EP0538371A4 - Streptomyces vectors for production of heterologous proteins - Google Patents

Streptomyces vectors for production of heterologous proteins

Info

Publication number
EP0538371A4
EP0538371A4 EP19910913400 EP91913400A EP0538371A4 EP 0538371 A4 EP0538371 A4 EP 0538371A4 EP 19910913400 EP19910913400 EP 19910913400 EP 91913400 A EP91913400 A EP 91913400A EP 0538371 A4 EP0538371 A4 EP 0538371A4
Authority
EP
European Patent Office
Prior art keywords
production
heterologous proteins
streptomyces vectors
streptomyces
vectors
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP19910913400
Other versions
EP0538371A1 (en
Inventor
Mary Ellen Brawner
James Allan Fornwald
James 380 Curtner Avenue Arthos
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Corp
Original Assignee
SmithKline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SmithKline Beecham Corp filed Critical SmithKline Beecham Corp
Publication of EP0538371A1 publication Critical patent/EP0538371A1/en
Publication of EP0538371A4 publication Critical patent/EP0538371A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/66—General methods for inserting a gene into a vector to form a recombinant vector using cleavage and ligation; Use of non-functional linkers or adaptors, e.g. linkers containing the sequence for a restriction endonuclease
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70514—CD4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/36—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Actinomyces; from Streptomyces (G)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • C12N15/76—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for Actinomyces; for Streptomyces
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/036—Fusion polypeptide containing a localisation/targetting motif targeting to the medium outside of the cell, e.g. type III secretion
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/32—Fusion polypeptide fusions with soluble part of a cell surface receptor, "decoy receptors"

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Cell Biology (AREA)
  • Toxicology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
EP19910913400 1990-07-11 1991-07-01 Streptomyces vectors for production of heterologous proteins Withdrawn EP0538371A4 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US55158490A 1990-07-11 1990-07-11
US551584 1990-07-11
US66521891A 1991-03-05 1991-03-05
US665218 2003-09-17

Publications (2)

Publication Number Publication Date
EP0538371A1 EP0538371A1 (en) 1993-04-28
EP0538371A4 true EP0538371A4 (en) 1993-08-04

Family

ID=27069812

Family Applications (1)

Application Number Title Priority Date Filing Date
EP19910913400 Withdrawn EP0538371A4 (en) 1990-07-11 1991-07-01 Streptomyces vectors for production of heterologous proteins

Country Status (8)

Country Link
EP (1) EP0538371A4 (en)
JP (1) JPH05508995A (en)
KR (1) KR930701464A (en)
AU (1) AU8239091A (en)
CA (1) CA2087017A1 (en)
IE (1) IE912416A1 (en)
NZ (1) NZ238888A (en)
WO (1) WO1992000985A1 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH08503125A (en) 1992-08-07 1996-04-09 プロジェニクス・ファーマスーティカルス・インコーポレーテッド CD4-gamma2 and CD4-IgG2 immunoconjugates complexed with non-peptidyl components and uses thereof
KR101879852B1 (en) * 2017-04-28 2018-07-19 주식회사 만방바이오 Novel Streptomyces sp. strain and use thereof
JP2021518171A (en) * 2018-03-21 2021-08-02 ザ スクリプス リサーチ インスティテュート CD4 Mutane and how to use it

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0264175A1 (en) * 1986-08-18 1988-04-20 Smithkline Beecham Corporation Protein protease inhibitor from streptomyces

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1295567C (en) * 1988-07-25 1992-02-11 Lawrence T. Malek Expression system for the secretion of bioactive human granulocyte, macrophage-colony stimulating factor (gm-csf) and other heterologous proteins from streptomyces
AU1299988A (en) * 1987-03-09 1988-10-10 Cetus Corporation Expression of heterologous genes in streptomyces species
AU3006789A (en) * 1988-02-24 1989-08-24 Smithkline Beckman Corporation Expression of hiv binding proteins

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0264175A1 (en) * 1986-08-18 1988-04-20 Smithkline Beecham Corporation Protein protease inhibitor from streptomyces

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
J. CELL. BIOCHEM. SUPPL O vol. 14A, 1990, page 103 M. BRAWNER ET AL. 'Expression of the soluble cd-4 receptor in sytreptomyces' *
NATURE vol. 339, no. 6219, 4 May 1989, MACMILLAN JOURNALS LTD., LONDON,UK; pages 68 - 70 A. TRAUNECKER ET AL. 'Highly efficient neutralization of HIV with recombinant CD4.immunglobulin molecules' *
See also references of WO9200985A1 *

Also Published As

Publication number Publication date
WO1992000985A1 (en) 1992-01-23
AU8239091A (en) 1992-02-04
KR930701464A (en) 1993-06-11
EP0538371A1 (en) 1993-04-28
CA2087017A1 (en) 1992-01-12
IE912416A1 (en) 1992-01-15
NZ238888A (en) 1993-08-26
JPH05508995A (en) 1993-12-16

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Legal Events

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PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

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Effective date: 19930121

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Effective date: 19930615

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Effective date: 19930212