EP0758891A4 - HALOMETHYL AMIDES USED AS IL-1-g (b) PROTEASE INHIBITORS. - Google Patents

HALOMETHYL AMIDES USED AS IL-1-g (b) PROTEASE INHIBITORS.

Info

Publication number
EP0758891A4
EP0758891A4 EP95918877A EP95918877A EP0758891A4 EP 0758891 A4 EP0758891 A4 EP 0758891A4 EP 95918877 A EP95918877 A EP 95918877A EP 95918877 A EP95918877 A EP 95918877A EP 0758891 A4 EP0758891 A4 EP 0758891A4
Authority
EP
European Patent Office
Prior art keywords
protease inhibitors
halomethyl
amides
halomethyl amides
protease
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP95918877A
Other languages
German (de)
English (en)
French (fr)
Other versions
EP0758891A1 (en
Inventor
Roland E Dolle
James M Rinker
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Vertex Pharmaceuticals Inc
Original Assignee
Sanofi Winthrop Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Winthrop Inc filed Critical Sanofi Winthrop Inc
Publication of EP0758891A1 publication Critical patent/EP0758891A1/en
Publication of EP0758891A4 publication Critical patent/EP0758891A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/12—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by halogen atoms or by nitro or nitroso groups
    • C07C233/13—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by halogen atoms or by nitro or nitroso groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/45—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C07C233/46—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/47—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/24—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the same saturated acyclic carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/24—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the same saturated acyclic carbon skeleton
    • C07C255/25—Aminoacetonitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
    • C07C311/02—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C311/03—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atoms of the sulfonamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C311/06—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atoms of the sulfonamide groups bound to hydrogen atoms or to acyclic carbon atoms to acyclic carbon atoms of hydrocarbon radicals substituted by carboxyl groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
EP95918877A 1994-04-29 1995-04-28 HALOMETHYL AMIDES USED AS IL-1-g (b) PROTEASE INHIBITORS. Withdrawn EP0758891A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US23642594A 1994-04-29 1994-04-29
US236425 1994-04-29
PCT/US1995/005347 WO1995029672A1 (en) 1994-04-29 1995-04-28 HALOMETHYL AMIDES AS IL-1β PROTEASE INHIBITORS

Publications (2)

Publication Number Publication Date
EP0758891A1 EP0758891A1 (en) 1997-02-26
EP0758891A4 true EP0758891A4 (en) 1997-12-03

Family

ID=22889450

Family Applications (1)

Application Number Title Priority Date Filing Date
EP95918877A Withdrawn EP0758891A4 (en) 1994-04-29 1995-04-28 HALOMETHYL AMIDES USED AS IL-1-g (b) PROTEASE INHIBITORS.

Country Status (9)

Country Link
EP (1) EP0758891A4 (fi)
JP (1) JPH09512556A (fi)
CN (1) CN1147201A (fi)
AU (1) AU705321B2 (fi)
CA (1) CA2189036A1 (fi)
FI (1) FI964342A0 (fi)
MX (1) MX9605196A (fi)
NO (1) NO964472D0 (fi)
WO (1) WO1995029672A1 (fi)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6204261B1 (en) 1995-12-20 2001-03-20 Vertex Pharmaceuticals Incorporated Inhibitors of interleukin-1β Converting enzyme inhibitors
US5874424A (en) * 1995-12-20 1999-02-23 Vertex Pharmaceuticals Incorporated Inhibitors of interleukin-1β converting enzyme
US6008217A (en) * 1995-12-20 1999-12-28 Vertex Pharmaceuticals Incorporated Inhibitors of interleukin-1β converting enzyme
US6420522B1 (en) 1995-06-05 2002-07-16 Vertex Pharmaceuticals Incorporated Inhibitors of interleukin-1β converting enzyme
CA2215211A1 (en) * 1995-03-31 1996-10-03 Takeda Chemical Industries, Ltd. Cysteine protease inhibitor
US5843904A (en) * 1995-12-20 1998-12-01 Vertex Pharmaceuticals, Inc. Inhibitors of interleukin-1βconverting enzyme
WO1999046248A1 (en) 1998-03-09 1999-09-16 Vertex Pharmaceuticals Incorporated 1,2-diazepane derivatives as interleukin-1beta converting enzyme inhibitors
PT1064298E (pt) 1998-03-19 2009-01-02 Vertex Pharma Inibidores de caspasas
GB9922830D0 (en) 1999-09-27 1999-11-24 Novartis Ag Processes
JP2003525874A (ja) * 2000-01-06 2003-09-02 メルク フロスト カナダ アンド カンパニー プロテアーゼ阻害剤としての新規化合物および組成物
PE20011350A1 (es) 2000-05-19 2002-01-15 Vertex Pharma PROFARMACO DE UN INHIBIDOR DE ENZIMA CONVERTIDORA DE INTERLEUCINA-1ß (ICE)
DE60311821T2 (de) 2002-08-30 2007-10-31 Japan Tobacco Inc. Dibenzylaminverbindung und deren medizinische verwendung
CN100441186C (zh) * 2003-12-03 2008-12-10 和记黄埔医药企业有限公司 伪石蒜碱的医药用途
CN1980658A (zh) 2004-05-27 2007-06-13 沃泰克斯药物股份有限公司 治疗自身炎性疾病的ice抑制剂
US9956260B1 (en) 2011-07-22 2018-05-01 The J. David Gladstone Institutes Treatment of HIV-1 infection and AIDS

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2193961A (en) * 1986-08-18 1988-02-24 Merck & Co Inc 3-hydroxybenzo(b)thiophene-2-carboxamides
US4874864A (en) * 1988-05-24 1989-10-17 Pfizer Inc. Benzamide protease inhibitors
US5258407A (en) * 1991-12-31 1993-11-02 Sterling Winthrop Inc. 3,4-disubstituted phenols-immunomodulating agents

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1806291A1 (de) * 1968-10-31 1970-05-14 Badische Anilin Und & Soda Fab Fungizid
US4195096A (en) * 1977-01-12 1980-03-25 Gaf Corporation Carboxylic amides as fungicides to eumycotina in phanerogamia plant life
DE2946910A1 (de) * 1979-11-21 1981-07-02 Hoechst Ag, 6230 Frankfurt Fungizide sulfonyl-, bzw. sulfinylacetanilide
DE3122738A1 (de) * 1980-06-12 1982-03-18 CIBA-GEIGY AG, 4002 Basel "verwendung von jodacetamid zur bekaempfung von schadorganismen und mittel fuer die bekaempfung"
US4377587A (en) * 1980-07-25 1983-03-22 Ciba-Geigy Corporation Arylamine derivatives and use thereof as microbicides
JPS5798202A (en) * 1980-12-09 1982-06-18 Kumiai Chem Ind Co Ltd Herbicide
DE3276110D1 (en) * 1981-03-04 1987-05-27 Ici Plc Amide derivatives, processes for preparing them, their use as fungicides and pesticidal compositions containing them
DE3339351A1 (de) * 1983-10-29 1985-05-09 Bayer Ag, 5090 Leverkusen Iodacetamide

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2193961A (en) * 1986-08-18 1988-02-24 Merck & Co Inc 3-hydroxybenzo(b)thiophene-2-carboxamides
US4874864A (en) * 1988-05-24 1989-10-17 Pfizer Inc. Benzamide protease inhibitors
US5258407A (en) * 1991-12-31 1993-11-02 Sterling Winthrop Inc. 3,4-disubstituted phenols-immunomodulating agents

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
RALPH HOWE ET AL.: "Selective B3-Adrenergic Agonists of Brown Adipose Tissue and Thermogenesis.", J. MED. CHEM., vol. 35, no. 10, 1992, pages 1759 - 63, XP002042383 *
SALMA JALEEL HASAN ET AL.: "Synthesis of N-Chloroacetyl-B-phenylethylamine derivatives", INDIAN J. CHEM., vol. 9, no. 9, 1971, pages 1022 - 24, XP002042384 *
See also references of WO9529672A1 *

Also Published As

Publication number Publication date
FI964342A (fi) 1996-10-28
AU705321B2 (en) 1999-05-20
WO1995029672A1 (en) 1995-11-09
FI964342A0 (fi) 1996-10-28
NO964472L (no) 1996-10-21
CN1147201A (zh) 1997-04-09
MX9605196A (es) 1997-12-31
CA2189036A1 (en) 1995-11-09
NO964472D0 (no) 1996-10-21
AU2463495A (en) 1995-11-29
EP0758891A1 (en) 1997-02-26
JPH09512556A (ja) 1997-12-16

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Legal Events

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PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

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Effective date: 19961018

AK Designated contracting states

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Effective date: 19971021

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RAP1 Party data changed (applicant data changed or rights of an application transferred)

Owner name: SANOFI PHARMACEUTICALS, INC.

RAP1 Party data changed (applicant data changed or rights of an application transferred)

Owner name: VERTEX PHARMACEUTICALS INCORPORATED

17Q First examination report despatched

Effective date: 19981229

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 20001101