EP0635131A1 - Vorrichtung zur analyse von blut und anderen proben - Google Patents
Vorrichtung zur analyse von blut und anderen probenInfo
- Publication number
- EP0635131A1 EP0635131A1 EP94906296A EP94906296A EP0635131A1 EP 0635131 A1 EP0635131 A1 EP 0635131A1 EP 94906296 A EP94906296 A EP 94906296A EP 94906296 A EP94906296 A EP 94906296A EP 0635131 A1 EP0635131 A1 EP 0635131A1
- Authority
- EP
- European Patent Office
- Prior art keywords
- sample
- head
- tubes
- centrifuge
- centrifugal
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 210000004369 blood Anatomy 0.000 title claims description 23
- 239000008280 blood Substances 0.000 title claims description 23
- 238000004458 analytical method Methods 0.000 claims description 17
- 230000003287 optical effect Effects 0.000 claims description 15
- 238000005534 hematocrit Methods 0.000 claims description 9
- 238000012360 testing method Methods 0.000 claims description 6
- 210000002700 urine Anatomy 0.000 claims description 5
- 230000000877 morphologic effect Effects 0.000 claims description 3
- 238000003909 pattern recognition Methods 0.000 claims description 3
- 230000000007 visual effect Effects 0.000 claims description 2
- 239000000523 sample Substances 0.000 description 39
- 210000004027 cell Anatomy 0.000 description 35
- 238000000034 method Methods 0.000 description 8
- 238000000926 separation method Methods 0.000 description 4
- 238000005119 centrifugation Methods 0.000 description 3
- 238000001085 differential centrifugation Methods 0.000 description 3
- 230000006870 function Effects 0.000 description 3
- 210000000265 leukocyte Anatomy 0.000 description 3
- 238000005259 measurement Methods 0.000 description 3
- 241000894007 species Species 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- 230000008901 benefit Effects 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 238000003745 diagnosis Methods 0.000 description 2
- 230000002489 hematologic effect Effects 0.000 description 2
- 238000011835 investigation Methods 0.000 description 2
- 238000001356 surgical procedure Methods 0.000 description 2
- 241000271566 Aves Species 0.000 description 1
- 241000283707 Capra Species 0.000 description 1
- 241000938605 Crocodylia Species 0.000 description 1
- 102000009123 Fibrin Human genes 0.000 description 1
- 108010073385 Fibrin Proteins 0.000 description 1
- BWGVNKXGVNDBDI-UHFFFAOYSA-N Fibrin monomer Chemical compound CNC(=O)CNC(=O)CN BWGVNKXGVNDBDI-UHFFFAOYSA-N 0.000 description 1
- 102000008946 Fibrinogen Human genes 0.000 description 1
- 108010049003 Fibrinogen Proteins 0.000 description 1
- 241001662043 Icterus Species 0.000 description 1
- 206010023126 Jaundice Diseases 0.000 description 1
- 241000124008 Mammalia Species 0.000 description 1
- 206010029825 Nucleated red cells Diseases 0.000 description 1
- 241001494479 Pecora Species 0.000 description 1
- 235000013361 beverage Nutrition 0.000 description 1
- 238000012742 biochemical analysis Methods 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 210000000601 blood cell Anatomy 0.000 description 1
- 230000023555 blood coagulation Effects 0.000 description 1
- 238000004820 blood count Methods 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 230000001086 cytosolic effect Effects 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000000428 dust Substances 0.000 description 1
- 235000013601 eggs Nutrition 0.000 description 1
- 239000008151 electrolyte solution Substances 0.000 description 1
- 210000003979 eosinophil Anatomy 0.000 description 1
- 210000003743 erythrocyte Anatomy 0.000 description 1
- 239000003925 fat Substances 0.000 description 1
- 229950003499 fibrin Drugs 0.000 description 1
- 229940012952 fibrinogen Drugs 0.000 description 1
- 239000012634 fragment Substances 0.000 description 1
- 230000001524 infective effect Effects 0.000 description 1
- 230000002757 inflammatory effect Effects 0.000 description 1
- 239000000644 isotonic solution Substances 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 210000004698 lymphocyte Anatomy 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 239000008267 milk Substances 0.000 description 1
- 235000013336 milk Nutrition 0.000 description 1
- 210000004080 milk Anatomy 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000001613 neoplastic effect Effects 0.000 description 1
- 210000000440 neutrophil Anatomy 0.000 description 1
- 244000045947 parasite Species 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- 229940021222 peritoneal dialysis isotonic solution Drugs 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 238000009877 rendering Methods 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 239000013049 sediment Substances 0.000 description 1
- 238000004062 sedimentation Methods 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 238000010186 staining Methods 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 230000002485 urinary effect Effects 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
- G01N33/487—Physical analysis of biological material of liquid biological material
- G01N33/49—Blood
- G01N33/491—Blood by separating the blood components
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/04—Investigating sedimentation of particle suspensions
- G01N15/042—Investigating sedimentation of particle suspensions by centrifuging and investigating centrifugates
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/04—Investigating sedimentation of particle suspensions
- G01N15/042—Investigating sedimentation of particle suspensions by centrifuging and investigating centrifugates
- G01N2015/045—Investigating sedimentation of particle suspensions by centrifuging and investigating centrifugates by optical analysis
Definitions
- This invention relates primarily to an auto-centrifuge analyser and associated diagnostic equipment such as for use by veterinary and medical practitioners .
- the invention is particularly useful for use in surgeries, offices, clinics, hospitals and so on, and largely adapted to perform haematology analysis.
- the invention also finds application in the analysis of other samples, including urine, river water and so on.
- the total number of white blood cells and the relative proportions of three different types of the cells, namely lymphocytes, neutrophils and eosinophiles is valuable to a clinician in the formation of a differential diagnoses in respect of many pathological conditions, especially inflammatory, infective and neoplastic diseases.
- a further particulate component of the blood which is of interest to the practitioner is the platelet.
- These are not cells but are cytoplasmic fragments formed from a specific cell type. Platelets play an important role in blood clotting.
- differential centrifugation analysers work by differential centrifugation of a stained blood sample.
- the interfaces between the different cell type segments are identified by microscopic examination and the relative proportion of the cell types calculated.
- the system is only really suitable to two species of mammals and some of the required blood parameters are not able to be measured.
- apparatus for analysing samples comprising sample carrying means, a centrifuge for rotating a said sample at a predetermined rotational velocity such that centrifugal force separates the various phases or components of the sample, sample reading means for reading or measuring predetermined characteristics of the sample, analysis means for analysing the data obtained by the sample reading means and display means for displaying data produced by the analysis means relating to the sample .
- the sample carrying means includes a centrifugal head having slots for supporting respective tubes.
- the sample carrying means also includes a cuvette receptor.
- the sample carrying means also includes a sample tube rotor.
- said tubes may be either blood centrifuge tubes or haematocrit tubes, wherein said blood centrifuge tubes are also adapted for containing urine.
- the centrifuge may include a DC servomotor and a drive shaft upon which the centrifugal head and sample tube rotor are adapted to be mounted.
- the sample reading means includes a haemoglobin photometer for reading predetermined characteristics relating to the sample contained in a cuvette positioned in the cuvette receptor, and a polychromatic optical head positioned on a scanning arm enabling radial readings of predetermined characteristics of the sample contained in a tube supported on the centrifugal head.
- the polychromatic optical head may typically include means for measuring the length of a sample within a tube, an interface detector and a multi-wavelength spectrophotometer.
- the scanning arm may be pivotably mounted at a position adjacent to the circumference of the centrifugal head such that one end of the arm supporting the polychromatic optical head may move from a first position outside of the circumference to a second position within the circumference defined by the centrifugal head.
- the scanning arm may include a linear track facilitating radial movement of the polychromatic optical head.
- the display means may comprise a visual display, such as an LCD screen or a printed output.
- the apparatus also includes a data input means such as a numeric and special function keyboard.
- a data input means such as a numeric and special function keyboard.
- the analysis means preferably includes a memory containing diagnostic data interpretation assistance, data comprising analytic reference ranges relevant to the sample being analysed and data comprising recommendations for further testing based on the associated analysis of the sample.
- the analysis means also includes means for calculating analytical concentrations and interpreting readings and measurements obtained by the sample reading means .
- the tubes are detachable from the cuvette receptor, rotor and centrifugal head and are disposable.
- said analyser is adapted to be connected to or integral with a pattern recognition means adapted to detect and record the size and morphological characteristics of a large number of cells.
- Fig. la and lb show pictorial views of an analyser in a respective closed and open position in accordance with the invention
- Figs. 2a and 2b show blood centrifuge tubes and haematocrit tubes respectively
- Fig. 3 shows a centrifugal head supporting four haematocrit tubes.
- Fig. 4 shows a rotor assembly with a tube rotor connected
- Fig. 5 shows a centrifuge drive assembly
- Fig. 6 shows a folded detector assembly for use in the optical head described in the invention.
- an auto centrifuge analyser 10 comprises a centrifuge 11, data- input means 12, data-display means 13 and a haemoglobin photometer (not shown) contained in the compartment 14.
- the data-display means 13 comprises an LED display while the data-input means 12 comprises a numeric and special function key pad.
- the analyser 10 in Fig. 1 is also provided with a lid 15 which enables access to the centrifuge 11, while protecting same when in a closed position from dust or other potential damage.
- An example embodiment of a drive assembly for the centrifuge 11 is shown in Fig. 5.
- a support frame provides a mounting for a DC servomotor 2 which drives a shaft 8 upon which is mounted a centrifugal head 16.
- the centrifugal head is shown in more detail in Fig. 3.
- Located just outside the circumference of the centrifugal head 16 is a second shaft 7 upon which may be pivotably mounted a scanning arm 17 supporting an optical head for reading predetermined characteristics of samples supported in tubes 22 on the centrifugal head 16.
- An example embodiment of a scanning arm 17 is also illustrated in Fig. 1.
- the shaft 8 upon which the centrifugal head 16 is adapted to be mounted may also be used to support a sample tube rotor 1.
- a sample tube rotor is adapted to support sample tubes 18 while being rigidly connected to the shaft 8 adapted to rotate the centrifugal head 16 and the tube rotor 1.
- the auto-centrifuge 11 is adapted to enable rotation of at least two different types of tubes, namely and by way of example only, a packed cell volume (PCV) or haematocrit tube supported on the centrifugal head 16 or a conical sample tube, supported in the sample tube rotor 1.
- PCV packed cell volume
- Fig. 2a shows a centrifuge conical sample tube 21 which is adapted to be located in one of the apertures in the sample tube rotor 1.
- the tube 21 may be disposable to maintain the integrity of the samples and, by way of example, might approximate a volume capacity of 1.5 millilitres.
- Such a tube may be equally used for the analysis of blood or urine or indeed other types of samples such as river water or beverages, whereby the rotational speed or duration of rotation may be varied in respect of the centrifuge 11.
- the haematocrit tube 22 shown in Fig. 2b is generally of a significantly thinner diameter and is adapted to be located in the slots 3 in the centrifugal head 16.
- the data-input means 12 may be used to control the rotational velocity of the centrifuge 11 to meet the requirements of the analysis test being conducted.
- the analyser 10 is also provided with an optical head mounted on a scanning arm 17.
- the head comprises a light source adapted to pass light through a sample, and a detector for detecting the non-absorbed light.
- the head is adapted to measure PCV and other similarly pertinent data, in addition to determining density of the sample film for cell counting and the like, in such circumstances where a contrifugal head 16 similar to that shown in Figure 3 is used.
- the analyser 10 is adapted to determine the packed cell volume of a sample placed in the haematocrit tube 22 by, having spun the sample using the centrifuge 11, using the optical head to measure the total length of the sample column (a) within the tube 22, search for interfaces between the different phases (for example, the plasma and the packed cell fraction) in the centrifuged sample, and then determine the percentage of packed cells (b) in the column (a) .
- the calculated PCV is then displayed by the display means 13 on the front of the analyser 10.
- the detector assembly generally described at 35 in Fig. 6 comprises a housing 30 which supports a mirror 31, a lens assembly 32 and a detector 33.
- light emitted from light source A is passed through the sample which might be located at B and thereafter reflected from the mirror 31 through the lens 32 to the detector 33.
- the detector signal is then analysed by the analysing means.
- the screws 34 may be used for adjustment of the mirror 31.
- the centrifuge 11 enables a plurality of functions to be performed. For example, it enables separation of red cells from plasma lserum by centrifugation, separation of urine sediment, cells and crystals by centrifugation, separation of fats and cells in milk by centrifugation, separation of particles in a water solution and floatation of parasite eggs in a preprepared faecal sample. Additionally, the auto- centrifuge enables a number of tests to be performed which are adapted to supply the clinician with important information in diagnosis and treatment.
- the auto-centrifuge may be an integral component of a larger blood cell counter.
- the auto-centrifuge for example, may be connected to an imager having a pattern recognition means adapted to detect and record, for example, the size and morphological characteristics of a large number of cells. It is recognised herein that software packages are in existence or may be produced which interpret cell patterns and provide the vast majority of haematological and other information required by practitioners. This would allow the device to perform both red and white blood cell counting, platelet estimates and many other tests. However, it may also be designed as a stand-alone device adapted to provide essential screening information to the practitioner.
- the analyser 10 is adapted to provide pertinent analytic data relating to the sample, together with preparing the sample for further study and analysis, in a particularly shortened time period to that previously experienced by practitioners.
- the preparatory ability of the analyser includes the preparation of plasma for biochemical analysis, urinary spun deposits, a haematocrit stained blood film. Furthermore, it uniquely combines a haemoglobin photometer with a centrifuge to synergistically increase the meaningful results that may be obtained.
- the optical head is adapted to move radially in respect to the centrifugal head 16, such that the light source A may pass light to the deflector assembly 35 throughout different points along the length of a haematocrit tube 22 located in the slots 3 of the centrifugal head 16.
- the invention provides, in a preferred embodiment, for the scanning arm 17 to be pivotably mounted such that the optical head is able to pass over the full length of a tube 22.
- An advantage of this pivotal movement is that the arm 17 may be cleared from the centrifugal head 16 when it is desired to position the rotor 1 on the centrifugal head 16.
- the arm 17 is U-shaped somewhat similar to a tuning fork, thereby providing a carrier for the light source above the head 16 and a carrier for the detector assembly 35 below the head 16.
- the optical head could be arranged with one or more linear tracks or bearings enabling radial movement of the head.
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Physics & Mathematics (AREA)
- Pathology (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Ecology (AREA)
- Dispersion Chemistry (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
- Centrifugal Separators (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB939302673A GB9302673D0 (en) | 1993-02-11 | 1993-02-11 | Apparatus for analysing blood and other samples |
GB9302673 | 1993-02-11 | ||
PCT/GB1994/000271 WO1994018557A1 (en) | 1993-02-11 | 1994-02-10 | Apparatus for analysing blood and other samples |
Publications (1)
Publication Number | Publication Date |
---|---|
EP0635131A1 true EP0635131A1 (de) | 1995-01-25 |
Family
ID=10730220
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP94906296A Withdrawn EP0635131A1 (de) | 1993-02-11 | 1994-02-10 | Vorrichtung zur analyse von blut und anderen proben |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP0635131A1 (de) |
AU (1) | AU6005594A (de) |
CA (1) | CA2117916A1 (de) |
GB (1) | GB9302673D0 (de) |
WO (1) | WO1994018557A1 (de) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
USRE36341E (en) * | 1993-10-14 | 1999-10-12 | Dade Behring Inc. | Automatic sample container handling centrifuge and a rotor for use therein |
KR960704634A (ko) * | 1993-10-14 | 1996-10-09 | 미리암 디. 메코너헤이 | 샘플 용기 자동 처리식 원심 분리기 및 원심 분리기용 회전자(Automatic Sample Container Handling Centrifuge and a Rotor for Use Therein) |
GB9424218D0 (en) * | 1994-11-30 | 1995-01-18 | Zynocyte Ltd | Apparatus for analysing blood and other samples |
IT1280143B1 (it) * | 1995-03-15 | 1998-01-05 | S I R E Sas Di De Monte Duic G | Procedimento per la determinazione della sedimentazione del sangue e relativo dispositivo |
GB9606559D0 (en) * | 1996-03-28 | 1996-06-05 | Zynocyte Ltd | Apparatus and method for analysing blood samples |
US6285450B1 (en) * | 1998-03-02 | 2001-09-04 | Bradley S. Thomas | Blood centrifugation device with movable optical reader |
US6002474A (en) * | 1998-03-02 | 1999-12-14 | Becton Dickinson And Company | Method for using blood centrifugation device with movable optical reader |
GB9804560D0 (en) * | 1998-03-05 | 1998-04-29 | Zynocyte Ltd | Method of measuring erthrocyte sedimentation rate (esr),plasma viscosity and plasma fibrinogen of a blood sample |
US6153148A (en) * | 1998-06-15 | 2000-11-28 | Becton, Dickinson And Company | Centrifugal hematology disposable |
US6087182A (en) * | 1998-08-27 | 2000-07-11 | Abbott Laboratories | Reagentless analysis of biological samples |
DE102004011387B4 (de) * | 2004-03-05 | 2010-04-29 | L.U.M. Gmbh | Verfahren und Vorrichtung zur Charakterisierung von multiplen Proben einer Dispersion |
DE102005048236A1 (de) | 2005-10-07 | 2007-04-12 | Ministerium für Wissenschaft, Forschung und Kunst Baden-Württemberg | Vorrichtung und Verfahren zur Bestimmung der Volumenanteile der Phasen in einer Suspension |
GB2573126B (en) * | 2018-04-24 | 2022-11-09 | Entia Ltd | A method and apparatus for determining haemoglobin concentration |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4135883A (en) * | 1977-08-29 | 1979-01-23 | Bio-Dynamics Inc. | Blood analyzer system |
JPS5663239A (en) * | 1979-10-29 | 1981-05-29 | Hitachi Koki Co Ltd | Measuring apparatus of spectroscopic absorption of centrifuge for separation |
JPS56142442A (en) * | 1980-04-09 | 1981-11-06 | Hitachi Koki Co Ltd | Photoelectric scanning device for ultracentrifugal machine |
JPS6093349A (ja) * | 1983-10-28 | 1985-05-25 | Mochida Pharmaceut Co Ltd | 血液成分測定装置及びその使用方法 |
US4830493A (en) * | 1987-10-29 | 1989-05-16 | Beckman Instruments, Inc. | UV scanning system for centrifuge |
JPH02269938A (ja) * | 1989-04-11 | 1990-11-05 | Idemitsu Petrochem Co Ltd | 分析装置 |
US5095451A (en) * | 1989-07-13 | 1992-03-10 | E. I. Du Pont De Nemours And Company | Centrifuge particle size analyzer |
-
1993
- 1993-02-11 GB GB939302673A patent/GB9302673D0/en active Pending
-
1994
- 1994-02-10 EP EP94906296A patent/EP0635131A1/de not_active Withdrawn
- 1994-02-10 WO PCT/GB1994/000271 patent/WO1994018557A1/en not_active Application Discontinuation
- 1994-02-10 AU AU60055/94A patent/AU6005594A/en not_active Abandoned
- 1994-02-10 CA CA 2117916 patent/CA2117916A1/en not_active Abandoned
Non-Patent Citations (1)
Title |
---|
See references of WO9418557A1 * |
Also Published As
Publication number | Publication date |
---|---|
WO1994018557A1 (en) | 1994-08-18 |
CA2117916A1 (en) | 1994-08-18 |
AU6005594A (en) | 1994-08-29 |
GB9302673D0 (en) | 1993-03-24 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US3009388A (en) | Apparatus for determining fluid fractions and sedimentataion rates | |
EP0830581B1 (de) | Bestimmung der erythrozytensedimentationsrate und des hämatokrit | |
EP1149277B1 (de) | Vorrichtung und verfahren zur voruntersuchung einer unbehandelten serumprobe in einem probenentnahmeröhrchen | |
US5827746A (en) | Method to determine the sedimentation of blood and relative device | |
WO1994018557A1 (en) | Apparatus for analysing blood and other samples | |
US5734468A (en) | Probe and method for determining serum indices of a serum sample | |
US20080138852A1 (en) | Identification of blood elements using inverted microscopy | |
US6632679B1 (en) | Method to determine the speed of sedimentation of blood and other parameters correlated thereto, and relative apparatus | |
US4135819A (en) | Apparatus for measuring the aggregation rate of particles | |
CA2537500C (en) | Integrated apparatus for hematological analyses and related method | |
JP2002506208A (ja) | 白血球百分率及び網状赤血球計数の決定 | |
JPH09101304A (ja) | 赤血球沈降速度測定用試験管 | |
KR102546374B1 (ko) | 적혈구 침강 속도 및 다른 연결된 파라미터를 결정하기 위한 장치 및 방법 | |
US20100129855A1 (en) | Blood cell analyzer, blood cell analyzing method, and computer program product | |
JPS59206744A (ja) | 遠心分析装置 | |
JP4055802B2 (ja) | 自動分析装置用反応ディスク | |
US5120979A (en) | Apparatus and method for analysis of a sample medium in a gap between a tube and a float | |
Stephen et al. | Analytical comparison between microhematocrit and automated methods for packed cell volume (PCV) determination | |
RU2256917C1 (ru) | Способ определения динамики изменения скорости оседания эритроцитов и устройство для его осуществления | |
Pannu et al. | Warfarin related nephropathy: a case report from a tertiary hospital of north India and review of literature | |
JP4062549B2 (ja) | 懸濁液からの不溶物分離用セル | |
RU2289133C1 (ru) | Способ определения гемоглобина, количества эритроцитов, лейкоцитов, тромбоцитов, гематокрита и скорости оседания эритроцитов в цельной крови | |
JP7319986B2 (ja) | 生体細胞を含む生体試料の分析方法及びその分析方法を実施する分析装置 | |
RU2803025C2 (ru) | Способ анализа биологического образца, содержащего биологические клетки, и анализирующее устройство для осуществления способа анализа | |
Saunders et al. | Hematologic automation by use of continuous flow systems |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE |
|
17P | Request for examination filed |
Effective date: 19950215 |
|
17Q | First examination report despatched |
Effective date: 19960510 |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
|
18D | Application deemed to be withdrawn |
Effective date: 19960921 |