EP0664706A4 - Hemmung der protein kinase c und neue verbindung balanol. - Google Patents
Hemmung der protein kinase c und neue verbindung balanol.Info
- Publication number
- EP0664706A4 EP0664706A4 EP19920919060 EP92919060A EP0664706A4 EP 0664706 A4 EP0664706 A4 EP 0664706A4 EP 19920919060 EP19920919060 EP 19920919060 EP 92919060 A EP92919060 A EP 92919060A EP 0664706 A4 EP0664706 A4 EP 0664706A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- balanol
- inhibition
- protein kinase
- novel compound
- novel
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/02—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D223/06—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D223/12—Nitrogen atoms not forming part of a nitro radical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US74863291A | 1991-08-22 | 1991-08-22 | |
US748632 | 1991-08-22 | ||
PCT/US1992/007124 WO1993003730A1 (en) | 1991-08-22 | 1992-08-21 | Protein kinase c inhibition and novel compound balanol |
Publications (2)
Publication Number | Publication Date |
---|---|
EP0664706A4 true EP0664706A4 (de) | 1995-06-14 |
EP0664706A1 EP0664706A1 (de) | 1995-08-02 |
Family
ID=25010269
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP92919060A Withdrawn EP0664706A1 (de) | 1991-08-22 | 1992-08-21 | Hemmung der protein kinase c und neue verbindung balanol |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP0664706A1 (de) |
JP (1) | JPH06510280A (de) |
AU (1) | AU2504192A (de) |
CA (1) | CA2115994A1 (de) |
WO (1) | WO1993003730A1 (de) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU6252794A (en) * | 1993-03-03 | 1994-09-26 | Eli Lilly And Company | Balanoids |
AU686691B2 (en) * | 1994-01-12 | 1998-02-12 | F. Hoffmann-La Roche Ag | Novel azepanes and homologs thereof |
US5583221A (en) * | 1994-05-04 | 1996-12-10 | Eli Lilly And Company | Substituted fused and bridged bicyclic compounds as therapeutic agents |
TW339325B (en) * | 1995-07-05 | 1998-09-01 | Hoffmann La Roche | Novel azepane derivatives, process for the preparation thereof and pharmaceutical composition containing the same |
JP2000504672A (ja) * | 1996-02-09 | 2000-04-18 | フィテラ シンビオン エイピーエス | バラノール類似体 |
US5902882A (en) * | 1996-04-17 | 1999-05-11 | Hoffmann-La Roche Inc. | Assymetric synthesis of azepines |
US6914140B1 (en) | 1996-04-17 | 2005-07-05 | Hoffmann-La Roche Inc. | Asymmetric synthesis process |
US6232299B1 (en) * | 1996-05-01 | 2001-05-15 | Eli Lilly And Company | Use of protein kinase C inhibitors to enhance the clinical efficacy of oncolytic agents and radiation therapy |
EP2601964B1 (de) | 2005-03-21 | 2018-07-25 | The Trustees of Columbia University in the City of New York | Balanol-verbindungen zur Anwendung bei der Behandlung von Schmerz |
US8846742B2 (en) | 2006-02-14 | 2014-09-30 | The Trustees Of Columbia University In The City Of New York | Neuronal pain pathway modulators |
-
1992
- 1992-08-21 CA CA002115994A patent/CA2115994A1/en not_active Abandoned
- 1992-08-21 WO PCT/US1992/007124 patent/WO1993003730A1/en not_active Application Discontinuation
- 1992-08-21 AU AU25041/92A patent/AU2504192A/en not_active Abandoned
- 1992-08-21 EP EP92919060A patent/EP0664706A1/de not_active Withdrawn
- 1992-08-21 JP JP5502446A patent/JPH06510280A/ja active Pending
Non-Patent Citations (3)
Title |
---|
C.BOROS ET AL.: "Comparision of Balanol from Verticillium balanoides and Ophiocordin from Cordyceps ophioglossoides", J.ANTIBIOT., vol. 47, no. 9, pages 1010 - 16 * |
See also references of WO9303730A1 * |
W.A.KÖNIG ET AL.: "Konstitution von Oghiocordin, einem Antibioticum mit antifungischen Eigenschaften", CHEM.BER., vol. 113, no. 6, pages 2221 - 26 * |
Also Published As
Publication number | Publication date |
---|---|
WO1993003730A1 (en) | 1993-03-04 |
CA2115994A1 (en) | 1993-03-04 |
AU2504192A (en) | 1993-03-16 |
JPH06510280A (ja) | 1994-11-17 |
EP0664706A1 (de) | 1995-08-02 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
A4 | Supplementary search report drawn up and despatched | ||
AK | Designated contracting states |
Kind code of ref document: A4 Designated state(s): AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL SE |
|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
17P | Request for examination filed |
Effective date: 19940228 |
|
AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL SE |
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STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
|
18D | Application deemed to be withdrawn |
Effective date: 19970206 |