EP0663827A4 - Tokolytische oxytocinrezeptorantagonisten. - Google Patents
Tokolytische oxytocinrezeptorantagonisten.Info
- Publication number
- EP0663827A4 EP0663827A4 EP93923134A EP93923134A EP0663827A4 EP 0663827 A4 EP0663827 A4 EP 0663827A4 EP 93923134 A EP93923134 A EP 93923134A EP 93923134 A EP93923134 A EP 93923134A EP 0663827 A4 EP0663827 A4 EP 0663827A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- receptor antagonists
- oxytocin receptor
- tocolytic oxytocin
- tocolytic
- antagonists
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/20—Spiro-condensed ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Reproductive Health (AREA)
- Endocrinology (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US95793892A | 1992-10-07 | 1992-10-07 | |
US957938 | 1992-10-07 | ||
PCT/US1993/009152 WO1994007496A1 (en) | 1992-10-07 | 1993-09-27 | Tocolytic oxytocin receptor antagonists |
Publications (2)
Publication Number | Publication Date |
---|---|
EP0663827A1 EP0663827A1 (de) | 1995-07-26 |
EP0663827A4 true EP0663827A4 (de) | 1995-11-15 |
Family
ID=25500372
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP93923134A Withdrawn EP0663827A4 (de) | 1992-10-07 | 1993-09-27 | Tokolytische oxytocinrezeptorantagonisten. |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP0663827A4 (de) |
JP (1) | JPH08502474A (de) |
AU (1) | AU5292393A (de) |
CA (1) | CA2143117A1 (de) |
WO (1) | WO1994007496A1 (de) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1995002587A1 (en) * | 1993-07-16 | 1995-01-26 | Merck & Co., Inc. | Substituted piperazinylcamphor derivatives as oxytocin antagonists |
CA2166975C (en) * | 1993-07-16 | 2005-04-05 | Mark G. Bock | Benzoxazinone and benzopyrimidinone piperidinyl tocolytic oxytocin receptor antagonists |
US5464788A (en) * | 1994-03-24 | 1995-11-07 | Merck & Co., Inc. | Tocolytic oxytocin receptor antagonists |
US5707985A (en) * | 1995-06-07 | 1998-01-13 | Tanabe Seiyaku Co. Ltd. | Naphthyl-, quinolyl- and isoquinolyl- sulfonamide derivatives as cell adhesion modulators |
WO1998046569A1 (fr) * | 1997-04-11 | 1998-10-22 | Sumitomo Pharmaceuticals Co., Ltd. | Derives de benzene |
GB9819860D0 (en) | 1998-09-12 | 1998-11-04 | Zeneca Ltd | Chemical compounds |
AU7178001A (en) | 2000-07-05 | 2002-01-14 | Ortho Mcneil Pharm Inc | Nonpeptide substituted spirobenzoazepines as vasopressin antagonists |
WO2004089307A2 (en) | 2003-04-04 | 2004-10-21 | Merck & Co. Inc. | Acylated spiropiperidine derivatives as melanocortin-4 receptor agonists |
US20040266752A1 (en) * | 2003-06-17 | 2004-12-30 | Mona Patel | Substituted spirobenzazepines |
DE102005000666B3 (de) | 2005-01-04 | 2006-10-05 | Sanofi-Aventis Deutschland Gmbh | Sulfonylpyrrolidine, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
EP2076517A1 (de) | 2006-09-22 | 2009-07-08 | Janssen Pharmaceutica N.V. | Spirobenzazepine als vasopressinantagonisten |
CA2665849A1 (en) | 2006-09-22 | 2008-03-27 | Janssen Pharmaceutica N.V. | Spiro benzazepines used as vasopressin antagonists |
BRPI0720004A2 (pt) | 2006-12-07 | 2013-12-17 | Hoffmann La Roche | Derivados de espiro-piperidina como antagonista de receptor v1a |
RU2009123133A (ru) * | 2006-12-22 | 2011-01-27 | Ф.Хоффманн-Ля Рош Аг (Ch) | Производные спиро-пиперидина |
US7501432B2 (en) | 2006-12-22 | 2009-03-10 | Hoffman-La Roche Inc. | Spiro-piperidine derivatives |
US20100022572A1 (en) | 2008-07-18 | 2010-01-28 | Kowa Company, Ltd. | Novel spiro compound and medicine comprising the same |
CN102884059B (zh) | 2010-03-11 | 2015-08-26 | 大日本住友制药株式会社 | N-酰基环胺衍生物或其可药用盐 |
US11717499B2 (en) * | 2011-06-28 | 2023-08-08 | Sandra Eve Reznik | Administration of N,N-dimethylacetamide for the treatment of preterm birth |
JP5715605B2 (ja) * | 2011-09-14 | 2015-05-07 | 大日本住友製薬株式会社 | N−アシル環状アミン誘導体またはその医薬上許容される塩からなる医薬 |
WO2014024993A1 (ja) * | 2012-08-09 | 2014-02-13 | 国立大学法人京都大学 | ピぺラジン誘導体およびその用途 |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0444945A2 (de) * | 1990-03-02 | 1991-09-04 | Merck & Co. Inc. | Verwendung von spirozyklischen Verbindungen als Oxytocinantagonisten |
EP0486280A2 (de) * | 1990-11-13 | 1992-05-20 | Merck & Co. Inc. | Piperdinylcamphorsulfonyl derivate als Oxytocin Antagonisten |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8917069D0 (en) * | 1989-07-26 | 1989-09-13 | Merck Sharp & Dohme | Therapeutic agents |
US5091387A (en) * | 1990-03-02 | 1992-02-25 | Merck & Co., Inc. | Spirocyclic oxytocin antagonists |
EP0445974A3 (en) * | 1990-03-05 | 1992-04-29 | Merck Sharp & Dohme Ltd. | Spirocyclic antipsychotic agents |
-
1993
- 1993-09-27 AU AU52923/93A patent/AU5292393A/en not_active Abandoned
- 1993-09-27 JP JP6509222A patent/JPH08502474A/ja active Pending
- 1993-09-27 WO PCT/US1993/009152 patent/WO1994007496A1/en not_active Application Discontinuation
- 1993-09-27 EP EP93923134A patent/EP0663827A4/de not_active Withdrawn
- 1993-09-27 CA CA002143117A patent/CA2143117A1/en not_active Abandoned
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0444945A2 (de) * | 1990-03-02 | 1991-09-04 | Merck & Co. Inc. | Verwendung von spirozyklischen Verbindungen als Oxytocinantagonisten |
EP0486280A2 (de) * | 1990-11-13 | 1992-05-20 | Merck & Co. Inc. | Piperdinylcamphorsulfonyl derivate als Oxytocin Antagonisten |
Non-Patent Citations (1)
Title |
---|
See also references of WO9407496A1 * |
Also Published As
Publication number | Publication date |
---|---|
WO1994007496A1 (en) | 1994-04-14 |
CA2143117A1 (en) | 1994-04-14 |
AU5292393A (en) | 1994-04-26 |
EP0663827A1 (de) | 1995-07-26 |
JPH08502474A (ja) | 1996-03-19 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AT BE CH DE DK ES FR GB GR IE IT LI LU NL PT SE |
|
17P | Request for examination filed |
Effective date: 19950508 |
|
A4 | Supplementary search report drawn up and despatched |
Effective date: 19951002 |
|
AK | Designated contracting states |
Kind code of ref document: A4 Designated state(s): AT BE CH DE DK ES FR GB GR IE IT LI LU NL PT SE |
|
17Q | First examination report despatched |
Effective date: 19990708 |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
|
18D | Application deemed to be withdrawn |
Effective date: 19991119 |