EP0545000B1 - An improved vessel for perfusion liquids - Google Patents

An improved vessel for perfusion liquids Download PDF

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Publication number
EP0545000B1
EP0545000B1 EP92114011A EP92114011A EP0545000B1 EP 0545000 B1 EP0545000 B1 EP 0545000B1 EP 92114011 A EP92114011 A EP 92114011A EP 92114011 A EP92114011 A EP 92114011A EP 0545000 B1 EP0545000 B1 EP 0545000B1
Authority
EP
European Patent Office
Prior art keywords
vessel
filling
perfusion
tubular body
microfilter
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
EP92114011A
Other languages
German (de)
English (en)
French (fr)
Other versions
EP0545000A1 (en
Inventor
Victor Grifols Lucas
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of EP0545000A1 publication Critical patent/EP0545000A1/en
Application granted granted Critical
Publication of EP0545000B1 publication Critical patent/EP0545000B1/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/05—Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
    • A61J1/10—Bag-type containers

Definitions

  • This invention refers to an improved vessel for containing perfusion liquids offering important novel characteristics in its utilization with respect to currently known vessels used for this purpose.
  • Perfusion liquid containers are used generally for the various types of fluids destined for perfusion or injection in the human body, their particular requirement being that they should contain the said fluid under sterile conditions which condition must be maintained up to the moment of the application of the fluid in a clinical operation.
  • a perfusion liquid vessel of this improved type is disclosed in, e.g. EP-A-0 116 362, having a flattened form, closed at one extremity and having connected to the other extremity a filling tube with a microfilter integrally formed therein for filling the vessel with a perfusion liquid, whereby the microfilter, when still in wet condition after a perfusion liquid has been filled into the vessel, prevents the passage of air under atmospheric pressure and permits its correct functioning to be verified by a bubble point test, and the vessel having also a zone where a syringe or abstraction needle of a catheter feed tube can be inserted.
  • the filling tube and the zone where the syringe can be inserted are located apart from each other at opposite ends of the vessel.
  • US-A-4 265 242, US-A-4 265 760, DE-A-33 33 283 and WO-A-92/12697 disclose similar perfusion liquid vessels.
  • This object is solved by providing the vessel at its upper extremity with a detachable element having a first tubular body and essentially parallel thereto a second tubular body, the first tubular body accomodating the filling tube protruding therefrom and the second tubular body forming the zone where the syringe or abstraction needle can be inserted and having at some intermediate position a thin diaphragm and at its upper extremity a manually operable closure tab.
  • the vessel which is the object of this invention has built therein a tube for filling the vessel and which tube has integral with it and inalienable thereto a sterilizing membrane filter with a porosity of between 0,20 and 0,25 microns, for preference being 0,22 microns maximum, such that filling the vessel is coincident with a sterilization action and then, having filled the vessel, given the considerable capilliary force exercised in passages of this fineness, air flow is prevented unless the pressure attains some 3 bars, this phenomenum permitting verification and eventually the integrity and correct operation of the filter.
  • This effect facilitates the control of the filter's correct operation since due to the surface tension in the fine passages of the filter the above pressure is required to overcome this tension and allow air to infiltrate the vessel.
  • Figure 1 shows a frontal view of the vessel in its vertical position.
  • Figure 2 is a cross sectional view on the plane so indicated in figure 1.
  • Figure 3 shows the detail of the filling tube assembly with its incorporated filter in cross-section.
  • Figure 4 is a cross sectional view on the plane so indicated in figure 3.
  • Figure 5 is a cross sectional view on the plane so indicated in figure 3.
  • this invention comprises a vessel -1-, made of a synthetic material that is clinically compatible having a flattened form generally, the front and rear faces -2- and -3- respectively being generally planar with the upper -5- and lower zones -4-being formed with half round or similar ribbing or projections so as to provide an adequate stiffness and strength to those areas.
  • the upper zone -5- has incorporated therein the filling tube -6- with the sterilization filter -7- in its upper part, integral with it and forming part of the inviolable system of a non-detachable assembly.
  • the filter has a porosity of between 0,20 and 0,25 microns, but preferably not exceeding 0,22 microns such that the vessel can be filled with the perfusion fluid through the tube -6- while the fluid's passage through the filter -7- effects its sterilization and thereafter this same filter with its above dimensioned pores operates as a stopper or closure in that for air to infiltrate through it a pressure of some 3 bars would have to be applied, this feature also providing an effective control by which the sterilizing characteristic of the filter may be monitored.
  • the vessel is provided with an access tube -8- parallel to the filling tube incorporating a thin diaphragm -9- which can be perforated by the needle of the perfusion catheter feed tube.
  • an access tube -8- parallel to the filling tube incorporating a thin diaphragm -9- which can be perforated by the needle of the perfusion catheter feed tube.
  • a further stopper or plug -10- is also fitted to the upper part of the orifice -8- with a tab -11- attached thereto to facilitate its opening but ensuring its closure until the time of its utilization.
  • Figure 3 shows the filter -7- as having two flat components -12- and -13- joined together by welding or pressing, the piece -13- having as part of it the filler tube -14- and the piece -12- being extended by a tubular connection -15- for attachment by welding or adhesive to the upper end of the tubular component -6-.

Landscapes

  • Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • External Artificial Organs (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
EP92114011A 1991-12-05 1992-08-17 An improved vessel for perfusion liquids Expired - Lifetime EP0545000B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ES9103692U 1991-12-05
ES19919103692U ES1019546Y (es) 1991-12-05 1991-12-05 Bolsa para liquidos de perfusion, perfeccionada.

Publications (2)

Publication Number Publication Date
EP0545000A1 EP0545000A1 (en) 1993-06-09
EP0545000B1 true EP0545000B1 (en) 1997-10-29

Family

ID=8275372

Family Applications (1)

Application Number Title Priority Date Filing Date
EP92114011A Expired - Lifetime EP0545000B1 (en) 1991-12-05 1992-08-17 An improved vessel for perfusion liquids

Country Status (10)

Country Link
EP (1) EP0545000B1 (it)
JP (1) JP2622056B2 (it)
AT (1) ATE159653T1 (it)
BR (1) BR7201541U (it)
CH (1) CH687585A5 (it)
DE (1) DE69222922T2 (it)
ES (2) ES1019546Y (it)
IT (1) IT1261651B (it)
MX (1) MX64B (it)
PT (1) PT100782B (it)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10617603B2 (en) 2016-01-22 2020-04-14 Baxter International Inc. Sterile solutions product bag
US11021275B2 (en) 2016-01-22 2021-06-01 Baxter International Inc. Method and machine for producing sterile solution product bags

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE168553T1 (de) * 1993-06-25 1998-08-15 Alcon Cusi S A Neue verwendung von polymeren membranen zum ausgeben von pharmazeutischen lösungen, die quarternäre, als konserviermittel dienende ammoniumverbindungen enthalten und entsprechender dosierbehälter
ES2070777B1 (es) * 1993-10-05 1995-12-16 Mejias David Gonzalez Recipiente sanitario para analisis de orina con adaptador femenino.
EP1236644B1 (en) 2001-02-28 2007-01-03 Grifols, S.A. Apparatus for filling containers for pharmaceutical uses and the like
ES2946064T3 (es) 2019-03-26 2023-07-12 Grifols Sa Procedimiento de calibración de una bomba peristáltica, procedimiento de dispensación de una cantidad de líquido mediante una bomba peristáltica y dispositivo para la elaboración de preparaciones estériles que puede ejecutar los mismos

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4265760A (en) * 1979-02-26 1981-05-05 Becton Dickinson & Company Device for dilution and delivery of in vivo chemicals
US4265242A (en) * 1979-07-23 1981-05-05 Cohen Milton J Filter device for injectable fluid
EP0116362A3 (en) * 1983-02-11 1985-05-15 Millipore Corporation Sterile package for therapeutic composition
DE3316043A1 (de) * 1983-05-03 1984-11-08 Sartorius GmbH, 3400 Göttingen Kleinfilter fuer die gasfiltration
DE3333283A1 (de) * 1983-09-15 1985-04-18 Gerhard 3429 Krebeck Lorenz Aufbereitungssystem fuer infusionsloesungen
US4906103A (en) * 1984-05-30 1990-03-06 Ti Kao Devices and methods for preparing a solution for medicinal purposes
US5484431A (en) * 1991-01-29 1996-01-16 The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration System for creating at a site, remote from a sterile environment, a parenteral solution

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10617603B2 (en) 2016-01-22 2020-04-14 Baxter International Inc. Sterile solutions product bag
US11021275B2 (en) 2016-01-22 2021-06-01 Baxter International Inc. Method and machine for producing sterile solution product bags
US11564867B2 (en) 2016-01-22 2023-01-31 Baxter International Inc. Sterile solutions product bag
US11623773B2 (en) 2016-01-22 2023-04-11 Baxter International Inc. Method and machine for producing sterile solution product bags

Also Published As

Publication number Publication date
ITMI922073A0 (it) 1992-09-07
IT1261651B (it) 1996-05-28
CH687585A5 (it) 1997-01-15
JPH05212115A (ja) 1993-08-24
MX64B (es) 1993-08-03
ES1019546U (es) 1992-04-01
ATE159653T1 (de) 1997-11-15
ITMI922073A1 (it) 1994-03-07
EP0545000A1 (en) 1993-06-09
JP2622056B2 (ja) 1997-06-18
PT100782B (pt) 1999-09-30
ES2110457T3 (es) 1998-02-16
ES1019546Y (es) 1992-11-01
DE69222922T2 (de) 1998-04-09
DE69222922D1 (de) 1997-12-04
PT100782A (pt) 1994-05-31
BR7201541U (pt) 1993-08-03

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