EP0664706A4 - Inhibition de proteine-kinase c et nouveau compose appele balanol. - Google Patents

Inhibition de proteine-kinase c et nouveau compose appele balanol.

Info

Publication number
EP0664706A4
EP0664706A4 EP19920919060 EP92919060A EP0664706A4 EP 0664706 A4 EP0664706 A4 EP 0664706A4 EP 19920919060 EP19920919060 EP 19920919060 EP 92919060 A EP92919060 A EP 92919060A EP 0664706 A4 EP0664706 A4 EP 0664706A4
Authority
EP
European Patent Office
Prior art keywords
balanol
inhibition
protein kinase
novel compound
novel
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP19920919060
Other languages
German (de)
English (en)
Other versions
EP0664706A1 (fr
Inventor
Yali F Hallock
William P Janzen
Lawrence M Ballas
Palaniappan Kulanthivel
Christie Boros
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Sphinx Pharmaceuticals Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sphinx Pharmaceuticals Corp filed Critical Sphinx Pharmaceuticals Corp
Publication of EP0664706A4 publication Critical patent/EP0664706A4/fr
Publication of EP0664706A1 publication Critical patent/EP0664706A1/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/02—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D223/06—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D223/12—Nitrogen atoms not forming part of a nitro radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
EP92919060A 1991-08-22 1992-08-21 Inhibition de proteine-kinase c et nouveau compose appele balanol Withdrawn EP0664706A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US748632 1985-06-24
US74863291A 1991-08-22 1991-08-22
PCT/US1992/007124 WO1993003730A1 (fr) 1991-08-22 1992-08-21 Inhibition de proteine-kinase c et nouveau compose appele balanol

Publications (2)

Publication Number Publication Date
EP0664706A4 true EP0664706A4 (fr) 1995-06-14
EP0664706A1 EP0664706A1 (fr) 1995-08-02

Family

ID=25010269

Family Applications (1)

Application Number Title Priority Date Filing Date
EP92919060A Withdrawn EP0664706A1 (fr) 1991-08-22 1992-08-21 Inhibition de proteine-kinase c et nouveau compose appele balanol

Country Status (5)

Country Link
EP (1) EP0664706A1 (fr)
JP (1) JPH06510280A (fr)
AU (1) AU2504192A (fr)
CA (1) CA2115994A1 (fr)
WO (1) WO1993003730A1 (fr)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU6252794A (en) * 1993-03-03 1994-09-26 Eli Lilly And Company Balanoids
AU686691B2 (en) * 1994-01-12 1998-02-12 F. Hoffmann-La Roche Ag Novel azepanes and homologs thereof
US5583221A (en) * 1994-05-04 1996-12-10 Eli Lilly And Company Substituted fused and bridged bicyclic compounds as therapeutic agents
TW339325B (en) * 1995-07-05 1998-09-01 Hoffmann La Roche Novel azepane derivatives, process for the preparation thereof and pharmaceutical composition containing the same
WO1997029091A1 (fr) * 1996-02-09 1997-08-14 Phytera Symbion Aps Analogues de balanol
US6914140B1 (en) 1996-04-17 2005-07-05 Hoffmann-La Roche Inc. Asymmetric synthesis process
US5902882A (en) * 1996-04-17 1999-05-11 Hoffmann-La Roche Inc. Assymetric synthesis of azepines
US6232299B1 (en) * 1996-05-01 2001-05-15 Eli Lilly And Company Use of protein kinase C inhibitors to enhance the clinical efficacy of oncolytic agents and radiation therapy
ES2696598T3 (es) 2005-03-21 2019-01-17 Univ Columbia Compuestos de balanol para su uso en el tratamiento de dolor
WO2007095586A2 (fr) 2006-02-14 2007-08-23 The Trustees Of Columbia University In The City Of New York Modulateurs des voies de la douleur neurologique

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
C.BOROS ET AL.: "Comparision of Balanol from Verticillium balanoides and Ophiocordin from Cordyceps ophioglossoides", J.ANTIBIOT., vol. 47, no. 9, pages 1010 - 16 *
See also references of WO9303730A1 *
W.A.KÖNIG ET AL.: "Konstitution von Oghiocordin, einem Antibioticum mit antifungischen Eigenschaften", CHEM.BER., vol. 113, no. 6, pages 2221 - 26 *

Also Published As

Publication number Publication date
CA2115994A1 (fr) 1993-03-04
AU2504192A (en) 1993-03-16
WO1993003730A1 (fr) 1993-03-04
JPH06510280A (ja) 1994-11-17
EP0664706A1 (fr) 1995-08-02

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