EP0711404B1 - Reagenzsystem zur eichung von pipetten und anderen volumetrischen messgeräten - Google Patents

Reagenzsystem zur eichung von pipetten und anderen volumetrischen messgeräten Download PDF

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Publication number
EP0711404B1
EP0711404B1 EP94921455A EP94921455A EP0711404B1 EP 0711404 B1 EP0711404 B1 EP 0711404B1 EP 94921455 A EP94921455 A EP 94921455A EP 94921455 A EP94921455 A EP 94921455A EP 0711404 B1 EP0711404 B1 EP 0711404B1
Authority
EP
European Patent Office
Prior art keywords
volume
absorbance
solution
container
wavelength
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
EP94921455A
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English (en)
French (fr)
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EP0711404A1 (de
Inventor
Richard H. Curtis
Ann E. Rundell
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Artel Inc
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Artel Inc
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Publication date
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Publication of EP0711404A1 publication Critical patent/EP0711404A1/de
Application granted granted Critical
Publication of EP0711404B1 publication Critical patent/EP0711404B1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01F—MEASURING VOLUME, VOLUME FLOW, MASS FLOW OR LIQUID LEVEL; METERING BY VOLUME
    • G01F25/00—Testing or calibration of apparatus for measuring volume, volume flow or liquid level or for metering by volume
    • G01F25/0092—Testing or calibration of apparatus for measuring volume, volume flow or liquid level or for metering by volume for metering by volume
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02—Burettes; Pipettes
    • B01L3/021—Pipettes, i.e. with only one conduit for withdrawing and redistributing liquids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01F—MEASURING VOLUME, VOLUME FLOW, MASS FLOW OR LIQUID LEVEL; METERING BY VOLUME
    • G01F17/00—Methods or apparatus for determining the capacity of containers or cavities, or the volume of solid bodies
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
    • G01N21/314—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry with comparison of measurements at specific and non-specific wavelengths
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/10—Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/10—Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
    • Y10T436/108331—Preservative, buffer, anticoagulant or diluent

Definitions

  • FIG. 6 A flow diagram of the volume calibration procedure in accordance with the present invention is shown in FIG. 6.
  • the nominal volume and serial number of the pipette to be calibrated is entered through keypad 30 in step 102. This information is used subsequently in printing the results of the calibration.
  • the photometer performs a self-calibration in step 104, during which the ambient temperature is measured and stored for later use.
  • the photometer includes a thermistor for measurement of ambient temperature.
  • the user inserts a reference reagent cuvette 78 into the photometer through hinged lid 41 in step 106.
  • the reference reagent cuvette 78 is located in the photometer in the position of cuvette 27 shown in FIG. 3 so that the light beam passes through the cuvette and the solution contained in it.

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  • Physics & Mathematics (AREA)
  • Fluid Mechanics (AREA)
  • General Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Claims (13)

  1. Reagenssystem zur Anwendung bei der Bestimmung des Volumens eines Gefäßes mit:
    a) einer Referenz-Lösung mit einem ersten pH-Puffer, einer ersten konservierenden Lösung, einem Anti-Agglomerationsmittel und einer absorbierenden Art mit einer ersten maximalen Absorptionsspitze, und
    b) einer Proben-Lösung, die einen zweiten pH-Puffer, eine zweite konservierende Lösung und einen organischen Farbstoff aufweist, der eine zweite maximale Absorptionsspitze zeigt, die sich wesentlich von der ersten maximalen Absorptionsspitze unterscheidet.
  2. System nach Anspruch 1, bei dem das erste und/oder zweite konservierende Mittel eine Mischung aus Methylparaben, Phenoxytol und EDTA, TSS aufweist.
  3. System nach Anspruch 1 oder 2, bei dem der erste und/oder zweite Puffer ein Phthalat-Puffer ist.
  4. System nach Anspruch 3, bei dem der Phthalat-Puffer eine Konzentration in einem Bereich von näherungsweise 0,01 M bis 0,1 M und einen pH-Wert in einem Bereich von näherungsweise 4 bis 6,2 aufweist.
  5. System nach einem der vorhergehenden Ansprüche, bei dem die absorbierende Art ein Kupfersalz aufweist.
  6. System nach Anspruch 5, bei dem die absorbierenden Art Kupferchlorid aufweist.
  7. System nach Anspruch 5 oder 6, bei dem die Referenz-Lösung weiterhin ein chelatierendes Mittel für Kupferionen aufweist.
  8. System nach Anspruch 7, bei dem das chelatierende Mittel für Kupferionen EDTA, TSS ist.
  9. System nach einem der vorhergehenden Ansprüche, bei dem der organische Farbstoff Ponceau S ist.
  10. System nach einem der vorhergehenden Ansprüche, bei dem das Anti-Agglomerationsmittel aus einer Gruppe ausgewählt ist, die Ethylenglykole, Diethylenglykole, Triethylenglykole, Polyethylenoxide, Polyethylenglykole, Pyridine und Propylenglykole aufweist.
  11. System nach Anspruch 10, bei dem das Anti-Agglomerationsmittel ein Polyethylenglykol mit einem Molekulargewicht von zwischen etwa 200 und 10.000 aufweist.
  12. Verfahren zur Bestimmung des Volumens eines Gefäßes unter Anwendung eines Fotometers, mit folgenden Schritten: Positionieren eines Behälters in einen Fotometer, wobei der Behälter eine bekannte Menge einer Referenz-Lösung mit einer maximalen Absorption bei einer ersten Wellenlänge enthält, Messen der Absorption des Behälters bei der ersten Wellenlänge und bei einer zweiten Wellenlänge, Berechnen der optischen Weglänge des Behälters bei der zweiten Wellenlänge aus den gemessenen Absorptionen bei den ersten und zweiten Wellenlängen, Einbringen eines Aliquots einer Proben-Lösung in den Behälter aus einem zu kalibrierenden Gefäß, wobei die Proben-Lösung eine maximale Absorption bei der zweiten Wellenlänge aufweist und Mischen der Proben-Lösung mit der Referenz-Lösung zur Bildung einer Mischung, Messen der Absorption der Mischung in dem Behälter bei der zweiten Wellenlänge und Berechnen des Volumens des Aliquots aus der Absorption der Mischung und der optischen Weglänge des Behälters auf der Basis des bekannten Volumens und der Konzentration der Referenz-Lösung und der bekannten Konzentration der Proben-Lösung, wobei das Volumen des Aliquots das Volumen des Gefäßes darstellt und wobei die Referenz-Lösung und die Proben-Lösung nach einem der vorhergehenden Ansprüche definiert sind.
  13. Verfahren nach Anspruch 12, das ferner eine Minimierung der Anwendung anderer Zusätze zu der Lösung, die eine Agglomeration des organischen Farbstoffs verursachen, beinhaltet.
EP94921455A 1993-07-09 1994-07-01 Reagenzsystem zur eichung von pipetten und anderen volumetrischen messgeräten Expired - Lifetime EP0711404B1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/089,036 US5492673A (en) 1992-02-28 1993-07-09 Reagent system for calibration of pipettes and other volumetric measuring devices
US89036 1993-07-09
PCT/US1994/007481 WO1995002166A1 (en) 1993-07-09 1994-07-01 Reagent system for calibration of pipettes and other volumetric measuring devices

Publications (2)

Publication Number Publication Date
EP0711404A1 EP0711404A1 (de) 1996-05-15
EP0711404B1 true EP0711404B1 (de) 1998-01-14

Family

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Family Applications (1)

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EP94921455A Expired - Lifetime EP0711404B1 (de) 1993-07-09 1994-07-01 Reagenzsystem zur eichung von pipetten und anderen volumetrischen messgeräten

Country Status (5)

Country Link
US (1) US5492673A (de)
EP (1) EP0711404B1 (de)
AT (1) ATE162302T1 (de)
DE (1) DE69407975T2 (de)
WO (1) WO1995002166A1 (de)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6496260B1 (en) * 1998-12-23 2002-12-17 Molecular Devices Corp. Vertical-beam photometer for determination of light absorption pathlength
DE29917940U1 (de) * 1999-10-12 2000-01-05 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V., 80636 München Vorrichtung zur gravimetrischen Prüfung von Mehrkanalpipetten
DE59912403D1 (de) * 1999-11-09 2005-09-15 Tecan Trading Ag Maennedorf Verfahren zur Bestimmung der Gewichte von Flüssigkeitseinheiten, Wägeeinsatz sowie Wägeanordnung
WO2002040161A1 (de) * 2000-11-17 2002-05-23 Tecan Trading Ag Verfahren und vorrichtung zur bestimmung des volumens einer flüssigkeitsprobe
FI20011756A0 (fi) * 2001-09-04 2001-09-04 Wallac Oy Menetelmä optisen mittauslaitteen toiminnan tarkistamiseksi ja tarkistuslaite
US6741365B2 (en) * 2001-12-12 2004-05-25 Artel, Inc. Photometric calibration of liquid volumes
DE10212557A1 (de) * 2002-03-14 2003-09-25 Univ Schiller Jena Verfahren zur Charakterisierung hochparallelisierter Liquidhandlingtechnik mittels Mikroplatten sowie Testkit zur Durchführung des Verfahrens
US7061608B2 (en) * 2004-01-30 2006-06-13 Artel, Inc. Apparatus and method for calibration of spectrophotometers
US7270013B2 (en) * 2005-03-31 2007-09-18 Streck, Inc. Dispenser volume determination method
JP2008542693A (ja) * 2005-05-24 2008-11-27 アジレント・テクノロジーズ・インク 多流路フローセルの補正
US8003405B2 (en) * 2005-12-16 2011-08-23 Artel, Inc. Calibrating dispensing device performance for complex and/or non-aqueous liquids
US7772008B2 (en) * 2006-01-06 2010-08-10 Artel, Inc. Method and apparatus for determining liquid volume
DE102006016822B4 (de) * 2006-04-07 2011-12-29 Söll Gmbh Volumenbestimmung von Gewässern
US7625115B2 (en) * 2006-06-23 2009-12-01 Exxonmobil Research And Engineering Company Method of blending lubricants using positive displacement liquid-handling equipment
EP1887330B1 (de) * 2006-08-11 2009-11-18 Biohit Oyj Testverfahren für Pipetten
US7998747B2 (en) * 2006-09-15 2011-08-16 Artel, Inc. Quantitative dual-dye photometric method for determining dilution impact
DE602006017388D1 (de) * 2006-09-19 2010-11-18 Suisse Electronique Microtech Vorrichtung und Verfahren zum Kalibrieren einer Pipette oder einer Dispenservorrichtung
CN100422696C (zh) * 2007-02-06 2008-10-01 王志刚 用铕原子标记法比对与校准移液器容量精确度的方法
DE102007019186B4 (de) * 2007-04-20 2011-11-17 Qiagen Instruments Ag Pipettiergerät und Verfahren für dem Betrieb des Pipettiergerätes
US7791716B2 (en) * 2008-04-07 2010-09-07 Artel, Inc. System and method for liquid delivery evaluation using solutions with multiple light absorbance spectral features
US8404158B2 (en) 2008-04-07 2013-03-26 Artel, Inc. System and method for liquid delivery evaluation using solutions with multiple light absorbance spectral features
JP5879127B2 (ja) * 2008-11-24 2016-03-08 ジーイー・ヘルスケア・バイオサイエンス・アクチボラグ フローセル光学検出システム
US9052289B2 (en) * 2010-12-13 2015-06-09 Schlumberger Technology Corporation Hydrogen sulfide (H2S) detection using functionalized nanoparticles
US9588132B2 (en) 2011-04-08 2017-03-07 Artel, Inc. Validation method for automated analyzers
CN104956205B (zh) 2012-07-13 2017-09-15 亚特尔公司 垂直和水平波束混合吸液管校准系统
US20140271369A1 (en) * 2013-03-15 2014-09-18 Abbott Laboratories System and Method for Processing Both Clinical Chemistry and Immunoassay Tests
CN107912055B (zh) * 2015-06-19 2024-05-03 安德鲁联合有限公司 用于测量液体体积的装置和方法
US10650527B2 (en) 2015-09-04 2020-05-12 Qualigen, Inc. Systems and methods for sample verification
USD809948S1 (en) * 2016-02-11 2018-02-13 Sartorius Lab Instruments Gmbh & Co. Kg Pumps
USD820704S1 (en) * 2016-02-11 2018-06-19 Sartorius Lab Instruments Gmbh & Co. Kg Pipettes calibration scale
CN117030646B (zh) * 2023-10-09 2024-01-26 中国计量科学研究院 基于光度法的多通道移液器现场测量装置及方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3737237A (en) * 1971-11-18 1973-06-05 Nasa Monitoring deposition of films
US3869211A (en) * 1972-06-29 1975-03-04 Canon Kk Instrument for measuring thickness of thin film
US3920580A (en) * 1973-07-12 1975-11-18 Miles Lab Liquid control solution
DE2638333C3 (de) * 1976-08-25 1984-02-23 Boehringer Mannheim Gmbh, 6800 Mannheim Photometer
US4354376A (en) * 1980-03-03 1982-10-19 Medical Laboratory Automation, Inc. Kit for calibrating pipettes
US4805623A (en) * 1987-09-04 1989-02-21 Vander Corporation Spectrophotometric method for quantitatively determining the concentration of a dilute component in a light- or other radiation-scattering environment
US5092677A (en) * 1989-08-02 1992-03-03 Artel, Inc. Photometer having a long lamp life, reduced warm-up period and resonant frequency mixing
US5061639A (en) * 1989-12-06 1991-10-29 E. I. Dupont De Nemours And Company Liquid dispenser accuracy verification method
US5125747A (en) * 1990-10-12 1992-06-30 Tytronics, Inc. Optical analytical instrument and method having improved calibration
US5298978A (en) * 1992-02-28 1994-03-29 Artel, Inc. Pipette calibration system

Also Published As

Publication number Publication date
DE69407975T2 (de) 1998-04-30
WO1995002166A1 (en) 1995-01-19
US5492673A (en) 1996-02-20
EP0711404A1 (de) 1996-05-15
DE69407975D1 (de) 1998-02-19
ATE162302T1 (de) 1998-01-15

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