a suitable template (templates) for the insulator layer (Insulator layers).
  • heating and / or temperature elements can be applied using thick-film technology. All conductive pastes suitable for thick-film technology (eg platinum, Ag / AgPd, gold or graphite pastes) can be used for the electrode surface, the thick layers such as electrodes, insulator layer etc. being produced preferably by means of screen printing.
  • the electrode surfaces and previously the corresponding supply lines are applied to the upper and lower substrates using screen printing technology.
  • the spacer is then applied by means of screen printing on the electrode side of at least one substrate provided with an electrode.
  • there are two cell halves namely a substrate provided with an electrode and a further substrate provided with an electrode and the insulator layer.
  • each cell half comprises a substrate provided with an electrode and a spacer.
  • the two cell halves are then coated with an adhesive, for example a superglue, once on the surface of the electrode and that of the spacer, or on the surfaces of the two spacers, and pressed together for adhesive in order to obtain the complete cell.
  • the cell halves produced according to the above two cases can be glued using screen-printable SMD glue.
  • conductive and non-conductive adhesives which are normally used to integrate active SMD elements into printed, passive circuits, can be screen-printed onto the corresponding adhesive surfaces of the cell halves (i.e., an electrode surface and the insulator layer surface or the two insulator layer surfaces), which results in the uniform thickness and the definition of the adhesive layer, ie the uniform coating of the adhesive surface with the adhesive layer, is guaranteed.
  • the insulator layer can be formed by the insulating SMD adhesive, whereby a cell is obtained which is produced entirely using screen printing technology. This enables automatic production of the screen printing cells.
  • the invention has the following advantages over known flow cells:
  • a flow cell according to the invention can be produced simply and inexpensively based on the thick-film technology.
  • a screen-printable adhesive is used to glue the cell halves, then the cell is manufactured entirely using screen printing technology and fully automated machine production is possible.
  • the liquid cannot get between the insulating layer (foil) and the electrode. This means that the active, liquid-wetted electrical the area defined by the insulator layer is constant.
  • the insulator layer Since the insulator layer has a solid structure and adheres firmly to the electrode layer, it cannot be damaged during assembly, in contrast to the film of the conventional flow cell.
  • Fig. 1 shows a schematic exploded view of a flow cell according to the invention.
  • the flow cell comprises an upper substrate 1, on the lower surface of which conductor tracks and solder tags 2 are applied. Subsequently, an upper flat electrode 3, for example made of platinum, gold or graphite or another conductive material, is applied by means of thick-film technology.
  • the upper electrode 3 is spaced from a lower electrode 5, which is also produced using thick-film technology, by means of a printed insulating layer 4, the flat recess 4a of which forms the flow path.
  • the lower electrode 5 is printed on a lower substrate 7, conductor tracks and soldering lugs 6 likewise being located between the lower electrode 5 and the lower substrate 7.
  • the upper 3 and lower Electrode 5 and the upper 1 or lower substrate 7 have corresponding recesses or holes 8, 9, 10, 11, which form the inflow / outflow for the flow path 4a.
  • temperature sensors and / or heating elements can be applied.
  • the dimensions of the flow cell according to the invention depend essentially on the requirements of the specific use. In a preferred embodiment, the cell is approximately 10 mm wide, 25 mm deep and 3 mm thick.
  • the flow cell according to the invention is produced by printing electrodes 3, 5 onto the lower and upper substrates 1, 7 provided with conductor tracks and soldering lugs 2, 6 using screen printing technology.
  • An insulator layer 4 is then applied to one of the substrates 3, 5 provided with an electrode by means of screen printing. Then the two cell halves are glued. A superglue can be used for gluing.
  • the insulator layer 4 is printed from a non-conductive SMD adhesive by means of screen printing and then the cell halves are glued directly by means of the insulator layer 4.
  • the SMD adhesive PD 860002, PD 860002 S, PD 860002SA, PD 860002 SP and PD 860002 M as well as the SMD adhesive PD945 and PD 944 from Heraeus can be used as SMD adhesive, whereby mainly the SMD adhesive PD 860002 was used.
  • FIG. 1 Furthermore, it can be seen without illustration that, for example, stacking or layering several flow cells according to FIG. 1 enables a multi-channel flow cell in a small space.
  • the combination of multilayer layers allows the design and the cost-effective production of larger numbers of flow cells with a few microliters of internal volume, the internal volume of the flow cell, as can be seen from FIG. 1, due to the size of the recess 4a in the insulator layer 4 or can be determined by the thickness of the insulator layer 4, so that the flow volume can be determined by the choice of parameters during the printing process.

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Electrochemistry (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Hybrid Cells (AREA)

Abstract

L'invention concerne des cellules électrochimiques à flux continu pourvues de capteurs à couches épaisses. La cellule électrochimique décrite comporte deux électrodes espacées l'une de l'autre et un canal d'écoulement situé entre ces deux électrodes, lequel est raccordé à une entrée et à une sortie. L'écarteur entre les deux électrodes est formé par une couche isolante réalisée à l'aide d'une technique à couches épaisses, un évidement plan de la couche isolante et l'épaisseur de cette dernière déterminant le volume interne du canal d'écoulement. Les électrodes sont ménagées sur des substrats et sont réalisées également à l'aide d'une technique à couches épaisses. La cellule est réalisée par collage de deux demi-cellules. De préférence, la couche isolante peut consister en un adhésif CMS non conducteur qui assure simultanément l'adhérence.
EP98905292A 1997-01-20 1998-01-13 Cellule electrochimique a flux continu Withdrawn EP0953151A1 (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
DE1997101798 DE19701798C2 (de) 1997-01-20 1997-01-20 Elektrochemische Durchflußzelle
DE19701798 1997-01-20
DE19745423 1997-10-16
DE1997145423 DE19745423A1 (de) 1997-10-16 1997-10-16 Elektrochemische Durchflußzelle
PCT/EP1998/000167 WO1998032008A1 (fr) 1997-01-20 1998-01-13 Cellule electrochimique a flux continu

Publications (1)

Publication Number Publication Date
EP0953151A1 true EP0953151A1 (fr) 1999-11-03

Family

ID=26033235

Family Applications (1)

Application Number Title Priority Date Filing Date
EP98905292A Withdrawn EP0953151A1 (fr) 1997-01-20 1998-01-13 Cellule electrochimique a flux continu

Country Status (3)

Country Link
EP (1) EP0953151A1 (fr)
CZ (1) CZ257199A3 (fr)
WO (1) WO1998032008A1 (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9929069D0 (en) * 1999-12-08 2000-02-02 Imperial College Potentiometric sensor
DE10064417A1 (de) * 2000-12-21 2002-07-04 Cpc Cellular Process Chemistry Mikroreaktor für elektrochemische Umsetzungen
CZ301131B6 (cs) * 2002-11-01 2009-11-11 Bvt Technologies, A.S. Zarízení pro chemické analýzy

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4332081A (en) * 1978-06-22 1982-06-01 North American Philips Corporation Temperature sensor
US4496454A (en) * 1983-10-19 1985-01-29 Hewlett-Packard Company Self cleaning electrochemical detector and cell for flowing stream analysis
KR970010981B1 (ko) * 1993-11-04 1997-07-05 엘지전자 주식회사 알콜농도 측정용 바이오센서 및 바이오센서 제조방법과 바이오센서를 이용한 음주 측정기

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See references of WO9832008A1 *

Also Published As

Publication number Publication date
WO1998032008A1 (fr) 1998-07-23
CZ257199A3 (cs) 1999-12-15

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