GB2267496A - Analogs of piscine LHRH - Google Patents
Analogs of piscine LHRHInfo
- Publication number
- GB2267496A GB2267496A GB9314141A GB9314141A GB2267496A GB 2267496 A GB2267496 A GB 2267496A GB 9314141 A GB9314141 A GB 9314141A GB 9314141 A GB9314141 A GB 9314141A GB 2267496 A GB2267496 A GB 2267496A
- Authority
- GB
- United Kingdom
- Prior art keywords
- amino acid
- absent
- gly
- piscine
- tyr
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 101000904173 Homo sapiens Progonadoliberin-1 Proteins 0.000 title 1
- 102100024028 Progonadoliberin-1 Human genes 0.000 title 1
- 101000996723 Sus scrofa Gonadotropin-releasing hormone receptor Proteins 0.000 title 1
- XLXSAKCOAKORKW-UHFFFAOYSA-N gonadorelin Chemical compound C1CCC(C(=O)NCC(N)=O)N1C(=O)C(CCCN=C(N)N)NC(=O)C(CC(C)C)NC(=O)CNC(=O)C(NC(=O)C(CO)NC(=O)C(CC=1C2=CC=CC=C2NC=1)NC(=O)C(CC=1NC=NC=1)NC(=O)C1NC(=O)CC1)CC1=CC=C(O)C=C1 XLXSAKCOAKORKW-UHFFFAOYSA-N 0.000 title 1
- 150000001413 amino acids Chemical group 0.000 abstract 4
- 235000001014 amino acid Nutrition 0.000 abstract 3
- 150000008574 D-amino acids Chemical class 0.000 abstract 1
- NMJREATYWWNIKX-UHFFFAOYSA-N GnRH Chemical compound C1CCC(C(=O)NCC(N)=O)N1C(=O)C(CC(C)C)NC(=O)C(CC=1C2=CC=CC=C2NC=1)NC(=O)CNC(=O)C(NC(=O)C(CO)NC(=O)C(CC=1C2=CC=CC=C2NC=1)NC(=O)C(CC=1NC=NC=1)NC(=O)C1NC(=O)CC1)CC1=CC=C(O)C=C1 NMJREATYWWNIKX-UHFFFAOYSA-N 0.000 abstract 1
- 101000857870 Squalus acanthias Gonadoliberin Proteins 0.000 abstract 1
- 150000001371 alpha-amino acids Chemical class 0.000 abstract 1
- 235000008206 alpha-amino acids Nutrition 0.000 abstract 1
- 125000005647 linker group Chemical group 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 230000035938 sexual maturation Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/23—Luteinising hormone-releasing hormone [LHRH]; Related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/26—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against hormones ; against hormone releasing or inhibiting factors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/42—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins
- C07K16/4208—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig
- C07K16/4241—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig against anti-human or anti-animal Ig
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Endocrinology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Physics & Mathematics (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Reproductive Health (AREA)
- Peptides Or Proteins (AREA)
- Magnetic Resonance Imaging Apparatus (AREA)
- Circuits Of Receivers In General (AREA)
- Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)
Abstract
An analog of piscine GnRH is disclosed having the amino acid sequence: pGlu-His-Trp-Ser-Tyr-W-Trp-Leu-Arg-Pro-Gly-X-Y-Z wherein W represents Gly or a D-amino acid, X represents a bond, or one or more amino acids which may be the same or different, Y represents Cys or Tyr or is absent, and Z is absent or represents one or more amino acids which may be the same or different or a continuous or discontinuous peptide chain, the or each discontinuity being a non- alpha amino acid polyfunctional linker moiety or a retro-inverso amino acid with the proviso that when W is Gly and X and Y are absent Z is present. The analog may be conjugated to a carrier and used, for example, to delay onset of sexual maturation and enhance growth.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB919100468A GB9100468D0 (en) | 1991-01-09 | 1991-01-09 | Improvements in and relating to hormones |
| PCT/GB1992/000040 WO1992012247A1 (en) | 1991-01-09 | 1992-01-08 | Analogs of piscine lhrh |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| GB9314141D0 GB9314141D0 (en) | 1993-09-22 |
| GB2267496A true GB2267496A (en) | 1993-12-08 |
| GB2267496B GB2267496B (en) | 1994-09-07 |
Family
ID=10688207
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB919100468A Pending GB9100468D0 (en) | 1991-01-09 | 1991-01-09 | Improvements in and relating to hormones |
| GB9314141A Expired - Fee Related GB2267496B (en) | 1991-01-09 | 1993-07-08 | Analogs of piscine LHRH |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB919100468A Pending GB9100468D0 (en) | 1991-01-09 | 1991-01-09 | Improvements in and relating to hormones |
Country Status (17)
| Country | Link |
|---|---|
| EP (1) | EP0566611A1 (en) |
| JP (1) | JPH06504537A (en) |
| KR (1) | KR930703444A (en) |
| CN (1) | CN1063109A (en) |
| AU (1) | AU652611B2 (en) |
| CA (1) | CA2100057A1 (en) |
| DK (1) | DK80993A (en) |
| FI (1) | FI933138A (en) |
| GB (2) | GB9100468D0 (en) |
| HU (1) | HUT66829A (en) |
| IE (1) | IE920055A1 (en) |
| IS (1) | IS3802A (en) |
| NO (1) | NO932491L (en) |
| NZ (1) | NZ241240A (en) |
| PT (1) | PT99991A (en) |
| WO (1) | WO1992012247A1 (en) |
| ZW (1) | ZW392A1 (en) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR9306984A (en) * | 1992-08-27 | 1999-01-12 | Deakin Res Ltd | Peptide antigen analog of a native peptide antigen vaccine antibody process to vaccinate a host in need of this treatment kit diagnostic processes to prepare an antigen analog of a native peptide antigen to prepare a vaccine to analyze a sample for a peptide antigen native and to analyze a sample for an antibody |
| US5688506A (en) * | 1994-01-27 | 1997-11-18 | Aphton Corp. | Immunogens against gonadotropin releasing hormone |
| US5760000A (en) * | 1994-05-13 | 1998-06-02 | University Technologies International,Inc. | Inhibition of liver cancer by the use of GnRH and GnRH analogs |
| AU1765300A (en) * | 1998-12-22 | 2000-07-12 | Dalhousie University | Compositions and methods for reducing or preventing fertilization in fish and birds |
| GB0226179D0 (en) | 2002-11-09 | 2002-12-18 | Millar Robert P | Vaccine |
| NO20075894L (en) * | 2007-11-15 | 2009-05-18 | Thia Medica As | Reduced maturation in fish |
| WO2017090722A1 (en) * | 2015-11-27 | 2017-06-01 | 日本水産株式会社 | Cell membrane-permeable peptide and fish feed using cell membrane-permeable peptide |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1984001771A1 (en) * | 1982-11-01 | 1984-05-10 | Salk Inst For Biological Studi | Peptides affecting gonadal function |
| EP0181236A2 (en) * | 1984-11-09 | 1986-05-14 | Pitman-Moore, Inc. | LHRH analogues useful in stimulating anti-LHRH antibodies and vaccines containing such analogues |
| EP0293530A2 (en) * | 1987-06-05 | 1988-12-07 | Proteus Molecular Design Limited | Improvements in or relating to hormones |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4410514A (en) * | 1982-12-06 | 1983-10-18 | The Salk Institute For Biological Studies | GnRH Agonists |
| CA2112566A1 (en) * | 1991-07-01 | 1993-02-18 | Graham J. Moore | Non-desensitizing analogs of gnrh and other biologically active ligands |
-
1991
- 1991-01-09 GB GB919100468A patent/GB9100468D0/en active Pending
-
1992
- 1992-01-07 NZ NZ241240A patent/NZ241240A/en unknown
- 1992-01-08 AU AU11617/92A patent/AU652611B2/en not_active Ceased
- 1992-01-08 CA CA002100057A patent/CA2100057A1/en not_active Abandoned
- 1992-01-08 KR KR1019930702060A patent/KR930703444A/en not_active Application Discontinuation
- 1992-01-08 WO PCT/GB1992/000040 patent/WO1992012247A1/en not_active Application Discontinuation
- 1992-01-08 HU HU9301979A patent/HUT66829A/en unknown
- 1992-01-08 PT PT99991A patent/PT99991A/en not_active Application Discontinuation
- 1992-01-08 EP EP92902189A patent/EP0566611A1/en not_active Withdrawn
- 1992-01-08 IS IS3802A patent/IS3802A/en unknown
- 1992-01-08 IE IE005592A patent/IE920055A1/en not_active Application Discontinuation
- 1992-01-08 JP JP4502565A patent/JPH06504537A/en active Pending
- 1992-01-09 ZW ZW3/92A patent/ZW392A1/en unknown
- 1992-01-09 CN CN92100141A patent/CN1063109A/en active Pending
-
1993
- 1993-07-06 DK DK080993A patent/DK80993A/en not_active Application Discontinuation
- 1993-07-08 GB GB9314141A patent/GB2267496B/en not_active Expired - Fee Related
- 1993-07-08 NO NO93932491A patent/NO932491L/en unknown
- 1993-07-08 FI FI933138A patent/FI933138A/en not_active Application Discontinuation
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1984001771A1 (en) * | 1982-11-01 | 1984-05-10 | Salk Inst For Biological Studi | Peptides affecting gonadal function |
| EP0181236A2 (en) * | 1984-11-09 | 1986-05-14 | Pitman-Moore, Inc. | LHRH analogues useful in stimulating anti-LHRH antibodies and vaccines containing such analogues |
| EP0293530A2 (en) * | 1987-06-05 | 1988-12-07 | Proteus Molecular Design Limited | Improvements in or relating to hormones |
Non-Patent Citations (2)
| Title |
|---|
| EMBO J. 1988,7(1),93-100 * |
| FEBS Letters 1987,214(1),65-70 * |
Also Published As
| Publication number | Publication date |
|---|---|
| AU1161792A (en) | 1992-08-17 |
| HUT66829A (en) | 1995-01-30 |
| EP0566611A1 (en) | 1993-10-27 |
| HU9301979D0 (en) | 1993-11-29 |
| KR930703444A (en) | 1993-11-30 |
| FI933138A0 (en) | 1993-07-08 |
| IE920055A1 (en) | 1992-07-15 |
| GB2267496B (en) | 1994-09-07 |
| IS3802A (en) | 1992-07-10 |
| WO1992012247A1 (en) | 1992-07-23 |
| DK80993D0 (en) | 1993-07-06 |
| NO932491D0 (en) | 1993-07-08 |
| PT99991A (en) | 1993-01-29 |
| GB9314141D0 (en) | 1993-09-22 |
| GB9100468D0 (en) | 1991-02-20 |
| FI933138A (en) | 1993-07-08 |
| ZW392A1 (en) | 1992-07-22 |
| CA2100057A1 (en) | 1992-07-10 |
| CN1063109A (en) | 1992-07-29 |
| DK80993A (en) | 1993-07-06 |
| AU652611B2 (en) | 1994-09-01 |
| NZ241240A (en) | 1992-11-25 |
| NO932491L (en) | 1993-07-08 |
| JPH06504537A (en) | 1994-05-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PCNP | Patent ceased through non-payment of renewal fee |
Effective date: 19960108 |