EP0783521B8 - Polypeptide compounds containing d-2-alkyltryptophan capable of promoting the release of growth hormone - Google Patents

Polypeptide compounds containing d-2-alkyltryptophan capable of promoting the release of growth hormone Download PDF

Info

Publication number
EP0783521B8
EP0783521B8 EP95932735A EP95932735A EP0783521B8 EP 0783521 B8 EP0783521 B8 EP 0783521B8 EP 95932735 A EP95932735 A EP 95932735A EP 95932735 A EP95932735 A EP 95932735A EP 0783521 B8 EP0783521 B8 EP 0783521B8
Authority
EP
European Patent Office
Prior art keywords
alkyltryptophan
growth hormone
promoting
release
compounds containing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
EP95932735A
Other languages
German (de)
English (en)
French (fr)
Other versions
EP0783521B1 (en
EP0783521A1 (en
Inventor
Romano Deghenghi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ardana Bioscience Ltd
Original Assignee
Ardana Bioscience Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from ITMI941954A external-priority patent/IT1270021B/it
Priority claimed from IT95MI001293A external-priority patent/IT1276734B1/it
Application filed by Ardana Bioscience Ltd filed Critical Ardana Bioscience Ltd
Publication of EP0783521A1 publication Critical patent/EP0783521A1/en
Publication of EP0783521B1 publication Critical patent/EP0783521B1/en
Application granted granted Critical
Publication of EP0783521B8 publication Critical patent/EP0783521B8/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
    • C07K5/1013—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing O or S as heteroatoms, e.g. Cys, Ser
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/25—Growth hormone-releasing factor [GH-RF], i.e. somatoliberin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
    • A61P5/04—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin for decreasing, blocking or antagonising the activity of the hypothalamic hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/60—Growth hormone-releasing factor [GH-RF], i.e. somatoliberin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0205—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)3-C(=0)-, e.g. statine or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1024—Tetrapeptides with the first amino acid being heterocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Endocrinology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)
EP95932735A 1994-09-27 1995-09-13 Polypeptide compounds containing d-2-alkyltryptophan capable of promoting the release of growth hormone Expired - Lifetime EP0783521B8 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
ITMI941954 1994-09-27
ITMI941954A IT1270021B (it) 1994-09-27 1994-09-27 "composti polipeptidici contenenti d-2-metiltriptofano aventi attivita'sull'aumento del camp intracellulare"
IT95MI001293A IT1276734B1 (it) 1995-06-16 1995-06-16 Composti polipeptidici contenenti d-2-alchiltriptofano in grado di promuovere la liberazione dell'ormone della
ITMI951293 1995-06-16
PCT/EP1995/003601 WO1996010040A1 (en) 1994-09-27 1995-09-13 Polypeptide compounds containing d-2-alkyltryptophan capable of promoting the release of growth hormone

Publications (3)

Publication Number Publication Date
EP0783521A1 EP0783521A1 (en) 1997-07-16
EP0783521B1 EP0783521B1 (en) 2002-10-09
EP0783521B8 true EP0783521B8 (en) 2003-04-09

Family

ID=26331189

Family Applications (1)

Application Number Title Priority Date Filing Date
EP95932735A Expired - Lifetime EP0783521B8 (en) 1994-09-27 1995-09-13 Polypeptide compounds containing d-2-alkyltryptophan capable of promoting the release of growth hormone

Country Status (21)

Country Link
US (1) US5795957A (zh)
EP (1) EP0783521B8 (zh)
JP (1) JP3810083B2 (zh)
KR (1) KR100369105B1 (zh)
CN (1) CN1121413C (zh)
AT (1) ATE225806T1 (zh)
AU (1) AU700066B2 (zh)
CA (1) CA2201122A1 (zh)
CZ (1) CZ291798B6 (zh)
DE (1) DE69528531T2 (zh)
DK (1) DK0783521T3 (zh)
ES (1) ES2186730T3 (zh)
HK (1) HK1001207A1 (zh)
HU (1) HU221481B (zh)
IL (1) IL115381A (zh)
MX (1) MX9702275A (zh)
PL (1) PL181588B1 (zh)
PT (1) PT783521E (zh)
RU (1) RU2157378C2 (zh)
SK (1) SK284550B6 (zh)
WO (1) WO1996010040A1 (zh)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020111461A1 (en) 1999-05-21 2002-08-15 Todd C. Somers Low molecular weight peptidomimetic growth hormone secretagogues
US5798337A (en) * 1994-11-16 1998-08-25 Genentech, Inc. Low molecular weight peptidomimetic growth hormone secretagogues
IT1277113B1 (it) * 1995-12-20 1997-11-04 Romano Deghenghi Composti oligopeptidici contenenti d-2-alchiltriptofano in grado di promuovere la liberazione dell'ormone della crescita
WO1999039730A1 (fr) * 1998-02-09 1999-08-12 Kaken Pharmaceutical Co., Ltd. Preparation a administration orale contenant des peptides favorisant la secretion d'hormone de croissance
US5932548A (en) * 1998-06-03 1999-08-03 Deghenghi; Romano Lysine containing peptides for treatment of heart disease
US6696063B1 (en) 1998-12-30 2004-02-24 Applied Research Systems Ars Holding N.V. Treatment of HIV-associated dysmorphia/dysmetabolic syndrome (HADDS) with or without lipodystrophy
US6211156B1 (en) * 1999-11-10 2001-04-03 Asta Medica A.G. Peptides for treatment of erectile dysfunction
TWI331922B (en) 2002-08-09 2010-10-21 Ipsen Pharma Sas Growth hormone releasing peptides
WO2006078320A2 (en) 2004-08-04 2006-07-27 Brookwood Pharmaceuticals, Inc. Methods for manufacturing delivery devices and devices thereof
GB0603295D0 (en) 2006-02-18 2006-03-29 Ardana Bioscience Ltd Methods and kits
US8728528B2 (en) 2007-12-20 2014-05-20 Evonik Corporation Process for preparing microparticles having a low residual solvent volume
US9119832B2 (en) 2014-02-05 2015-09-01 The Regents Of The University Of California Methods of treating mild brain injury
WO2017075535A1 (en) 2015-10-28 2017-05-04 Oxeia Biopharmaceuticals, Inc. Methods of treating neurodegenerative conditions

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1080470A (en) * 1963-12-31 1967-08-23 Merck & Co Inc Indole derivatives
US4411890A (en) * 1981-04-14 1983-10-25 Beckman Instruments, Inc. Synthetic peptides having pituitary growth hormone releasing activity
US4228156A (en) * 1979-03-30 1980-10-14 Beckman Instruments, Inc. Synthetic peptides having pituitary growth hormone releasing activity
US4228158A (en) * 1979-03-30 1980-10-14 Beckman Instruments, Inc. Synthetic peptides having pituitary growth hormone releasing activity
US4228155A (en) * 1979-03-30 1980-10-14 Beckman Instruments, Inc. Synthetic peptides having pituitary growth hormone releasing activity
US4223019A (en) * 1979-03-30 1980-09-16 Beckman Instruments, Inc. Synthetic peptides having pituitary growth hormone releasing activity
US4224316A (en) * 1979-03-30 1980-09-23 Beckman Instruments, Inc. Synthetic peptides having pituitary growth hormone releasing activity
US4223021A (en) * 1979-03-30 1980-09-16 Beckman Instruments, Inc. Synthetic peptides having pituitary growth hormone releasing activity
US4223020A (en) * 1979-03-30 1980-09-16 Beckman Instruments, Inc. Synthetic peptides having pituitary growth hormone releasing activity
US4226857A (en) * 1979-03-30 1980-10-07 Beckman Instruments, Inc. Synthetic peptides having pituitary growth hormone releasing activity
US4228157A (en) * 1979-03-30 1980-10-14 Beckman Instruments, Inc. Synthetic peptides having pituitary growth hormone releasing activity
BR8208035A (pt) * 1981-12-28 1983-11-22 Beckman Instruments Inc Peptideos sinteticos tendo atividade liberadora de hormonio do crescimento da pituitaria
US4410512A (en) * 1981-12-28 1983-10-18 Beckman Instruments, Inc. Combinations having synergistic pituitary growth hormone releasing activity
US4410513A (en) * 1981-12-28 1983-10-18 Beckman Instruments, Inc. Synthetic peptides having pituitary growth hormone releasing activity
US4725577A (en) * 1985-04-25 1988-02-16 Administrators Of The Tulane Educational Fund Biologically active lysine containing octapeptides
US4839344A (en) * 1987-06-12 1989-06-13 Eastman Kodak Company Polypeptide compounds having growth hormone releasing activity
WO1989007110A1 (en) * 1988-01-28 1989-08-10 Eastman Kodak Company Polypeptide compounds having growth hormone releasing activity
DE3915361A1 (de) * 1989-05-11 1990-11-15 Merck Patent Gmbh Cyclopeptide
IT1240643B (it) * 1990-05-11 1993-12-17 Mediolanum Farmaceutici Spa Peptidi biologicamente attivi contenenti in catena 2-alchiltriptofano
EP0663834A4 (en) * 1992-09-25 1996-01-24 Smithkline Beecham Corp GROWTH HORMONE RELEASING PEPTIDES.

Also Published As

Publication number Publication date
IL115381A (en) 2000-07-16
US5795957A (en) 1998-08-18
KR100369105B1 (ko) 2003-04-07
EP0783521B1 (en) 2002-10-09
DE69528531T2 (de) 2003-06-05
ES2186730T3 (es) 2003-05-16
ATE225806T1 (de) 2002-10-15
WO1996010040A1 (en) 1996-04-04
JPH10506114A (ja) 1998-06-16
EP0783521A1 (en) 1997-07-16
DK0783521T3 (da) 2003-01-27
MX9702275A (es) 1997-06-28
CA2201122A1 (en) 1996-04-04
CZ91497A3 (en) 1997-09-17
AU700066B2 (en) 1998-12-17
PT783521E (pt) 2003-02-28
CZ291798B6 (cs) 2003-05-14
CN1158622A (zh) 1997-09-03
AU3566895A (en) 1996-04-19
CN1121413C (zh) 2003-09-17
JP3810083B2 (ja) 2006-08-16
HUT77525A (hu) 1998-05-28
DE69528531D1 (de) 2002-11-14
PL319382A1 (en) 1997-08-04
IL115381A0 (en) 1995-12-31
RU2157378C2 (ru) 2000-10-10
HU221481B (en) 2002-10-28
SK284550B6 (sk) 2005-06-02
PL181588B1 (pl) 2001-08-31
SK39997A3 (en) 1997-09-10
HK1001207A1 (en) 1998-06-05
KR970706305A (ko) 1997-11-03

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