EP0402422A1 - Certaines combinaisons d'antagonistes/antihistamines de paf (facteur d'activation plaquettaire) et procedes - Google Patents
Certaines combinaisons d'antagonistes/antihistamines de paf (facteur d'activation plaquettaire) et procedesInfo
- Publication number
- EP0402422A1 EP0402422A1 EP89905952A EP89905952A EP0402422A1 EP 0402422 A1 EP0402422 A1 EP 0402422A1 EP 89905952 A EP89905952 A EP 89905952A EP 89905952 A EP89905952 A EP 89905952A EP 0402422 A1 EP0402422 A1 EP 0402422A1
- Authority
- EP
- European Patent Office
- Prior art keywords
- carbon atoms
- triazolo
- formula
- paf
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Abstract
On a mis au point des procédés et des compositions employant des combinaisons d'antihistamines avec certains composés antagonistes du PAF, de diaryle tétrahydrofurane, diaryle tétrahydrothiophène, triazolobenzodiazépine ou thiénotriazolodiazépine, dans le traitement de réactions allergiques.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US18653588A | 1988-04-27 | 1988-04-27 | |
US186535 | 1988-04-27 |
Publications (1)
Publication Number | Publication Date |
---|---|
EP0402422A1 true EP0402422A1 (fr) | 1990-12-19 |
Family
ID=22685331
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP89304068A Expired - Lifetime EP0345931B1 (fr) | 1988-04-27 | 1989-04-24 | Certains mélanges PAF antagonistes/antihistamine et procédés |
EP89905952A Pending EP0402422A1 (fr) | 1988-04-27 | 1989-04-24 | Certaines combinaisons d'antagonistes/antihistamines de paf (facteur d'activation plaquettaire) et procedes |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP89304068A Expired - Lifetime EP0345931B1 (fr) | 1988-04-27 | 1989-04-24 | Certains mélanges PAF antagonistes/antihistamine et procédés |
Country Status (15)
Country | Link |
---|---|
EP (2) | EP0345931B1 (fr) |
JP (1) | JPH0655673B2 (fr) |
KR (1) | KR930009786B1 (fr) |
AT (1) | ATE84724T1 (fr) |
AU (1) | AU619555B2 (fr) |
CA (1) | CA1327316C (fr) |
DE (1) | DE68904475T2 (fr) |
DK (1) | DK255190D0 (fr) |
ES (1) | ES2044100T4 (fr) |
IE (1) | IE63697B1 (fr) |
IL (1) | IL90100A (fr) |
MY (1) | MY106956A (fr) |
NZ (1) | NZ228879A (fr) |
WO (1) | WO1989010143A1 (fr) |
ZA (1) | ZA893101B (fr) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PH30676A (en) * | 1986-07-22 | 1997-09-16 | Boehringer Ingelhein Kg | Hetrazepine compounds which have useful pharmaceutical utility |
US6277846B1 (en) * | 1990-05-31 | 2001-08-21 | Allergan Sales, Inc. | Use of platelet activating factor antagonists as anti-pruritic agents |
EP0469477B1 (fr) * | 1990-08-02 | 1995-09-20 | F. Hoffmann-La Roche Ag | Mélange anti-allergique |
US5227378A (en) * | 1990-08-02 | 1993-07-13 | Hoffmann-La Roche Inc. | Combination of PAF antagonists and LTD4 antagonists for the treatment of allergic reactions |
FR2673842B1 (fr) * | 1991-03-13 | 1993-12-24 | Rhone Poulenc Rorer Sa | Nouvelles compositions liquides a base de derives de la piperidine substitues en 1,4. |
FR2684298B1 (fr) * | 1991-12-03 | 1994-03-11 | Rhone Poulenc Rorer Sa | Nouvelles compositions pharmaceutiques solides a base de derives de lapiperidine substitues en 1,4. |
JP3060287B2 (ja) * | 1995-10-09 | 2000-07-10 | 参天製薬株式会社 | アパファントを主薬とする水性点眼剤 |
DE10007203A1 (de) * | 2000-02-17 | 2001-08-23 | Asta Medica Ag | Neue Kombination nichtsedierender Antihistaminika mit Substanzen, die die Leukotrienwirkung beeinflussen, zur Behandlung der Rhinitis/Konjunktivitis |
US8492376B2 (en) * | 2010-04-21 | 2013-07-23 | Hoffmann-La Roche Inc. | Heteroaryl-cyclohexyl-tetraazabenzo[e]azulenes |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4539332A (en) * | 1983-11-14 | 1985-09-03 | Merck & Co., Inc. | 2,5-Diaryl tetrahydrofurans and analogs thereof as PAF-antagonists |
NZ211146A (en) * | 1984-02-29 | 1987-10-30 | Merck & Co Inc | 2,5-diaryl-tetrahydrothiophene derivatives and pharmaceutical compositions |
US4595693A (en) * | 1984-06-04 | 1986-06-17 | Merck & Co., Inc. | Method of use of 2,5-diaryl tetrahydrofurans and analogs thereof as PAF-antagonists |
DE3502392A1 (de) * | 1985-01-25 | 1986-07-31 | Boehringer Ingelheim KG, 6507 Ingelheim | Neue thieno-triazolo-1,4-diazepino-2- carbonsaeureamide, verfahren zu ihrer herstellung und pharmazeutische zusammensetzungen |
US4910206A (en) * | 1986-07-14 | 1990-03-20 | Sandoz Pharmaceuticals Corp. | 5-hetero-or aryl-substituted-imidazo(2,1-a)isoquinolines and their use as PAF receptor antagonists |
-
1989
- 1989-04-24 ES ES89304068T patent/ES2044100T4/es not_active Expired - Lifetime
- 1989-04-24 KR KR1019890702438A patent/KR930009786B1/ko not_active IP Right Cessation
- 1989-04-24 EP EP89304068A patent/EP0345931B1/fr not_active Expired - Lifetime
- 1989-04-24 JP JP1505865A patent/JPH0655673B2/ja not_active Expired - Lifetime
- 1989-04-24 AU AU35782/89A patent/AU619555B2/en not_active Ceased
- 1989-04-24 AT AT89304068T patent/ATE84724T1/de not_active IP Right Cessation
- 1989-04-24 WO PCT/US1989/001671 patent/WO1989010143A1/fr not_active Application Discontinuation
- 1989-04-24 EP EP89905952A patent/EP0402422A1/fr active Pending
- 1989-04-24 DE DE8989304068T patent/DE68904475T2/de not_active Expired - Fee Related
- 1989-04-26 IE IE136289A patent/IE63697B1/en not_active IP Right Cessation
- 1989-04-26 CA CA000597855A patent/CA1327316C/fr not_active Expired - Fee Related
- 1989-04-26 ZA ZA893101A patent/ZA893101B/xx unknown
- 1989-04-26 NZ NZ228879A patent/NZ228879A/en unknown
- 1989-04-26 MY MYPI89000538A patent/MY106956A/en unknown
- 1989-04-27 IL IL9010089A patent/IL90100A/en not_active IP Right Cessation
-
1990
- 1990-10-23 DK DK255190A patent/DK255190D0/da not_active Application Discontinuation
Non-Patent Citations (1)
Title |
---|
See references of WO8910143A1 * |
Also Published As
Publication number | Publication date |
---|---|
ATE84724T1 (de) | 1993-02-15 |
NZ228879A (en) | 1992-08-26 |
JPH0655673B2 (ja) | 1994-07-27 |
ES2044100T4 (es) | 1996-07-16 |
ZA893101B (en) | 1989-12-27 |
DE68904475D1 (de) | 1993-03-04 |
KR900700136A (ko) | 1990-08-11 |
JPH03502097A (ja) | 1991-05-16 |
ES2044100T3 (es) | 1994-01-01 |
IL90100A (en) | 1995-01-24 |
EP0345931B1 (fr) | 1993-01-20 |
AU3578289A (en) | 1989-11-24 |
KR930009786B1 (ko) | 1993-10-11 |
DK255190A (da) | 1990-10-23 |
AU619555B2 (en) | 1992-01-30 |
IE63697B1 (en) | 1995-05-31 |
DK255190D0 (da) | 1990-10-23 |
IL90100A0 (en) | 1989-12-15 |
MY106956A (en) | 1995-08-30 |
WO1989010143A1 (fr) | 1989-11-02 |
CA1327316C (fr) | 1994-03-01 |
DE68904475T2 (de) | 1993-05-13 |
IE891362L (en) | 1989-10-27 |
EP0345931A1 (fr) | 1989-12-13 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: REQUEST FOR EXAMINATION WAS MADE |
|
17P | Request for examination filed |
Effective date: 19901010 |
|
AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AT BE CH DE FR GB IT LI LU NL SE |
|
XX | Miscellaneous (additional remarks) |
Free format text: VERFAHREN ABGESCHLOSSEN INFOLGE VERBINDUNG MIT89304068.3/0345931 (EUROPAEISCHE ANMELDENUMMER/VEROEFFENTLICHUNGSNUMMER) VOM 18.03.91. |