EP0932424B1 - Method and apparatus for making an article from a formable material - Google Patents

Method and apparatus for making an article from a formable material Download PDF

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Publication number
EP0932424B1
EP0932424B1 EP97941096A EP97941096A EP0932424B1 EP 0932424 B1 EP0932424 B1 EP 0932424B1 EP 97941096 A EP97941096 A EP 97941096A EP 97941096 A EP97941096 A EP 97941096A EP 0932424 B1 EP0932424 B1 EP 0932424B1
Authority
EP
European Patent Office
Prior art keywords
pin
forming
tool
forming tool
orifice
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
EP97941096A
Other languages
German (de)
English (en)
French (fr)
Other versions
EP0932424A1 (en
Inventor
Terence Edward Weston
Christopher John Briggs
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Weston Medical Ltd
Original Assignee
Weston Medical Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9620173.6A external-priority patent/GB9620173D0/en
Priority claimed from GBGB9624870.3A external-priority patent/GB9624870D0/en
Application filed by Weston Medical Ltd filed Critical Weston Medical Ltd
Publication of EP0932424A1 publication Critical patent/EP0932424A1/en
Application granted granted Critical
Publication of EP0932424B1 publication Critical patent/EP0932424B1/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C33/00—Moulds or cores; Details thereof or accessories therefor
    • B29C33/0033—Moulds or cores; Details thereof or accessories therefor constructed for making articles provided with holes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/30—Syringes for injection by jet action, without needle, e.g. for use with replaceable ampoules or carpules
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C33/00—Moulds or cores; Details thereof or accessories therefor
    • B29C33/30—Mounting, exchanging or centering
    • B29C33/303—Mounting, exchanging or centering centering mould parts or halves, e.g. during mounting
    • B29C33/304—Mounting, exchanging or centering centering mould parts or halves, e.g. during mounting centering cores
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C43/00—Compression moulding, i.e. applying external pressure to flow the moulding material; Apparatus therefor
    • B29C43/32—Component parts, details or accessories; Auxiliary operations
    • B29C43/36—Moulds for making articles of definite length, i.e. discrete articles
    • B29C43/42—Moulds for making articles of definite length, i.e. discrete articles for undercut articles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C57/00—Shaping of tube ends, e.g. flanging, belling or closing; Apparatus therefor, e.g. collapsible mandrels
    • C—CHEMISTRY; METALLURGY
    • C03—GLASS; MINERAL OR SLAG WOOL
    • C03B—MANUFACTURE, SHAPING, OR SUPPLEMENTARY PROCESSES
    • C03B11/00—Pressing molten glass or performed glass reheated to equivalent low viscosity without blowing
    • C03B11/06—Construction of plunger or mould
    • C03B11/10—Construction of plunger or mould for making hollow or semi-hollow articles
    • C—CHEMISTRY; METALLURGY
    • C03—GLASS; MINERAL OR SLAG WOOL
    • C03B—MANUFACTURE, SHAPING, OR SUPPLEMENTARY PROCESSES
    • C03B21/00—Severing glass sheets, tubes or rods while still plastic
    • C03B21/04—Severing glass sheets, tubes or rods while still plastic by punching out
    • C—CHEMISTRY; METALLURGY
    • C03—GLASS; MINERAL OR SLAG WOOL
    • C03B—MANUFACTURE, SHAPING, OR SUPPLEMENTARY PROCESSES
    • C03B23/00—Re-forming shaped glass
    • C03B23/04—Re-forming tubes or rods
    • C03B23/09—Reshaping the ends, e.g. as grooves, threads or mouths
    • C03B23/092—Reshaping the ends, e.g. as grooves, threads or mouths by pressing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C43/00—Compression moulding, i.e. applying external pressure to flow the moulding material; Apparatus therefor
    • B29C43/32—Component parts, details or accessories; Auxiliary operations
    • B29C43/36—Moulds for making articles of definite length, i.e. discrete articles
    • B29C43/361—Moulds for making articles of definite length, i.e. discrete articles with pressing members independently movable of the parts for opening or closing the mould, e.g. movable pistons
    • B29C2043/3615—Forming elements, e.g. mandrels or rams or stampers or pistons or plungers or punching devices
    • B29C2043/3618—Forming elements, e.g. mandrels or rams or stampers or pistons or plungers or punching devices plurality of counteracting elements
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29K—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES B29B, B29C OR B29D, RELATING TO MOULDING MATERIALS OR TO MATERIALS FOR MOULDS, REINFORCEMENTS, FILLERS OR PREFORMED PARTS, e.g. INSERTS
    • B29K2105/00—Condition, form or state of moulded material or of the material to be shaped
    • B29K2105/25—Solid
    • B29K2105/253—Preform
    • B29K2105/258—Tubular
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29L—INDEXING SCHEME ASSOCIATED WITH SUBCLASS B29C, RELATING TO PARTICULAR ARTICLES
    • B29L2031/00—Other particular articles
    • B29L2031/753—Medical equipment; Accessories therefor
    • B29L2031/7544—Injection needles, syringes

Definitions

  • the invention is in the field of needleless injectors which use a capsule for containing a liquid drug to be injected, and needle-type hypodermic syringe bodies.
  • Needleless injectors are used as an alternative to conventional hypodermic injectors to deliver medicaments through the patient's skin into the underlying tissues.
  • Such injectors use a high pressure piston pump to dispense a jet of liquid drug with sufficient force to penetrate the skin, and thereafter deposit the drug into the dermal, subcutaneous or muscular tissues.
  • the drug is dispensed from a cylindrical chamber, having a fine orifice at one end through which the drug is discharged.
  • a piston is slidingly and sealingly located in the chamber, and the drug is contained within the space between the orifice and piston.
  • the orifice is placed on the skin, and by operating a release mechanism, the piston is acted upon by a force which may be derived from a spring, pressurised gas or chemical reaction.
  • the capsule may be filled by the user, or may be prefilled and pre-assembled to an actuator.
  • the materials from which the capsule and piston are constructed must be inert to the drug - i.e. they must not react with the drug chemically, nor physically, and must not contain harmful extractives that might contaminate the drug.
  • the choice of materials is small: borosilicate glass is the most favoured capsule material when drugs must be stored for more than a few hours. If an alternative material is selected for the capsule, years of testing must be done to validate that material, whereas borosilicate glass has a known compatibility with most drugs.
  • the pressure generated in the capsule is at least 100 bars, and it is preferable, in order to avoid leakage during injection, that the orifice is integral with the cylindrical chamber. Furthermore, the form and dimension of the orifice is critical to the injection performance, and for repeatable results these features should be made to close tolerances.
  • glass is a difficult material to mould and maintain such close tolerances over many millions of components.
  • One traditional method is to work the heated and softened end of a glass tube on a lathe, and by applying a shaping wheel or paddle, to close up one end onto a mandrel to form the orifice.
  • US-A-3,237,243 discloses a method of manufacturing seamless plastics containers, with a top orifice.
  • the method involves deforming a blank positioned over a mandrel using a die.
  • the mandrel has a pin and the die has a corresponding opening, for receiving the pin.
  • the orifice is defined by a part of the pin not received in the opening.
  • DE-C-525515 discloses a method of forming a neck in a glass tube which defines a narrow opening.
  • a mandrel is used to define the inner profile of the neck opening, and is inserted into the opposite end of the tube.
  • An outer forming tool is used to define the outer contour of the neck.
  • the present invention seeks to overcome the drawbacks of current glass tube forming methods by providing a means of forming the orifice, and the inside and outside profiles of a needleless injector capsule or hypodermic syringe body, which means has excellent repeatability and is capable of high speed production.
  • the invention also aims to provide a process which enables an unobstructed orifice to be formed, even if the quantity of material in the starting blank is greater than required to form the article.
  • a method of making an article from a formable material the article having a cylindrical cavity communicating with the exterior via an orifice, wherein a blank having an open end is mounted on a first forming tool in a tube support with clearance therebetween, and the open end is engaged by a second forming tool while an end region of the blank adjacent the said open end is in a condition to permit it to be formed, the first forming tool having a pin extending therefrom, and the first and second tools are brought together to form the said end region into a desired shape, with the pin defining the said orifice, wherein the pin has a distal end, and the second tool has a distal face which, prior to forming, faces the distal end of the pin at a distance therefrom, and wherein during forming the said distal end of the pin and the said distal face of the second tool are brought into contact with one another, one of the pin and the distal face of the second tool being biased by a plunger, wherein the pin extends from the first
  • the invention further provides an apparatus for making an article from a formable material, the article having a cylindrical cavity communicating with the exterior via an orifice, comprising a first forming tool having a tube support for receiving an open-ended blank with clearance therebetween, and a second forming tool for engaging an end region of the blank adjacent the open end thereof to form the same, the first forming tool having a pin extending therefrom, the tools being so arranged that when they are brought together to form the said end region into a desired shape the pin defines the said orifice, wherein the pin has a distal end, and the second tool has a distal face which, prior to forming, faces the distal end of the pin at a distance therefrom, the apparatus further comprising means for bringing the said distal end of the pin and the said distal face of the second tool into contact with one another during forming, one of the pin and the distal face of the second tool being biased by a plunger, wherein the pin extends from the first forming tool at the end of forming by a length equal to
  • a glass tube, cut to length, is placed onto a mandrel having a profile to which the glass may be formed.
  • the mandrel has a pin at its extreme for forming the orifice.
  • the glass is rotated and heated on the end to be formed.
  • a form tool having a profile to which the outside of the tube is to be formed is applied to the exterior of the glass tube and presses the softened glass onto the mandrel and pin.
  • the rotation of the glass tube is stopped; alternatively the external forming tool is rotated at the same speed as the tube, so that there is no relative movement between the tube and external form tool.
  • capsule 2 is a cylinder containing drug 2, and a piston 3 in contact with drug 2.
  • the capsule 1 is retained in the nose 4 of a needleless injector actuator by retaining cap 5 bearing on shoulder 8 of the capsule 1.
  • Cap 5 may be retained by screw threads 10, snap means or other suitable device.
  • the discharge end of the interior of capsule 1 is characterised by a frusto-conical form 7 leading into the orifice 6.
  • a ram 9 biassed in direction Y is released so as to engage and drive the piston 3 to discharge the drug 2 through orifice 6.
  • the ratio of the orifice length to diameter should be as small as practicable, and it is desirable that this should be no more than 2:1. This ratio has a significant effect on the flow resistance of the orifice: too high and the orifice resembles a tube with a corresponding increase in flow resistance.
  • the orifice diameter may be within the range of 0.1mm to 0.5mm, with corresponding lengths within the range of 0.2mm to 1.0mm.
  • the face 11 of the retainer 5 When performing an injection, the face 11 of the retainer 5 is pressed lightly on the patient's skin, and the area of face 11 provides sufficient support to prevent the injector capsule assembly sinking into the tissues. If the face 12 is flush or slightly behind face 11, the orifice is in very light contact with the skin, and an intradermal injection will result; a firm contact - i.e. face 12 protrudes slightly from face 11 - will result in a subcutaneous injection; and if face 12 protrudes considerably from face 11 thereby displacing and compressing adipose tissue, then the injection may be intramuscular. This is, of course, a generalisation, since other factors such as pressure and orifice size may be adjusted to achieve the required injection characteristics. Nevertheless, the relationship of the capsule face and retainer face must be controlled to achieve repeatable high quality injections.
  • frusto-conical form 7 which joins the cylindrical section of capsule 1 to the orifice 6 is to reduce turbulent energy losses as the drug is forced into the orifice 6, and also to minimise during injection the stresses within the glass walls of capsule 1 as the cylindrical bore reduces to the orifice 6.
  • the material for the capsule 1 is a length of glass tube 1a, which is located over mandrel 20 and rests on tube support 23.
  • the mandrel 20 has a frusto-conical form 7a, terminating in a pin 21.
  • Located concentrically above the mandrel 20 is a form tool 22, which has a forming surface 27.
  • a hole 24 in the form tool 22 is a close clearance fit relative to pin 21.
  • the forming process commences by heating the tube 1a in the area of the frusto-conical section 7a of mandrel 20 to a temperature sufficient to soften the glass.
  • a temperature sufficient to soften the glass.
  • at least the mandrel 20 is rotated, (and more preferably the tube support 23 and mandrel 20 are rotated in unison, i.e. at the same speed and in the same direction), together with the glass tube 1a, during heating, so that the temperature of the glass is evenly distributed.
  • the parts may remain stationary, the glass being heated by a ring burner.
  • the form tool 22 is pressed onto the softened glass as shown in Figure 3, and thus shapes the glass tube 1a to form the capsule 1.
  • Figure 4 shows one possible method of overcoming this problem.
  • the form tool 22a has a hole 24a which is substantially larger in cross-section than the corresponding pin 21a. This pin is shorter than the pin shown in Figure 2.
  • hole 24 is frusto-conical, and has a substantially larger cross-section than the pin 21a at least for that length of the hole over which the pin extends. In other words, there is a substantial clearance between the pin and the surface defining the hole.
  • the glass tube is cut so that the volume is slightly greater than required for the finished capsule, and during forming, any excess material is forced along hole 24a to form a blob 40, whereby the hole formed by pin 21a is closed.
  • the blob 40 is cut at X-X and the cut face is flame polished to remove sharp edges and to smooth out any surface roughness. If necessary, after cutting, the face may be ground before flame polishing.
  • Figure 5 shows another possible method of dealing with excess material. Again, the volume of the glass tube is slightly more than the finished capsule, and during forming, the excess glass is allowed to spread into the form tool to make a rim 50, the length Z of which may vary according to the amount of excess glass. This method has the additional advantage that the diameter of the rim 50 is controlled, regardless of the wall thickness tolerance.
  • Figures 7a and 7b show a method according to the present invention of preventing flash formation around the orifice without the necessity of very accurate tool alignment.
  • Plunger 60 is a sliding fit within forming tool 22b and a compression spring 64 bears on plunger 60 which carries a collar 63 fixed thereto. The total sliding movement permitted is controlled by the faces of the collar 63 and abutment faces 65 and 67 within a cavity 66 in the forming tool 22b.
  • the mandrel 20b carries a pin 21b which has a flat distal face 62, and plunger 60 has a flat distal face 61.
  • the faces 61 and 62 cooperate to form a tight "shut-off" to prevent molten glass forming a thin skin over the end of the orifice in the capsule.
  • the force of the shut-off is determined by the spring 64.
  • Figures 8a and 8b show a similar arrangement, but in this case the pin 21c is spring loaded by a compression spring 64c and slides in mandrel 20c.
  • a face 70 of pin 21c cooperates with a face 71 of the forming tool 22c to form a tight shut-off.
  • the foregoing methods of forming the glass tube may be applied with equal efficacy to the production of glass syringes, as shown in Figure 6.
  • the diameter of hole 100 may be required to be closely controlled to accept a hollow needle: the needle may be bonded into the glass with a minimum thickness of adhesive.
  • the frusto-conical tip 200 may be dimensioned to accept a so-called Luer-fitting needle, i.e. a needle with an adaptor having a co-operating internal taper by which means the needle may be frictionally retained on the syringe tip.
  • the method of forming tubing to make needleless injector capsules and hypodermic syringes may be applied to materials other than glass where conventional forming methods are inappropriate.

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  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Mechanical Engineering (AREA)
  • Materials Engineering (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Vascular Medicine (AREA)
  • Veterinary Medicine (AREA)
  • Manufacturing & Machinery (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Telephone Function (AREA)
  • Adornments (AREA)
  • Footwear And Its Accessory, Manufacturing Method And Apparatuses (AREA)
  • Press Drives And Press Lines (AREA)
  • Injection Moulding Of Plastics Or The Like (AREA)
  • Perforating, Stamping-Out Or Severing By Means Other Than Cutting (AREA)
  • Forging (AREA)
  • Sewing Machines And Sewing (AREA)
  • Lift Valve (AREA)
  • Processing And Handling Of Plastics And Other Materials For Molding In General (AREA)
EP97941096A 1996-09-25 1997-09-22 Method and apparatus for making an article from a formable material Expired - Lifetime EP0932424B1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB9620173 1996-09-25
GBGB9620173.6A GB9620173D0 (en) 1996-09-25 1996-09-25 Needleless injector capsule
GB9624870 1996-11-29
GBGB9624870.3A GB9624870D0 (en) 1996-11-29 1996-11-29 Injection capsule
PCT/GB1997/002560 WO1998013086A1 (en) 1996-09-25 1997-09-22 Method and apparatus for making an article from a formable material

Publications (2)

Publication Number Publication Date
EP0932424A1 EP0932424A1 (en) 1999-08-04
EP0932424B1 true EP0932424B1 (en) 2002-06-19

Family

ID=26310116

Family Applications (1)

Application Number Title Priority Date Filing Date
EP97941096A Expired - Lifetime EP0932424B1 (en) 1996-09-25 1997-09-22 Method and apparatus for making an article from a formable material

Country Status (16)

Country Link
US (2) US6216493B1 (hu)
EP (1) EP0932424B1 (hu)
JP (1) JP2001501571A (hu)
KR (1) KR20000048584A (hu)
CN (1) CN1238703A (hu)
AT (1) ATE219382T1 (hu)
AU (1) AU729365B2 (hu)
BR (1) BR9711409A (hu)
CA (1) CA2266678A1 (hu)
DE (1) DE69713513T2 (hu)
ES (1) ES2177999T3 (hu)
HU (1) HUP0000436A3 (hu)
IL (1) IL129014A0 (hu)
NO (1) NO991426D0 (hu)
NZ (1) NZ334782A (hu)
WO (1) WO1998013086A1 (hu)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU729365B2 (en) * 1996-09-25 2001-02-01 Weston Medical Limited Method and apparatus for making an article from a formable material
GB0127942D0 (en) * 2001-11-21 2002-01-16 Weston Medical Ltd Needleless injector drug capsule and a method for filing thereof
DE102004007257A1 (de) * 2004-02-10 2005-09-08 Primojex Gmbh Nadellose Injektionseinrichtung und Ampulle für eine solche
JP5238255B2 (ja) 2004-09-30 2013-07-17 ベクトン・ディキンソン・アンド・カンパニー ガラス製容器内の残留物を削減又は除去するための方法及びそれにしたがって製造されたガラス製容器
US7530982B1 (en) * 2004-10-07 2009-05-12 Biomet Manufacturing Corp. Composite allograft formation instrument
KR100682551B1 (ko) * 2005-06-09 2007-02-15 한국전력공사 지상형 가스절연 부하개폐기의 고압팽창가스 방출장치설치방법 및 그 체결구조
KR100594610B1 (ko) * 2006-05-09 2006-06-30 (주)대경기술단 공동주택용 부하개폐기의 고압가스 방출장치
US7942845B2 (en) * 2006-09-19 2011-05-17 Bioject, Inc. Needle-free injector and process for providing serial injections
US7547293B2 (en) 2006-10-06 2009-06-16 Bioject, Inc. Triggering mechanism for needle-free injector
WO2008103997A2 (en) * 2007-02-23 2008-08-28 Bioject Inc. Needle-free injection devices and drug delivery systems therefor
US20090137949A1 (en) * 2007-11-26 2009-05-28 Bioject Inc. Needle-free injection device with nozzle auto-disable
US8617099B2 (en) * 2007-11-26 2013-12-31 Bioject Inc. Injection device plunger auto-disable
EP2756756B1 (en) 2008-04-28 2016-01-06 Zogenix, Inc. Novel formulations for treatment of migraine
DE102009008723B4 (de) * 2009-02-06 2011-07-07 Schott Ag, 55122 Verfahren zur Herstellung eines pharmazeutischen Behälters aus der Schmelze und Behälter
DE102010045094B4 (de) * 2010-09-13 2013-03-07 Schott Ag Verfahren und Vorrichtung zur lasergestützten Glasformung
US8734384B2 (en) 2010-09-15 2014-05-27 Zogenix, Inc. Needle-free injectors and design parameters thereof that optimize injection performance
EP2442320B1 (de) * 2010-10-15 2013-01-09 ABB Technology AG Form zum Herstellen von hohlzylinderähnlichen Formteilen
FR2966453B1 (fr) * 2010-10-26 2018-01-19 Shiseido International France Moule et procede pour fabriquer un flacon en verre et flacon ainsi obtenu.
WO2012085619A1 (en) * 2010-12-20 2012-06-28 Becton Dickinson France Tool for forming medical glass containers free of contamination by a foreign element
US10940167B2 (en) 2012-02-10 2021-03-09 Cvdevices, Llc Methods and uses of biological tissues for various stent and other medical applications
US20140142500A1 (en) 2012-04-23 2014-05-22 Zogenix, Inc. Piston closures for drug delivery capsules
AU2014214700B2 (en) 2013-02-11 2018-01-18 Cook Medical Technologies Llc Expandable support frame and medical device
CN105163719B (zh) 2013-03-11 2019-03-08 度瑞公司 包含高粘度液体载体的可注射控制释放组合物
CN103656802A (zh) * 2014-01-07 2014-03-26 北京快舒尔医疗技术有限公司 一种无针注射器的药管制造方法
DE102014214083C5 (de) * 2014-07-18 2021-04-08 Schott Ag Vorrichtung und Verfahren zum thermischen Behandeln eines ringförmigen Bereichs einer inneren Oberfläche eines aus einem Borosilikat-Rohrglas hergestellten Glasbehälters
EP2987601A1 (en) * 2014-08-21 2016-02-24 Sulzer Mixpac AG Method for producing an apparatus for dispensing a medium
DE102015117215B4 (de) * 2015-10-08 2019-03-14 Gerresheimer Bünde Gmbh Vorrichtung und Verfahren zur Herstellung eines medizinischen Glasbehälters
DE102016114104A1 (de) 2016-07-29 2018-02-01 Schott Ag Verfahren zur lasergestützen Umformung von Glaskörpern
DE102016123865A1 (de) * 2016-12-08 2018-06-14 Schott Ag Verfahren zum Weiterverarbeiten eines Glasrohr-Halbzeugs einschließlich einer thermischen Umformung
DE102016124833A1 (de) 2016-12-19 2018-06-21 Schott Ag Verfahren zum Herstellen eines Hohlglasprodukts aus einem Glasrohr-Halbzeug mit Markierungen, sowie Verwendungen hiervon
US11957162B2 (en) * 2020-05-12 2024-04-16 R.Y.L. Inc. Method for manufacturing a glass filter
EP4162964A1 (en) * 2020-06-05 2023-04-12 Daicel Corporation Needleless syringe

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE525515C (de) * 1931-05-26 Jakob Dichter Verfahren zum Formen von Haelsen an Glasgefaessen
US1999525A (en) * 1933-06-02 1935-04-30 Corning Glass Works Shaping glass
US2392104A (en) * 1941-12-10 1946-01-01 Macgregor Instr Company Fabricated glass article and method
US2403042A (en) * 1944-08-10 1946-07-02 Bogoslowsky Boris Apparatus for making collapsible tubes
US2736992A (en) * 1951-04-16 1956-03-06 Becton Dickinson Co Method of making hypodermic syringes
BE523287A (hu) * 1952-10-21
DE1087325B (de) * 1959-02-07 1960-08-18 Jenaer Glaswerk Schott & Gen Vorrichtung zum Fertigen von Verbindungs-Flanschenden an Glasrohren
US2958898A (en) * 1959-02-12 1960-11-08 Voumard Bertrand Method for the manufacture of a collapsible tube and machine for carrying it out
US3237243A (en) * 1961-09-11 1966-03-01 Thatcher Glass Mfg Company Inc Apparatus for making plastic containers
NL135472C (hu) * 1963-02-22 1900-01-01
FR2361217A1 (fr) * 1976-10-15 1978-03-10 Barba Garcia Pablo Procede et outillage pour fabriquer des tubes
US4254075A (en) * 1977-04-01 1981-03-03 Reed Irrigation Systems Method for forming holes in a member
CH657088A5 (de) * 1982-12-02 1986-08-15 Maegerle Karl Lizenz Formwerkzeug fuer einen behaelter-kopfteil aus kunststoff.
US5312577A (en) * 1992-05-08 1994-05-17 Bioject Inc. Method for manufacturing an ampule
AU729365B2 (en) * 1996-09-25 2001-02-01 Weston Medical Limited Method and apparatus for making an article from a formable material

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AU4312197A (en) 1998-04-17
AU729365B2 (en) 2001-02-01
CN1238703A (zh) 1999-12-15
NO991426L (no) 1999-03-24
KR20000048584A (ko) 2000-07-25
US6415631B1 (en) 2002-07-09
NO991426D0 (no) 1999-03-24
IL129014A0 (en) 2000-02-17
WO1998013086A1 (en) 1998-04-02
DE69713513D1 (de) 2002-07-25
JP2001501571A (ja) 2001-02-06
BR9711409A (pt) 2000-04-25
HUP0000436A3 (en) 2000-07-28
EP0932424A1 (en) 1999-08-04
US6216493B1 (en) 2001-04-17
ES2177999T3 (es) 2002-12-16
DE69713513T2 (de) 2002-10-31
NZ334782A (en) 2000-07-28
CA2266678A1 (en) 1998-04-02
HUP0000436A2 (hu) 2000-06-28
ATE219382T1 (de) 2002-07-15

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