EP0566611A1 - Analogs of piscine lhrh - Google Patents
Analogs of piscine lhrhInfo
- Publication number
- EP0566611A1 EP0566611A1 EP92902189A EP92902189A EP0566611A1 EP 0566611 A1 EP0566611 A1 EP 0566611A1 EP 92902189 A EP92902189 A EP 92902189A EP 92902189 A EP92902189 A EP 92902189A EP 0566611 A1 EP0566611 A1 EP 0566611A1
- Authority
- EP
- European Patent Office
- Prior art keywords
- analogue
- gly
- amino acid
- fish
- antibody
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/23—Luteinising hormone-releasing hormone [LHRH]; Related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/26—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against hormones ; against hormone releasing or inhibiting factors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/42—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins
- C07K16/4208—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig
- C07K16/4241—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig against anti-human or anti-animal Ig
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
Definitions
- N- ⁇ -maleimidobutyryloxysuccinimide (Calbiochem) may be used to conjugate via a thioether bond analogues of piscine GnRH containing a Cys-residue at position Y to lysine side-chains of the carrier protein, whilst a diazo bond may be formed with N-(4-diazophenyl) - maleimide for the conjugation of analogues containing a Tyr residue at position Y.
- Peptides and conjugates can readily be purified to the necessary degree using methods well known in the art including, for example, high-performance liquid chromatography, sodium dodecyl sulphate-polyacrylamide gel electrophoresis and fast-performance liquid chromatography.
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Endocrinology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Physics & Mathematics (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Reproductive Health (AREA)
- Peptides Or Proteins (AREA)
- Magnetic Resonance Imaging Apparatus (AREA)
- Circuits Of Receivers In General (AREA)
- Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB919100468A GB9100468D0 (en) | 1991-01-09 | 1991-01-09 | Improvements in and relating to hormones |
| GB9100468 | 1991-01-09 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| EP0566611A1 true EP0566611A1 (en) | 1993-10-27 |
Family
ID=10688207
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EP92902189A Withdrawn EP0566611A1 (en) | 1991-01-09 | 1992-01-08 | Analogs of piscine lhrh |
Country Status (17)
| Country | Link |
|---|---|
| EP (1) | EP0566611A1 (da) |
| JP (1) | JPH06504537A (da) |
| KR (1) | KR930703444A (da) |
| CN (1) | CN1063109A (da) |
| AU (1) | AU652611B2 (da) |
| CA (1) | CA2100057A1 (da) |
| DK (1) | DK80993A (da) |
| FI (1) | FI933138A0 (da) |
| GB (2) | GB9100468D0 (da) |
| HU (1) | HUT66829A (da) |
| IE (1) | IE920055A1 (da) |
| IS (1) | IS3802A (da) |
| NO (1) | NO932491D0 (da) |
| NZ (1) | NZ241240A (da) |
| PT (1) | PT99991A (da) |
| WO (1) | WO1992012247A1 (da) |
| ZW (1) | ZW392A1 (da) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1091138A (zh) * | 1992-08-27 | 1994-08-24 | 迪金研究有限公司 | 疫苗 |
| US5688506A (en) * | 1994-01-27 | 1997-11-18 | Aphton Corp. | Immunogens against gonadotropin releasing hormone |
| US5760000A (en) * | 1994-05-13 | 1998-06-02 | University Technologies International,Inc. | Inhibition of liver cancer by the use of GnRH and GnRH analogs |
| WO2000037100A2 (en) * | 1998-12-22 | 2000-06-29 | Dalhousie University | Compositions and methods for reducing or preventing fertilization in fish and birds |
| GB0226179D0 (en) | 2002-11-09 | 2002-12-18 | Millar Robert P | Vaccine |
| NO20075894L (no) * | 2007-11-15 | 2009-05-18 | Thia Medica As | Redusert kjonnsmodning i fisk |
| JP6909160B2 (ja) * | 2015-11-27 | 2021-07-28 | 日本水産株式会社 | 細胞膜透過性ペプチド及び細胞膜透過性ペプチドを用いた魚類飼料 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4443368A (en) * | 1982-11-01 | 1984-04-17 | The Salk Institute For Biological Studies | Peptides affecting gonadal function |
| US4410514A (en) * | 1982-12-06 | 1983-10-18 | The Salk Institute For Biological Studies | GnRH Agonists |
| US4608251A (en) * | 1984-11-09 | 1986-08-26 | Pitman-Moore, Inc. | LHRH analogues useful in stimulating anti-LHRH antibodies and vaccines containing such analogues |
| GB8713240D0 (en) * | 1987-06-05 | 1987-07-08 | Proteus Biotech Ltd | Hormones |
| WO1993003058A2 (en) * | 1991-07-01 | 1993-02-18 | University Technologies International Inc. | NON-DESENSITIZING ANALOGS OF GnRH AND OTHER BIOLOGICALLY ACTIVE LIGANDS |
-
1991
- 1991-01-09 GB GB919100468A patent/GB9100468D0/en active Pending
-
1992
- 1992-01-07 NZ NZ241240A patent/NZ241240A/xx unknown
- 1992-01-08 CA CA002100057A patent/CA2100057A1/en not_active Abandoned
- 1992-01-08 WO PCT/GB1992/000040 patent/WO1992012247A1/en not_active Application Discontinuation
- 1992-01-08 AU AU11617/92A patent/AU652611B2/en not_active Ceased
- 1992-01-08 IE IE005592A patent/IE920055A1/en not_active Application Discontinuation
- 1992-01-08 PT PT99991A patent/PT99991A/pt not_active Application Discontinuation
- 1992-01-08 HU HU9301979A patent/HUT66829A/hu unknown
- 1992-01-08 JP JP4502565A patent/JPH06504537A/ja active Pending
- 1992-01-08 KR KR1019930702060A patent/KR930703444A/ko not_active Application Discontinuation
- 1992-01-08 IS IS3802A patent/IS3802A/is unknown
- 1992-01-08 EP EP92902189A patent/EP0566611A1/en not_active Withdrawn
- 1992-01-09 ZW ZW3/92A patent/ZW392A1/xx unknown
- 1992-01-09 CN CN92100141A patent/CN1063109A/zh active Pending
-
1993
- 1993-07-06 DK DK080993A patent/DK80993A/da not_active Application Discontinuation
- 1993-07-08 GB GB9314141A patent/GB2267496B/en not_active Expired - Fee Related
- 1993-07-08 FI FI933138A patent/FI933138A0/fi not_active Application Discontinuation
- 1993-07-08 NO NO932491A patent/NO932491D0/no unknown
Non-Patent Citations (1)
| Title |
|---|
| See references of WO9212247A1 * |
Also Published As
| Publication number | Publication date |
|---|---|
| NZ241240A (en) | 1992-11-25 |
| CA2100057A1 (en) | 1992-07-10 |
| GB2267496A (en) | 1993-12-08 |
| FI933138A (fi) | 1993-07-08 |
| GB2267496B (en) | 1994-09-07 |
| AU652611B2 (en) | 1994-09-01 |
| WO1992012247A1 (en) | 1992-07-23 |
| HUT66829A (en) | 1995-01-30 |
| NO932491L (no) | 1993-07-08 |
| PT99991A (pt) | 1993-01-29 |
| DK80993D0 (da) | 1993-07-06 |
| NO932491D0 (no) | 1993-07-08 |
| IE920055A1 (en) | 1992-07-15 |
| DK80993A (da) | 1993-07-06 |
| AU1161792A (en) | 1992-08-17 |
| GB9314141D0 (en) | 1993-09-22 |
| FI933138A0 (fi) | 1993-07-08 |
| ZW392A1 (en) | 1992-07-22 |
| JPH06504537A (ja) | 1994-05-26 |
| HU9301979D0 (en) | 1993-11-29 |
| CN1063109A (zh) | 1992-07-29 |
| IS3802A (is) | 1992-07-10 |
| GB9100468D0 (en) | 1991-02-20 |
| KR930703444A (ko) | 1993-11-30 |
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| Date | Code | Title | Description |
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| PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
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