Classifications

• • C—CHEMISTRY; METALLURGY
  • C07—ORGANIC CHEMISTRY
  • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
  • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
  • C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
  • C07C235/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated
  • C07C235/08—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K8/00—Cosmetics or similar toiletry preparations
  • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
  • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
  • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
  • A61K8/42—Amides
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K8/00—Cosmetics or similar toiletry preparations
  • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
  • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
  • A61K8/60—Sugars; Derivatives thereof
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
  • A61P17/00—Drugs for dermatological disorders
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
  • A61Q1/00—Make-up preparations; Body powders; Preparations for removing make-up
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
  • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
  • A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
  • A61Q19/00—Preparations for care of the skin
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
  • A61Q19/00—Preparations for care of the skin
  • A61Q19/007—Preparations for dry skin
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
  • A61Q19/00—Preparations for care of the skin
  • A61Q19/008—Preparations for oily skin
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
  • A61Q19/00—Preparations for care of the skin
  • A61Q19/04—Preparations for care of the skin for chemically tanning the skin
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
  • A61Q19/00—Preparations for care of the skin
  • A61Q19/10—Washing or bathing preparations

Definitions

• the present invention relates to N-alkoxyalkylamides and to the use of such compounds in cosmetic compositions, including compositions and processes for providing moisturizing and/or softening properties to human skin, particularly common or mild to moderate "dry skin".
• cosmetic compositions including compositions and processes for providing moisturizing and/or softening properties to human skin, particularly common or mild to moderate "dry skin".
• the invention will be described initially in connection with its use to treat dry skin conditions.
• the cosmetic composition of the present invention can be used advantageously for other types of cosmetic applications.
• dry skin The human skin disorder known as "dry skin” is characterized by cracking, flaking or scaling of the skin of the hands, feet, neck, face or other parts of the body. This disorder may result from a hereditary disorder known as ichthyosis which is a severe form of dry skin. This form of dry skin is not too prevalent.
• An object of the present invention is to provide novel compounds useful for the treatment of the mild to moderate form of dry skin.
• a further object of the present invention is to provide novel cosmetic compositions based on N-alkoxyalkylamides, including the novel compounds of the present invention and/or known compounds, which are useful for a variety of cosmetic purposes, including the treatment of mild to moderate dry ' - skin. Summary of the Present Invention It has now been found that these and other objects of the present invention may be accomplished by the use, for dry skin treating and other cosmetic purposes, of N-alkoxyalkylamides as described below.
• one aspect of the present invention comprises a cosmetic composition having, as one of its essen ⁇ tial constituents, one or more N-alkoxyalkylamides of the general formula - O H
• (C m H 2m+1 ) is a straight or branched chain alkylene group in which m is a whole number of 1 to about 6, and is preferably 1.
• alkoxyamides compounds within the scope of Formula I above are hereafter sometimes referred to as "alkoxyamides".
• the cosmetic composition of the present invention includes also as an essential constituent a material, hereafter referred to as "a carrier, " which is effective in providing the alkoxyamide-containing composition in a form such that the composition can be applied to external portions of the body, for example, the skin.
• Another aspect of the present invention comprises novel N-alkoxyalkylamide compounds having the general formula O H
• (C m H 2m+1 ) is a straight or branched chain alkylene group in which, m is a whole number of 1 to 4, and is preferably 1.
• amide compound of Formula II above is that wherein p is 4, n is 3 and m is 1.
• PG methoxy propyl gluconamide
• the particularly-preferred MPG exhibits unusually good properties in the cosmetic composition of the present invention as will be discussed more fully below, and as is exemplified by use of various of the exemplary compositions set forth below.
• Another aspect of the present invention comprises a process in which one or more compounds of Formula I above or a cosmetic composition comprising one_orjngre .
• _compounds of Formula I above and a carrier therefor is applied to an external portion of the body for the purpose of cosmetically treating said body portion, for example, for the purpose of moisturizing and softening the human skin.
• cosmetic composition is used herein in its usually understood sense, that is, to define a composition which is applied to external body portions, typically a human body, for beautifying, cleansing, moisturizing or otherwise treating the external surface of the body, including by cleansing, coloring, conditioning, or protecting the external surface of the body part, such as, for example, the skin and ftairr.
• cosmetic compositions in which the alkoxyamides of the present invention can be used are skin moisturizers, sun screens, makeup, protein concentrates, skin firming compositions and cleansers, including decongestant cleansers.
• the cosmetic composition of the present invention is to be distinguished from pharmaceutical compositions of the type disclosed in West German OLS No. 2,321,752 and its Patent of Addition OLS No. 2,338,087. These patents disclose various acid amides, including an acid amide within the scope of
• the cosmetic composition of the present invention is in a form such that it can be applied to the exterior of the body and does not enter the interior of the body, that is, it does not pass beyond the basal membrane
• the term "applied cosmetically" (or variant thereof) as used herein in connection with the application of an alkoxyamide or of the cosmetic composition of the present invention to an external body portion means that the alkoxy ⁇ amide is in a form such that none of it or a therapeutically
• the novel alkoxyamides have a neutral pH, enabling the use of a neutral pH carrier.
• Most prior art moisturizers such as aliphatic hydroxyacids, are 0 acidic, and must be neutralized or incorporated into a basic carrier to be effective and non-irritating to human skin.
• the alkoxyamides are also easily handled and stored, as they are generally iro he; form of a plain white powder. They are also water-soluble, enabling them to be easily incorporated into water-based compositions. They can also be easily manufac ⁇ tured by known methods from readily available precursors.
• compositions of the present invention are one or more os£fthe.- alkoxyamides of Structure I above and a carrier therefor.
• the composition will include one or more additional ingredients, the identity of which will depend on the intended use of the composition and the selection of which can be made in accordance with available knowledge in the art.
• the alkoxyamides of Structure I can be prepared by any suitable method.
• the aforementioned OLS Nos. 2,321,752 and 2,338,087 contain information on preparing compounds within the scopes of Structure I.
• Structure I compounds of the present invention are prepared by reacting one mole of an amine compound having the structure
• Structure IV amine compounds is methoxy propyl amine, i.e., wherein m is 1 and n is 3.
• the preferred of such Structure V carboxylic acids is gluconic acid.
• an excess of the amine is usually used to help drive the reaction to completion. Such excess is usually in the amount of about 0.1 to about 0.5 mole %.
• the la ⁇ tone/acid is first heated with stirring in a refluxing alcoholic solvent, at atmospheric pressure, to slurry the solids.
• the alcohol used is aliphatic and has a reflux temperature of about 65 to about 86°C.
• the amine is added dropwise to the slurry, in the refluxing solvent, and the solids therein are dissolved to produce a light yellow colored solution.
• the reaction takes about 10 to 30 minutes at reflux temperatures.
• the reaction is slightly exothermic. Any temperature rise, however, is only noticeable when the amine is added at room temperature, but is not detectable at solvent reflux temperatures.
• the heating is then discontinued and the solution is allowed to cool with stirring.
• a " precipitate generally starts to form approximately 20 degrees below the refluxing temperature of the solvent.
• the carrier for use in formulating the composition of the present invention can comprise one or more compounds which will be selected based on the particular intended use of the composition.
• the carrier functions to 10. " permit,formulation? ⁇ f a composition that allows the alkoxyamide to b& applied to an exterior body surface in the desired way.
• the carrier may be inorganic or organic in nature, and like the alkoxyamide, it must be non- oxic and non-irritating and should also be inoffensive to the user. 15
• the carrier must, of course, be compatible with the alkoxyamide. Examples below are illustrative of a variety of carriers that can be used.
• composition of the present invention can include also one 20 or more optional ingredients, also referred to herein as
• auxiliary components examples include lubricants ⁇ preservatives,- perfumes and colorants.
• composition of the present invention will be used most widely in applications that are 25 designed: fer use in treating humans having a dry skin condition.
• active ingredients used in such compositions for such purposes will comprise one or more of the Structure I compounds disclosed above, and most preferably the compound of Structure III.
• the composition of the present invention may be used for prophylactic as well as therapeutic purposes, relative to their propxcsed use in treating dry skin by the topical application thereto, so as to prevent or cure the occurrence of any cracking, flaking, scaling or chapping of the skin.
• the compositions of the present invention may be used to prevent, cure, or ameliorate dry skin conditions, acne, psoriasis, seborrhea, keratose, diaper rash, sunburn and windburn.
• compositions of the present invention may be prepared and used in the form of a lotion, cream, ointment, stick, soap, or other forms commonly employed in the art of cosmetic, including skin care, formulations. They are preferably used in an emulsified form.
• compositions of the present invention are prepared employing skin-softening and moisturizing effective amounts (for example, up to about 25 wt.%) of one or more of the alkoxyamide compounds of the present invention in a cosmetically acceptable carrier, such as a hydrophilic ointment (USP) or petrolatum.
• a cosmetically acceptable carrier such as a hydrophilic ointment (USP) or petrolatum.
• USP hydrophilic ointment
• petrolatum preferably about 1 to about 20, and most preferably about 5 to about 15, weight % of the alkoxyamide compound(s) are used therein.
• alkoxyamide can be used in compositions within the scope of the present invention, for example, in compositions which include one or more other skin-moisturizers or softeners or when used in compositions that are designed primarily for other types of cosmetic functions. This is discussed more fully below.
• the bulk of such compositions of the present invention will comprise about 30 to about 75, and preferably about 55 to about 65, weight % of distilled water, and about 10 to about 40, and preferably about 15 to about 30 weight %, of a combination of other commonly usied cosmetically effective auxiliary components of the various types of compositions in question (i.e., lotion, cream, ointment, stick or soap).
• auxiliary components are chemically inert with respect to each other, and with respect to the alkoxyamide compounds of the present invention.
• compositions of the present invention for dry skin applications (weight %, based on total weight of the composition): about 0.75 to about 7 % emulsifying agents about: 3 to- about 15 % emollients about H to about 2 % medicament of the present invention about 0.1 to about 5% lubricant about 0.2 to about 1% preservative about 0.2 to about 1% perfume about 0.01 to about 0.1% colorant
• the alkoxyamide compounds themselves can be topically applied cosmetically in uncompounded form to the areas of the skin to be treated therewith. Whether used as is, or in compounded or compositional f ⁇ r ⁇ r, £or dry skin treating purposes, the alkoxyamide compounds of the present invention are topically applied one or more, and preferably about 2 to 4, times per day to the area of skin to be treated therewith for a period of about 7 to 21 days in order to achieve the desired amelioration of the dry skin condition.
• the alkoxyamides can be used effectively also in applications that are designed primarily to treat conditions other than dry skin conditions, for example, in makeup, cleansers, sunscreens, self-tanning and lightening compositions, skin firmers, shaving preparations, shampoos, topically applied therapeutic compositions and depilatories.
• the alkoxyamides can be used in quite small amounts.
• Makeup compositions can effectively incorporate the alkoxyamide in small amounts, generally about 0.01 to about 5 wt.%, preferably about 0.02 to about 0.1 wt.% of the composition.
• makeup compositions of the present invention generally comprise about 1 to about 40 wt.%, preferably about 10 to about 20 wt.%, of a coloring agent (for example, pigment) in a suitable carrier.
• a coloring agent for example, pigment
• Suitable pigments include all inorganic and organic pigments which are usable in cosmetic formulations. Examples include carmine, bismuth oxychloride, zinc oxide, ferric oxide, ferrous oxide, kaolin, ultramarine violet, ultramarine blue, chromium oxide, chromium hydroxide, silica and manganese violet.
• lakes of organic colorants such as FD&C Red No. 7 calcium lake, FD&C Yellow No. 5 aluminum lake, FD&C Red No. 9 barium lake and FD&C Red No. 30.
• Additional examples include talc, mica, and titanium oxide; any of the foregoing carried on the surface of talc, mica or titanium oxide; and titanated mica.
• pigment includes within its meaning a mixture of two or more pigments.
• the compounds of the present invention may be stored as is, or in the form of the compositions disclosed herein, in closed containers at room temperature for extended periods of time without a change in their utility for dry skin treating " purposes.
• Example 1 Glucono delta lactone (352 grams) was heated in 1000 ml of isopropyl alcohol to reflux temperatures, about 86°C (at atmospheric pressure), in a two-liter-3 neck-glass flask equipped with a stirrer, reflux condenser column and a stoppered inlet port. Then 180 grams of methoxy propyl amine was added to the refluxing lactone slurry over a period of about 10 minutes through the inlet port.
• Example 1 as a skin moisturizing or softening material.
• the creams were emulsions prepared as described below. These two formulations, in weight %, were as follows:
• Polawax (Croda, Inc.) is a preparation of higher fatty alcohols and ethylene oxide reaction products.
• Phase A is made of 52.36% water, 1.00?r propylene glycol and 0.3O% methyl-p-hydroxy benzoate.
• Phase D is made of 15.00% water and 15.00% of the additive being comparatively evaluated, i.e., methoxy propyl gluconamide or glucono delta lactone.
• Phase B contains all the remaining components except the imidazolidinyl urea.
• Phase A The components of Phase A are first mixed together with heating at 80°C, and the components of Phase B are also mixed together at 80°C. Then Phase B is added to Phase A and heating - (at 80°C) and mixing is continued for about 10 minutes and then the heating is stopped.
• Phase C is formed by dissolving the imidazolidinyl urea in the water and heating to 50°C. Phase C is then added to the Phase A/B admixture. Phase D is made by dissolving the additive of choice in water and heating to 45°C, then Phase D is added to the Phase A/B/C admixture. The resulting product is then cooled, to 35°C with mixing and packaged.
• Example 2 to 3 The formulations of Examples 2 to 3 were comparatively evaluated by a text panel of 10 panelists with dry skin.
• the panelists cleansed both of their forearms with their regular soap once in the morning and once in the evening and than applied the test formulation to one forearm.
• the other forearm was left untreated as a control.
• Each formulation was thus tested twice daily for a two week period. At the end of this time, the forearms of each panelist were compared.
• Example 2 provided some amelioration of the dry skin condition of the treated 5 forearms, as compared to the untreated forearms
• the use of the formulation of Example 3 provided a noticeably improved difference in its effect on the dry skin of the forearms treated therewith as compared to the effect provided by the use of the formulation of Example 2.
• This example illustrates the compatibility of methoxy propyl gluconamide with other cosmetic ingredients including sunscreening agents.
• the methoxy propyl gluconamide was physically, chemically and functionally compatible with the other components of the Example 4 formulation.
• the use -of the methoxy propyl gluconamide in the Example 4 formulation provides noticeably improved dry skin treating properties as compared to the use of the same formulation without such amide therein.
• the formulation is also useful for sunscreening purposes.
• Example 5 The following illustrates the compatibility of the " subject amide compound in a water in oil emulsion formulation.
• Carbopol 1342 (Carbomer 1342) 0. .110
• Abil R WS08 (Goldsch idt AG) is a combination of Cetyl Dimethicone Copolyol Cetyl Dimethicone, Polyglyceryl-3 Oleate and Hexyl Laurate.
• the methoxy propyl gluconamide was physically, chemically and functionally compatible with the other components of the Example 5 formulation.
• the use of the methoxy propyl gluconamide in the Example 5 formulation provides noticeably improved dry skin treating properties as compared to the use, for such purposes, of the same formulations without such amide therein.
• the next example is illustrative of a skin moisturizer of the present invention.
• compositions for firming, plumping or tightening the skin can incorporate advantageously the alkoxyamide.
• Such compositions can comprise also a skin-firming agent such as, for example, xanthan gum, carboxy methyl cellulose or related cellulosic material, and fibronectin or other proteinaceous material, and a compatible carrier.
• the skin-firming agent will generally comprise about 0.1 to about 35 wt.%, preferably about 2 to about 15 wt.%, of the total composition.
• the alkoxyamide will generally comprise about 0.1 to about 20 wt.%,, pmsferrably about 1 to about 15 wt.%, of the total compositions Tables 1 and 2 below identify the ingredients and concentrations of eight skin-firming compositions of the present invention.
• Glycereth-7 triacetate 1 5 Arnica extract, barley extract and hydrolyzed marine polypeptides* 2.5 2.5 2.5 2.5 2 Isopropyl EPG-2-isodeceth-
• Alkoxyamides are ideal for use in products used for skin tanning type applications where their superior moisturizing properties aid in preventing drying of the skin caused by exposure to the sun and/or wind.
• the essential components for a sunscreen formulation of the present invention comprise a sunscreening agent, the alkoxyamide and a suitable carrier.
• sunscreening agents available.
• sunscreening agents include: p-aminobenzoic acid (PABA) and derivatives such as octyl dimethyl PABA, amyl-p-dimethylaminobenzoate and glyceryl mono- p-aminobenzoate; cinnamates such as octyl me hoxycinnamate, 5 .
• PABA p-aminobenzoic acid
• derivatives such as octyl dimethyl PABA, amyl-p-dimethylaminobenzoate and glyceryl mono- p-aminobenzoate
• cinnamates such as octyl me hoxycinnamate, 5 .
• the concentration of the sunscreening agent depends on 5 its efficacy as a sunscreen, but is generally about 0.25 to about 33 wt.%, preferably about 1 to about 15 wt.%, of the total weight of the composition.
• the amount of the alkoxyamide comprises preferably about 0.01 to about 10 wt.%, and most preferably about 0.1 to about 5 wt.%, of the total 0 weight of the composition.
• Table 3 below identifies the ingredients and concentrations of four sunscreen compositions of the present invention.
• the term in parentheses is the approximate Sun Protection Factor (SPF) for each composition.
• Examples 15 to 5 17 are aqueous-based compositions, while Example 18 is a non- aqueous composition.
• SPF Sun Protection Factor
• PVP/Eicosene copolymer 2 3 2.25 -
• the alkoxyamide can also be used advantageously in self- tanning compositions.
• Such compositions contain tanning agents capable of darkening the skin without exposure to ultraviolet radiation.
• the preferred, and most commonly used, tanning agent is dihydroxyacetone, which generally comprises about 1 to about 12 wt.%, preferably about 2 to about 7 wt.%, of the total composition.
• the alkoxyamide will generally comprise, about Q-.01 to about 10 wt.%, preferably about 0.1 to about 5) wt.%, of the total composition.
• Table 4 below identifies the ingredients from which Example 19, a self- tanning composition, was made.
• the alkoxyamide can also be used advantageously in compositions for treating the skin before or after exposure to tanning radiation.
• Such compositions contain at least one moisturizer, and do not require sunscreens or self-tanning agents.
• Optional ingredients include antioxidants such as tocopheryl acetate (vitamin E), healing agents such as allantoin, protein extracts and amino acid preparations.
• the alkoxyamide will generally comprise about 0.01 to about 10 wt.%, preferably about 0.1 to about 5 wt.%, of the total composition. Table 5 below identifies the ingredients from which Example 20, a pre-tanning conditioner, was made.
• the alkoxyamide can be incorporated into skin cleaning compositions to reduce drying out the skin by washing.
• Essential components of such compositions include also a detergent, or cleansing agent, such as cocamidopropyl betaine, sodium lauryl (and laureth) sulfate and sucrose cocoate, and a compatible carrier.
• the cleansing agent generally comprises about 1 to about 20 wt.%, preferably about 2 to about 11 wt.%, of the total composition, based on the solids content of the cleansing agents, which usually are aqueous solutions.
• the alkoxyamide will generally comprise about 0.1 to about 10 wt.%, preferably about 0.5 to about 5 wt.%, of the total composition.
• Example 21 is formulated for normal skin.
• Example 22 for dry skin, and Example 23 for oily skin.
• the alkoxyamide can be incorporated into compositions containing proteinaceous material applied to the skin.
• proteinaceous material examples include protein and protein concentrates of such proteins such as collagen,
• proteinaceous material includes also partially and fully hydrolyzed forms thereof, for example, polypeptide fragments and substituent amino acids.
• the proteinaceous material generally comprises about 0.1 to about
• the alkoxyamide will generally comprise about 0.01 to about 10 wt.%, preferably about 0.1 to about 3 wt.%, of the total composition.
• Table 7 below identifies the ingredients and concentrations from which Example 24, a
• the present invention affords the means for providing improved cosmetic compositions which can be tailor made into a variety of different types of formulations to suit particular needs.

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