EP0695171A1 - Lyospheres contenant de la gonadotrophine - Google Patents

Lyospheres contenant de la gonadotrophine

Info

Publication number
EP0695171A1
EP0695171A1 EP94915121A EP94915121A EP0695171A1 EP 0695171 A1 EP0695171 A1 EP 0695171A1 EP 94915121 A EP94915121 A EP 94915121A EP 94915121 A EP94915121 A EP 94915121A EP 0695171 A1 EP0695171 A1 EP 0695171A1
Authority
EP
European Patent Office
Prior art keywords
lyospheres
gonadotropin
preparation
well
same
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP94915121A
Other languages
German (de)
English (en)
Other versions
EP0695171B1 (fr
Inventor
Arnold Titus Philip Skrabanja
Herman Vromans
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Organon NV
Original Assignee
Akzo Nobel NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Akzo Nobel NV filed Critical Akzo Nobel NV
Priority to EP94915121A priority Critical patent/EP0695171B1/fr
Publication of EP0695171A1 publication Critical patent/EP0695171A1/fr
Application granted granted Critical
Publication of EP0695171B1 publication Critical patent/EP0695171B1/fr
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/24—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g. HCG; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

L'invention concerne des lyosphères contenant de la gonadotrophine, leur préparation ainsi que des préparations pharmaceutiques les contenant.
EP94915121A 1993-04-28 1994-04-25 Lyospheres contenant de la gonadotrophine Expired - Lifetime EP0695171B1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP94915121A EP0695171B1 (fr) 1993-04-28 1994-04-25 Lyospheres contenant de la gonadotrophine

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP93201215 1993-04-28
EP93201215 1993-04-28
EP94915121A EP0695171B1 (fr) 1993-04-28 1994-04-25 Lyospheres contenant de la gonadotrophine
PCT/EP1994/001303 WO1994025005A1 (fr) 1993-04-28 1994-04-25 Lyospheres contenant de la gonadotrophine

Publications (2)

Publication Number Publication Date
EP0695171A1 true EP0695171A1 (fr) 1996-02-07
EP0695171B1 EP0695171B1 (fr) 1996-12-18

Family

ID=8213798

Family Applications (1)

Application Number Title Priority Date Filing Date
EP94915121A Expired - Lifetime EP0695171B1 (fr) 1993-04-28 1994-04-25 Lyospheres contenant de la gonadotrophine

Country Status (16)

Country Link
US (1) US5656597A (fr)
EP (1) EP0695171B1 (fr)
JP (1) JPH08509483A (fr)
KR (1) KR100334856B1 (fr)
AT (1) ATE146360T1 (fr)
AU (1) AU679986B2 (fr)
CA (1) CA2150251C (fr)
DE (1) DE69401204T2 (fr)
DK (1) DK0695171T3 (fr)
ES (1) ES2098140T3 (fr)
FI (1) FI112324B (fr)
GR (1) GR3022510T3 (fr)
HK (1) HK1002017A1 (fr)
NO (1) NO311168B1 (fr)
NZ (1) NZ265956A (fr)
WO (1) WO1994025005A1 (fr)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL120202A (en) * 1996-03-07 2001-03-19 Akzo Nobel Nv Container with freeze-dried vaccine components
GB2329124B (en) * 1997-09-12 2002-05-08 Hiran Asoka Malinga Ratwatte Method of forming dose units of active agents
DK1165050T3 (da) 1999-04-05 2006-05-01 Mannkind Corp Fremgangsmåde til dannelse af fint pulver
EP1658840A1 (fr) * 1999-04-05 2006-05-24 Mannkind Corporation Procédé de formation d'une poudre fine
US9006175B2 (en) 1999-06-29 2015-04-14 Mannkind Corporation Potentiation of glucose elimination
EP1894591B1 (fr) 2002-03-20 2013-06-26 MannKind Corporation Cartouche pour un appareil d'inhalation
US20040248784A1 (en) * 2003-06-03 2004-12-09 Marco Filicori Unitary combinations of FSH and hCG
US20060222694A1 (en) * 2003-06-27 2006-10-05 Oh Choon K Stabilized topotecan liposomal composition and methods
DK1786784T3 (da) 2004-08-20 2011-02-14 Mannkind Corp Katalyse af diketopiperazinsyntese
CN104436170B (zh) 2004-08-23 2018-02-23 曼金德公司 用于药物输送的二酮哌嗪盐
HUE028623T2 (en) 2005-09-14 2016-12-28 Mannkind Corp Active substance formulation method based on increasing the affinity of the active ingredient for binding to the surface of crystalline microparticles
IN2015DN00888A (fr) 2006-02-22 2015-07-10 Mannkind Corp
TWI436789B (zh) 2008-01-21 2014-05-11 Intervet Int Bv 含有藥學化合物的顆粒之冷凍乾燥方法及含有此顆粒的藥學包
MX2010008799A (es) 2008-03-05 2010-09-07 Sanofi Pasteur Proceso para estabilizar una composicion de vacuna que contiene adyuvante.
CN101269215B (zh) * 2008-05-15 2011-03-23 上海天伟生物制药有限公司 一种糖蛋白激素组合物
US8485180B2 (en) 2008-06-13 2013-07-16 Mannkind Corporation Dry powder drug delivery system
ES2570400T3 (es) 2008-06-13 2016-05-18 Mannkind Corp Un inhalador de polvo seco y un sistema para el suministro de fármacos
JP5479465B2 (ja) 2008-06-20 2014-04-23 マンカインド コーポレイション 吸入努力をリアルタイムにプロファイルする対話式機器および方法
TWI532497B (zh) 2008-08-11 2016-05-11 曼凱公司 超快起作用胰島素之用途
US8314106B2 (en) 2008-12-29 2012-11-20 Mannkind Corporation Substituted diketopiperazine analogs for use as drug delivery agents
EP2405963B1 (fr) 2009-03-11 2013-11-06 MannKind Corporation Appareil, système et procédé de mesure de résistance d'un inhalateur
KR101875969B1 (ko) 2009-06-12 2018-07-06 맨카인드 코포레이션 한정된 비표면적을 갖는 디케토피페라진 마이크로입자
JP5784622B2 (ja) 2009-11-03 2015-09-24 マンカインド コーポレ−ション 吸入活動をシミュレートするための装置及び方法
MX359281B (es) 2010-06-21 2018-09-21 Mannkind Corp Sistema y metodos para suministrar un farmaco en polvo seco.
MX353285B (es) 2011-04-01 2018-01-05 Mannkind Corp Paquete de blister para cartuchos farmaceuticos.
WO2012174472A1 (fr) 2011-06-17 2012-12-20 Mannkind Corporation Microparticules de dicétopipérazine de capacité élevée
CN103945859A (zh) 2011-10-24 2014-07-23 曼金德公司 用于治疗疼痛的方法和组合物
WO2014012069A2 (fr) 2012-07-12 2014-01-16 Mannkind Corporation Systèmes et procédés de libération de médicament en poudre sèche
EP2911690A1 (fr) 2012-10-26 2015-09-02 MannKind Corporation Compositions et procédés de vaccin antigrippal inhalable
AU2014228415B2 (en) 2013-03-15 2018-08-09 Mannkind Corporation Microcrystalline diketopiperazine compositions and methods
US11446127B2 (en) 2013-08-05 2022-09-20 Mannkind Corporation Insufflation apparatus and methods
US10307464B2 (en) 2014-03-28 2019-06-04 Mannkind Corporation Use of ultrarapid acting insulin
US10561806B2 (en) 2014-10-02 2020-02-18 Mannkind Corporation Mouthpiece cover for an inhaler
EP3362052A4 (fr) * 2015-10-16 2019-06-19 Merck Sharp & Dohme Corp. Procédés pour préparer des préparations pour thérapies ciblant le tractus gastro-intestinal

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3932943A (en) * 1970-08-14 1976-01-20 E. I. Du Pont De Nemours And Company Method of preparation of lyophilized biological products
DE3264450D1 (en) * 1981-12-11 1985-08-01 Wyeth John & Brother Ltd Process and apparatus for freezing a liquid medium
JPS60258125A (ja) * 1984-06-06 1985-12-20 Hayashibara Biochem Lab Inc 蛋白性生理活性物質を含有する水溶性乾燥物
DE69005800T2 (de) * 1989-05-01 1994-05-19 Alkermes Inc Verfahren zur herstellung von kleinen partikeln von biologisch aktiven molekülen.
IE64738B1 (en) * 1990-03-20 1995-09-06 Akzo Nv Stabilized gonadotropin containing preparations

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See references of WO9425005A1 *

Also Published As

Publication number Publication date
KR950703934A (ko) 1995-11-17
FI112324B (fi) 2003-11-28
FI953442A0 (fi) 1995-07-14
NO954320L (no) 1995-10-27
NZ265956A (en) 1996-09-25
NO954320D0 (no) 1995-10-27
CA2150251A1 (fr) 1994-11-10
HK1002017A1 (en) 1998-07-24
GR3022510T3 (en) 1997-05-31
ES2098140T3 (es) 1997-04-16
AU679986B2 (en) 1997-07-17
DE69401204D1 (de) 1997-01-30
EP0695171B1 (fr) 1996-12-18
JPH08509483A (ja) 1996-10-08
DK0695171T3 (da) 1997-06-02
ATE146360T1 (de) 1997-01-15
CA2150251C (fr) 2005-02-22
NO311168B1 (no) 2001-10-22
AU6648894A (en) 1994-11-21
KR100334856B1 (ko) 2002-11-07
US5656597A (en) 1997-08-12
WO1994025005A1 (fr) 1994-11-10
FI953442A (fi) 1995-07-14
DE69401204T2 (de) 1997-06-05

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