EP0528468A1 - Verwendung von Triclosan zur Herstellung eines Arzneimittels zur Inhibierung der Cyclooxygenase - Google Patents

Verwendung von Triclosan zur Herstellung eines Arzneimittels zur Inhibierung der Cyclooxygenase Download PDF

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Publication number
EP0528468A1
EP0528468A1 EP92202287A EP92202287A EP0528468A1 EP 0528468 A1 EP0528468 A1 EP 0528468A1 EP 92202287 A EP92202287 A EP 92202287A EP 92202287 A EP92202287 A EP 92202287A EP 0528468 A1 EP0528468 A1 EP 0528468A1
Authority
EP
European Patent Office
Prior art keywords
triclosan
medicament
cyclo
manufacture
oxygenase
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP92202287A
Other languages
English (en)
French (fr)
Other versions
EP0528468B1 (de
Inventor
Franciscus J. Unilever Research Van Der Ouderaa
Diane Unilever Research Cummins
Derek Michael C. Unilever Research Hull
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Unilever PLC
Unilever NV
Original Assignee
Unilever PLC
Unilever NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Unilever PLC, Unilever NV filed Critical Unilever PLC
Publication of EP0528468A1 publication Critical patent/EP0528468A1/de
Application granted granted Critical
Publication of EP0528468B1 publication Critical patent/EP0528468B1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/075—Ethers or acetals
    • A61K31/085—Ethers or acetals having an ether linkage to aromatic ring nuclear carbon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/27—Zinc; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A61K8/347—Phenols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/36—Carboxylic acids; Salts or anhydrides thereof
    • A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/74—Biological properties of particular ingredients
    • A61K2800/78—Enzyme modulators, e.g. Enzyme agonists
    • A61K2800/782—Enzyme inhibitors; Enzyme antagonists
EP92202287A 1991-08-08 1992-07-24 Verwendung von Triclosan zur Herstellung eines Arzneimittels zur Inhibierung der Cyclooxygenase Expired - Lifetime EP0528468B1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB919117140A GB9117140D0 (en) 1991-08-08 1991-08-08 Treatment of periodontitis
GB9117140 1991-08-08

Publications (2)

Publication Number Publication Date
EP0528468A1 true EP0528468A1 (de) 1993-02-24
EP0528468B1 EP0528468B1 (de) 1996-03-20

Family

ID=10699703

Family Applications (1)

Application Number Title Priority Date Filing Date
EP92202287A Expired - Lifetime EP0528468B1 (de) 1991-08-08 1992-07-24 Verwendung von Triclosan zur Herstellung eines Arzneimittels zur Inhibierung der Cyclooxygenase

Country Status (8)

Country Link
US (1) US5240696A (de)
EP (1) EP0528468B1 (de)
JP (1) JPH05194203A (de)
AT (1) ATE135569T1 (de)
AU (1) AU2081592A (de)
CA (1) CA2075551C (de)
DE (1) DE69209190T2 (de)
GB (1) GB9117140D0 (de)

Cited By (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994026258A1 (en) * 1993-05-13 1994-11-24 Unilever N.V. Oral compositions containing triclosan for the treatment of aphthous ulcers
US5945089A (en) * 1998-11-05 1999-08-31 I-Dent International Corporation Method of treating mucositis
US5998487A (en) * 1998-04-08 1999-12-07 Colgate-Palmolive Company Anti-inflammatory and antibacterial benzyl phenol agents and their use in oral compositions
WO2000006109A1 (de) * 1998-07-30 2000-02-10 Henkel Kommanditgesellschaft Auf Aktien Entzündungshemmende zahnpflegemittel
US6045800A (en) * 1997-10-02 2000-04-04 Lg Chemical Ltd. Composition for preventing or treating periodontal diseases comprising extract from Achyranthis radix or Ulmus cortex
EP0992238A1 (de) * 1998-10-06 2000-04-12 I-Dent International Corporation Verwendung von Triclosan zur Behandlung und Prävention von mukosale und dermatologische Beschwerden
US6440395B1 (en) 1992-06-22 2002-08-27 Barry M. Libin Antiplaque mouth rinse
WO2003061704A2 (en) * 2002-01-23 2003-07-31 Pharmacia & Upjohn Company Combination therapy for the treatment of bacterial infections
EP1508323A1 (de) * 2003-08-20 2005-02-23 Unilever N.V. Verwendung einer zinkhaltigen oralen Zubereitung
WO2007082181A3 (en) * 2006-01-10 2007-09-27 Colgate Palmolive Co Methods of modulating cell surface receptors to prevent or reduce inflammation
US8617523B2 (en) 2009-04-01 2013-12-31 Colgate-Palmolive Company Anti-biofilm carbonate compounds for use in oral care compositions
US8637266B2 (en) 2009-04-01 2014-01-28 Colgate-Palmolive Company Anti bone-loss and anti attachment-loss effects of an oral composition
US8753820B2 (en) 2009-04-01 2014-06-17 Colgate-Palmolive Company Protein biomarkers for soft tissue disease diagnosis and as therapeutic targets for oral care intervention
US9968803B2 (en) 2009-10-29 2018-05-15 Colgate-Palmolive Company Low water stannous fluoride plus zinc citrate dentifrice with improved stability, rheology, and efficacy
US10426752B2 (en) 2009-04-01 2019-10-01 Colgate-Palmolive Company Menthol-derivative compounds and use thereof as oral and systemic active agents

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2979446B2 (ja) * 1991-11-06 1999-11-15 ライオン株式会社 口腔用組成物
US5843409A (en) * 1994-08-08 1998-12-01 Colgate Palmolive Company Two component dentifrice for the treatment of dentinal hypersensitivity
US5807541A (en) * 1996-04-22 1998-09-15 Sepracor, Inc. NSAID/fluoride periodontal compositions and methods
US5958911A (en) * 1996-11-05 1999-09-28 The Research Foundation Of State University Of New York Method of relieving inflammation by using 5-alkylsulfonylsalicylanilides
US5932192A (en) * 1997-04-23 1999-08-03 Colgate-Palmolive Company Lower astringent two component stannous and potassium salt containing dentifrice
US6117859A (en) * 1997-11-04 2000-09-12 The Research Foundation Of State University Of New York Method of relieving chronic inflammation by using 5-alkylsulfonylsalicylanilides
ES2248015T3 (es) 1999-03-12 2006-03-16 Pfizer Products Inc. Composiciones orales que comprenden una sal de potasio para reducir la sensibilidad del nervio central y de la dentina.
CN1347304A (zh) * 1999-04-19 2002-05-01 荷兰联合利华有限公司 口腔护理组合物
FR2812190B1 (fr) * 2000-07-28 2003-01-31 Oreal Utilisation d'agonistes non prostanoiques des recepteurs des prostaglandines ep-2 et/ou ep-4 comme agent cosmetique permettant d'attenuer, de diminuer ou d'arreter la chute des cheveux et des poils
FR2812192B1 (fr) * 2000-07-28 2003-01-31 Oreal Utilisation d'antagonistes de recepteur des prostaglandines ep-3 comme agent cosmetique permettant d'attenuer, de diminuer ou d'arreter la chute des cheveux et des poils
ES2214135B1 (es) * 2003-02-21 2005-05-01 Laboratorios Kin S.A. Composicion para el tratamiento de la cavidad bucal y utilizaciones correspondientes.
US20060134025A1 (en) * 2004-12-17 2006-06-22 Colgate-Palmolive Company Oral compositions containing extracts of Rosmarinus and related methods
EP1827464A4 (de) * 2004-12-23 2010-06-23 Swiss American Products Inc Zusammensetzungen auf zinkbasis und anwendungsverfahren
AU2006330508B2 (en) * 2005-12-21 2010-02-25 Colgate-Palmolive Company Improved oral compositions comprising zinc citrate and/or tocopherol agents
US7897800B2 (en) 2006-02-03 2011-03-01 Jr Chem, Llc Chemical compositions and methods of making them
CA2641420C (en) 2006-02-03 2013-06-25 Jr Chem, Llc Anti-aging treatment using copper and zinc compositions
US7687650B2 (en) 2006-02-03 2010-03-30 Jr Chem, Llc Chemical compositions and methods of making them
US7867522B2 (en) 2006-09-28 2011-01-11 Jr Chem, Llc Method of wound/burn healing using copper-zinc compositions
US8273791B2 (en) 2008-01-04 2012-09-25 Jr Chem, Llc Compositions, kits and regimens for the treatment of skin, especially décolletage
WO2010085753A1 (en) 2009-01-23 2010-07-29 Jr Chem, Llc Rosacea treatments and kits for performing them
US8952057B2 (en) 2011-01-11 2015-02-10 Jr Chem, Llc Compositions for anorectal use and methods for treating anorectal disorders
EP2921173A1 (de) 2014-03-21 2015-09-23 Omya International AG Oberflächenreaktives Calciumkarbonat zum Desensibilisieren von Zähnen
JP7412869B2 (ja) * 2016-08-05 2024-01-15 小林製薬株式会社 歯肉ケア剤及びそれを含有する歯肉ケア用口腔用組成物

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0161898A2 (de) * 1984-05-09 1985-11-21 Unilever Plc Zahnpflegemittel
EP0295954A2 (de) * 1987-06-18 1988-12-21 Block Drug Company Inc. Präparate zur Behandlung von Beschwerden der Wurzelhaut der Zähne
EP0474597A2 (de) * 1990-09-05 1992-03-11 Ciba-Geigy Ag Arachidonsäurestoffwechselhemmende Diphenylverbindungen und ihre Verwendung in pharmazeutischen Zusammensetzungen
WO1992010994A1 (en) * 1990-12-18 1992-07-09 The Procter & Gamble Company Oral compositions effective against plaque and gingivitis

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DE2501548A1 (de) * 1974-01-25 1975-07-31 Procter & Gamble Mundbehandlungsmittel
GB1550139A (en) * 1975-07-04 1979-08-08 Gaba Ag Anti-inflammatory compositions for oral application
US4287191A (en) * 1980-04-14 1981-09-01 The Research Foundation Of State University Of New York Novel salicylanilides and microbiocidal compositions and uses thereof
US4358443A (en) * 1980-04-14 1982-11-09 The Research Foundation Of State University Of New York Method and composition for controlling the growth of microorganisms
GB2084870B (en) * 1980-10-10 1985-05-09 Muhlemann R Hans Oral compositions containing pyrimidine amine compounds and zinc salts
US4742083A (en) * 1983-08-24 1988-05-03 Lever Brothers Company Method of relieving pain and inflammatory conditions employing substituted salicylamides
US4575457A (en) * 1984-05-24 1986-03-11 American Home Products Corporation Periodontal toothpaste with wound-healing properties
US4664906A (en) * 1984-08-30 1987-05-12 Johnson & Johnson Products Inc. Oral compositions
GB8729564D0 (en) * 1987-12-18 1988-02-03 Unilever Plc Oral compositions
GB8922594D0 (en) * 1989-10-06 1989-11-22 Unilever Plc Oral compositions
US4961924A (en) * 1989-11-15 1990-10-09 Gillette Canada Inc. Stabilized stannous fluoride toothpaste
JPH03266468A (ja) * 1990-03-15 1991-11-27 Nec Corp 電界効果トランジスタ
US5015467A (en) * 1990-06-26 1991-05-14 The Procter & Gamble Company Combined anticalculus and antiplaque compositions
GB9107833D0 (en) * 1991-04-12 1991-05-29 Unilever Plc Treatment of periodontitis

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0161898A2 (de) * 1984-05-09 1985-11-21 Unilever Plc Zahnpflegemittel
EP0295954A2 (de) * 1987-06-18 1988-12-21 Block Drug Company Inc. Präparate zur Behandlung von Beschwerden der Wurzelhaut der Zähne
EP0474597A2 (de) * 1990-09-05 1992-03-11 Ciba-Geigy Ag Arachidonsäurestoffwechselhemmende Diphenylverbindungen und ihre Verwendung in pharmazeutischen Zusammensetzungen
WO1992010994A1 (en) * 1990-12-18 1992-07-09 The Procter & Gamble Company Oral compositions effective against plaque and gingivitis

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
AGENTS AND ACTIONS vol. 29, no. 3/4, 1990, pages 232 - 238; S.OFFENBACHER ET AL.: 'Inhibition of human periodontal prostaglandin E2 synthesis with selected agents' *
J.CLIN.PERIODONTOL. vol. 17, no. 8, 1990, pages 570 - 574; C.L.JONES ET AL.: 'Microbiological and clinical effects of a dentifrice containing zinc citrate and Triclosan in the human experimental gingivitis model' *
J.CLIN.PERIODONTOL. vol. 18, no. 6, July 1990, pages 462 - 467; P.D.MARSH: 'Dentifrices containing new agents for the control of plaque and gingivitis: microbiological aspects' *
J.CLIN.PERIODONTOL. vol. 18, no. 6, July 1991, pages 468 - 473; PER GJERMO ET AL.: 'Antibacterial dentifrices' *
R.BERKOW 'The Merck Manual' 1982 , MERCK SHARP & DOHME RESEARCH LABORATORIES , RAHWAY, N.J., USA *

Cited By (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6440395B1 (en) 1992-06-22 2002-08-27 Barry M. Libin Antiplaque mouth rinse
WO1994026258A1 (en) * 1993-05-13 1994-11-24 Unilever N.V. Oral compositions containing triclosan for the treatment of aphthous ulcers
US5500448A (en) * 1993-05-13 1996-03-19 Chesebrough-Pond's Usa Co., Division Of Conopoco, Inc. Recurrent aphthous ulcer treatment method
US6045800A (en) * 1997-10-02 2000-04-04 Lg Chemical Ltd. Composition for preventing or treating periodontal diseases comprising extract from Achyranthis radix or Ulmus cortex
US5998487A (en) * 1998-04-08 1999-12-07 Colgate-Palmolive Company Anti-inflammatory and antibacterial benzyl phenol agents and their use in oral compositions
WO2000006109A1 (de) * 1998-07-30 2000-02-10 Henkel Kommanditgesellschaft Auf Aktien Entzündungshemmende zahnpflegemittel
US6491899B1 (en) 1998-07-30 2002-12-10 Henkel Kommanditgesellschaft Auf Aktien Anti-inflammatory dental care agents
EP0992238A1 (de) * 1998-10-06 2000-04-12 I-Dent International Corporation Verwendung von Triclosan zur Behandlung und Prävention von mukosale und dermatologische Beschwerden
US5945089A (en) * 1998-11-05 1999-08-31 I-Dent International Corporation Method of treating mucositis
WO2003061704A2 (en) * 2002-01-23 2003-07-31 Pharmacia & Upjohn Company Combination therapy for the treatment of bacterial infections
WO2003061704A3 (en) * 2002-01-23 2003-12-18 Upjohn Co Combination therapy for the treatment of bacterial infections
EP1508323A1 (de) * 2003-08-20 2005-02-23 Unilever N.V. Verwendung einer zinkhaltigen oralen Zubereitung
WO2007082181A3 (en) * 2006-01-10 2007-09-27 Colgate Palmolive Co Methods of modulating cell surface receptors to prevent or reduce inflammation
EP2177621A3 (de) * 2006-01-10 2010-09-08 Colgate-Palmolive Company Verfahren zur Modulierung von Zellenoberflächenrezeptoren zur Vermeidung oder Verringerung von Entzündung
US9157914B2 (en) 2006-01-10 2015-10-13 Colgate-Palmolive Company Methods of modulating cell surface receptors to prevent or reduce inflammation
US8617523B2 (en) 2009-04-01 2013-12-31 Colgate-Palmolive Company Anti-biofilm carbonate compounds for use in oral care compositions
US8637266B2 (en) 2009-04-01 2014-01-28 Colgate-Palmolive Company Anti bone-loss and anti attachment-loss effects of an oral composition
US8753820B2 (en) 2009-04-01 2014-06-17 Colgate-Palmolive Company Protein biomarkers for soft tissue disease diagnosis and as therapeutic targets for oral care intervention
US10426752B2 (en) 2009-04-01 2019-10-01 Colgate-Palmolive Company Menthol-derivative compounds and use thereof as oral and systemic active agents
US9968803B2 (en) 2009-10-29 2018-05-15 Colgate-Palmolive Company Low water stannous fluoride plus zinc citrate dentifrice with improved stability, rheology, and efficacy
US10668306B2 (en) 2009-10-29 2020-06-02 Colgate-Palmolive Company Low water stannous fluoride plus zinc citrate dentifrice with improved stability, rheology, and efficacy
US10682532B2 (en) 2009-10-29 2020-06-16 Colgate-Palmolive Company Low water stannous fluoride plus zinc citrate dentifrice with improved stability, rheology, and efficacy
US11147992B2 (en) 2009-10-29 2021-10-19 Colgate-Palmolive Company Low water stannous fluoride plus zinc citrate dentifrice with improved stability, rheology, and efficacy
US11285342B2 (en) 2009-10-29 2022-03-29 Colgate-Palmolive Company Low water stannous fluoride plus zinc citrate dentifrice with improved stability, rheology, and efficacy

Also Published As

Publication number Publication date
US5240696A (en) 1993-08-31
GB9117140D0 (en) 1991-09-25
EP0528468B1 (de) 1996-03-20
AU2081592A (en) 1993-02-11
CA2075551A1 (en) 1993-02-09
DE69209190D1 (de) 1996-04-25
ATE135569T1 (de) 1996-04-15
JPH05194203A (ja) 1993-08-03
CA2075551C (en) 1996-05-07
DE69209190T2 (de) 1996-08-08

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