EP0550626A4 - Method of improving the yield of heterologous proteins produced by streptomyces lividans - Google Patents

Method of improving the yield of heterologous proteins produced by streptomyces lividans

Info

Publication number
EP0550626A4
EP0550626A4 EP19910917765 EP91917765A EP0550626A4 EP 0550626 A4 EP0550626 A4 EP 0550626A4 EP 19910917765 EP19910917765 EP 19910917765 EP 91917765 A EP91917765 A EP 91917765A EP 0550626 A4 EP0550626 A4 EP 0550626A4
Authority
EP
European Patent Office
Prior art keywords
yield
improving
heterologous proteins
proteins produced
streptomyces lividans
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP19910917765
Other languages
English (en)
Other versions
EP0550626A1 (en
Inventor
Edward J. Arcuri
Mary E. Brawner
Mary Jo Donovan
Robert G. Gerber
John A. Keller
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Corp
Original Assignee
SmithKline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SmithKline Beecham Corp filed Critical SmithKline Beecham Corp
Publication of EP0550626A1 publication Critical patent/EP0550626A1/en
Publication of EP0550626A4 publication Critical patent/EP0550626A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70514—CD4
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • C12N15/76—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for Actinomyces; for Streptomyces

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Cell Biology (AREA)
  • Physics & Mathematics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Plant Pathology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
EP19910917765 1990-09-28 1991-09-20 Method of improving the yield of heterologous proteins produced by streptomyces lividans Withdrawn EP0550626A4 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US589979 1990-09-28
US07/589,979 US5223418A (en) 1990-09-28 1990-09-28 Method of improving the yield of heterologous proteins produced by streptomyces lividans

Publications (2)

Publication Number Publication Date
EP0550626A1 EP0550626A1 (en) 1993-07-14
EP0550626A4 true EP0550626A4 (en) 1993-09-15

Family

ID=24360383

Family Applications (1)

Application Number Title Priority Date Filing Date
EP19910917765 Withdrawn EP0550626A4 (en) 1990-09-28 1991-09-20 Method of improving the yield of heterologous proteins produced by streptomyces lividans

Country Status (11)

Country Link
US (1) US5223418A (pt)
EP (1) EP0550626A4 (pt)
JP (1) JPH06501390A (pt)
AU (1) AU653178B2 (pt)
CA (1) CA2090965A1 (pt)
IE (1) IE913347A1 (pt)
MX (1) MX9101259A (pt)
NZ (1) NZ239898A (pt)
PT (1) PT99049A (pt)
WO (1) WO1992006175A1 (pt)
ZA (1) ZA917558B (pt)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU5209399A (en) 1998-07-10 2000-02-01 Cornell Research Foundation Inc. Recombinant constructs and systems for secretion of proteins via type iii secretion systems
US6255099B1 (en) 2000-02-17 2001-07-03 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College High-yield dual-buffered bacterial growth medium
CN102517244B (zh) * 2011-12-31 2014-02-19 北京林业大学 一种提高螺旋藻金属硫蛋白含量的方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0331356A2 (en) * 1988-02-24 1989-09-06 Smithkline Beckman Corporation Expression of HIV binding proteins

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4717666A (en) * 1984-03-05 1988-01-05 Smithkline Beckman Corporation Cloned streptomycete lividans excretable β-galactosidase gene
US4894334A (en) * 1984-03-28 1990-01-16 Cetus Corporation Method of improving the yield of heterologous protein produced by cultivating recombinant bacteria
US4656132A (en) * 1984-03-28 1987-04-07 Cetus Corporation Method of improving the yield of heterologous protein produced by cultivating recombinant bacteria
US4745056A (en) * 1984-10-23 1988-05-17 Biotechnica International, Inc. Streptomyces secretion vector
JPS62179381A (ja) * 1986-01-31 1987-08-06 Nisshin Seika Kk 高分泌プロテア−ゼ活性の機能を有する微生物の製造方法
JPS62179382A (ja) * 1986-01-31 1987-08-06 Nisshin Seika Kk Ｂａｃｉｌｌｕｓ属の菌体外分泌酵素の培地組成
DE3751131T2 (de) * 1986-08-18 1995-07-06 Smithkline Beckman Corp Proteinartiger Proteaseinhibitor aus Streptomyces.

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0331356A2 (en) * 1988-02-24 1989-09-06 Smithkline Beckman Corporation Expression of HIV binding proteins

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
PATENT ABSTRACTS OF JAPAN vol. 012, no. 028 (C-471)27 January 1988 & JP-A-62 179 381 ( NISSHIN SEIKA KK ) *
PATENT ABSTRACTS OF JAPAN vol. 12, no. 28 (C-471)27 January 1988 & JP-A-62 179 382 ( NISSHIN SEIKA KK ) *
See also references of WO9206175A1 *

Also Published As

Publication number Publication date
CA2090965A1 (en) 1992-03-29
PT99049A (pt) 1992-08-31
IE913347A1 (en) 1992-11-18
MX9101259A (es) 1993-09-01
NZ239898A (en) 1993-09-27
WO1992006175A1 (en) 1992-04-16
JPH06501390A (ja) 1994-02-17
AU8715891A (en) 1992-04-28
AU653178B2 (en) 1994-09-22
EP0550626A1 (en) 1993-07-14
ZA917558B (en) 1992-06-24
US5223418A (en) 1993-06-29

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Legal Events

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PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

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17P Request for examination filed

Effective date: 19930310

AK Designated contracting states

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A4 Supplementary search report drawn up and despatched

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Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 19960407