ZA893101B - Certain paf antagonist/antihistamine combinations and methods - Google Patents

Certain paf antagonist/antihistamine combinations and methods

Info

Publication number
ZA893101B
ZA893101B ZA893101A ZA893101A ZA893101B ZA 893101 B ZA893101 B ZA 893101B ZA 893101 A ZA893101 A ZA 893101A ZA 893101 A ZA893101 A ZA 893101A ZA 893101 B ZA893101 B ZA 893101B
Authority
ZA
South Africa
Prior art keywords
methods
certain
paf antagonist
combinations
antihistamine
Prior art date
Application number
ZA893101A
Inventor
M Motasim Billah
Motasim Billah M
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of ZA893101B publication Critical patent/ZA893101B/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

Methods and compositions are disclosed employing combinations of antihistamines with certain diaryl tetrahydrofuran, diaryl tetrahydrothiophene, triazolobenzodiazepine or thienotriazolodiazepine PAF-antagonist compounds in the treatment of allergic reactions.
ZA893101A 1988-04-27 1989-04-26 Certain paf antagonist/antihistamine combinations and methods ZA893101B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US18653588A 1988-04-27 1988-04-27

Publications (1)

Publication Number Publication Date
ZA893101B true ZA893101B (en) 1989-12-27

Family

ID=22685331

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA893101A ZA893101B (en) 1988-04-27 1989-04-26 Certain paf antagonist/antihistamine combinations and methods

Country Status (15)

Country Link
EP (2) EP0402422A1 (en)
JP (1) JPH0655673B2 (en)
KR (1) KR930009786B1 (en)
AT (1) ATE84724T1 (en)
AU (1) AU619555B2 (en)
CA (1) CA1327316C (en)
DE (1) DE68904475T2 (en)
DK (1) DK255190D0 (en)
ES (1) ES2044100T4 (en)
IE (1) IE63697B1 (en)
IL (1) IL90100A (en)
MY (1) MY106956A (en)
NZ (1) NZ228879A (en)
WO (1) WO1989010143A1 (en)
ZA (1) ZA893101B (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PH30676A (en) * 1986-07-22 1997-09-16 Boehringer Ingelhein Kg Hetrazepine compounds which have useful pharmaceutical utility
US6277846B1 (en) * 1990-05-31 2001-08-21 Allergan Sales, Inc. Use of platelet activating factor antagonists as anti-pruritic agents
EP0469477B1 (en) * 1990-08-02 1995-09-20 F. Hoffmann-La Roche Ag Antiallergic combination
US5227378A (en) * 1990-08-02 1993-07-13 Hoffmann-La Roche Inc. Combination of PAF antagonists and LTD4 antagonists for the treatment of allergic reactions
FR2673842B1 (en) * 1991-03-13 1993-12-24 Rhone Poulenc Rorer Sa NOVEL LIQUID COMPOSITIONS BASED ON 1,4-SUBSTITUTED PIPERIDINE DERIVATIVES.
FR2684298B1 (en) * 1991-12-03 1994-03-11 Rhone Poulenc Rorer Sa NOVEL SOLID PHARMACEUTICAL COMPOSITIONS BASED ON 1,4-SUBSTITUTED LAPIPERIDINE DERIVATIVES.
JP3060287B2 (en) * 1995-10-09 2000-07-10 参天製薬株式会社 Aqueous eye drops containing apaphant as the main drug
DE10007203A1 (en) 2000-02-17 2001-08-23 Asta Medica Ag Composition for treating allergic and/or vasomotor rhinitis or allergic conjunctivitis by topical or oral administration, contains synergistic combination of non-sedating antihistamine and leukotriene antagonist
US8492376B2 (en) * 2010-04-21 2013-07-23 Hoffmann-La Roche Inc. Heteroaryl-cyclohexyl-tetraazabenzo[e]azulenes

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4539332A (en) * 1983-11-14 1985-09-03 Merck & Co., Inc. 2,5-Diaryl tetrahydrofurans and analogs thereof as PAF-antagonists
NZ211146A (en) * 1984-02-29 1987-10-30 Merck & Co Inc 2,5-diaryl-tetrahydrothiophene derivatives and pharmaceutical compositions
US4595693A (en) * 1984-06-04 1986-06-17 Merck & Co., Inc. Method of use of 2,5-diaryl tetrahydrofurans and analogs thereof as PAF-antagonists
DE3502392A1 (en) * 1985-01-25 1986-07-31 Boehringer Ingelheim KG, 6507 Ingelheim NEW THIENO-TRIAZOLO-1,4-DIAZEPINO-2-CARBONIC ACID AMIDES, METHOD FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL COMPOSITIONS
US4910206A (en) * 1986-07-14 1990-03-20 Sandoz Pharmaceuticals Corp. 5-hetero-or aryl-substituted-imidazo(2,1-a)isoquinolines and their use as PAF receptor antagonists

Also Published As

Publication number Publication date
EP0402422A1 (en) 1990-12-19
JPH03502097A (en) 1991-05-16
MY106956A (en) 1995-08-30
KR900700136A (en) 1990-08-11
DE68904475T2 (en) 1993-05-13
DE68904475D1 (en) 1993-03-04
NZ228879A (en) 1992-08-26
EP0345931A1 (en) 1989-12-13
WO1989010143A1 (en) 1989-11-02
IL90100A (en) 1995-01-24
IE891362L (en) 1989-10-27
CA1327316C (en) 1994-03-01
EP0345931B1 (en) 1993-01-20
IL90100A0 (en) 1989-12-15
IE63697B1 (en) 1995-05-31
JPH0655673B2 (en) 1994-07-27
DK255190A (en) 1990-10-23
ATE84724T1 (en) 1993-02-15
ES2044100T3 (en) 1994-01-01
ES2044100T4 (en) 1996-07-16
AU3578289A (en) 1989-11-24
DK255190D0 (en) 1990-10-23
AU619555B2 (en) 1992-01-30
KR930009786B1 (en) 1993-10-11

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