EP0805681A4 - Tokolytische oxytocin-rezeptor-antagonisten - Google Patents

Tokolytische oxytocin-rezeptor-antagonisten

Info

Publication number
EP0805681A4
EP0805681A4 EP96903618A EP96903618A EP0805681A4 EP 0805681 A4 EP0805681 A4 EP 0805681A4 EP 96903618 A EP96903618 A EP 96903618A EP 96903618 A EP96903618 A EP 96903618A EP 0805681 A4 EP0805681 A4 EP 0805681A4
Authority
EP
European Patent Office
Prior art keywords
receptor antagonists
oxytocin receptor
tocolytic oxytocin
tocolytic
antagonists
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP96903618A
Other languages
English (en)
French (fr)
Other versions
EP0805681A1 (de
Inventor
Peter D Williams
Roger M Freidinger
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of EP0805681A1 publication Critical patent/EP0805681A1/de
Publication of EP0805681A4 publication Critical patent/EP0805681A4/de
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
EP96903618A 1995-01-24 1996-01-19 Tokolytische oxytocin-rezeptor-antagonisten Withdrawn EP0805681A4 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US37811395A 1995-01-24 1995-01-24
US378113 1995-01-24
PCT/US1996/000850 WO1996022775A1 (en) 1995-01-24 1996-01-19 Tocolytic oxytocin receptor antagonists

Publications (2)

Publication Number Publication Date
EP0805681A1 EP0805681A1 (de) 1997-11-12
EP0805681A4 true EP0805681A4 (de) 1998-05-06

Family

ID=23491770

Family Applications (1)

Application Number Title Priority Date Filing Date
EP96903618A Withdrawn EP0805681A4 (de) 1995-01-24 1996-01-19 Tokolytische oxytocin-rezeptor-antagonisten

Country Status (4)

Country Link
EP (1) EP0805681A4 (de)
AU (1) AU4763896A (de)
CA (1) CA2210138A1 (de)
WO (1) WO1996022775A1 (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2310660A (en) * 1996-03-01 1997-09-03 Merck & Co Inc Benzoxazinone oxytocin receptor antagonists
GB2326410A (en) * 1997-06-18 1998-12-23 Merck & Co Inc Tocolytic Oxytocin Receptor Antagonists
BR0109900A (pt) 2000-03-27 2003-06-03 Applied Research Systems Derivados de pirolidina farmaceuticamente ativos, uso de derivados de pirolidina, composição farmacêutica e processo para preparação de um derivado de pirolidina
US7312358B2 (en) 2000-10-17 2007-12-25 Laboratoires Serono Sa Pharmaceutically active sulfanilide derivatives
CA2440002A1 (en) 2001-03-20 2002-09-26 Applied Research Systems Ars Holding N.V. Pyrrolidine ester derivatives with oxytocin modulating activity
US7022699B2 (en) 2001-04-12 2006-04-04 Wyeth Cyclohexenyl phenyl diazepines vasopressin and oxytocin receptor modulators
US7202239B2 (en) 2001-04-12 2007-04-10 Wyeth Cyclohexylphenyl carboxamides tocolytic oxytocin receptor antagonists
US7064120B2 (en) 2001-04-12 2006-06-20 Wyeth Tricyclic pyridyl carboxamides and derivatives thereof tocolytic oxytocin receptor antagonists
US7109193B2 (en) 2001-04-12 2006-09-19 Wyeth Tricyclic diazepines tocolytic oxytocin receptor antagonists
US7326700B2 (en) 2001-04-12 2008-02-05 Wyeth Cyclohexenyl phenyl carboxamides tocolytic oxytocin receptor antagonists
US6900200B2 (en) 2001-04-12 2005-05-31 Wyeth Tricyclic hydroxy carboxamides and derivatives thereof tocolytic oxytocin receptor antagonists
US6977254B2 (en) 2001-04-12 2005-12-20 Wyeth Hydroxy cyclohexenyl phenyl carboxamides tocolytic oxytocin receptor antagonists
AU2002319237B2 (en) 2001-06-18 2008-01-03 Merck Serono Sa Pyrrolidine oxadiazole- and thiadiazole oxime derivatives being oxytocin receptor antagonists
IL162615A0 (en) 2001-12-20 2005-11-20 Applied Research Systems Triazole derivatives, their preparation and pharmaceutical compositions containing them

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0043940A1 (de) * 1980-07-12 1982-01-20 C.H. Boehringer Sohn 3,1-Benzoxazin-2-one, ihre Herstellung und Verwendung
EP0470514A1 (de) * 1990-08-07 1992-02-12 Otsuka Pharmaceutical Co., Ltd. Carbostyrilderivate und diese enthaltende pharmazeutische Zusammensetzungen
WO1994001113A1 (en) * 1992-07-02 1994-01-20 Otsuka Pharmaceutical Company, Limited Oxytocin antagonist
WO1997025992A1 (en) * 1996-01-16 1997-07-24 Merck & Co., Inc. Tocolytic oxytocin receptor antagonists

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2166975C (en) * 1993-07-16 2005-04-05 Mark G. Bock Benzoxazinone and benzopyrimidinone piperidinyl tocolytic oxytocin receptor antagonists

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0043940A1 (de) * 1980-07-12 1982-01-20 C.H. Boehringer Sohn 3,1-Benzoxazin-2-one, ihre Herstellung und Verwendung
EP0470514A1 (de) * 1990-08-07 1992-02-12 Otsuka Pharmaceutical Co., Ltd. Carbostyrilderivate und diese enthaltende pharmazeutische Zusammensetzungen
WO1994001113A1 (en) * 1992-07-02 1994-01-20 Otsuka Pharmaceutical Company, Limited Oxytocin antagonist
WO1997025992A1 (en) * 1996-01-16 1997-07-24 Merck & Co., Inc. Tocolytic oxytocin receptor antagonists

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
PETTIBONE ET AL: "Progres in the development of oxytocin antagonists for use in preterm labor.", ADV.EXP.MED.BIOL., vol. 395, 1995, pages 601 - 612, XP002056092 *
See also references of WO9622775A1 *

Also Published As

Publication number Publication date
AU4763896A (en) 1996-08-14
CA2210138A1 (en) 1996-08-01
EP0805681A1 (de) 1997-11-12
WO1996022775A1 (en) 1996-08-01

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Legal Events

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PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

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