EP0399234A1 - Ampoule - Google Patents

Ampoule Download PDF

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Publication number
EP0399234A1
EP0399234A1 EP19900107913 EP90107913A EP0399234A1 EP 0399234 A1 EP0399234 A1 EP 0399234A1 EP 19900107913 EP19900107913 EP 19900107913 EP 90107913 A EP90107913 A EP 90107913A EP 0399234 A1 EP0399234 A1 EP 0399234A1
Authority
EP
European Patent Office
Prior art keywords
ampoule
cone
neck
wall
section
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP19900107913
Other languages
German (de)
English (en)
Other versions
EP0399234B1 (fr
Inventor
Bernd Dipl.-Ing. Hansen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of EP0399234A1 publication Critical patent/EP0399234A1/fr
Application granted granted Critical
Publication of EP0399234B1 publication Critical patent/EP0399234B1/fr
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/05—Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
    • A61J1/06—Ampoules or carpules
    • A61J1/067—Flexible ampoules, the contents of which are expelled by squeezing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2068—Venting means
    • A61J1/2075—Venting means for external venting
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2096—Combination of a vial and a syringe for transferring or mixing their contents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S215/00—Bottles and jars
    • Y10S215/902—Vent

Definitions

  • the invention relates to an ampoule, preferably made of plastic, for a liquid which is withdrawn from the ampoule by means of a syringe body which has a cone at its end to be inserted into the ampoule neck.
  • the neck forms an inner cone which is adapted to the standardized cone of the syringes. This avoids the fact that a first injection needle to be inserted into the ampoule must first be connected to the cone of the syringe before a second injection needle can be attached to the syringe.
  • the cone forms a tight connection with the inner cone, the ampoule must be able to collapse in order to be able to completely remove the liquid contained in it.
  • connection between the ampoule and the syringe be tight during withdrawal of the liquid from the ampoule, so that the ampoule is pre-dispensed ganges can also be turned upside down without losing liquid.
  • a lack of dimensional stability of the ampoule is disruptive until the liquid is removed.
  • the invention is therefore based on the object of creating an ampoule, the contents of which can be removed by means of a syringe without the aid of a cannula, even if the neck of the cannula points downward, but which can nevertheless be designed to be dimensionally stable.
  • This object is achieved by an ampoule with the features of claim 1.
  • the seal according to the invention can be realized in a simple manner by restricting the contact of the cone on the inner wall of the ampoule neck to a circular line. No liquid can flow out along the conical surface and / or the inner wall of the ampoule neck if the ampoule neck points downward. Nevertheless, the sealing achieved does not prevent air from entering the ampoule to the extent that the liquid is removed from it, which is why the ampoule can be dimensionally stable.
  • Another possible implementation of the seal according to the invention is that one or more longitudinal grooves are provided on the inner wall of the ampoule neck, through which the otherwise tight contact of the cone on the inner wall of the ampoule neck is interrupted. You can form this longitudinal groove or grooves so that the entry of air into the ampoule is less hindered than in an embodiment with a system along a closed, circular line.
  • the free end of the ampoule neck is used as a contact surface for the the cone-bearing end face of the syringe body.
  • the design of the ampoule neck can be such that the inner wall of the ampoule neck has a conical or circular cylindrical shape, at least in the area intended for receiving the cone.
  • a section can be calibrated relatively easily during ampoule production to the desired value and with the desired tolerance.
  • a dimensionally stable ampoule 1 made of plastic in a blowing process contains a pharmaceutical liquid to be injected by means of a syringe.
  • a neck 3 of the ampoule 1, which is designated as a whole by 2 is followed by a head 3 which is formed in one piece with it and which is in turn formed in one piece with a molded-on toggle 4.
  • the neck 2, the head 3 and the gag 4 are shaped in a known manner following the filling of the ampoule body, the ampoule 1 being closed at the same time.
  • a first section 5 of the neck 2 the diameter of which is smaller than that of the ampoule body.
  • This section is followed by a cylindrical section 6 with a smaller diameter, the inside diameter of which is somewhat larger than the largest diameter of a standardized cone 7 for medical devices, which is provided on one end face of a syringe body 8.
  • the end of the cylindrical section 6 facing away from the first section 5 is followed by a third section 9, which forms an annular bead projecting inward beyond the inner wall of the cylindrical section 6.
  • the inner diameter of the neck 2 at the narrowest point formed by the annular bead is somewhat smaller than the largest diameter of the cone 7.
  • the third section 9 merges into a fourth section 10, which extends outward via the cylindrical section 6 and the third section 9 protruding bead forms and a larger inner diameter than the third section 9.
  • the fourth section 10 is connected to the head 3 via a predetermined breaking point with reduced wall thickness.
  • the head 3 can be separated from the neck 2 by twisting or tilting the toggle 4. Since the exposed after the separation of the head 3 from the neck 2 end face 10 'of the fourth section 10 forms the contact surface for the cone 7-bearing end face of the syringe body 8, the measured in the longitudinal direction of the neck 2 is the distance of the end face 10' from the narrowest point of the neck 2 in the region of the third section 9 is selected such that the cone inserted into the neck 2 lies at a defined, relatively low pressure on the third section 9 of the neck 2 when the end face of the syringe body 8 carrying the cone 7 is on the end face 10 'Is present.
  • the contact pressure between the cone 7 and the inner surface of the third section 9 is chosen so that air can enter the ampoule 1 to the extent that its content is sucked through the cone 7 by means of a piston contained in the syringe body 8, but that the liquid contained in the ampoule 1 is not along the jacket of the cone 7 or the inner lateral surface of the neck 2 can emerge, even if the ampoule 1, as usual, is upside down during the withdrawal of the liquid, that is to say its neck 2 points downward.
  • the second embodiment which is shown incompletely in FIG. 4, differs from the first embodiment in that the neck 102 of the ampoule 101 has only three sections because the third section forming the inwardly projecting annular bead is missing. So that a self-contained, linear contact between the cone 7 inserted into the neck 102 and the inner wall of the neck 102 is achieved, which prevents the passage of liquid but allows the passage of air, the inner diameter of the cylindrical portion 106 is somewhat smaller chosen as the largest diameter of the cone 7, but somewhat larger than its smallest diameter.
  • the axial length of the section 110 which adjoins the cylindrical section 106 and forms an outwardly projecting annular bead, is selected such that the cone 7 has the required, relatively low contact pressure which is necessary to prevent the passage of liquid the inner wall of the cylindrical portion 106 abuts when the cone 7-bearing end face of the syringe body 8 bears against the free end face 110 'of the neck 102.
  • the neck 102 is provided at two diametrically arranged locations, each with an inwardly open longitudinal groove III, the cross section of which is selected such that the inflowing air prevents liquid from escaping.
  • the cross section of which is selected such that the inflowing air prevents liquid from escaping.
  • only a single longitudinal groove could also be provided or the groove arrangement could be selected differently.
  • One or more longitudinal grooves of this type could be provided on the inside of the third section 9 of the neck 2 of the first embodiment.
EP90107913A 1989-05-24 1990-04-26 Ampoule Expired - Lifetime EP0399234B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3916840 1989-05-24
DE19893916840 DE3916840A1 (de) 1988-09-21 1989-05-24 Ampulle

Publications (2)

Publication Number Publication Date
EP0399234A1 true EP0399234A1 (fr) 1990-11-28
EP0399234B1 EP0399234B1 (fr) 1994-06-08

Family

ID=6381265

Family Applications (1)

Application Number Title Priority Date Filing Date
EP90107913A Expired - Lifetime EP0399234B1 (fr) 1989-05-24 1990-04-26 Ampoule

Country Status (9)

Country Link
US (1) US5046627A (fr)
EP (1) EP0399234B1 (fr)
JP (1) JPH037162A (fr)
CA (1) CA2016892C (fr)
DE (1) DE3916840A1 (fr)
DK (1) DK0399234T3 (fr)
ES (1) ES2054142T3 (fr)
FI (1) FI100020B (fr)
MX (1) MX171693B (fr)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0489572A1 (fr) * 1990-12-04 1992-06-10 Automatic Liquid Packaging, Inc. Fiole fermée hermétiquement
EP0588028A2 (fr) * 1992-09-12 1994-03-23 Bernd Dipl.-Ing. Hansen Ampule
EP0737485A1 (fr) * 1993-12-28 1996-10-16 HIGASHIKAWA, Tetsuro Seringue
EP1496301A2 (fr) * 2003-07-08 2005-01-12 Mann+Hummel Gmbh Raccordement a fiches

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2086916A1 (fr) * 1992-01-17 1993-07-18 John D. Culter Bouteille flexible avec fermeture integree amelioree
US5188250B1 (en) * 1992-06-05 1994-07-05 Kraft Gen Foods Inc Plastic beverage bottle with twist-off closure
US5305658A (en) * 1992-07-01 1994-04-26 Sterling Winthrop Inc. Capsule transfer device
US5758637A (en) 1995-08-31 1998-06-02 Aerogen, Inc. Liquid dispensing apparatus and methods
EP0801940A3 (fr) * 1996-04-18 1998-04-08 Nizell-Produkte Ampoule et utilisation de l'ampoule
US6203870B1 (en) 1998-02-24 2001-03-20 Plastipak Packaging, Inc. Liner and preform
GB9804005D0 (en) * 1998-02-25 1998-04-22 Nycomed Imaging As Container
US6068148A (en) 1998-05-26 2000-05-30 Automatic Liquid Packaging, Inc. Hermetically sealed container including a nozzle with a sealing bead
US6235177B1 (en) 1999-09-09 2001-05-22 Aerogen, Inc. Method for the construction of an aperture plate for dispensing liquid droplets
FR2804940B1 (fr) * 2000-02-10 2002-08-30 Au Liegeur Ets J Pontneau Deni Bouchon pour bouteilles a vins effervescents et procede de fabrication d'un tel bouchon
US7100600B2 (en) * 2001-03-20 2006-09-05 Aerogen, Inc. Fluid filled ampoules and methods for their use in aerosolizers
US7971588B2 (en) 2000-05-05 2011-07-05 Novartis Ag Methods and systems for operating an aerosol generator
US8336545B2 (en) 2000-05-05 2012-12-25 Novartis Pharma Ag Methods and systems for operating an aerosol generator
EP1598059A1 (fr) 2001-05-18 2005-11-23 Chiron Corporation Méthodes et formulations en doses unitaires pour l'administration d'aminoglycosides par inhalation
CA2447600C (fr) 2001-05-18 2015-10-20 Chiron Corporation Methodes et formulations en dose unitaire servant a l'administration d'aminosides par inhalation
WO2003057291A1 (fr) 2002-01-07 2003-07-17 Aerogen, Inc. Dispositifs et procedes pour la nebulisation de fluides d'inhalation
US7677467B2 (en) 2002-01-07 2010-03-16 Novartis Pharma Ag Methods and devices for aerosolizing medicament
WO2003059424A1 (fr) 2002-01-15 2003-07-24 Aerogen, Inc. Procedes et systemes de fonctionnement d'un generateur d'aerosol
US6915962B2 (en) 2002-05-20 2005-07-12 Aerogen, Inc. Apparatus for providing aerosol for medical treatment and methods
DE10317665A1 (de) * 2003-04-17 2004-11-11 Bernd Hansen Ampulle
US8616195B2 (en) 2003-07-18 2013-12-31 Novartis Ag Nebuliser for the production of aerosolized medication
US7946291B2 (en) 2004-04-20 2011-05-24 Novartis Ag Ventilation systems and methods employing aerosol generators
EA012656B1 (ru) 2005-05-25 2009-12-30 Аэроджен, Инк. Вибрационные системы и их применение
US20080000798A1 (en) * 2006-03-20 2008-01-03 Werner Gutmann Dose packaging system for load-dose titration administration of a liquid formulation
US7862841B1 (en) * 2006-07-05 2011-01-04 Michael D Boyd Multiple serving container
US20080228162A1 (en) * 2007-03-16 2008-09-18 Medlmmune Vaccines, Inc. Single-use ampoule
EP2525766A1 (fr) * 2010-01-19 2012-11-28 Cambridge Enterprise Ltd. Appareil et procédés
US20160221707A1 (en) * 2015-02-03 2016-08-04 Avail Vapor Llc Disposable refill ampule
DE102017009012A1 (de) * 2017-09-26 2019-03-28 Kocher-Plastik Maschinenbau Gmbh Behälter sowie Verbindungs- und Herstellvorrichtung

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0088056A1 (fr) * 1982-02-08 1983-09-07 Astra Läkemedel Aktiebolag Flacon à dose unitaire
EP0326391A2 (fr) * 1988-01-26 1989-08-02 Waverley Pharmaceutical Limited Ampoules
EP0327397A2 (fr) * 1988-02-03 1989-08-09 Waverley Pharmaceutical Limited Ampoules
EP0344476A2 (fr) * 1988-06-01 1989-12-06 Deussen Kunststofftechnik Inhaber Heino Deussen Ampoule

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3143251A (en) * 1961-06-09 1964-08-04 Baxter Don Inc Additive container for medicants or the like
US3356244A (en) * 1966-03-28 1967-12-05 Leco Industries Ltd Container for convenient opening
US3608550A (en) * 1969-05-07 1971-09-28 Becton Dickinson Co Transfer needle assembly
DE3823428A1 (de) * 1988-07-11 1990-01-18 Hansen Bernd Ampulle aus kunststoff

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0088056A1 (fr) * 1982-02-08 1983-09-07 Astra Läkemedel Aktiebolag Flacon à dose unitaire
EP0326391A2 (fr) * 1988-01-26 1989-08-02 Waverley Pharmaceutical Limited Ampoules
EP0327397A2 (fr) * 1988-02-03 1989-08-09 Waverley Pharmaceutical Limited Ampoules
EP0344476A2 (fr) * 1988-06-01 1989-12-06 Deussen Kunststofftechnik Inhaber Heino Deussen Ampoule

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0489572A1 (fr) * 1990-12-04 1992-06-10 Automatic Liquid Packaging, Inc. Fiole fermée hermétiquement
EP0588028A2 (fr) * 1992-09-12 1994-03-23 Bernd Dipl.-Ing. Hansen Ampule
EP0588028A3 (fr) * 1992-09-12 1994-08-03 Hansen Bernd
EP0737485A1 (fr) * 1993-12-28 1996-10-16 HIGASHIKAWA, Tetsuro Seringue
EP0737485A4 (fr) * 1993-12-28 1998-02-04 Tetsuro Higashikawa Seringue
US5830193A (en) * 1993-12-28 1998-11-03 Higashikawa; Tetsuro Syringe
EP1496301A2 (fr) * 2003-07-08 2005-01-12 Mann+Hummel Gmbh Raccordement a fiches
EP1496301A3 (fr) * 2003-07-08 2005-12-21 Mann+Hummel Gmbh Raccordement a fiches

Also Published As

Publication number Publication date
MX171693B (es) 1993-11-10
DE3916840C2 (fr) 1993-06-09
JPH0352984B2 (fr) 1991-08-13
DE3916840A1 (de) 1990-03-29
JPH037162A (ja) 1991-01-14
EP0399234B1 (fr) 1994-06-08
FI902502A0 (fi) 1990-05-21
CA2016892C (fr) 1997-11-18
ES2054142T3 (es) 1994-08-01
FI100020B (fi) 1997-08-29
CA2016892A1 (fr) 1990-11-24
US5046627A (en) 1991-09-10
DK0399234T3 (da) 1994-09-19

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