EP0588958A1 - Methode de detection de ligands specifiques - Google Patents

Methode de detection de ligands specifiques

Info

Publication number
EP0588958A1
EP0588958A1 EP92914168A EP92914168A EP0588958A1 EP 0588958 A1 EP0588958 A1 EP 0588958A1 EP 92914168 A EP92914168 A EP 92914168A EP 92914168 A EP92914168 A EP 92914168A EP 0588958 A1 EP0588958 A1 EP 0588958A1
Authority
EP
European Patent Office
Prior art keywords
antigen
analyte antibody
sample
solid phase
labelled
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP92914168A
Other languages
German (de)
English (en)
Inventor
Sinfu Tzeng
Dou-Mei Wang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pacific Biotech Inc
Original Assignee
Pacific Biotech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pacific Biotech Inc filed Critical Pacific Biotech Inc
Publication of EP0588958A1 publication Critical patent/EP0588958A1/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/558—Immunoassay; Biospecific binding assay; Materials therefor using diffusion or migration of antigen or antibody
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N23/00—Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups G01N3/00 – G01N17/00, G01N21/00 or G01N22/00
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
    • G01N33/535—Production of labelled immunochemicals with enzyme label or co-enzymes, co-factors, enzyme inhibitors or enzyme substrates
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54306—Solid-phase reaction mechanisms
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56911—Bacteria
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/585—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with a particulate label, e.g. coloured latex

Abstract

L'invention se rapporte au domaine d'analyses en une étape et de tests d'agglutination de particules. Dans un mode de réalisation de l'invention on décrit un dispositif analytique servant à la détection ou à la détermination d'un anticorps d'analyte dans un liquide biologique comprenant une couche présentant une pluralité de zones planes contiguës en contact absorbant l'une par rapport à l'autre, la couche comprenant une zone d'application d'un échantillon, une zone conjuguée contenant un antigène lié à des particules mobiles, ainsi qu'une zone de détection contenant un antigène immobilisé. L'antigène est le même dans la zone conjuguée et dans la zone de détection, il s'agit d'un antigène qui se lie à l'anticorps de l'analyte; l'échantillon de liquide est capable de se déplacer d'une zone d'application d'échantillon jusqu'à la zone de détection à travers la zone conjuguée et si l'anticorps de l'analyte est présent dans l'échantillon, il est détecté dans la zone de détection. L'invention concerne également des procédés de détection de divers analytes, particulièrement des anticorps d'analyte, y compris des immunoglobulines spécifiques. L'invention décrit, de plus, des procédés améliorés de préparation et d'utilisation d'analyses en une étape ainsi que des procédés améliorés de préparation de particules pourvues d'un revêtement s'utilisant dans des méthodes de diagnostic.
EP92914168A 1991-06-13 1992-05-05 Methode de detection de ligands specifiques Withdrawn EP0588958A1 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US71540791A 1991-06-13 1991-06-13
US71511991A 1991-06-14 1991-06-14
US715119 1991-06-14
US715407 1996-09-18

Publications (1)

Publication Number Publication Date
EP0588958A1 true EP0588958A1 (fr) 1994-03-30

Family

ID=27109275

Family Applications (1)

Application Number Title Priority Date Filing Date
EP92914168A Withdrawn EP0588958A1 (fr) 1991-06-13 1992-05-05 Methode de detection de ligands specifiques

Country Status (6)

Country Link
EP (1) EP0588958A1 (fr)
JP (1) JPH06508689A (fr)
KR (1) KR940701542A (fr)
AU (1) AU2247192A (fr)
CA (1) CA2110920A1 (fr)
WO (1) WO1992022797A2 (fr)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6653066B1 (en) * 1994-06-17 2003-11-25 Trinity Biotech Device and method for detecting polyvalent substances
GB2300914B (en) * 1995-04-28 1998-04-29 Tepnel Medical Ltd Analytical device
US5753517A (en) * 1996-03-29 1998-05-19 University Of British Columbia Quantitative immunochromatographic assays
CA2293677C (fr) 1998-04-14 2009-01-27 Otsuka Pharmaceutical Co., Ltd. Procedes de detection d'anticorps et dispositif de detection d'anticorps
EP0973034A1 (fr) * 1998-07-16 2000-01-19 Microbe Scope AG Immunoessais et dispositifs pour leur fonctionnement
GB9823397D0 (en) * 1998-10-27 1998-12-23 Rsr Ltd Assays for thyroid autoantibodies
US7410808B1 (en) 2003-12-08 2008-08-12 Charm Sciences, Inc. Method and assay for detection of residues
JP5414424B2 (ja) * 2009-08-31 2014-02-12 シスメックス株式会社 目的物質の検出方法、及び目的物質を検出するためのクロマトグラフィー用試験キット
PT2566949T (pt) 2010-05-06 2023-05-18 Charm Sciences Inc Aparelho leitor e incubador
KR101353930B1 (ko) * 2012-02-20 2014-01-27 주식회사 나노엔텍 신규한 항원의 검출방법 및 그를 이용한 장치
JP2013185858A (ja) * 2012-03-06 2013-09-19 Gc Corp 外膜ヴェシクルを用いた歯周病原細菌の検査方法及び測定用器具

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK590288D0 (da) * 1988-10-24 1988-10-24 Symbicom Ab Kemiske forbindelser
AU5280086A (en) * 1985-01-30 1986-08-07 Genetic Diagnostics Corp. Self timed immunoassay device
IT1200382B (it) * 1985-02-08 1989-01-18 Boehringer Biochemia Srl Sistema di rilevazione e/o dosaggio di parametri clinici per via immuno enzimatica
US4888276A (en) * 1986-06-26 1989-12-19 Minnesota Mining And Manufacturing Company Method and composition for the diagnosis of Lyme disease
US5120643A (en) * 1987-07-13 1992-06-09 Abbott Laboratories Process for immunochromatography with colloidal particles
ES2084581T3 (es) * 1987-10-30 1996-05-16 Abbott Lab Inmunoensayos que utilizan antigenos producidos en organismos hetereologicos.
CA1307462C (fr) * 1988-06-20 1992-09-15 Victor E.O. Valli Epreuve rapide a l'aide d'un batonnet pour diagnostiquer une infection par le virus de la leucemie bovine dans le serum ou le lait
US5075078A (en) * 1989-10-05 1991-12-24 Abbott Laboratories Self-performing immunochromatographic device

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See references of WO9222797A2 *

Also Published As

Publication number Publication date
WO1992022797A3 (fr) 1993-04-01
WO1992022797A2 (fr) 1992-12-23
AU2247192A (en) 1993-01-12
KR940701542A (ko) 1994-05-28
JPH06508689A (ja) 1994-09-29
CA2110920A1 (fr) 1992-12-23

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Legal Events

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PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

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17P Request for examination filed

Effective date: 19931216

AK Designated contracting states

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Designated state(s): AT BE CH DE DK ES FR GB GR IT LI LU MC NL SE

17Q First examination report despatched

Effective date: 19950124

STAA Information on the status of an ep patent application or granted ep patent

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18D Application deemed to be withdrawn

Effective date: 19950604