EP0931147A1 - ANTI-ErbB2 ANTIBODIES - Google Patents
ANTI-ErbB2 ANTIBODIESInfo
- Publication number
- EP0931147A1 EP0931147A1 EP97912708A EP97912708A EP0931147A1 EP 0931147 A1 EP0931147 A1 EP 0931147A1 EP 97912708 A EP97912708 A EP 97912708A EP 97912708 A EP97912708 A EP 97912708A EP 0931147 A1 EP0931147 A1 EP 0931147A1
- Authority
- EP
- European Patent Office
- Prior art keywords
- antibody
- cell
- erbb2
- cells
- antibodies
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Definitions
- Protein tyrosine kinases are enzymes that are involved in this process. Receptor protein tyrosine kinases are believed to direct cellular growth via ligand-stimulated tyrosine phosphorylation of intracellular substrates.
- the class I subfamily of growth factor receptor protein tyrosine kinases includes the 170 kDa epidermal growth factor receptor (EGFR) encoded by the erbB ⁇ gene. erbBl has been causally implicated in human malignancy. In particular, increased expression of this gene has been observed in carcinomas of the breast, bladder, lung, head, neck and stomach.
- the antibodies will bind to the ErbB2 epitope bound by the 7C2 and/or 7F3 antibodies described herein.
- Preferred antibodies are monoclonal antibodies e.g. humanized antibodies.
- Antibodies of particular interest are those which, in addition to the above-described properties, bind the ErbB2 receptor with an affinity of at least about lOnM, more preferably at least about InM.
- the invention also provides: an isolated nucleic acid molecule encoding the antibody of the preceding paragraphs which may further comprise a promoter operably linked thereto; an expression vector comprising the nucleic acid molecule operably linked to control sequences recognized by a host cell transformed with the vector, a host cell comprising the nucleic acid (e g a hyb ⁇ doma cell line), and a process for making the antibody comprising cultu ⁇ ng a cell comprising the nucleic acid so as to express the ant ⁇ -ErbB2 antibody and, optionally, recovering the antibody from the host cell culture and, preferably, the host cell culture medium
- the invention also provides methods for using the ant ⁇ -ErbB2 antibodies disclosed herein
- the invention provides a method for inducing cell death comprising exposmg a cell, such as a cancer cell which overexpresses ErbB2, to ant ⁇ -ErbB2 antibody described herein in an amount effective to induce cell death
- the cell may be in cell culture or in
- the monoclonal antibodies herein specifically include "chime ⁇ c" antibodies (immunoglobulins) in which a portion of the heavy and/or light chain is identical with or homologous to corresponding sequences in antibodies derived from a particular species or belonging to a particular antibody class or subclass, while the remainder of the cha ⁇ n(s) is identical with or homologous to corresponding sequences in antibodies derived from another species or belonging to another antibody class or subclass, as well as fragments of such antibodies, so long as they exhibit the desired biological activity (U S Patent No 4,816,567, Morrison et al , Proc Natl Acad Sci USA, 81 6851-6855 (1984))
- the prodrugs of this invention include, but are not limited to, phosphate-containing prodrugs, thiophosphate-containing prodrugs, sulfate-containing prodrugs, peptide-containing prodrugs, D-amino acid-modified prodrugs, glycosylated prodrugs, ⁇ -lactam- containing prodrugs, optionally substituted phenoxyacetamide-containing prodrugs or optionally substituted phenylacetamide-containing prodrugs, 5-fluorocytosine and other 5-fluorouridine prodrugs which can be converted into the more active cytotoxic free drug.
- Eukaryotic cells are known to utilize promoters, polyadenylation signals, and enhancers.
- Nucleic acid is "operably linked" when it is placed into a functional relationship with another nucleic acid sequence.
- DNA for a presequence or secretory leader is operably linked to DNA for a polypeptide if it is expressed as a preprotein that participates in the secretion of the polypeptide;
- a promoter or enhancer is operably linked to a coding sequence if it affects the transcription of the sequence; or a ribosome binding site is operably linked to a coding sequence if it is positioned so as to facilitate translation.
- Antibodies with more than two valencies are contemplated
- t ⁇ specific antibodies can be prepared ⁇ utt et al J Immunol 147 60 (1991)
- the early and late promoters of the SV40 virus are conveniently obtained as an SV40 restriction fragment that also contains the SV40 viral origin of replication
- the immediate early promoter of the human cytomegalovirus is conveniently obtained as a Hmdlll E restriction fragment
- a system for expressing DNA in mammalian hosts using the bovine papilloma virus as a vector is disclosed in U S Patent No 4,419,446
- a modification of this system is described in U S Patent No 4,601,978 See also Reyes et al , Nature 297 598-601 (1982) on expression of human ⁇ -mterferon cDNA in mouse cells under the control of a thymidine kinase promoter from he ⁇ es simplex virus
- the rous sarcoma virus long terminal repeat can be used as the promoter (v) Enhancer element component
- the antibody can be produced lntracellularly, in the periplasmic space, or directly secreted into the medium If the antibody is produced lntracellularly, as a first step, the particulate debris, either host cells or lysed fragments, is removed, for example, by centrifugation or ultrafiltration Carter et al , Bio/Technology 10 163- 167 ( 1992) describe a procedure for isolating antibodies which are secreted to the periplasmic space of £ coli Briefly, cell paste is thawed in the presence of sodium acetate (pH 3 5), EDTA, and phenylmethylsulfonylfluo ⁇ de (PMSF) over about 30 mm Cell debris can be removed by centrifugation Where the antibody is secreted into the medium, supematants from such expression systems are preferably first concentrated using a commercially available protem concentration filter, for example, an Amicon or Millipore Pellicon ultrafiltration unit A protease
- Suitable dosages for the growth inhibitory agent are those presently used and may be lowered due to the combined action (synergy) of the growth inhibitory agent and anti-ErbB2 antibody.
- the appropriate dosage of antibody will depend on the type of disease to be treated, as defined above, the severity and course of the disease, whether the antibody is administered for preventive or therapeutic pu ⁇ oses, previous therapy, the patient's clinical history and response to the antibody, and the discretion of the attending physician.
- the antibody is suitably administered to the patient at one time or over a series of treatments.
- the data from 1 x 10 4 cells were collected and stored using LYSYS IITM software and analyzed using PAINT-A-GATETM software (Becton Dickinson) (Darzynkiewica et al. Cytometry 13:795-808 (1992) and Picker et al. J. Immunol. 150(3):1 105-1121 (1993)).
- the viability and percentage of cells in each stage of the cell cycle were determined on gated single cells using 7AAD and Hoechst staining, respectively. (Cell doublets were excluded by pulse analysis of width vs. area of the Hoechst signal.) Cell numbers were determined using a hemocytometer. DNA synthesis.
- the binding affinities of anti-ErbB2 antibodies (7C2 and 4D5) were determined by Scatchard analysis.
- the binding constants (K d ) were 6.5 x 10 "9 M (4D5) and 2.9 x 10 "9 M (7C2).
- Blocking experiments were carried out using unlabelled antibodies followed by FITC-7C2.
- 4D5 reacts with a different epitope than 7C2.
- the effect of these antibodies on the growth of the BT474 human breast cancer cells which overexpress ErbB2 was then investigated.
- Fig. 3A shows the results of flow cytometric analysis of cells incubated with an isotype-matched control. 10-12% of the cells were dead and 28% of the viable cells were in the S-G2-M phases of the cell cycle.
- Irrelevant antibody ( ⁇ gpl20) (isotype matched) - lOmg/kg in 100 ⁇ l IP twice weekly
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Oncology (AREA)
- Urology & Nephrology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Vascular Medicine (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Cardiology (AREA)
- Dermatology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Gastroenterology & Hepatology (AREA)
- Neurology (AREA)
- Transplantation (AREA)
- Neurosurgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Pulmonology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP01101031A EP1106183A3 (en) | 1996-10-18 | 1997-10-09 | Antibodies to erbB2 and their therapeutic uses |
EP06007998.5A EP1695986B1 (en) | 1996-10-18 | 1997-10-09 | Anti-erb B2 antibodies |
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US73179496A | 1996-10-18 | 1996-10-18 | |
US731794 | 1996-10-18 | ||
PCT/US1997/018385 WO1998017797A1 (en) | 1996-10-18 | 1997-10-09 | ANTI-ErbB2 ANTIBODIES |
Related Child Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP06007998.5A Division EP1695986B1 (en) | 1996-10-18 | 1997-10-09 | Anti-erb B2 antibodies |
EP01101031A Division EP1106183A3 (en) | 1996-10-18 | 1997-10-09 | Antibodies to erbB2 and their therapeutic uses |
Publications (1)
Publication Number | Publication Date |
---|---|
EP0931147A1 true EP0931147A1 (en) | 1999-07-28 |
Family
ID=24940967
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP01101031A Withdrawn EP1106183A3 (en) | 1996-10-18 | 1997-10-09 | Antibodies to erbB2 and their therapeutic uses |
EP97912708A Withdrawn EP0931147A1 (en) | 1996-10-18 | 1997-10-09 | ANTI-ErbB2 ANTIBODIES |
EP06007998.5A Expired - Lifetime EP1695986B1 (en) | 1996-10-18 | 1997-10-09 | Anti-erb B2 antibodies |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP01101031A Withdrawn EP1106183A3 (en) | 1996-10-18 | 1997-10-09 | Antibodies to erbB2 and their therapeutic uses |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP06007998.5A Expired - Lifetime EP1695986B1 (en) | 1996-10-18 | 1997-10-09 | Anti-erb B2 antibodies |
Country Status (12)
Country | Link |
---|---|
EP (3) | EP1106183A3 (ko) |
JP (6) | JP2001504326A (ko) |
KR (2) | KR20060079258A (ko) |
CN (2) | CN100415772C (ko) |
AU (1) | AU4982097A (ko) |
BR (1) | BR9712410A (ko) |
CA (1) | CA2269204C (ko) |
IL (2) | IL129354A0 (ko) |
NZ (2) | NZ519191A (ko) |
TR (1) | TR199901615T2 (ko) |
WO (1) | WO1998017797A1 (ko) |
ZA (1) | ZA979185B (ko) |
Families Citing this family (86)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6267958B1 (en) | 1995-07-27 | 2001-07-31 | Genentech, Inc. | Protein formulation |
US5783186A (en) | 1995-12-05 | 1998-07-21 | Amgen Inc. | Antibody-induced apoptosis |
AU4982097A (en) * | 1996-10-18 | 1998-05-15 | Board Of Regents, The University Of Texas System | Anti-erbb2 antibodies |
ZA9811162B (en) | 1997-12-12 | 2000-06-07 | Genentech Inc | Treatment with anti-ERBB2 antibodies. |
EP1745799B1 (en) | 1998-03-04 | 2015-09-02 | The Trustees of The University of Pennsylvania | Compositions and methods of treating tumors |
US6417168B1 (en) | 1998-03-04 | 2002-07-09 | The Trustees Of The University Of Pennsylvania | Compositions and methods of treating tumors |
WO1999054494A2 (en) * | 1998-04-17 | 1999-10-28 | Rigel Pharmaceuticals, Inc. | Multiparameter facs assays to detect alterations in cellular parameters |
US6620382B1 (en) * | 1998-05-22 | 2003-09-16 | Biopheresis Technologies, Llc. | Method and compositions for treatment of cancers |
AUPQ105799A0 (en) * | 1999-06-18 | 1999-07-08 | Victor Chang Cardiac Research Institute, The | Cell growth inhibition |
NZ515975A (en) | 1999-06-25 | 2004-01-30 | Genentech Inc | Anti-ErbB antibody-maytansinoid conjugates useful in the treatment of tumors characterised by the overexpression of an ErbB receptor |
KR100850389B1 (ko) * | 1999-06-25 | 2008-08-04 | 제넨테크, 인크. | 인간화 항-ErbB2 항체 및 항-ErbB2 항체를 사용한치료 방법 |
EP1189634B1 (en) * | 1999-06-25 | 2007-02-28 | Genentech, Inc. | Treating prostate cancer with anti-erbb2 antibodies |
CA2373721C (en) | 1999-07-02 | 2013-10-15 | Genentech, Inc. | Compounds that bind her2 |
WO2001008636A2 (en) * | 1999-08-03 | 2001-02-08 | The Ohio State University | Polypeptides and polynucleotides for enhancing immune reactivity to her-2 protein |
PL202369B1 (pl) | 1999-08-27 | 2009-06-30 | Genentech Inc | Zastosowanie przeciwciała skierowanego przeciw ErbB2, zastosowanie przeciwciała skierowanego przeciw ErbB oraz zestaw zawierający to przeciwciało |
EP1229934B1 (en) | 1999-10-01 | 2014-03-05 | Immunogen, Inc. | Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents |
WO2001055178A2 (en) | 2000-01-25 | 2001-08-02 | Genentech, Inc. | Liv-1 related protein, polynucleotides encoding the same and use thereof for treatment of cancer |
US7097840B2 (en) | 2000-03-16 | 2006-08-29 | Genentech, Inc. | Methods of treatment using anti-ErbB antibody-maytansinoid conjugates |
AU2001247616B2 (en) | 2000-04-11 | 2007-06-14 | Genentech, Inc. | Multivalent antibodies and uses therefor |
EP1282443B1 (en) | 2000-05-19 | 2009-09-02 | Genentech, Inc. | Gene detection assay for improving the likelihood of an effective response to an erbb antagonist cancer therapy |
EP1236740B1 (de) * | 2001-02-28 | 2012-07-18 | Bio Life Science Forschungs- und Entwicklungsges.m.b.H. | Vakzine gegen Krebserkrankungen, die mit dem HER-2/neu Onkogen assoziiert sind |
US7638598B2 (en) | 2001-04-06 | 2009-12-29 | The Trustees Of The University Of Pennsylvania | ErbB interface peptidomimetics and methods of use thereof |
DE10210427A1 (de) | 2002-03-09 | 2003-10-09 | Hans Konrad Mueller-Hermelink | Humaner monoklonaler Antikörper |
EP1495123B1 (en) | 2002-03-26 | 2013-10-30 | Zensun (Shanghai) Science and Technology Limited | Erbb3 based methods and compositions for treating neoplasms |
JP2005535297A (ja) * | 2002-04-11 | 2005-11-24 | アムジェン インコーポレイテッド | Her−2レセプターチロシンキナーゼ分子およびその使用 |
CA2490542C (en) | 2002-05-23 | 2013-07-16 | Mark I. Greene | Fas peptide mimetics and uses thereof |
EP1521776A2 (en) | 2002-07-04 | 2005-04-13 | Oncomab Gmbh | Neoplasm specific antibodies and uses thereof |
US7803372B2 (en) * | 2002-10-08 | 2010-09-28 | Immunomedics, Inc. | Antibody therapy |
DE10311248A1 (de) | 2003-03-14 | 2004-09-30 | Müller-Hermelink, Hans Konrad, Prof. Dr. | Humaner monoklonaler Antikörper |
US8088387B2 (en) | 2003-10-10 | 2012-01-03 | Immunogen Inc. | Method of targeting specific cell populations using cell-binding agent maytansinoid conjugates linked via a non-cleavable linker, said conjugates, and methods of making said conjugates |
EP1531162A1 (en) | 2003-11-14 | 2005-05-18 | Heinz Vollmers | Adenocarcinoma specific antibody SAM-6, and uses thereof |
DE10353175A1 (de) | 2003-11-14 | 2005-06-16 | Müller-Hermelink, Hans Konrad, Prof. Dr. | Humaner monoklonaler Antikörper mit fettsenkender Wirkung |
MX2007000723A (es) | 2004-07-22 | 2007-03-12 | Genentch Inc | Composicion de anticuerpos her2. |
JO3000B1 (ar) | 2004-10-20 | 2016-09-05 | Genentech Inc | مركبات أجسام مضادة . |
TWI441646B (zh) | 2005-01-21 | 2014-06-21 | Genentech Inc | 帕妥珠單抗(pertuzumab)用於製備治療人類病患癌症之藥物的用途 |
CN101163503B (zh) | 2005-02-23 | 2013-05-08 | 健泰科生物技术公司 | 使用her二聚化抑制剂在癌症患者中延长病情进展前时间或存活 |
DE102005017712A1 (de) | 2005-04-15 | 2006-12-14 | Abb Patent Gmbh | Automatisierungssystem |
EP1912680B1 (en) | 2005-06-15 | 2014-11-26 | The Ohio State University Research Foundation | Her-2 peptides |
US20070009976A1 (en) | 2005-07-06 | 2007-01-11 | Helmut Lenz | Detection of a target antigen irrespective of the presence or absence of a corresponding therapeutic antibody |
US7700299B2 (en) | 2005-08-12 | 2010-04-20 | Hoffmann-La Roche Inc. | Method for predicting the response to a treatment |
EP1957540B1 (en) | 2005-12-02 | 2012-06-13 | Genentech, Inc. | Binding polypeptides and uses thereof |
TW200812615A (en) | 2006-03-22 | 2008-03-16 | Hoffmann La Roche | Tumor therapy with an antibody for vascular endothelial growth factor and an antibody for human epithelial growth factor receptor type 2 |
KR20090058512A (ko) * | 2006-08-04 | 2009-06-09 | 아스트라제네카 아베 | Erbb2에 대한 인간 항체 |
ES2546066T3 (es) | 2006-08-21 | 2015-09-18 | F. Hoffmann-La Roche Ag | Terapia tumoral con un anticuerpo anti-VEGF |
EP2899541A1 (en) | 2007-03-02 | 2015-07-29 | Genentech, Inc. | Predicting response to a HER dimerisation inhbitor based on low HER3 expression |
CA3006428A1 (en) | 2007-06-08 | 2008-12-18 | Genentech, Inc. | Gene expression markers of tumor resistance to her2 inhibitor treatment |
US9551033B2 (en) | 2007-06-08 | 2017-01-24 | Genentech, Inc. | Gene expression markers of tumor resistance to HER2 inhibitor treatment |
TWI472339B (zh) | 2008-01-30 | 2015-02-11 | Genentech Inc | 包含結合至her2結構域ii之抗體及其酸性變異體的組合物 |
BRPI0812682A2 (pt) | 2008-06-16 | 2010-06-22 | Genentech Inc | tratamento de cáncer de mama metastático |
JP2012507299A (ja) | 2008-10-31 | 2012-03-29 | バイオジェン・アイデック・エムエイ・インコーポレイテッド | Light標的分子およびその使用 |
US20100234283A1 (en) | 2009-02-04 | 2010-09-16 | The Ohio State University Research Foundation | Immunogenic epitopes, peptidomimetics, and anti-peptide antibodies, and methods of their use |
CA2755640C (en) | 2009-03-20 | 2018-05-22 | Genentech, Inc. | Bispecific antibody with a single antigen-binding domain specific for both her3 and egfr |
EP2435071A1 (en) | 2009-05-29 | 2012-04-04 | F. Hoffmann-La Roche AG | Modulators for her2 signaling in her2 expressing patients with gastric cancer |
CA2784211C (en) | 2010-02-18 | 2019-12-24 | Genentech, Inc. | Neuregulin antagonists and use thereof in treating cancer |
WO2011146568A1 (en) | 2010-05-19 | 2011-11-24 | Genentech, Inc. | Predicting response to a her inhibitor |
CN103153339B (zh) | 2010-05-27 | 2021-05-04 | 根马布股份公司 | 针对her2表位的单克隆抗体 |
NZ604003A (en) | 2010-05-27 | 2015-04-24 | Genmab As | Monoclonal antibodies against her2 |
US20130245233A1 (en) | 2010-11-24 | 2013-09-19 | Ming Lei | Multispecific Molecules |
WO2012085111A1 (en) | 2010-12-23 | 2012-06-28 | F. Hoffmann-La Roche Ag | Polypeptide-polynucleotide-complex and its use in targeted effector moiety delivery |
LT3489255T (lt) | 2011-02-10 | 2021-08-25 | Roche Glycart Ag | Mutantiniai interleukino-2 polipeptidai |
US20140170149A1 (en) | 2011-04-20 | 2014-06-19 | Genmab A/S | Bispecific antibodies against her2 and cd3 |
EA201892619A1 (ru) | 2011-04-29 | 2019-04-30 | Роше Гликарт Аг | Иммуноконъюгаты, содержащие мутантные полипептиды интерлейкина-2 |
BR112014003431A2 (pt) | 2011-08-17 | 2017-06-13 | Genentech Inc | anticorpo, ácido nucleico, célula hospedeira, método de produção de um anticorpo, imunoconjugado, formulação farmacêutica, agente farmacêutico, uso do anticorpo, método de tratamento de um indivíduo que tem câncer e método de aumento de tempo para recorrência de tumor |
WO2013063229A1 (en) | 2011-10-25 | 2013-05-02 | The Regents Of The University Of Michigan | Her2 targeting agent treatment in non-her2-amplified cancers having her2 expressing cancer stem cells |
EP2785864A2 (en) | 2011-11-30 | 2014-10-08 | F. Hoffmann-La Roche AG | Erbb3 mutations in cancer |
EP2788500A1 (en) | 2011-12-09 | 2014-10-15 | F.Hoffmann-La Roche Ag | Identification of non-responders to her2 inhibitors |
RU2014136886A (ru) | 2012-03-27 | 2016-05-20 | Дженентек, Инк. | Диагностика и виды лечения, связанные с ингибиторами her3 |
CA2889298C (en) | 2012-11-30 | 2024-01-02 | Anton Belousov | Identification of patients in need of pd-l1 inhibitor cotherapy |
KR101453462B1 (ko) * | 2013-05-16 | 2014-10-23 | 앱클론(주) | Her2에 특이적으로 결합하는 항체 |
AU2015243377A1 (en) | 2014-04-11 | 2016-09-15 | Medimmune, Llc | Bispecific HER2 antibodies |
SI3191135T1 (sl) * | 2014-09-12 | 2021-01-29 | Genentech, Inc. | Anti-HER2 protitelesa in imunokonjugati |
MX2017003472A (es) | 2014-09-17 | 2017-10-31 | Genentech Inc | Inmunoconjugados que comprenden anticuerpos anti-her2. |
LT3303373T (lt) | 2015-05-30 | 2020-07-10 | Molecular Templates, Inc. | Deimunizuoto shiga toksino a subvieneto karkasai ir juos apimančios ląstelės taikinio molekulės |
US10017577B2 (en) | 2015-06-15 | 2018-07-10 | Genentech, Inc. | Antibodies and immunoconjugates |
MA43345A (fr) | 2015-10-02 | 2018-08-08 | Hoffmann La Roche | Conjugués anticorps-médicaments de pyrrolobenzodiazépine et méthodes d'utilisation |
CN106729743B (zh) | 2015-11-23 | 2021-09-21 | 四川科伦博泰生物医药股份有限公司 | 抗ErbB2抗体-药物偶联物及其组合物、制备方法和应用 |
RU2640259C2 (ru) * | 2015-12-09 | 2017-12-27 | Федеральное государственное бюджетное учреждение науки Институт теоретической и экспериментальной биофизики Российской академии наук (ИТЭБ РАН) | Антитело МАТ40, которое связывается с доменом I экстраклеточной части рецептора эпидермального фактора роста HER2/CD340, и его применение для лечения рака |
US10914720B2 (en) | 2016-02-10 | 2021-02-09 | Becton Dickinson France | Method to evaluate the stability of a protein-based formulation |
EP3454863A1 (en) | 2016-05-10 | 2019-03-20 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Combinations therapies for the treatment of cancer |
WO2018102682A1 (en) | 2016-12-01 | 2018-06-07 | Regeneron Pharmaceuticals, Inc. | Radiolabeled anti-pd-l1 antibodies for immuno-pet imaging |
SG10201801219VA (en) * | 2018-02-13 | 2019-09-27 | Agency Science Tech & Res | Anti-HER2 Antibodies |
GB201814281D0 (en) | 2018-09-03 | 2018-10-17 | Femtogenix Ltd | Cytotoxic agents |
GB201901197D0 (en) | 2019-01-29 | 2019-03-20 | Femtogenix Ltd | G-A Crosslinking cytotoxic agents |
CA3134363A1 (en) * | 2019-03-22 | 2020-10-01 | Olivia Newton-John Cancer Research Institute | Anti-her2 binding molecules |
GB2597532A (en) | 2020-07-28 | 2022-02-02 | Femtogenix Ltd | Cytotoxic compounds |
WO2023044483A2 (en) | 2021-09-20 | 2023-03-23 | Voyager Therapeutics, Inc. | Compositions and methods for the treatment of her2 positive cancer |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP3040121B2 (ja) * | 1988-01-12 | 2000-05-08 | ジェネンテク,インコーポレイテッド | 増殖因子レセプターの機能を阻害することにより腫瘍細胞を処置する方法 |
NZ242000A (en) * | 1991-03-17 | 1994-03-25 | Yeda Res & Dev | Purified mammalian proteinaceous factor which stimulates neu receptor |
US5783404A (en) * | 1995-04-13 | 1998-07-21 | Amgen Inc. | Methods and compositions for determining HER-2/neu expression using monoclonal antibodies |
US5783186A (en) * | 1995-12-05 | 1998-07-21 | Amgen Inc. | Antibody-induced apoptosis |
AU4982097A (en) * | 1996-10-18 | 1998-05-15 | Board Of Regents, The University Of Texas System | Anti-erbb2 antibodies |
-
1997
- 1997-10-09 AU AU49820/97A patent/AU4982097A/en not_active Abandoned
- 1997-10-09 IL IL12935497A patent/IL129354A0/xx unknown
- 1997-10-09 CA CA2269204A patent/CA2269204C/en not_active Expired - Lifetime
- 1997-10-09 WO PCT/US1997/018385 patent/WO1998017797A1/en not_active Application Discontinuation
- 1997-10-09 JP JP51943798A patent/JP2001504326A/ja not_active Withdrawn
- 1997-10-09 EP EP01101031A patent/EP1106183A3/en not_active Withdrawn
- 1997-10-09 CN CNB971989478A patent/CN100415772C/zh not_active Expired - Lifetime
- 1997-10-09 NZ NZ519191A patent/NZ519191A/en not_active IP Right Cessation
- 1997-10-09 NZ NZ509480A patent/NZ509480A/en not_active IP Right Cessation
- 1997-10-09 KR KR1020067010438A patent/KR20060079258A/ko not_active Application Discontinuation
- 1997-10-09 BR BR9712410-9A patent/BR9712410A/pt not_active Application Discontinuation
- 1997-10-09 EP EP97912708A patent/EP0931147A1/en not_active Withdrawn
- 1997-10-09 KR KR1019997003370A patent/KR100628846B1/ko not_active IP Right Cessation
- 1997-10-09 CN CNA2008101361389A patent/CN101412758A/zh active Pending
- 1997-10-09 TR TR1999/01615T patent/TR199901615T2/xx unknown
- 1997-10-09 EP EP06007998.5A patent/EP1695986B1/en not_active Expired - Lifetime
- 1997-10-14 ZA ZA979185A patent/ZA979185B/xx unknown
-
1999
- 1999-04-06 IL IL129354A patent/IL129354A/en not_active IP Right Cessation
-
2001
- 2001-03-01 JP JP2001057365A patent/JP2001302540A/ja not_active Withdrawn
-
2008
- 2008-02-06 JP JP2008026980A patent/JP2008188013A/ja not_active Withdrawn
- 2008-09-11 JP JP2008233962A patent/JP2009095339A/ja not_active Withdrawn
-
2009
- 2009-05-25 JP JP2009125625A patent/JP2009189371A/ja active Pending
-
2010
- 2010-06-16 JP JP2010137503A patent/JP2010222375A/ja active Pending
Non-Patent Citations (1)
Title |
---|
See references of WO9817797A1 * |
Also Published As
Publication number | Publication date |
---|---|
ZA979185B (en) | 1999-04-14 |
JP2001302540A (ja) | 2001-10-31 |
KR20060079258A (ko) | 2006-07-05 |
NZ519191A (en) | 2005-04-29 |
IL129354A0 (en) | 2000-02-17 |
CA2269204A1 (en) | 1998-04-30 |
CA2269204C (en) | 2012-01-24 |
CN101412758A (zh) | 2009-04-22 |
EP1106183A3 (en) | 2001-09-12 |
KR100628846B1 (ko) | 2006-09-29 |
KR20000049261A (ko) | 2000-07-25 |
JP2001504326A (ja) | 2001-04-03 |
JP2010222375A (ja) | 2010-10-07 |
NZ509480A (en) | 2005-05-27 |
WO1998017797A1 (en) | 1998-04-30 |
IL129354A (en) | 2009-06-15 |
CN100415772C (zh) | 2008-09-03 |
JP2009189371A (ja) | 2009-08-27 |
CN1234072A (zh) | 1999-11-03 |
EP1695986A2 (en) | 2006-08-30 |
BR9712410A (pt) | 1999-10-19 |
EP1695986B1 (en) | 2016-12-14 |
JP2009095339A (ja) | 2009-05-07 |
EP1106183A2 (en) | 2001-06-13 |
JP2008188013A (ja) | 2008-08-21 |
TR199901615T2 (en) | 1999-11-22 |
EP1695986A3 (en) | 2012-11-07 |
AU4982097A (en) | 1998-05-15 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US20180282428A1 (en) | ANTI-ErbB2 ANTIBODIES | |
EP1695986B1 (en) | Anti-erb B2 antibodies | |
AU765003B2 (en) | Apo-2 ligand-anti-her-2 antibody synergism | |
EP0896586B1 (en) | ErbB3 ANTIBODIES | |
US7892549B2 (en) | Treatment with anti-ErbB2 antibodies | |
AU2004202600B2 (en) | Anti-ErbB2 antibodies | |
AU2478901A (en) | anti-ErbB2 antibodies | |
EP1941905A1 (en) | APO-2 Ligand-anti-her-2 antibody synergism | |
AU2007201622A1 (en) | APO-2 ligand-anti-her-2 antibody synergism |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
17P | Request for examination filed |
Effective date: 19990510 |
|
AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE |
|
AX | Request for extension of the european patent |
Free format text: AL PAYMENT 19990510;LT PAYMENT 19990510;LV PAYMENT 19990510;RO PAYMENT 19990510;SI PAYMENT 19990510 |
|
RIN1 | Information on inventor provided before grant (corrected) |
Inventor name: UHR, JONATHAN, W. Inventor name: SCHEUERMANN, RICHARD, H. Inventor name: PHILLIPS, GAIL, DIANNE Inventor name: FENDLY, BRIAN, M. |
|
17Q | First examination report despatched |
Effective date: 20030605 |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION HAS BEEN WITHDRAWN |
|
18W | Application withdrawn |
Effective date: 20060421 |