EP0659104A1 - Procede et dispositif de melange sous vide de substances - Google Patents
Procede et dispositif de melange sous vide de substancesInfo
- Publication number
- EP0659104A1 EP0659104A1 EP93919202A EP93919202A EP0659104A1 EP 0659104 A1 EP0659104 A1 EP 0659104A1 EP 93919202 A EP93919202 A EP 93919202A EP 93919202 A EP93919202 A EP 93919202A EP 0659104 A1 EP0659104 A1 EP 0659104A1
- Authority
- EP
- European Patent Office
- Prior art keywords
- filter
- vessel
- mixing
- substances
- mixture
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F33/00—Other mixers; Mixing plants; Combinations of mixers
- B01F33/70—Mixers specially adapted for working at sub- or super-atmospheric pressure, e.g. combined with de-foaming
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/56—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
- A61B17/58—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws, setting implements or the like
- A61B17/88—Osteosynthesis instruments; Methods or means for implanting or extracting internal or external fixation devices
- A61B17/8802—Equipment for handling bone cement or other fluid fillers
- A61B17/8805—Equipment for handling bone cement or other fluid fillers for introducing fluid filler into bone or extracting it
- A61B17/8827—Equipment for handling bone cement or other fluid fillers for introducing fluid filler into bone or extracting it with filtering, degassing, venting or pressure relief means
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B50/00—Containers, covers, furniture or holders specially adapted for surgical or diagnostic appliances or instruments, e.g. sterile covers
- A61B2050/005—Containers, covers, furniture or holders specially adapted for surgical or diagnostic appliances or instruments, e.g. sterile covers with a lid or cover
- A61B2050/0062—Containers, covers, furniture or holders specially adapted for surgical or diagnostic appliances or instruments, e.g. sterile covers with a lid or cover closable by a combination of rotation and translation
- A61B2050/0063—Bayonet coupling
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
- A61F2002/30316—The prosthesis having different structural features at different locations within the same prosthesis; Connections between prosthetic parts; Special structural features of bone or joint prostheses not otherwise provided for
- A61F2002/30329—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements
- A61F2002/30426—Bayonet coupling
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/46—Special tools or methods for implanting or extracting artificial joints, accessories, bone grafts or substitutes, or particular adaptations therefor
- A61F2002/4685—Special tools or methods for implanting or extracting artificial joints, accessories, bone grafts or substitutes, or particular adaptations therefor by means of vacuum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2220/00—Fixations or connections for prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2220/0025—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F2101/00—Mixing characterised by the nature of the mixed materials or by the application field
- B01F2101/20—Mixing of ingredients for bone cement
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F33/00—Other mixers; Mixing plants; Combinations of mixers
- B01F33/50—Movable or transportable mixing devices or plants
- B01F33/501—Movable mixing devices, i.e. readily shifted or displaced from one place to another, e.g. portable during use
- B01F33/5011—Movable mixing devices, i.e. readily shifted or displaced from one place to another, e.g. portable during use portable during use, e.g. hand-held
Definitions
- the invention relates to an apparatus and a method for evacuating and mixing a substance mixture or substance mixture consisting of at least two components.
- the invention relates to an apparatus and a method for degassing a polymer powder and for mixing the polymer powder with a monomer component in a mixing vessel from which the resulting gas-free substance can be transferred to an application container.
- Mixing is generally understood to mean the use of two different substances. If one of the substances to be mixed is a liquid and the other substance is a powder, air is usually introduced into the mixture and introduced via the powder, to which air particles can adhere. The mixing process as such generally introduces even more air into the mixture.
- the aim of the mixing is, on the one hand, to obtain the most homogeneous possible distribution of the various components in the mixture, for example in order to achieve a time-dependent chemical reaction between the components that is as uniform as possible
- REPLACEMENT LEAF initiate or promote, for example, the subsequent polymerization of a two- or multi-component mixture, such as bone cement.
- a mixture which is as low as possible in inclusion or a mixture which contains no foreign substances should be formed during the mixing, for example as little air bubbles as possible should be included in the mixture. The fewer air bubbles are trapped, the higher, for example, the strength of the mixed and hardened bone cement.
- the mixing can take place, for example, by stirring, mixing, rolling, kneading, emulsifying, suspending, centrifuging and / or dissolving or by the action of ultrasound or vibrators.
- the known mixing devices and methods usually have the disadvantage that impurities, for example air, can be introduced into the mixing system during mixing, and that, in addition, those contained in the substances to be mixed at the beginning of the mixing process and, for example, during the mixing process Gas inclusions resulting from the chemical reaction of the substances cannot be removed from the mixing system. Attempts have already been made to prevent the formation of gas inclusions by means of vacuum mixing systems, for example by means of the mixing device described in WO 87/05492 or WO 88/09209 or the system according to European patent application 85 11 3251.6.
- impurities for example air
- REPLACEMENT LEAF becomes. Since a certain reaction between the pulverulent and liquid components of the mixture of substances, for example polymerization, has already begun, not all air can be completely removed.
- the invention has for its object to provide a device and a method for vacuum mixing a substance mixture, with which the occurrence of impurities, in particular gas inclusions, is prevented in the substance mixture.
- the invention is based on the basic idea of evacuating the substances to be mixed before the actual mixing process in a mixing vessel, so that the substances to be mixed are degassed before the mixing process, and then the substances to be mixed in the same mixing vessel during the actual mixing process Keep vacuum so that no air is introduced into the mixture even during the mixing process.
- the substances to be mixed are preferably a cold-curing two-component system, the first component being, for example, a polymer powder and the second component being a liquid monomer of a bone cement which is conventionally commercially available.
- the invention is described below primarily on the basis of such two-component systems, but can also be used for any other substance mixture.
- the powder component is in a bag and the monomer in an amphiole.
- the two components are prepared in a mixing vessel in such a way that the liquid phase or component is initially introduced and the powder phase, for example a bead polymer, is then poured in.
- the powder phase for example a bead polymer
- the powder which has a much larger volume in conventional bone cements, survives the liquid phase, e.g. B. the monomer, by far.
- the air bubbles present between the polymer spheres of the powder are, however, collected and enclosed again in the subsequent powder mass in the conventional mixing process.
- the powders in the conventional mixing process, often fill the rest of the mixing vessel and are very difficult to stir in. With the increasing wetting of the powder by the liquid this can succeed, but a certain time, sometimes up to 40 seconds, is lost; on the other hand, e.g. B. with bone cements it can be shown that the early mixing phase, especially the first 3 seconds, are crucial for the elimination of air bubbles from the powder component in order to remove the microporosity formed by the air inclusions in the finished bone cement (cf.Draenert, research and
- the above problem is solved in that the mixing vessel, preferably a mixing cup, with which the polymer powder projecting from the monomer is evacuated before the mixing.
- the mixing vessel preferably a mixing cup
- the polymer powder is degassed by the evacuation. It must be ensured that the polymer powder is not sucked out of the mixing vessel by the evacuation. This is done by means of a piston-shaped body which is axially movable in the mixing vessel and which has devices which slide the piston so as to move towards the vessel wall, but which seal essentially in a vacuum-tight manner.
- the body is designed in such a way that it allows air to pass through but prevents the polymer powder from passing through.
- This can be achieved in that the material of the piston-shaped body itself has a suitable porosity which is adapted to the particle size of the polymer powder, the diameter of the open pores having to be at least somewhat smaller than the diameter of the smallest powder particles.
- the piston can also have a continuous larger opening and, for example, be in the form of a ring, the opening being covered with a porous filter, for example a membrane filter.
- a porous filter for example a membrane filter.
- the same considerations apply to the porosity of the filter as set out above with the embodiment of a porous piston-shaped body.
- the filter can also be designed such that it itself effects the sealing against the inner vessel wall.
- REPLACEMENT LEAF Mixing vessel sucked.
- the powder is compacted to a fraction of its original volume, preferably to less than three quarters, for example to about two thirds of its original volume.
- monomer is sucked in from the bottom of the mixing vessel into the spaces between the spherical particles of the bead polymer powder, so that an almost simultaneous strengthening of the polymerization reaction can be achieved in the entire powder volume.
- the raw mixture obtained in this way can then be mixed very easily with a stirring rod, a vacuum also being applied, as described, for example, in WO 87/05492.
- stirring is preferably only very turbulent for 15 seconds and then likewise in laminar layers for about 15 seconds; in this way bubble-free mixtures can be obtained.
- the body movable in the mixing vessel is preferably designed as a lamellar body with lamellas sealing against the vessel wall, a filter in the form of a filter paper or textile filter being coated or fitted over the surface of the lamellar body facing the powder; a metal filter can also be biased, put over or interposed.
- the filter must be designed in such a way that air can be sucked through the filter, but not the powdery component.
- the body can also be designed as a ring or have a ring which can be displaced in the mixing vessel, preferably over its entire length, and on whose side facing the powder a filter is arranged upstream or slipped over.
- the ring On the side facing away from the powder, the ring can have a guide which receives a stirring rod, preferably by means of an interference fit, with which the ring can be pushed back and forth along the vessel wall.
- the filter is preferably designed so that it penetrates the stirring rod
- REPLACEMENT LEAF can be made without filter parts falling into the substances to be mixed.
- the filter can have predetermined, not continuously perforated predetermined tear points and / or predetermined tear lines.
- a strong, tear-resistant filter paper or crepe paper is preferably used as the filter.
- the annular body preferably has a device on its outer contour or on the lamellae, for example a retention structure, with which it can be held on the edge of the vessel when it is pulled out of the vessel.
- a device on its outer contour or on the lamellae for example a retention structure, with which it can be held on the edge of the vessel when it is pulled out of the vessel.
- the mixing device according to the invention as part of a semi-closed or closed system, the raw mixture of powder and monomer being initially closed off by the membrane of the filter and the mixture being able to be stirred after the membrane has been pierced.
- the guide for the stir bar can be fitted into the central opening of the annular body and can be removed with the stir bar.
- a central insert or inlay is provided, which has openings or slots for air passage and carries a microporous filter with high crack resistance.
- the inlay can also itself be designed as such a filter.
- the air-permeable inlay can be formed in one piece with the guide
- the central opening or inner recess of the ring-shaped body can be dimensioned such that the ring can optionally accommodate the filter insert described and an adapter in the form of an adapter lamella for a cartridge into which the bone cement can subsequently be intruded, as for example in WO 87 / 05492.
- the adapter lamella for the cartridge can be fixed in the ring-shaped body or piston ring with a snap ring or clamping ring after the filter insert has been removed with the stirring rod.
- the ring has a porosity with the dimensions explained above over its entire, slightly concave surface facing the powder.
- the ring can be designed in the form of a lamellar body which has a plurality of lamellas sealing against the vessel wall and a cylindrical inner ring.
- One or more channels are formed in the inner ring, so that air can be sucked out of the mixture of substances over the porous surface of the piston ring through the channel or channels of the inner ring during evacuation, even after the filter has been used.
- the porosity of the body or the filter is in each case matched to the size of the particles of the powdery component of the mixture of substances in such a way that the particles are not allowed to pass through, and when conventional bone cements are mixed it is for example between 1 and 40 ⁇ m, preferably about 1 to 10 ⁇ m since the smallest particles of the powder component each have slightly larger dimensions.
- the powdery component of the mixture to be mixed preferably consists of PMMA bead polymers, i. H. Acrylic acid ester or methacrylic acid ester prepolymers or derivatives thereof.
- the liquid monomeric phase preferably consists of acrylic or methacrylic acid derivatives, e.g. B. from methacrylic acid methyl ester.
- All parts of the device according to the invention are preferably made of such materials that they can be sterilized and used directly in the operating room.
- FIG. 2 shows a second embodiment of the vacuum mixing device according to the invention in partial section
- FIG. 3A is a side view of a filter holder in partial section, which can alternatively be used in the embodiment according to FIG. 1, with a filter and a clamping ring in an exploded view, and
- Fig. 3B is a bottom view of the filter holder of Fig. 3A.
- a conventional cartridge 2 as can also be used for the subsequent application of the bone cement, has at its front end a body 4 in the form of a lamellar cylinder which is fastened by means of a bayonet catch 3.
- the lamellar cylinder can be inserted into the vessel 1 with the aid of the cartridge 2.
- the lamellar cylinder 4 carries a plurality of lamellas 5, 6 and 7 on its outer circumference. The lamellas are designed such that they seal the body 4 from the inner wall of the vessel 1.
- the frontmost plate facing the vessel bottom 7 is equipped with a filter 9, e.g. B. filter paper spanned, which is held over by an arranged between the slats 6 and 7 ring 8, for example a rubber ring.
- a filter 9 e.g. B. filter paper spanned
- the front end of the cartridge 2 is a mouth 10 for later application of the
- a cap 11 with a handle 12 is provided at the rear end of the cartridge 2.
- the cap 11 also has a vacuum connection 13 which is sealed with sealing rings 14.
- the cap 11 is connected to the cartridge 2 with a bayonet lock 15, at least one sealing ring 16 also being provided between the cap 11 and the cartridge 2.
- the body 4 in the form of a lamellar cylinder is first inserted into the vessel 1 with the aid of the cartridge 2 until the filter 9 comes into contact with the polymer powder of the bone cement.
- the cap 11 is then placed on the cartridge 2 by means of the bayonet catch 12.
- the vacuum connection 13 is connected via a hose to a vacuum pump (not shown), and the mixing vessel is evacuated via the vacuum pump. Due to the sealing by the fins 5, 6 and 7 and the sealing rings 14 and 16, a negative pressure is created in the mixing vessel. This is preferably about 250 mbar.
- the body 4 is advanced further through the cartridge 2 by means of the handle 12.
- the body 4 can move towards the bottom of the vessel within less than a second and compress the polymer powder, for example to about two thirds of its original volume.
- the liquid monomer is sucked into the polymer powder by evacuation, so that the polymerization reaction between powder and monomer in the entire mixture is started almost simultaneously.
- the resulting crude mixture can be mixed completely homogeneously in a known manner with a stir bar after pulling back the body 4 by means of the handle 12, preferably again applying a vacuum, such as. B. explained in WO 87/05492.
- REPLACEMENT LEAF 2 is suitable for use in a semi-closed or closed system.
- the device according to FIG. 2 also has a cup vessel 1 for receiving the substances to be mixed and a body 4 'axially movable in the vessel 1 in the form of a piston or lamellar cylinder.
- the lamellar cylinder 4 ' has a plurality of lamellas 5', 6 'and 7', the lamellas 5 'and 6', similar to the embodiment according to FIG. 1, sealing against the inner wall of the vessel 1.
- the foremost lamella 7 'facing the bottom of the vessel is perforated and has a predetermined porosity.
- a stirring rod 17 is inserted into a central filter holder or guide in the body 4 '(explained in more detail below). Furthermore, a vacuum lid 18 is provided for tightly closing the vessel 1, which is similar to the vacuum lid described in WO 88/09209.
- the vacuum cover 18 has a vacuum cannula 19, through which a vacuum can be applied via a hose and a vacuum pump (not shown).
- the central insert 20 is firmly but detachably connected to the body 4 ', and preferably has preformed detachment points for this purpose.
- a further insert part 22 which serves as a guide for the stirring rod 17 in a press fit a " ⁇ " * - J - " ⁇ J.
- the insert parts 20 and 22 can also be formed in one piece with one another.
- the One or more channels 23 are provided between the lamellae 6 'and 7'.
- the rearmost lamella 5 'facing away from the bottom of the vessel has a thickening 24 on its outer edge.
- a corresponding recess 25 is provided on the inside of the vacuum cover 18.
- the stirring rod 17 is returned, whereby the remaining parts 20, 22 on one of the inner cuffs or beads, preferably the lowest cuff of the vacuum cover 18, can be stripped and remain loosely on the lamella 5 'which is still snapped into the recess 25.
- the stirring rod 17, which is now freely movable, can then be pushed again into the depth of the vessel 1 and can be used in a known manner to mix the mixture of polymer powder and monomer.
- the mixing is preferably first turbulent and then in laminar layers.
- the vacuum can be increased from the previously described values of approximately 250 mbar and a negative pressure of 840 to 950 mbar can be generated compared to the external pressure.
- the vacuum pump can optionally be switched off during the pulling-out of the stirring rod described above. 2 is completely free of bubbles after removing the stirring rod and switching off the vacuum pump, since due to the early evacuation the mixing batch is already very low in bubbles and no new bubbles can form during the entire mixing process carried out under vacuum.
- FIG. 3 shows a preferred embodiment of a filter holder 30 with a bayonet lock 32 for receiving a normal cement cartridge as an extension tube.
- the filter holder 30 can alternatively be placed on the cartridge 2 instead of the body 4.
- the filter holder 30 has ribs in the form of circular segments 36 on its underside facing the vessel bottom, between which slots 34 are arranged, which form concave grooves or trenches 35 on the underside of the filter holder 30.
- a filter 40 is attached to the underside of the filter holder by means of a clamping ring 37. With 38 a contact surface is designated.
- the filter 40 lies flat on the circular segments 36 on the side of the filter holder facing the powder.
- the concave course of the grooves 35 ensures a favorable, preferably vortex-free course of the gas flow during suction.
- the gas can also pass through
- the filter seals against the inner wall of the vessel 1 even during evacuation.
Landscapes
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Materials For Medical Uses (AREA)
- Prostheses (AREA)
- Mixers Of The Rotary Stirring Type (AREA)
- Dental Tools And Instruments Or Auxiliary Dental Instruments (AREA)
Abstract
Un procédé et un dispositif permettent de mélanger sous vide au moins un composant pulvérulent et au moins un composant liquide, notamment du ciment osseux. Le dispositif comprend un récipient de mélange (1) dans lequel on peut faire le vide et un corps (4) se déplaçant dans le récipient de mélange. La circonférence extérieure du corps (4) forme une fermeture hermétique sur la paroi intérieure du récipient de mélange (1). Le corps (4) comprend une ouverture intérieure recouverte d'un filtre (9). Le filtre (9) laisse passer l'air mais non le composant pulvérulent du mélange de substances. Ce dispositif permet de préparer un mélange de substances exempt de bulles d'air.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE4228780 | 1992-08-28 | ||
DE4228780A DE4228780A1 (de) | 1992-08-28 | 1992-08-28 | Vorrichtung und Verfahren zum Vakuummischen eines Stoffgemisches |
PCT/EP1993/002322 WO1994005415A1 (fr) | 1992-08-28 | 1993-08-27 | Procede et dispositif de melange sous vide de substances |
Publications (1)
Publication Number | Publication Date |
---|---|
EP0659104A1 true EP0659104A1 (fr) | 1995-06-28 |
Family
ID=6466718
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP93919202A Ceased EP0659104A1 (fr) | 1992-08-28 | 1993-08-27 | Procede et dispositif de melange sous vide de substances |
Country Status (5)
Country | Link |
---|---|
US (1) | US5857771A (fr) |
EP (1) | EP0659104A1 (fr) |
JP (1) | JPH08500525A (fr) |
DE (1) | DE4228780A1 (fr) |
WO (1) | WO1994005415A1 (fr) |
Cited By (1)
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US9962158B2 (en) | 2008-02-14 | 2018-05-08 | Ethicon Llc | Surgical stapling apparatuses with lockable end effector positioning systems |
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SE500430C2 (sv) * | 1993-05-10 | 1994-06-27 | Cemvac System Ab | Anordning för inmatning av bencementkomponenter i ett under undertryck stående blandningskärl |
US5549381A (en) * | 1995-05-19 | 1996-08-27 | Hays; Greta J. | Method and apparatus for mixing polymeric bone cement components |
DE19624757A1 (de) * | 1996-06-21 | 1998-01-08 | Feinmechanik Gmbh | Vorrichtung zum Mischen und Aufbringen eines Mehrkomponentenstoffes |
US6120174A (en) * | 1999-01-14 | 2000-09-19 | Bristol-Myers Squibb | Apparatus and method for mixing and dispensing bone cement |
US6116773A (en) * | 1999-01-22 | 2000-09-12 | Murray; William M. | Bone cement mixer and method |
JP2003527197A (ja) * | 2000-02-28 | 2003-09-16 | コリファルム メディツィンプロダクテ ゲーエムベーハー ウント コンパニー カーゲー | 埋植材料用の調製および注入装置 |
US6655828B2 (en) * | 2000-12-01 | 2003-12-02 | Depuy Orthopaedics, Inc. | Bone cement mixing apparatus having improved mixing blade configuration |
DK1395208T3 (da) | 2001-06-14 | 2007-05-07 | Cemvac System Ab | Fremgangsmåde ved fremstilling af knoglecement og indretning til udövelse af fremgangsmåden |
GB0506186D0 (en) * | 2005-03-29 | 2005-05-04 | Univ Belfast | Apparatus and method |
SE530232C2 (sv) * | 2006-08-11 | 2008-04-08 | Biomet Cementing Technologies | Vätskebehållare för bencementblandare |
SE530233C2 (sv) | 2006-08-11 | 2008-04-08 | Biomet Cementing Technologies | Vätskebehållare för bencementblandare |
US8840592B2 (en) | 2008-03-12 | 2014-09-23 | Warsaw Orthopedic, Inc. | Piston for material delivery system |
EP3876804A1 (fr) | 2019-03-08 | 2021-09-15 | SharkNinja Operating LLC | Système de traitement d'aliments sous vide |
CN213129232U (zh) | 2019-03-08 | 2021-05-07 | 沙克忍者运营有限责任公司 | 用于食物处理系统的储集器组件及食物处理系统 |
CN113329673B (zh) | 2019-03-08 | 2024-04-16 | 尚科宁家运营有限公司 | 真空食品处理系统 |
USD924007S1 (en) | 2019-06-06 | 2021-07-06 | Sharkninja Operating Llc | Strainer blender accessory |
USD925270S1 (en) | 2019-06-06 | 2021-07-20 | Sharkninja Operating Llc | Blender |
USD927256S1 (en) | 2019-06-06 | 2021-08-10 | Sharkninja Operating Llc | Blender |
USD940500S1 (en) | 2019-06-06 | 2022-01-11 | Sharkninja Operating Llc | Lid |
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DE3609672A1 (de) * | 1986-03-21 | 1987-09-24 | Klaus Draenert | Evakuierbare knochenzementspritze |
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US4973168A (en) * | 1989-01-13 | 1990-11-27 | Chan Kwan Ho | Vacuum mixing/bone cement cartridge and kit |
US4889432A (en) * | 1989-02-07 | 1989-12-26 | Roosevelt Patterson | Dental mixer apparatus |
SE462315B (sv) * | 1989-05-03 | 1990-06-11 | Surgitec Ab | Anordning foer tillverkning av bencement |
IT1236864B (it) * | 1989-12-29 | 1993-04-22 | Tecres Spa | Procedimento per miscelare e somministrare direttamente in loco un cemento osseo a due componenti, e dispositivo che lo realizza |
SE510490C2 (sv) * | 1992-02-07 | 1999-05-31 | Scandimed International Ab | Förfarande för framställning av bencement och anordning för genomförande av förfarandet |
-
1992
- 1992-08-28 DE DE4228780A patent/DE4228780A1/de not_active Withdrawn
-
1993
- 1993-08-27 JP JP6506848A patent/JPH08500525A/ja active Pending
- 1993-08-27 EP EP93919202A patent/EP0659104A1/fr not_active Ceased
- 1993-08-27 US US08/974,018 patent/US5857771A/en not_active Expired - Fee Related
- 1993-08-27 WO PCT/EP1993/002322 patent/WO1994005415A1/fr not_active Application Discontinuation
Non-Patent Citations (1)
Title |
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See references of WO9405415A1 * |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9962158B2 (en) | 2008-02-14 | 2018-05-08 | Ethicon Llc | Surgical stapling apparatuses with lockable end effector positioning systems |
Also Published As
Publication number | Publication date |
---|---|
DE4228780A1 (de) | 1994-03-03 |
JPH08500525A (ja) | 1996-01-23 |
US5857771A (en) | 1999-01-12 |
WO1994005415A1 (fr) | 1994-03-17 |
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