EP0454373B1 - Gellan-Gummi-Fasern - Google Patents

Gellan-Gummi-Fasern Download PDF

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Publication number
EP0454373B1
EP0454373B1 EP19910303521 EP91303521A EP0454373B1 EP 0454373 B1 EP0454373 B1 EP 0454373B1 EP 19910303521 EP19910303521 EP 19910303521 EP 91303521 A EP91303521 A EP 91303521A EP 0454373 B1 EP0454373 B1 EP 0454373B1
Authority
EP
European Patent Office
Prior art keywords
gum
fibers
gellan gum
gellan
alginate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
EP19910303521
Other languages
English (en)
French (fr)
Other versions
EP0454373A2 (de
EP0454373A3 (en
Inventor
George T. Colegrove
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Monsanto Co
Original Assignee
Merck and Co Inc
Monsanto Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc, Monsanto Co filed Critical Merck and Co Inc
Publication of EP0454373A2 publication Critical patent/EP0454373A2/de
Publication of EP0454373A3 publication Critical patent/EP0454373A3/en
Application granted granted Critical
Publication of EP0454373B1 publication Critical patent/EP0454373B1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • D—TEXTILES; PAPER
    • D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
    • D01F—CHEMICAL FEATURES IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS; APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OF CARBON FILAMENTS
    • D01F9/00—Artificial filaments or the like of other substances; Manufacture thereof; Apparatus specially adapted for the manufacture of carbon filaments

Definitions

  • GB-A-653,341 is an example of an early disclosure of the use of calcium alginate materials in surgical dressings. The earliest such materials were calcium alginate fibers, but they suffered from the disadvantage of being quite insoluble in water or wound exudate matter. Later a portion of the calcium ions in calcium alginate was exchanged with other cations, whose alginate salts are soluble. GB-A-653,341 therefore proposed that some of the calcium ions be replaced with sodium ions, to form a mixed salt alginate.
  • alginate fibers have been proposed which involve shaping the fibers as by weaving or knitting into sheets or pads. These materials are useful because they absorb water and swell but retain their shape and structural integrity.
  • GB-A-1 207 352 describes a water absorbent product of absorbent fibers prepared from one of several fiber forming materials, including guar gum.
  • the guar gum fibers are formed by adding guar to an organic liquid, e.g. isopropyl alcohol, and adding the resulting slurry to excess water to precipitate a hydrate of the guar. The hydrate is then extruded into a coagulating bath to form the fibers.
  • gellan gum fibers may be produced by extrusion of a gum solution into a gelling bath.
  • the process advantageously, does not require esterification and subsequent hydrolysis.
  • the process also produces hybrid fibers comprising gellan and one or more additional gums.
  • gellan gum is meant the extracellularly produced gum made by the heteropolysaccharide-producing bacterium Pseudomonas elodea , ATCC 31461, by the whole culture fermentation under a variety of conditions of a medium comprising: a fermentable carbohydrate, a nitrogen source, and other appropriate nutrients. Included is the native, deacylated, partially deacylated, and clarified forms therefore. Gellan gum is also known as S-60.
  • deacylated gellan gum described in U.S-A-4,326,052.
  • gellan gum solutions containing 2-6% gum are extruded through fine orifices into coagulating baths containing various cations to produce filamentous fibers which can be used in wound dressings, catamenial devices, etc.
  • Gellan gum may be used by itself or in combination with other polysaccharides such as alginates, xanthan gum, and locust bean gum. Solutions may be extruded cold (room temperature-50°C) or hot (50°-80°C); if hot, the addition of another gum is usually necessary. Gellan gum is especially useful for producing fibers containing magnesium for controlled release of that cation.
  • the fibers may also contain known wound healing agents.
  • the bath of gelling salts is an aqueous solution of 0.5-5% of a soluble salt, the cation of which may be mono-, di-, or tri-valent and selected from those of Groups I, II, and III of the Perodic Table, especially Na+, K+, Ca++, Mg++, and Al+++. Ca++ and Mg++ are especially preferred.
  • the anion may be chloride sulfate, lactate, phosphate, carbonate, gluconate, or tartrate. Residence time is the bath is 5 seconds - 5 minutes.
  • a second polysaccharide When a second polysaccharide is used it is one which exhibits a high viscosity when hot; in particular, algin, xanthan gum, and locust bean gum or combinations of these.
  • the second gum can replace up to 33 1/3% of the gellan gum; i.e., up to 2% of a 6% gum solution may be comprised of one or more of a second polysaccharide.
  • the ratio of gellan gum to said second gum is at least 2:1.
  • algin is meant the soluble derivatives of alginic acid, which may be chemically extracted from all species of Phaeophyceae , brown algae.
  • the term is intended to include the soluble salts of alginic acid (e.g., sodium, potassium, or ammonium alginate) and the salts of its ethers (e.g., propylene glycol alginate).
  • xanthan gum is meant the biosynthetic polysaccharide produced by the organism Xanthomonas campestris by the whole culture fermentation of a medium comprising a fermentable carbohydrate, a nitrogen source and appropriate other nutrients.
  • Xanthan gum preparation is described in numerous publications and patents, e.g., U.S. Patents 3,671,398; 3,594,280; 3,591,578; 3,481,889; 3,433,708; 3,427,226; 3,391,061; 3,391,060; 3,271,267; 3,251,749; and 3,020,206.
  • Locust bean gum is an extract of the locust bean or carob, Ceratonia siligua . It is commercially available and used as a stabilizer in foods such as ice cream, sausages, and cheese.
  • Gellan gum is normally gelled by heating an aqueous solution to dissolve the gum then simply cooling to produce a gel, provided cations are present. It is also known that solutions may be prepared cold in distilled or deionized water by the addition of a small amount of sequestrant.
  • the sequestrants which can be used in this invention include trisodium orthophosphate (TSP), ethylenediaminetetraacetic acid (EDTA), sodium citrate, tetrasodium pyrophosphate (TSPP), sodium hexametaphosphate (Calgon) and the like.
  • Gellan gum fibers can therefore be prepared by forcing a solution of 2.0% deacylated, clarified gellan gum containing 0.25% sodium citrate in deionized water through a nozzle having a diameter of eleven thousandth of an inch into a 2% calcium chloride bath where fiber formation immediately occurs.
  • Gellan gum is particularly useful for forming fibers containing magnesium ions as it also gels in the presence of magnesium salts.
  • the 2% gellan gum solution above was also forced into a bath containing 2% magnesium sulfate wherein fiber formation also immediately occurred.
  • Fibers containing a source of magnesium are valuable additives to catamenial devices such as tampons where magnesium ions are said to prevent toxic shock syndrome.
  • Magnesium alginate is soluble in water; therefore it cannot be formed by useful methods but must be formed by ion exchange from insoluble calcium alginate fibers already produced by the usual methods.
  • a small amount can be formed simultaneously with gellan gum fibers however, by incorporating sodium alginate into gellan gum solutions before extrusion into the gelling bath.
  • Fiber formation from hot solutions is more complicated.
  • Gellan gum solutions have high viscosity when cold but low viscosity when heated, which makes it possible to prepare more concentrated solutions which gel more rapidly with higher gel strength. Fiber production by extrusion from hot gum solutions into a bath were not successful, however, because the low viscosity solution dispersed into flocs without forming a continuous fiber. It has been found that the addition of another polysaccharide which produces more viscosity at temperatures of 50-80°C make fiber formation possible.
  • the high viscosity thickeners xanthan gum and locust bean gum or a combination of the two also produced fibers when combined with the gellan gum at levels of 0.5-1.0%.
  • the fibers of this invention can be used in various forms. If a non-woven fabric is to be prepared, and this is the fabric of choice, a cotton card may be used to form a web, which may then be cross-lapped and then needle punched in conventional equipment.
  • the fibers may be carded and then spun into a yarn, which can be woven in a conventional loom. Alternatively, the fibers may be collected in a spinning box, according to the method of Tallis (GB-A-568,177) and woven. If a knitted fabric is to be prepared, the fibers can be prepared as a continuous filament yarn (again according to GB-A-568,177) which is then knitted on a conventional knitting machine.
  • the fiber end product (e.g., a pad) may include one or more antimicrobial (for example, antibacterial or antifungal) agents and/or one or more local anesthetics (for example, procaine) and additionally or alternatively one or more pharmaceutical agents.
  • antimicrobial for example, antibacterial or antifungal
  • local anesthetics for example, procaine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Textile Engineering (AREA)
  • Materials For Medical Uses (AREA)
  • Artificial Filaments (AREA)

Claims (4)

  1. Faser, umfassend Gellan-Gummi und einen oder mehrere von einem zweiten Gummi, der Algin, Xanthan oder Carobin-Gummi ist, worin das Verhältnis von Gellan-Gummi zu dem genannten zweiten Gummi wenigstens 2:1 beträgt.
  2. Verfahren zur Herstellung von Fasern aus Gellan-Gummi, welches umfaßt Extrudieren einer 2- bis 6%igen Lösung aus Gellan-Gummi in ein Koagulationsbad, das 0,5-5,0 % Gelierungssalze umfaßt.
  3. Verfahren nach Anspruch 2, bei dem die Gelierungssalze Calcium- oder Magensiumsalze sind.
  4. Verfahren nach Anspruch 2, bei dem die Gummilösung eine oder mehrere von einem zweiten Gummi umfaßt, der Algin-Xanthan- oder Carobin-Gummi ist, und worin das Verhältnis von Gellan zu dem genannten zweiten Gummi wenigstens 2:1 beträgt.
EP19910303521 1990-04-23 1991-04-19 Gellan-Gummi-Fasern Expired - Lifetime EP0454373B1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US51341290A 1990-04-23 1990-04-23
US513412 1990-04-23

Publications (3)

Publication Number Publication Date
EP0454373A2 EP0454373A2 (de) 1991-10-30
EP0454373A3 EP0454373A3 (en) 1993-01-20
EP0454373B1 true EP0454373B1 (de) 1995-08-23

Family

ID=24043154

Family Applications (1)

Application Number Title Priority Date Filing Date
EP19910303521 Expired - Lifetime EP0454373B1 (de) 1990-04-23 1991-04-19 Gellan-Gummi-Fasern

Country Status (4)

Country Link
EP (1) EP0454373B1 (de)
JP (1) JP2557572B2 (de)
CA (1) CA2040959A1 (de)
DE (1) DE69112260T2 (de)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6387978B2 (en) 1996-07-11 2002-05-14 Boston Scientific Corporation Medical devices comprising ionically and non-ionically crosslinked polymer hydrogels having improved mechanical properties
USRE38158E1 (en) 1994-07-27 2003-06-24 Minnesota Mining And Manufacturing Company Adhesive sealant composition

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5531716A (en) * 1993-09-29 1996-07-02 Hercules Incorporated Medical devices subject to triggered disintegration
AU4526296A (en) * 1994-12-27 1996-07-19 Monsanto Company Gelled, alcohol-free carbonated beverage
GB2310668B (en) * 1996-02-28 2000-04-19 Johnson & Johnson Medical Solid polysaccharide materials for use as wound dressings
US6368356B1 (en) 1996-07-11 2002-04-09 Scimed Life Systems, Inc. Medical devices comprising hydrogel polymers having improved mechanical properties
AU3868297A (en) * 1996-08-27 1998-03-19 San-Ei Gen F.F.I., Inc. Novel use of native gellan gum
US6453608B1 (en) * 1997-10-31 2002-09-24 Monsanto Company Gellan gum seed coating
US6913765B2 (en) 2001-03-21 2005-07-05 Scimed Life Systems, Inc. Controlling resorption of bioresorbable medical implant material
US8685943B2 (en) 2003-03-12 2014-04-01 Hill's Pet Nutrition, Inc. Methods for reducing diarrhea in a companion animal
EP1666075A1 (de) 2004-10-04 2006-06-07 Switch Biotech Aktiengesellschaft Wundverband zur Freisetzung von Proteaseinhibitoren
GB201500430D0 (en) 2015-01-12 2015-02-25 Univ Birmingham Dressing
WO2018078562A1 (en) * 2016-10-26 2018-05-03 Association For The Advancement Of Tissue Engineering And Cell Based Technologies & Therapies (A4Tec) Fibers with segments, their preparation and applications thereof

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1207352A (en) * 1967-10-16 1970-09-30 David Torr Disposable absorbent products
JPS63267361A (ja) * 1987-04-24 1988-11-04 San Ei Chem Ind Ltd 賦香等性ゲル状物

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USRE38158E1 (en) 1994-07-27 2003-06-24 Minnesota Mining And Manufacturing Company Adhesive sealant composition
US6387978B2 (en) 1996-07-11 2002-05-14 Boston Scientific Corporation Medical devices comprising ionically and non-ionically crosslinked polymer hydrogels having improved mechanical properties

Also Published As

Publication number Publication date
DE69112260T2 (de) 1996-04-11
CA2040959A1 (en) 1991-10-24
JPH04222223A (ja) 1992-08-12
JP2557572B2 (ja) 1996-11-27
EP0454373A2 (de) 1991-10-30
DE69112260D1 (de) 1995-09-28
EP0454373A3 (en) 1993-01-20

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