EP0516636B1 - Distributeur pour milieux - Google Patents
Distributeur pour milieux Download PDFInfo
- Publication number
- EP0516636B1 EP0516636B1 EP91902680A EP91902680A EP0516636B1 EP 0516636 B1 EP0516636 B1 EP 0516636B1 EP 91902680 A EP91902680 A EP 91902680A EP 91902680 A EP91902680 A EP 91902680A EP 0516636 B1 EP0516636 B1 EP 0516636B1
- Authority
- EP
- European Patent Office
- Prior art keywords
- valve
- valve body
- dispenser according
- piston
- channel portion
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000006073 displacement reaction Methods 0.000 claims description 13
- 239000007788 liquid Substances 0.000 abstract description 2
- 239000012530 fluid Substances 0.000 description 4
- 239000000463 material Substances 0.000 description 3
- 238000011161 development Methods 0.000 description 2
- 230000018109 developmental process Effects 0.000 description 2
- 210000003811 finger Anatomy 0.000 description 2
- 239000011521 glass Substances 0.000 description 2
- 230000005764 inhibitory process Effects 0.000 description 2
- 239000011324 bead Substances 0.000 description 1
- 238000013016 damping Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000013013 elastic material Substances 0.000 description 1
- 230000009969 flowable effect Effects 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- 235000011837 pasties Nutrition 0.000 description 1
- 238000005086 pumping Methods 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 210000003813 thumb Anatomy 0.000 description 1
- 230000007704 transition Effects 0.000 description 1
Images
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
- B05B11/00—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use
- B05B11/0005—Components or details
- B05B11/0062—Outlet valves actuated by the pressure of the fluid to be sprayed
- B05B11/007—Outlet valves actuated by the pressure of the fluid to be sprayed being opened by deformation of a sealing element made of resiliently deformable material, e.g. flaps, skirts, duck-bill valves
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
- B05B11/00—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use
- B05B11/0005—Components or details
- B05B11/0027—Means for neutralising the actuation of the sprayer ; Means for preventing access to the sprayer actuation means
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
- B05B11/00—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use
- B05B11/01—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use characterised by the means producing the flow
- B05B11/02—Membranes or pistons acting on the contents inside the container, e.g. follower pistons
Definitions
- the invention relates to a discharge device according to independent claims 1 and 10 for flowable and similar media, which can be gaseous, liquid, pasty, powdered or the like.
- a discharge device in which the pump chamber is formed by a cup-shaped container, in the middle of which a pin is formed, which protrudes with a sleeve into an outlet channel.
- the invention is based on the object, in particular to achieve a high degree of positional security or a very secure closure by the respective valve.
- At least one valve is fixed in at least one position, in particular in the closed position, by at least one escapement in the manner of a catch or the like, so that it e.g. in the case of an open position immovable or in the case of a closed position it can be held in this position in such a way that it only overcomes the inhibition with the application of a predetermined disengagement force and then suddenly in order to get into another position.
- the catch is expediently formed directly by the contact between a valve body and a valve seat.
- the valve body is designed to be axially symmetrical or centrically symmetrical, and it can be inserted as a self-contained structural unit with pretension in a channel section which forms a valve seat located in its jacket.
- the inhibition or detent can also be generated by a fluid against which the valve works under pressure changes during the transfer between two positions, so that there is a kind of fluid suspension or damping.
- the valve body can narrow a pressure chamber which is formed, for example, by a gas-filled or air-filled blind hole section adjoining the valve seat.
- the inhibiting force can be adjusted by changing the ratio between the two volumes of the pressure chamber belonging to the two valve positions.
- the fluid pressure can also be used as a return spring for returning the valve to at least one position, in particular the closed position.
- the discharge device can have a pressure chamber connected via an outlet channel to a discharge opening, such as a nozzle, and / or at least one valve, which can be an inlet valve, an outlet valve or another valve, so that operation which can be controlled reliably is possible.
- valve as an outlet valve can also only be hermetically sealed form a tight seal of the media or pump chamber in the area of the outlet channel. This closure is then transferred to its open position under the pump pressure, in which it is secured by clamping, detent or stop.
- the valve design is particularly suitable for discharge devices according to DE-OS 35 32 890, to which reference is made for further details and effects.
- the discharge device is designed in accordance with the independent claim 10 in a further development of DE-A 39 09 031, to which reference is made accordingly, it can be advantageous to use a displacement or valve body which is mechanically connected to a pump cylinder to form a separate component, which consists of a different material than the cylinder and with this, for example is connected via a fixed connector.
- a displacement or valve body which is mechanically connected to a pump cylinder to form a separate component, which consists of a different material than the cylinder and with this, for example is connected via a fixed connector.
- the cylinder e.g. can be formed in a simple manner as a container made of glass or a material having similar properties which would be too inelastic for the valve or displacement body.
- the more elastic displacement body forms a self-contained structural unit with the harder glass container.
- the discharge device 1 has a one-piece base body 2 which essentially forms its entire outer boundary and has at one end a cap-shaped housing 3 which is flat oval in longitudinal view and a connecting piece 4 projecting beyond the outside of its end wall.
- the socket 4 is formed by an end connected to the end wall of the housing 3 outer sleeve 5 and an inner sleeve 6, which connects in one piece in the region of the free end to the outer sleeve 5, otherwise lies essentially without contact inside the outer sleeve 5 and over the inside the cap end wall protrudes into the housing 3.
- the inner sleeve 6 carries an essentially completely inside the housing 3 or the outer sleeve 5 thrust piston pump 7, which essentially consists of one Piston 8 and a cup-shaped cylinder 9, which is closed in one piece on the bottom and which delimits an externally hermetically sealed pump chamber with the piston 8.
- the piston 8, which rests with a plurality of sawtooth-shaped piston lips under prestress on the cylinder raceway and essentially connects directly to the associated end of the inner sleeve 6 projecting into the cylinder 9, is formed in one piece with an essentially continuously cylindrical piston shaft 10 which extends up to to the inner end of a discharge opening 11 is sufficient.
- the discharge opening 11 is provided at the free end of the connecting piece 4 in the end wall of a nozzle cap which is formed by the transition region between the two sleeves 5, 6 and on the end wall of which the piston skirt 10 connects with its end face remote from the piston 8.
- a channel 14 designed as a blind hole extends into the piston shaft 10, which is connected at a distance from its bottom of the blind hole via a transverse channel 16 to a channel section 15 which runs along the associated section of the piston shaft 10 between its outer circumference and the inner circumference of the inner sleeve 6 up to the swirl device runs.
- valve seat 18 lying in a ring on an imaginary spherical surface for a preferably completely spherical valve body 17 which is spherically curved at least in its area on the outer circumference and whose ball radius is slightly larger than that of the valve seat 18 or as the radius of the channel section 14.
- the valve body 17 is pressed through the channel section 14 until it is slightly prestressed against the valve seat 18, is supported on the jacket region of the channel section 14 opposite the valve seat 18 and is then at a distance from the bottom of the blind hole corresponding to its outer diameter.
- a receiving chamber 19 for the valve body 17 is formed between this base and the valve body 17, which is completely sealed off from the outlet channel 12 or the channel section 14 and the transverse channel 16 by the valve body 17.
- the control movement of the valve body is approximately the same direction as or a continuation of the assembly insertion direction without a separate securing part against falling out or a valve spring being required.
- the resilient position catch 20 of the valve body 17 formed by the described design is overcome, which then rolls in the manner of a valve piston and / or is displaced out of the valve seat 18 and is pressed into the receiving chamber 19 according to FIG. 3.
- the volume of the receiving chamber 19 can be chosen so large that its gas filling of the opening movement of the valve body 17 is none opposes significant resistance or the receiving chamber 19 may be provided with a suitable vent for this purpose. Essentially all of the components mentioned are expediently located in a common central axis 21.
- the outer width of the inner sleeve 6 corresponds at least in the area of the cylinder 9 to its inner width, so that the cylinder 9 is guided on the inner sleeve 6 essentially without play or tilting.
- the outer circumference of the inner sleeve 6 in the region of the valve 13 is supported radially on the cylinder wall via the piston skirt 10, which is sleeve-shaped in this region.
- the piston skirt consists at least in the area of the valve body 17 or the valve seat 18 from a compression-elastic material, while the inner sleeve 6 consists of a much harder material.
- the valve body can be rigid or resilient.
- the end wall of the housing 3 forms an actuating handle 22 in the form of finger pressure surfaces on both sides of the connector 4.
- two mutually opposite, approximately identical and mutually aligned cutouts 23 are provided for the simultaneous engagement of a thumb, which start from the fully open end of the housing shell 3 and through which a handle provided as a finger pressure surface on the cylinder 9 24 is accessible, which is formed by the bottom of the cylinder 9.
- the connecting piece 4 can lie essentially completely in a removable cap 25, which extends approximately to the end wall of the housing 3 and, with the associated end, lies in a sealed manner on the outer circumference of the outer sleeve 5.
- a further seal is advantageously provided closer to or in the area of the nozzle cap and is formed by an inner sleeve 26 which projects freely from the inside of the cap end wall and which rests with an annular bead under prestress on the outer surface of the nozzle 4.
- the discharge opening 11 lies in a relatively small, separate cap chamber, and moreover the outer end of the otherwise non-contact cap 25 is centered exactly opposite the associated end of the nozzle 4.
- FIG. 4 the same reference numerals are used for corresponding parts as in FIGS. 1 to 3, but with the index "a”, which is why the description applies analogously to this embodiment.
- a valve body 17a which is located at the end of a shaft 27 and resiliently radially constrictable in the manner of a cup sleeve or annular lip is guided in the channel section 14a and forms a displacement body with the shaft 27, which at the end of the pump stroke extends the channel section 14a up to almost completely fills a narrow annular gap.
- the shaft 27 is formed in one piece with an enlarged collar 28, which is expediently inserted with pressure from the open end into the cylinder 9a and abuts the entire surface of the cylinder.
- the collar 28 forms the annular bottom boundary of the pump chamber opposite the piston 8a.
- the component 30 having the displacement body can be inserted into the cylinder 9a as desired be or not, so that one and the same cylinder can optionally be equipped differently.
- the valve body 17a forms on its end face a depression or a sleeve interior which is flared conically in the direction of movement, into which, at the end of the pump stroke, a displacement projection 31 which is adapted thereto and which projects from the blind hole bottom of the channel section 14a against the valve body 17a is immersed.
- the transverse channel 16a is provided adjacent to the jacket of the displacement projection 31 or immediately after the bottom of the blind hole, so that the medium displaced from the valve body 17a is pressed directly into the transverse channel 16a at the end of the pump stroke in a last volume surge.
- the bottom delimitation 29 is adapted to the spherically hollowed out end face of the pump piston 8a and to the frustoconical jacket of its foremost piston lip, so that here too a complete emptying takes place.
Landscapes
- Reciprocating Pumps (AREA)
- Electrical Discharge Machining, Electrochemical Machining, And Combined Machining (AREA)
- Photographic Developing Apparatuses (AREA)
- Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
- Pens And Brushes (AREA)
- Self-Closing Valves And Venting Or Aerating Valves (AREA)
- Taps Or Cocks (AREA)
- Closures For Containers (AREA)
- Details Of Reciprocating Pumps (AREA)
Claims (13)
- Dispositif distributeur de produits, comprenant au moins une soupape (13) qui comporte un corps de soupape (17) et un siège de soupape et dans laquelle le corps de soupape peut être amené d'une position de fermeture à une position d'ouverture en étant maintenu par auto-blocage dans l'une au moins des positions de la soupape, caractérisé par le fait que le corps de soupape (17), dans l'une au moins de ces positions de la soupape, est bloqué par des moyens d'encliquetage (20) qui l'empêchent de passer dans une autre position de la soupape.
- Dispositif distributeur selon la revendication 1, dans lequel les moyens d'encliquetage (20) sont des moyens d'encliquetage qui sont élastiques et/ou qui viennent directement en prise avec l'un des éléments de la soupape.
- Dispositif distributeur selon la revendication 1 ou 2, dans lequel le corps de soupape (17) est maintenu dans la position de fermeture par les moyens d'encliquetage (20).
- Dispositif distributeur selon l'une des revendications précédentes, dans lequel l'un des deux éléments de la soupape est un corps de soupape (17), pour l'essentiel en forme de bille, qui est réalisé en vue de sa venue en prise avec encliquetage et qui est monté coulissant dans une partie de canal (14) de l'autre élément de la soupape, cependant qu'au moins une ouverture d'encliquetage destinée au corps de soupape (17) est prévue dans la paroi du canal.
- Dispositif distributeur selon l'une des revendications précédentes, caractérisé par le fait que les moyens d'encliquetage (20) sont constitués par le siège de soupape (18) qui est destiné au corps de soupape (17), et en particulier par l'extrémité située à l'intérieur dans le sens radial d'un canal transversal (16), lequel relie de préférence une partie de canal (14) qui reçoit le corps de soupape (17) à une partie de canal (15) qui est décalée latéralement par rapport à la première.
- Dispositif distributeur selon l'une des revendications précédentes, caractérisé par le fait que le corps de soupape (17) peut être poussé hors de la position de fermeture en fonction de la pression des produits, et qu'à la façon d'un piston soumis à l'action de la pression des produits, il est disposé dans une partie de canal (14) qui est destinée au produit et qui est réalisée en particulier sous la forme d'un perçage en trou borgne.
- Dispositif distributeur selon l'une des revendications précédentes, caractérisé par le fait que la force de commande servant à modifier la position du corps de soupape (17) peut être réglée grâce au choix des dimensions d'une chambre de compression (19) dans laquelle se déplace le corps de soupape (17).
- Dispositif distributeur selon l'une des revendications précédentes, caractérisé par le fait que la soupape (13) est réalisée sous la forme d'une soupape de sortie, et que le corps de soupape (17) est disposé dans une tige de piston (10) d'une pompe à piston de refoulement (7), la tige de piston (10) étant traversée de préférence jusqu'à son extrémité antérieure par la partie de canal (14) qui reçoit le corps de soupape (17) et qui est ouverte vers la chambre de la pompe.
- Dispositif distributeur selon la revendication 8, caractérisé par le fait que la tige de piston (10) est entourée dans la région de la soupape (13) par un manchon (6) qui délimite de préférence par son pourtour intérieur le canal transversal (16) à l'extrémité extérieure de celui-ci et/ou la partie de canal (15) raccordée à celui-ci et décalée latéralement, et qui est guidé en particulier dans le cylindre (9) de la pompe (7).
- Dispositif distributeur comprenant une chambre de compression et un corps de soupape ou un corps de refoulement (17a), respectivement, qui pénètre d'une manière coulissante dans une partie de canal (14a) d'un canal de sortie (12a), dans lequel le corps de soupape ou le corps de refoulement (17a), respectivement, est formé par un élément constitutif (30) qui est séparé de la chambre de compression et qui est monté fixe dans la chambre de compression.
- Dispositif distributeur selon la revendication 10, caractérisé par le fait que l'élément constitutif (30) comporte un collet élargi (28) qui constitue une délimitation du fond (29) de la chambre de compression (9a) et depuis lequel fait librement saillie le corps de soupape ou le corps de refoulement (17a), respectivement, qui est réalisé en forme de tige.
- Dispositif distributeur selon la revendication 10 ou 11, caractérisé par le fait que l'élément constitutif (30) est posé sur une paroi fermée du fond d'un corps de cylindre qui constitue la chambre de compression (9a), et par le fait que la forme d'une surface annulaire du collet (28) qui est tournée vers le piston (8a) de la pompe est de préférence adaptée à une surface frontale antérieure du piston (8a) de la pompe qui reçoit d'une manière coulissante le corps de soupape ou le corps de refoulement (17a), respectivement.
- Dispositif distributeur selon l'une des revendications 10 à 12, caractérisé par le fait que le corps de soupape ou le corps de refoulement (17a), respectivement, présente un renfoncement, pour l'essentiel annulaire, qui est ménagé dans sa surface frontale, et que s'ajuste à ce renfoncement un prolongement de refoulement (31) qui est situé à l'extrémité de la partie de canal (14a) et qui remplit le renfoncement, complètement pour l'essentiel, dans la position finale de la course de la pompe.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE4005528 | 1990-02-22 | ||
DE4005528A DE4005528C2 (de) | 1990-02-22 | 1990-02-22 | Austragvorrichtung für Medien |
PCT/EP1990/002280 WO1991013281A1 (fr) | 1990-02-22 | 1990-12-21 | Distributeur pour milieux |
Publications (2)
Publication Number | Publication Date |
---|---|
EP0516636A1 EP0516636A1 (fr) | 1992-12-09 |
EP0516636B1 true EP0516636B1 (fr) | 1994-09-14 |
Family
ID=6400693
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP91902680A Expired - Lifetime EP0516636B1 (fr) | 1990-02-22 | 1990-12-21 | Distributeur pour milieux |
Country Status (7)
Country | Link |
---|---|
US (1) | US5368201A (fr) |
EP (1) | EP0516636B1 (fr) |
AT (1) | ATE111577T1 (fr) |
AU (1) | AU7064591A (fr) |
DE (2) | DE4005528C2 (fr) |
ES (1) | ES2060361T3 (fr) |
WO (1) | WO1991013281A1 (fr) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2002074336A2 (fr) | 2001-02-23 | 2002-09-26 | Glaxosmithkline Biologicals S.A. | Vaccin |
Families Citing this family (40)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1993000172A1 (fr) * | 1991-06-26 | 1993-01-07 | Valois (Societe Anonyme) | Dispositif pour projeter une dose predeterminee d'un produit fluide, et son procede de remplissage |
DE19525734A1 (de) * | 1995-07-14 | 1997-01-16 | Pfeiffer Erich Gmbh & Co Kg | Austragvorrichtung für fließfähige Medien, insbesondere für den Austrag in nur einem Hub |
DE19604626A1 (de) * | 1996-02-08 | 1997-08-14 | Uhu Gmbh | Klebstift mit kolbenförmiger Haltevorrichtung für die Stiftmasse |
FR2746676B1 (fr) * | 1996-04-02 | 1998-05-22 | Valois | Dispositif de distribution d'une dose unique de produit fluide |
DE19749514A1 (de) | 1997-11-08 | 1999-05-12 | Pfeiffer Erich Gmbh & Co Kg | Verfahren zum Ausbringen von wenigstens zwei verschiedenen Medien und Spender dafür |
WO1999046055A1 (fr) * | 1998-03-10 | 1999-09-16 | Valois S.A. | Reservoir, procede de remplissage du reservoir et dispositif de distribution du produit fluide contenu dans le reservoir |
USD421120S (en) * | 1998-08-21 | 2000-02-22 | Pharmacia & Upjohn Company | Spray bottle grip |
US6276568B1 (en) | 1998-08-21 | 2001-08-21 | Pharmacia & Upjohn Company | Spray bottle grip |
USD428141S (en) * | 1999-08-04 | 2000-07-11 | Pharmacia & Upjohn Company | Spray bottle grip |
DE10006368A1 (de) * | 2000-02-12 | 2001-08-16 | Pfeiffer Erich Gmbh & Co Kg | Austragvorrichtung für Medien |
GB0024089D0 (en) * | 2000-10-02 | 2000-11-15 | Smithkline Beecham Biolog | Novel compounds |
FR2817847B1 (fr) * | 2000-12-08 | 2003-03-28 | Tebro | Dispositif de distribution de produit fluide ou pulverulent |
GB0302536D0 (en) * | 2003-02-04 | 2003-03-12 | Bespak Plc | Container |
DE102004034629A1 (de) * | 2004-06-14 | 2006-01-05 | Seaquist Perfect Dispensing Gmbh | Vorrichtung und Sprühkopf zur Zerstäubung einer vorzugsweise kosmetischen Flüssigkeit sowie Verfahren zum Herstellen einer derartigen Vorrichtung |
HUE027837T2 (en) | 2005-03-23 | 2016-11-28 | Glaxosmithkline Biologicals Sa | Adjuvant use of influenza virus and oil-in-water emulsion to induce CD4 T-cell and / or enhanced B-cell cellular response |
TWI457133B (zh) | 2005-12-13 | 2014-10-21 | Glaxosmithkline Biolog Sa | 新穎組合物 |
US20070212307A1 (en) * | 2006-02-10 | 2007-09-13 | Daniel Wermeling | Pharmaceutical Compositions Comprising an Opioid Receptor Antagonist and Methods of Using Same |
SI2422810T1 (sl) | 2006-07-17 | 2015-01-30 | Glaxosmithkline Biologicals S.A. | Influenčno cepivo |
TW200908994A (en) | 2007-04-20 | 2009-03-01 | Glaxosmithkline Biolog Sa | Vaccine |
FR2916429B1 (fr) * | 2007-05-22 | 2012-10-05 | Valois Sas | Capot de protection pour tete de distribution de produit fluide. |
WO2011026198A1 (fr) * | 2009-09-07 | 2011-03-10 | Mk International Pty Ltd | Pompe pour pulvérisation nasale |
GB0919117D0 (en) | 2009-10-30 | 2009-12-16 | Glaxosmithkline Biolog Sa | Process |
JP6045499B2 (ja) | 2010-10-27 | 2016-12-14 | グラクソスミスクライン バイオロジカルズ ソシエテ アノニム | 赤痢菌リポ多糖及び外膜タンパク質を含む免疫原性組成物 |
BR112013029514A2 (pt) | 2011-05-17 | 2019-09-24 | Glaxosmithkline Biologicals Sa | composição imunogênica, vacina, e, método de tratar ou impedir uma doença |
GB201205189D0 (en) | 2012-03-23 | 2012-05-09 | Glaxosmithkline Biolog Sa | Novel medical use |
FR3004128B1 (fr) * | 2013-04-08 | 2017-01-13 | Aptar France Sas | Tete de pulverisation amelioree. |
CN109562137A (zh) | 2015-09-01 | 2019-04-02 | 第波生物公司 | 用于治疗与异常炎性反应有关的病况的方法和组合物 |
GB201603625D0 (en) | 2016-03-02 | 2016-04-13 | Glaxosmithkline Biolog Sa | Novel influenza antigens |
WO2017167768A1 (fr) | 2016-03-28 | 2017-10-05 | Glaxosmithkline Biologicals S.A. | Nouvelle composition vaccinale |
GB201610599D0 (en) | 2016-06-17 | 2016-08-03 | Glaxosmithkline Biologicals Sa | Immunogenic Composition |
DE102016212893A1 (de) * | 2016-07-14 | 2018-01-18 | F. Holzer Gmbh | Pumpkopf sowie Dosiervorrichtung |
GB201721576D0 (en) | 2017-12-21 | 2018-02-07 | Glaxosmithkline Biologicals Sa | Hla antigens and glycoconjugates thereof |
GB201721582D0 (en) | 2017-12-21 | 2018-02-07 | Glaxosmithkline Biologicals Sa | S aureus antigens and immunogenic compositions |
US20230102999A1 (en) | 2020-01-10 | 2023-03-30 | First Wave Bio, Inc. | Deuterated niclosamide |
US10980756B1 (en) | 2020-03-16 | 2021-04-20 | First Wave Bio, Inc. | Methods of treatment |
WO2021188564A1 (fr) | 2020-03-16 | 2021-09-23 | First Wave Bio, Inc. | Méthodes de traitement de la covid-19 avec un composé de niclosamide |
WO2022212365A1 (fr) | 2021-03-29 | 2022-10-06 | Chimerix, Inc. | Nucléosides de pyrrolopyrimidine pour le traitement ou la prévention d'une infection par sras-cov-2 |
CA3222568A1 (fr) | 2021-06-28 | 2023-01-05 | Glaxosmithkline Biologicals Sa | Nouveaux antigenes de la grippe |
GB202219228D0 (en) | 2022-12-20 | 2023-02-01 | Glaxosmithkline Biologicals Sa | Novel influenza antigens |
DE102023100940A1 (de) | 2023-01-17 | 2024-07-18 | Eckehard Völkening | Verschlussvorrichtung in Form einer Kappe zum fluiddichten Verschließen einer Düse und System mit einer Verschlussvorrichtung und einer Düse |
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US4371097A (en) * | 1980-05-07 | 1983-02-01 | Diamond International Corporation | Liquid dispensing pump |
US4440325A (en) * | 1981-07-24 | 1984-04-03 | Treuhaft Martin B | Actuator |
DE3513575A1 (de) * | 1985-04-16 | 1986-10-16 | Ing. Erich Pfeiffer GmbH & Co KG, 7760 Radolfzell | Handbetaetigte ausgabeeinrichtung fuer medien |
DE3530486A1 (de) * | 1985-08-27 | 1987-03-05 | Pfeiffer Erich Gmbh & Co Kg | Austragvorrichtung fuer fliessfaehige medien |
DE8526339U1 (de) * | 1985-09-14 | 1987-05-07 | Ing. Erich Pfeiffer GmbH & Co KG, 7760 Radolfzell | Austragvorrichtung für fließfähige Medien |
FR2612890B1 (fr) * | 1987-03-26 | 1989-12-29 | Step Soc Tech Pulverisation | Ensemble doseur pour produit pateux ou semi-liquide |
DE3734306A1 (de) * | 1987-10-10 | 1989-04-27 | Pfeiffer Erich Gmbh & Co Kg | Austragvorrichtung fuer fliessfaehige medien |
DE68902989T2 (de) * | 1988-12-20 | 1993-04-15 | Step Soc Tech Pulverisation | Vorrichtung zum spenden einer fluessigkeit oder einer creme in tropfen kleinen volumens. |
DE3909031A1 (de) * | 1989-03-18 | 1990-09-27 | Pfeiffer Erich Gmbh & Co Kg | Austragvorrichtung fuer medien |
-
1990
- 1990-02-22 DE DE4005528A patent/DE4005528C2/de not_active Expired - Fee Related
- 1990-12-21 ES ES91902680T patent/ES2060361T3/es not_active Expired - Lifetime
- 1990-12-21 DE DE59007175T patent/DE59007175D1/de not_active Expired - Fee Related
- 1990-12-21 EP EP91902680A patent/EP0516636B1/fr not_active Expired - Lifetime
- 1990-12-21 WO PCT/EP1990/002280 patent/WO1991013281A1/fr active IP Right Grant
- 1990-12-21 AT AT91902680T patent/ATE111577T1/de active
- 1990-12-21 AU AU70645/91A patent/AU7064591A/en not_active Abandoned
- 1990-12-21 US US07/934,617 patent/US5368201A/en not_active Expired - Lifetime
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2002074336A2 (fr) | 2001-02-23 | 2002-09-26 | Glaxosmithkline Biologicals S.A. | Vaccin |
EP2269639A2 (fr) | 2001-02-23 | 2011-01-05 | GlaxoSmithKline Biologicals s.a. | Formulations de vaccins contre la grippe dispositif pour administration intradermique |
EP2281573A2 (fr) | 2001-02-23 | 2011-02-09 | GlaxoSmithKline Biologicals s.a. | Formulations de vaccins contre la grippe dispositif pour administration intradermique |
Also Published As
Publication number | Publication date |
---|---|
WO1991013281A1 (fr) | 1991-09-05 |
DE4005528C2 (de) | 1998-01-15 |
DE4005528A1 (de) | 1991-08-29 |
US5368201A (en) | 1994-11-29 |
AU7064591A (en) | 1991-09-18 |
ES2060361T3 (es) | 1994-11-16 |
DE59007175D1 (de) | 1994-10-20 |
ATE111577T1 (de) | 1994-09-15 |
EP0516636A1 (fr) | 1992-12-09 |
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