EP0399234A1 - Ampoule - Google Patents
Ampoule Download PDFInfo
- Publication number
- EP0399234A1 EP0399234A1 EP19900107913 EP90107913A EP0399234A1 EP 0399234 A1 EP0399234 A1 EP 0399234A1 EP 19900107913 EP19900107913 EP 19900107913 EP 90107913 A EP90107913 A EP 90107913A EP 0399234 A1 EP0399234 A1 EP 0399234A1
- Authority
- EP
- European Patent Office
- Prior art keywords
- ampoule
- cone
- neck
- wall
- section
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/05—Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
- A61J1/06—Ampoules or carpules
- A61J1/067—Flexible ampoules, the contents of which are expelled by squeezing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
- A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
- A61J1/2068—Venting means
- A61J1/2075—Venting means for external venting
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
- A61J1/2096—Combination of a vial and a syringe for transferring or mixing their contents
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S215/00—Bottles and jars
- Y10S215/902—Vent
Definitions
- the invention relates to an ampoule, preferably made of plastic, for a liquid which is withdrawn from the ampoule by means of a syringe body which has a cone at its end to be inserted into the ampoule neck.
- the neck forms an inner cone which is adapted to the standardized cone of the syringes. This avoids the fact that a first injection needle to be inserted into the ampoule must first be connected to the cone of the syringe before a second injection needle can be attached to the syringe.
- the cone forms a tight connection with the inner cone, the ampoule must be able to collapse in order to be able to completely remove the liquid contained in it.
- connection between the ampoule and the syringe be tight during withdrawal of the liquid from the ampoule, so that the ampoule is pre-dispensed ganges can also be turned upside down without losing liquid.
- a lack of dimensional stability of the ampoule is disruptive until the liquid is removed.
- the invention is therefore based on the object of creating an ampoule, the contents of which can be removed by means of a syringe without the aid of a cannula, even if the neck of the cannula points downward, but which can nevertheless be designed to be dimensionally stable.
- This object is achieved by an ampoule with the features of claim 1.
- the seal according to the invention can be realized in a simple manner by restricting the contact of the cone on the inner wall of the ampoule neck to a circular line. No liquid can flow out along the conical surface and / or the inner wall of the ampoule neck if the ampoule neck points downward. Nevertheless, the sealing achieved does not prevent air from entering the ampoule to the extent that the liquid is removed from it, which is why the ampoule can be dimensionally stable.
- Another possible implementation of the seal according to the invention is that one or more longitudinal grooves are provided on the inner wall of the ampoule neck, through which the otherwise tight contact of the cone on the inner wall of the ampoule neck is interrupted. You can form this longitudinal groove or grooves so that the entry of air into the ampoule is less hindered than in an embodiment with a system along a closed, circular line.
- the free end of the ampoule neck is used as a contact surface for the the cone-bearing end face of the syringe body.
- the design of the ampoule neck can be such that the inner wall of the ampoule neck has a conical or circular cylindrical shape, at least in the area intended for receiving the cone.
- a section can be calibrated relatively easily during ampoule production to the desired value and with the desired tolerance.
- a dimensionally stable ampoule 1 made of plastic in a blowing process contains a pharmaceutical liquid to be injected by means of a syringe.
- a neck 3 of the ampoule 1, which is designated as a whole by 2 is followed by a head 3 which is formed in one piece with it and which is in turn formed in one piece with a molded-on toggle 4.
- the neck 2, the head 3 and the gag 4 are shaped in a known manner following the filling of the ampoule body, the ampoule 1 being closed at the same time.
- a first section 5 of the neck 2 the diameter of which is smaller than that of the ampoule body.
- This section is followed by a cylindrical section 6 with a smaller diameter, the inside diameter of which is somewhat larger than the largest diameter of a standardized cone 7 for medical devices, which is provided on one end face of a syringe body 8.
- the end of the cylindrical section 6 facing away from the first section 5 is followed by a third section 9, which forms an annular bead projecting inward beyond the inner wall of the cylindrical section 6.
- the inner diameter of the neck 2 at the narrowest point formed by the annular bead is somewhat smaller than the largest diameter of the cone 7.
- the third section 9 merges into a fourth section 10, which extends outward via the cylindrical section 6 and the third section 9 protruding bead forms and a larger inner diameter than the third section 9.
- the fourth section 10 is connected to the head 3 via a predetermined breaking point with reduced wall thickness.
- the head 3 can be separated from the neck 2 by twisting or tilting the toggle 4. Since the exposed after the separation of the head 3 from the neck 2 end face 10 'of the fourth section 10 forms the contact surface for the cone 7-bearing end face of the syringe body 8, the measured in the longitudinal direction of the neck 2 is the distance of the end face 10' from the narrowest point of the neck 2 in the region of the third section 9 is selected such that the cone inserted into the neck 2 lies at a defined, relatively low pressure on the third section 9 of the neck 2 when the end face of the syringe body 8 carrying the cone 7 is on the end face 10 'Is present.
- the contact pressure between the cone 7 and the inner surface of the third section 9 is chosen so that air can enter the ampoule 1 to the extent that its content is sucked through the cone 7 by means of a piston contained in the syringe body 8, but that the liquid contained in the ampoule 1 is not along the jacket of the cone 7 or the inner lateral surface of the neck 2 can emerge, even if the ampoule 1, as usual, is upside down during the withdrawal of the liquid, that is to say its neck 2 points downward.
- the second embodiment which is shown incompletely in FIG. 4, differs from the first embodiment in that the neck 102 of the ampoule 101 has only three sections because the third section forming the inwardly projecting annular bead is missing. So that a self-contained, linear contact between the cone 7 inserted into the neck 102 and the inner wall of the neck 102 is achieved, which prevents the passage of liquid but allows the passage of air, the inner diameter of the cylindrical portion 106 is somewhat smaller chosen as the largest diameter of the cone 7, but somewhat larger than its smallest diameter.
- the axial length of the section 110 which adjoins the cylindrical section 106 and forms an outwardly projecting annular bead, is selected such that the cone 7 has the required, relatively low contact pressure which is necessary to prevent the passage of liquid the inner wall of the cylindrical portion 106 abuts when the cone 7-bearing end face of the syringe body 8 bears against the free end face 110 'of the neck 102.
- the neck 102 is provided at two diametrically arranged locations, each with an inwardly open longitudinal groove III, the cross section of which is selected such that the inflowing air prevents liquid from escaping.
- the cross section of which is selected such that the inflowing air prevents liquid from escaping.
- only a single longitudinal groove could also be provided or the groove arrangement could be selected differently.
- One or more longitudinal grooves of this type could be provided on the inside of the third section 9 of the neck 2 of the first embodiment.
Landscapes
- Health & Medical Sciences (AREA)
- Hematology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19893916840 DE3916840A1 (de) | 1988-09-21 | 1989-05-24 | Ampulle |
DE3916840 | 1989-05-24 |
Publications (2)
Publication Number | Publication Date |
---|---|
EP0399234A1 true EP0399234A1 (fr) | 1990-11-28 |
EP0399234B1 EP0399234B1 (fr) | 1994-06-08 |
Family
ID=6381265
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP90107913A Expired - Lifetime EP0399234B1 (fr) | 1989-05-24 | 1990-04-26 | Ampoule |
Country Status (9)
Country | Link |
---|---|
US (1) | US5046627A (fr) |
EP (1) | EP0399234B1 (fr) |
JP (1) | JPH037162A (fr) |
CA (1) | CA2016892C (fr) |
DE (1) | DE3916840A1 (fr) |
DK (1) | DK0399234T3 (fr) |
ES (1) | ES2054142T3 (fr) |
FI (1) | FI100020B (fr) |
MX (1) | MX171693B (fr) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0489572A1 (fr) * | 1990-12-04 | 1992-06-10 | Automatic Liquid Packaging, Inc. | Fiole fermée hermétiquement |
EP0588028A2 (fr) * | 1992-09-12 | 1994-03-23 | Bernd Dipl.-Ing. Hansen | Ampule |
EP0737485A1 (fr) * | 1993-12-28 | 1996-10-16 | HIGASHIKAWA, Tetsuro | Seringue |
EP1496301A2 (fr) * | 2003-07-08 | 2005-01-12 | Mann+Hummel Gmbh | Raccordement a fiches |
Families Citing this family (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2086916A1 (fr) * | 1992-01-17 | 1993-07-18 | John D. Culter | Bouteille flexible avec fermeture integree amelioree |
US5188250B1 (en) * | 1992-06-05 | 1994-07-05 | Kraft Gen Foods Inc | Plastic beverage bottle with twist-off closure |
US5305658A (en) * | 1992-07-01 | 1994-04-26 | Sterling Winthrop Inc. | Capsule transfer device |
US5758637A (en) | 1995-08-31 | 1998-06-02 | Aerogen, Inc. | Liquid dispensing apparatus and methods |
EP0801940A3 (fr) * | 1996-04-18 | 1998-04-08 | Nizell-Produkte | Ampoule et utilisation de l'ampoule |
US6203870B1 (en) | 1998-02-24 | 2001-03-20 | Plastipak Packaging, Inc. | Liner and preform |
GB9804005D0 (en) * | 1998-02-25 | 1998-04-22 | Nycomed Imaging As | Container |
US6068148A (en) | 1998-05-26 | 2000-05-30 | Automatic Liquid Packaging, Inc. | Hermetically sealed container including a nozzle with a sealing bead |
US6235177B1 (en) | 1999-09-09 | 2001-05-22 | Aerogen, Inc. | Method for the construction of an aperture plate for dispensing liquid droplets |
FR2804940B1 (fr) * | 2000-02-10 | 2002-08-30 | Au Liegeur Ets J Pontneau Deni | Bouchon pour bouteilles a vins effervescents et procede de fabrication d'un tel bouchon |
US7971588B2 (en) | 2000-05-05 | 2011-07-05 | Novartis Ag | Methods and systems for operating an aerosol generator |
US7100600B2 (en) * | 2001-03-20 | 2006-09-05 | Aerogen, Inc. | Fluid filled ampoules and methods for their use in aerosolizers |
US8336545B2 (en) | 2000-05-05 | 2012-12-25 | Novartis Pharma Ag | Methods and systems for operating an aerosol generator |
ES2261735T3 (es) | 2001-05-18 | 2006-11-16 | Chiron Corporation | Sistema para la administracion de una formulacion de tobramicina. |
EP1598059A1 (fr) | 2001-05-18 | 2005-11-23 | Chiron Corporation | Méthodes et formulations en doses unitaires pour l'administration d'aminoglycosides par inhalation |
US7677467B2 (en) | 2002-01-07 | 2010-03-16 | Novartis Pharma Ag | Methods and devices for aerosolizing medicament |
AU2003202925B2 (en) | 2002-01-07 | 2008-12-18 | Aerogen, Inc. | Devices and methods for nebulizing fluids for inhalation |
WO2003059424A1 (fr) | 2002-01-15 | 2003-07-24 | Aerogen, Inc. | Procedes et systemes de fonctionnement d'un generateur d'aerosol |
WO2003097126A2 (fr) | 2002-05-20 | 2003-11-27 | Aerogen, Inc. | Appareil de realisation d'aerosol pour traitement medical et procedes correspondants |
DE10317665A1 (de) | 2003-04-17 | 2004-11-11 | Bernd Hansen | Ampulle |
US8616195B2 (en) | 2003-07-18 | 2013-12-31 | Novartis Ag | Nebuliser for the production of aerosolized medication |
US7946291B2 (en) | 2004-04-20 | 2011-05-24 | Novartis Ag | Ventilation systems and methods employing aerosol generators |
KR101314052B1 (ko) | 2005-05-25 | 2013-10-02 | 노바르티스 아게 | 진동 시스템 및 방법 |
WO2007109684A2 (fr) * | 2006-03-20 | 2007-09-27 | Pre Holding, Inc. | Système d'emballage sous forme de doses utilisé pour l'administration d'une formulation liquide à titrage charge-dose |
US7862841B1 (en) * | 2006-07-05 | 2011-01-04 | Michael D Boyd | Multiple serving container |
US20080228162A1 (en) * | 2007-03-16 | 2008-09-18 | Medlmmune Vaccines, Inc. | Single-use ampoule |
WO2011101651A1 (fr) * | 2010-01-19 | 2011-08-25 | Cambridge Enterprise Limited | Appareil et procédés |
US20160221707A1 (en) * | 2015-02-03 | 2016-08-04 | Avail Vapor Llc | Disposable refill ampule |
DE102017009012A1 (de) | 2017-09-26 | 2019-03-28 | Kocher-Plastik Maschinenbau Gmbh | Behälter sowie Verbindungs- und Herstellvorrichtung |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0088056A1 (fr) * | 1982-02-08 | 1983-09-07 | Astra Läkemedel Aktiebolag | Flacon à dose unitaire |
EP0326391A2 (fr) * | 1988-01-26 | 1989-08-02 | Waverley Pharmaceutical Limited | Ampoules |
EP0327397A2 (fr) * | 1988-02-03 | 1989-08-09 | Waverley Pharmaceutical Limited | Ampoules |
EP0344476A2 (fr) * | 1988-06-01 | 1989-12-06 | Deussen Kunststofftechnik Inhaber Heino Deussen | Ampoule |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3143251A (en) * | 1961-06-09 | 1964-08-04 | Baxter Don Inc | Additive container for medicants or the like |
US3356244A (en) * | 1966-03-28 | 1967-12-05 | Leco Industries Ltd | Container for convenient opening |
US3608550A (en) * | 1969-05-07 | 1971-09-28 | Becton Dickinson Co | Transfer needle assembly |
DE3823428A1 (de) * | 1988-07-11 | 1990-01-18 | Hansen Bernd | Ampulle aus kunststoff |
-
1989
- 1989-05-24 DE DE19893916840 patent/DE3916840A1/de active Granted
-
1990
- 1990-04-26 ES ES90107913T patent/ES2054142T3/es not_active Expired - Lifetime
- 1990-04-26 EP EP90107913A patent/EP0399234B1/fr not_active Expired - Lifetime
- 1990-04-26 DK DK90107913T patent/DK0399234T3/da active
- 1990-05-10 US US07/521,378 patent/US5046627A/en not_active Expired - Lifetime
- 1990-05-16 JP JP2128091A patent/JPH037162A/ja active Granted
- 1990-05-16 CA CA 2016892 patent/CA2016892C/fr not_active Expired - Lifetime
- 1990-05-21 FI FI902502A patent/FI100020B/fi active IP Right Grant
- 1990-05-23 MX MX2084990A patent/MX171693B/es unknown
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0088056A1 (fr) * | 1982-02-08 | 1983-09-07 | Astra Läkemedel Aktiebolag | Flacon à dose unitaire |
EP0326391A2 (fr) * | 1988-01-26 | 1989-08-02 | Waverley Pharmaceutical Limited | Ampoules |
EP0327397A2 (fr) * | 1988-02-03 | 1989-08-09 | Waverley Pharmaceutical Limited | Ampoules |
EP0344476A2 (fr) * | 1988-06-01 | 1989-12-06 | Deussen Kunststofftechnik Inhaber Heino Deussen | Ampoule |
Cited By (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0489572A1 (fr) * | 1990-12-04 | 1992-06-10 | Automatic Liquid Packaging, Inc. | Fiole fermée hermétiquement |
EP0588028A2 (fr) * | 1992-09-12 | 1994-03-23 | Bernd Dipl.-Ing. Hansen | Ampule |
EP0588028A3 (fr) * | 1992-09-12 | 1994-08-03 | Hansen Bernd | |
EP0737485A1 (fr) * | 1993-12-28 | 1996-10-16 | HIGASHIKAWA, Tetsuro | Seringue |
EP0737485A4 (fr) * | 1993-12-28 | 1998-02-04 | Tetsuro Higashikawa | Seringue |
US5830193A (en) * | 1993-12-28 | 1998-11-03 | Higashikawa; Tetsuro | Syringe |
EP1496301A2 (fr) * | 2003-07-08 | 2005-01-12 | Mann+Hummel Gmbh | Raccordement a fiches |
EP1496301A3 (fr) * | 2003-07-08 | 2005-12-21 | Mann+Hummel Gmbh | Raccordement a fiches |
Also Published As
Publication number | Publication date |
---|---|
MX171693B (es) | 1993-11-10 |
DE3916840A1 (de) | 1990-03-29 |
JPH0352984B2 (fr) | 1991-08-13 |
DE3916840C2 (fr) | 1993-06-09 |
US5046627A (en) | 1991-09-10 |
EP0399234B1 (fr) | 1994-06-08 |
FI902502A0 (fi) | 1990-05-21 |
CA2016892C (fr) | 1997-11-18 |
JPH037162A (ja) | 1991-01-14 |
CA2016892A1 (fr) | 1990-11-24 |
DK0399234T3 (da) | 1994-09-19 |
ES2054142T3 (es) | 1994-08-01 |
FI100020B (fi) | 1997-08-29 |
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