EP0907661A4 - PROCEDES ET COMPOSITIONS SERVANT A L'INHIBITION DE L'ANGIOGENESE LIEE A LA PRESENCE DE alpha v beta 5 - Google Patents
PROCEDES ET COMPOSITIONS SERVANT A L'INHIBITION DE L'ANGIOGENESE LIEE A LA PRESENCE DE alpha v beta 5Info
- Publication number
- EP0907661A4 EP0907661A4 EP97927814A EP97927814A EP0907661A4 EP 0907661 A4 EP0907661 A4 EP 0907661A4 EP 97927814 A EP97927814 A EP 97927814A EP 97927814 A EP97927814 A EP 97927814A EP 0907661 A4 EP0907661 A4 EP 0907661A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- alpha
- beta
- inhibition
- mediated angiogenesis
- growth factor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6489—Metalloendopeptidases (3.4.24)
- C12N9/6491—Matrix metalloproteases [MMP's], e.g. interstitial collagenase (3.4.24.7); Stromelysins (3.4.24.17; 3.2.1.22); Matrilysin (3.4.24.23)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/4886—Metalloendopeptidases (3.4.24), e.g. collagenase
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
- C07C279/14—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
- C07C311/02—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
- C07C311/03—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atoms of the sulfonamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C311/06—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atoms of the sulfonamide groups bound to hydrogen atoms or to acyclic carbon atoms to acyclic carbon atoms of hydrocarbon radicals substituted by carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
- C07C311/10—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of a saturated carbon skeleton containing rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/36—One oxygen atom
- C07D263/38—One oxygen atom attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
- C07K14/75—Fibrinogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2839—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2839—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily
- C07K16/2848—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily against integrin beta3-subunit-containing molecules, e.g. CD41, CD51, CD61
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/36—Systems containing two condensed rings the rings having more than two atoms in common
- C07C2602/42—Systems containing two condensed rings the rings having more than two atoms in common the bicyclo ring system containing seven carbon atoms
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Immunology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Zoology (AREA)
- Rheumatology (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Microbiology (AREA)
- Pain & Pain Management (AREA)
- Pulmonology (AREA)
- Toxicology (AREA)
- Physical Education & Sports Medicine (AREA)
- Biotechnology (AREA)
- Ophthalmology & Optometry (AREA)
- Orthopedic Medicine & Surgery (AREA)
- General Engineering & Computer Science (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US1586996P | 1996-05-31 | 1996-05-31 | |
US1873396P | 1996-05-31 | 1996-05-31 | |
US18733P | 1996-05-31 | ||
US15869P | 1996-05-31 | ||
PCT/US1997/009099 WO1997045447A1 (fr) | 1996-05-31 | 1997-05-30 | PROCEDES ET COMPOSITIONS SERVANT A L'INHIBITION DE L'ANGIOGENESE LIEE A LA PRESENCE DE αvβ¿5? |
Publications (2)
Publication Number | Publication Date |
---|---|
EP0907661A1 EP0907661A1 (fr) | 1999-04-14 |
EP0907661A4 true EP0907661A4 (fr) | 2000-07-26 |
Family
ID=26687899
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP97927814A Withdrawn EP0907661A4 (fr) | 1996-05-31 | 1997-05-30 | PROCEDES ET COMPOSITIONS SERVANT A L'INHIBITION DE L'ANGIOGENESE LIEE A LA PRESENCE DE alpha v beta 5 |
EP97928698A Expired - Lifetime EP0951295B1 (fr) | 1996-05-31 | 1997-05-30 | Compositions pour l'utilisation afin d'inhiber l'angiogenese mediee par alpha-v- beta3 |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP97928698A Expired - Lifetime EP0951295B1 (fr) | 1996-05-31 | 1997-05-30 | Compositions pour l'utilisation afin d'inhiber l'angiogenese mediee par alpha-v- beta3 |
Country Status (14)
Country | Link |
---|---|
EP (2) | EP0907661A4 (fr) |
JP (1) | JP2002515036A (fr) |
KR (2) | KR20000016301A (fr) |
CN (1) | CN1226254A (fr) |
AT (1) | ATE470450T1 (fr) |
BR (1) | BR9709514A (fr) |
CA (2) | CA2256588A1 (fr) |
CZ (2) | CZ383498A3 (fr) |
DE (1) | DE69739907D1 (fr) |
DK (1) | DK0951295T3 (fr) |
HU (2) | HUP9901628A3 (fr) |
NO (2) | NO985574L (fr) |
PL (2) | PL330240A1 (fr) |
WO (2) | WO1997045137A1 (fr) |
Families Citing this family (35)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20040063790A1 (en) * | 1996-05-31 | 2004-04-01 | The Scripps Research Institute | Methods for inhibition of angiogenesis |
US6759047B1 (en) | 1998-06-17 | 2004-07-06 | Beth Israel Deaconess Hospital Corp. | Anti-angiogenic proteins and methods of use thereof |
US6962974B1 (en) | 1998-06-17 | 2005-11-08 | Beth Israel Deaconess Medical Center | Anti-angiogenic proteins and fragments and methods of use thereof |
US7387779B2 (en) | 1998-06-17 | 2008-06-17 | Beth Israel Deaconess Medical Center | Anti-angiogenic proteins and fragments and methods of use thereof |
WO2000003710A1 (fr) | 1998-07-14 | 2000-01-27 | Pharmacia & Upjohn Company | Oxazolidinones pour le traitement d'infections oculaires |
DE19842415A1 (de) * | 1998-09-16 | 2000-03-23 | Merck Patent Gmbh | Pharmazeutische Zubereitung |
US6521593B1 (en) * | 1999-02-01 | 2003-02-18 | Childrens Hospital Los Angeles | Methods for inhibiting brain tumor growth |
US6344484B1 (en) | 1999-02-12 | 2002-02-05 | 3-Dimensional Pharmaceuticals, Inc. | Tyrosine alkoxyguanidines as integrin inhibitors |
SK287357B6 (sk) | 1999-02-12 | 2010-08-09 | The Scripps Research Institute | Použitie antagonistu alfa v beta 3 na prípravu farmaceutickej kompozície na liečbu tumorových buniek a terapeutická kompozícia a súprava na liečenie tumoru alebo tumorových metastáz |
UA71608C2 (en) * | 1999-03-11 | 2004-12-15 | Merck Patent Gmbh | A method for producing the cyclic pentapeptide |
US7037666B2 (en) * | 2000-05-26 | 2006-05-02 | Smithkline Beecham Corporation | Methods for identifying modulators of the interaction between lap (latency associated peptide) and intergrin αvβ3 and medical use thereof |
CN1329167A (zh) * | 2000-06-19 | 2002-01-02 | 上海博德基因开发有限公司 | 一种新的多肽——人非整合蛋白-金属蛋白酶10.67和编码这种多肽的多核苷酸 |
US6486174B2 (en) | 2000-08-07 | 2002-11-26 | 3-Dimensional Pharmaceuticals, Inc. | Tetrahydroisoquinoline-3-carboxylic acid alkoxyguanidines as integrin antagonists |
EP1381382B1 (fr) | 2000-11-01 | 2008-11-26 | MERCK PATENT GmbH | Methodes et compositions de traitement de maladies de l'oeil |
JP4615826B2 (ja) | 2001-01-29 | 2011-01-19 | オーソ−マクニール・フアーマシユーチカル・インコーポレーテツド | 置換インドールおよびインテグリンアンタゴニストとしてのそれらの使用 |
CA2444821C (fr) | 2001-04-24 | 2012-07-10 | Merck Patent Gesellschaft Mit Beschraenkter Haftung | Polytherapie a base d'agents antiangiogeniques et de facteur de necrose tumorale tnfa |
US6872730B2 (en) | 2001-04-27 | 2005-03-29 | 3-Dimensional Pharmaceuticals, Inc. | Substituted benzofurans and benzothiophenes, methods of making and methods of use as integrin antagonists |
US7019108B2 (en) | 2001-06-01 | 2006-03-28 | University Of Southern California | Method and composition for inhibition of angiogenesis and tumor growth using compounds based on a sequence within MMP-2 |
RU2311177C2 (ru) * | 2001-08-01 | 2007-11-27 | Мерк Патент Гмбх | Ингибиторы интегрина для лечения заболевания глаз |
DE10159453A1 (de) * | 2001-12-04 | 2003-06-18 | Merck Patent Gmbh | Verwendung von 1-Phenyl-oxazolidin-2-on-Verbindungen als Protease |
GB0217017D0 (en) * | 2002-07-23 | 2002-08-28 | Bioacta Ltd | Peptide 2 |
FR2856598B1 (fr) * | 2003-06-25 | 2005-10-28 | Inst Nat Sante Rech Med | Peptides derives de la proteine mmp-2 et leur utilisation en immunotherapie antitumorale |
US7196061B2 (en) * | 2003-09-10 | 2007-03-27 | Wyeth | Compounds that modulate neuronal growth and their uses |
WO2007084670A2 (fr) | 2006-01-18 | 2007-07-26 | Merck Patent Gmbh | Traitement specifique utilisant des ligands de l’integrine destine a traiter un cancer |
EP1862541A1 (fr) * | 2006-06-01 | 2007-12-05 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Polypeptides dérivés du domaine de type hémopexine de la métalloprotéinase MMP-2 |
AU2008207095B2 (en) | 2007-01-18 | 2013-08-29 | Merck Patent Gmbh | Specific therapy and medicament using integrin ligands for treating cancer |
US20110243927A1 (en) * | 2007-08-24 | 2011-10-06 | University Health Network | Methods of inhibiting tumor growth using beta 5 integrin antagonists |
US8258111B2 (en) | 2008-05-08 | 2012-09-04 | The Johns Hopkins University | Compositions and methods related to miRNA modulation of neovascularization or angiogenesis |
US20120130146A1 (en) | 2009-05-25 | 2012-05-24 | Merck Patent Gmbh | Continuous administration of cilengitide in cancer treatments |
EP2504035B8 (fr) * | 2009-11-10 | 2019-06-05 | Allegro Pharmaceuticals, LLC | Compositions et méthodes d'inhibition de l'adhésion cellulaire ou du ciblage d'agents diagnostiques ou thérapeutiques vers des sites de liaison de rgd |
US11673914B2 (en) | 2009-11-10 | 2023-06-13 | Allegro Pharmaceuticals, LLC | Peptide therapies for reduction of macular thickening |
WO2014163156A1 (fr) * | 2013-04-04 | 2014-10-09 | 味の素株式会社 | Procédé de déprotection |
WO2016040839A1 (fr) * | 2014-09-12 | 2016-03-17 | Biogen Ma Inc. | Anticorps anti-alpha v bêta 5 humanisés et leurs utilisations |
CN111748041B (zh) * | 2019-03-11 | 2021-09-14 | 中国科学院苏州纳米技术与纳米仿生研究所 | 微环境控释型功能化水凝胶、其制备方法及应用 |
CN116239704B (zh) * | 2023-05-09 | 2023-07-14 | 北京青云智创科技有限公司 | 一种治疗新生血管性眼病的多肽及其制剂 |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1995028426A2 (fr) * | 1994-04-13 | 1995-10-26 | La Jolla Cancer Research Foundation | Peptide limitant ou empechant la resorption osseuse, l'angiogenese et la restenose |
WO1997014716A1 (fr) * | 1995-10-18 | 1997-04-24 | MERCK Patent Gesellschaft mit beschränkter Haftung | Derives cyclopeptidiques |
EP0770622A2 (fr) * | 1995-09-15 | 1997-05-02 | MERCK PATENT GmbH | Inhibiteurs cycliques de l'adhésion |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1997006791A1 (fr) * | 1995-08-14 | 1997-02-27 | The Scripps Research Institute | PROCEDE ET COMPOSITIONS UTILES POUR INHIBER L'ANGIOGENESE MEDIEE PAR αvβ¿5? |
-
1997
- 1997-05-30 PL PL97330240A patent/PL330240A1/xx unknown
- 1997-05-30 AT AT97928698T patent/ATE470450T1/de active
- 1997-05-30 CA CA002256588A patent/CA2256588A1/fr not_active Abandoned
- 1997-05-30 DK DK97928698.6T patent/DK0951295T3/da active
- 1997-05-30 KR KR1019980709874A patent/KR20000016301A/ko not_active Application Discontinuation
- 1997-05-30 CZ CZ983834A patent/CZ383498A3/cs unknown
- 1997-05-30 EP EP97927814A patent/EP0907661A4/fr not_active Withdrawn
- 1997-05-30 HU HU9901628A patent/HUP9901628A3/hu unknown
- 1997-05-30 PL PL97330241A patent/PL330241A1/xx unknown
- 1997-05-30 WO PCT/US1997/009158 patent/WO1997045137A1/fr not_active Application Discontinuation
- 1997-05-30 CN CN97196818A patent/CN1226254A/zh active Pending
- 1997-05-30 BR BR9709514A patent/BR9709514A/pt not_active IP Right Cessation
- 1997-05-30 KR KR1019980709875A patent/KR20000016302A/ko not_active Application Discontinuation
- 1997-05-30 DE DE69739907T patent/DE69739907D1/de not_active Expired - Lifetime
- 1997-05-30 CZ CZ983800A patent/CZ380098A3/cs unknown
- 1997-05-30 JP JP54291497A patent/JP2002515036A/ja not_active Abandoned
- 1997-05-30 EP EP97928698A patent/EP0951295B1/fr not_active Expired - Lifetime
- 1997-05-30 CA CA2256543A patent/CA2256543C/fr not_active Expired - Fee Related
- 1997-05-30 HU HU9902099A patent/HUP9902099A3/hu unknown
- 1997-05-30 WO PCT/US1997/009099 patent/WO1997045447A1/fr not_active Application Discontinuation
-
1998
- 1998-11-27 NO NO985574A patent/NO985574L/no not_active Application Discontinuation
- 1998-11-27 NO NO985575A patent/NO985575L/no not_active Application Discontinuation
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1995028426A2 (fr) * | 1994-04-13 | 1995-10-26 | La Jolla Cancer Research Foundation | Peptide limitant ou empechant la resorption osseuse, l'angiogenese et la restenose |
EP0770622A2 (fr) * | 1995-09-15 | 1997-05-02 | MERCK PATENT GmbH | Inhibiteurs cycliques de l'adhésion |
WO1997014716A1 (fr) * | 1995-10-18 | 1997-04-24 | MERCK Patent Gesellschaft mit beschränkter Haftung | Derives cyclopeptidiques |
Non-Patent Citations (5)
Title |
---|
AM. J. PATHOL., vol. 148, no. 5, May 1996 (1996-05-01), pages 1407 - 1421 * |
CHEMICAL ABSTRACTS, vol. 125, no. 1, 1 July 1996, Columbus, Ohio, US; abstract no. 7248, R A CLARK ET AL.: "Transient functional expression of alpha.v.beta.3 on vascular cells during wound repair" XP002138525 * |
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Also Published As
Publication number | Publication date |
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HUP9901628A2 (hu) | 1999-08-30 |
WO1997045137A1 (fr) | 1997-12-04 |
KR20000016301A (ko) | 2000-03-25 |
PL330241A1 (en) | 1999-05-10 |
DK0951295T3 (da) | 2010-09-13 |
CA2256543C (fr) | 2010-12-07 |
CA2256543A1 (fr) | 1997-12-04 |
CA2256588A1 (fr) | 1997-12-04 |
NO985574L (no) | 1999-02-01 |
PL330240A1 (en) | 1999-05-10 |
WO1997045447A1 (fr) | 1997-12-04 |
HUP9901628A3 (en) | 2002-11-28 |
WO1997045137A8 (fr) | 2001-02-01 |
CZ380098A3 (cs) | 1999-05-12 |
NO985574D0 (no) | 1998-11-27 |
CN1226254A (zh) | 1999-08-18 |
HUP9902099A3 (en) | 2001-10-29 |
NO985575D0 (no) | 1998-11-27 |
DE69739907D1 (de) | 2010-07-22 |
JP2002515036A (ja) | 2002-05-21 |
BR9709514A (pt) | 1999-08-10 |
CZ383498A3 (cs) | 1999-05-12 |
HUP9902099A2 (hu) | 1999-09-28 |
ATE470450T1 (de) | 2010-06-15 |
KR20000016302A (ko) | 2000-03-25 |
EP0951295A1 (fr) | 1999-10-27 |
EP0951295B1 (fr) | 2010-06-09 |
EP0951295A4 (fr) | 2000-07-26 |
EP0907661A1 (fr) | 1999-04-14 |
NO985575L (no) | 1999-02-01 |
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