EP0349560A1 - Verfahren und vorrichtung zur dosierung von pulvern - Google Patents
Verfahren und vorrichtung zur dosierung von pulvernInfo
- Publication number
- EP0349560A1 EP0349560A1 EP88902461A EP88902461A EP0349560A1 EP 0349560 A1 EP0349560 A1 EP 0349560A1 EP 88902461 A EP88902461 A EP 88902461A EP 88902461 A EP88902461 A EP 88902461A EP 0349560 A1 EP0349560 A1 EP 0349560A1
- Authority
- EP
- European Patent Office
- Prior art keywords
- nozzle
- particles
- vibrations
- vibration
- frequency
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 238000000034 method Methods 0.000 title claims abstract description 23
- 239000000843 powder Substances 0.000 title claims abstract description 18
- 230000008569 process Effects 0.000 title claims abstract description 13
- 239000002245 particle Substances 0.000 claims abstract description 26
- 230000008859 change Effects 0.000 claims description 3
- 230000005284 excitation Effects 0.000 claims description 2
- 230000000694 effects Effects 0.000 abstract description 3
- 238000007599 discharging Methods 0.000 abstract 1
- 238000003860 storage Methods 0.000 description 13
- 239000012528 membrane Substances 0.000 description 6
- 239000004480 active ingredient Substances 0.000 description 5
- 239000000919 ceramic Substances 0.000 description 5
- 239000003814 drug Substances 0.000 description 5
- 229940079593 drug Drugs 0.000 description 5
- 239000003380 propellant Substances 0.000 description 5
- 239000000126 substance Substances 0.000 description 5
- 230000008878 coupling Effects 0.000 description 4
- 238000010168 coupling process Methods 0.000 description 4
- 238000005859 coupling reaction Methods 0.000 description 4
- 238000005516 engineering process Methods 0.000 description 4
- 239000007789 gas Substances 0.000 description 4
- 230000033001 locomotion Effects 0.000 description 4
- 239000000463 material Substances 0.000 description 4
- 230000007246 mechanism Effects 0.000 description 4
- 239000007787 solid Substances 0.000 description 3
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
- 238000005411 Van der Waals force Methods 0.000 description 2
- 239000000443 aerosol Substances 0.000 description 2
- 230000005672 electromagnetic field Effects 0.000 description 2
- 239000010419 fine particle Substances 0.000 description 2
- 239000004033 plastic Substances 0.000 description 2
- 230000001105 regulatory effect Effects 0.000 description 2
- 239000011343 solid material Substances 0.000 description 2
- 239000000725 suspension Substances 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 238000004804 winding Methods 0.000 description 2
- 229920000544 Gore-Tex Polymers 0.000 description 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 230000000712 assembly Effects 0.000 description 1
- 238000000429 assembly Methods 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 230000001276 controlling effect Effects 0.000 description 1
- 210000003298 dental enamel Anatomy 0.000 description 1
- 239000002274 desiccant Substances 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 230000004907 flux Effects 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 238000000265 homogenisation Methods 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 238000002664 inhalation therapy Methods 0.000 description 1
- 229910052742 iron Inorganic materials 0.000 description 1
- 239000007791 liquid phase Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000000968 medical method and process Methods 0.000 description 1
- 229940126601 medicinal product Drugs 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 230000010355 oscillation Effects 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000002787 reinforcement Effects 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 238000005204 segregation Methods 0.000 description 1
- 239000000741 silica gel Substances 0.000 description 1
- 229910002027 silica gel Inorganic materials 0.000 description 1
- 239000007790 solid phase Substances 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 238000002604 ultrasonography Methods 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J4/00—Feed or outlet devices; Feed or outlet control devices
- B01J4/02—Feed or outlet devices; Feed or outlet control devices for feeding measured, i.e. prescribed quantities of reagents
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J8/00—Chemical or physical processes in general, conducted in the presence of fluids and solid particles; Apparatus for such processes
- B01J8/0015—Feeding of the particles in the reactor; Evacuation of the particles out of the reactor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0065—Inhalators with dosage or measuring devices
- A61M15/0066—Inhalators with dosage or measuring devices with means for varying the dose size
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0085—Inhalators using ultrasonics
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J8/00—Chemical or physical processes in general, conducted in the presence of fluids and solid particles; Apparatus for such processes
- B01J8/0015—Feeding of the particles in the reactor; Evacuation of the particles out of the reactor
- B01J8/002—Feeding of the particles in the reactor; Evacuation of the particles out of the reactor with a moving instrument
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D88/00—Large containers
- B65D88/54—Large containers characterised by means facilitating filling or emptying
- B65D88/64—Large containers characterised by means facilitating filling or emptying preventing bridge formation
- B65D88/66—Large containers characterised by means facilitating filling or emptying preventing bridge formation using vibrating or knocking devices
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. ventilators; Tracheal tubes
- A61M16/0003—Accessories therefor, e.g. sensors, vibrators, negative pressure
- A61M2016/0015—Accessories therefor, e.g. sensors, vibrators, negative pressure inhalation detectors
- A61M2016/0018—Accessories therefor, e.g. sensors, vibrators, negative pressure inhalation detectors electrical
- A61M2016/0021—Accessories therefor, e.g. sensors, vibrators, negative pressure inhalation detectors electrical with a proportional output signal, e.g. from a thermistor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/06—Solids
- A61M2202/062—Desiccants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/06—Solids
- A61M2202/064—Powder
Definitions
- the quantity applied can be varied according to the process requirements (different output quantity per unit of time);
- the vibrations are not applied electromagnetically in the form of a coil with an armature, but rather by an electric motor.
- the dosing system is coupled to an electric motor with an imbalance. The change in frequency and amplitude are caused by changing the speed of the motor and changing its unbalance.
- the vibration is applied by mechanical assemblies, e.g. a spring motor with unbalance.
- mechanical assemblies e.g. a spring motor with unbalance.
- the dosing system be so compact that it is built up in the order of a small spray can.
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Veterinary Medicine (AREA)
- Pulmonology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Mechanical Engineering (AREA)
- Biophysics (AREA)
- Feeding, Discharge, Calcimining, Fusing, And Gas-Generation Devices (AREA)
- Special Spraying Apparatus (AREA)
- Containers And Packaging Bodies Having A Special Means To Remove Contents (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19873708933 DE3708933A1 (de) | 1987-03-19 | 1987-03-19 | Verfahren mit den dazu gehoerigen vorrichtungen zur dosierung feiner und fester werkstoff- und wirkstoffteilchen mit hilfe schwingungserzeugender systeme |
| DE3708933 | 1987-03-19 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| EP0349560A1 true EP0349560A1 (de) | 1990-01-10 |
Family
ID=6323457
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EP88902461A Withdrawn EP0349560A1 (de) | 1987-03-19 | 1988-03-15 | Verfahren und vorrichtung zur dosierung von pulvern |
| EP88104041A Withdrawn EP0282958A1 (de) | 1987-03-19 | 1988-03-15 | Verfahren und Vorrichtung zur Dosierung von Pulvern |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EP88104041A Withdrawn EP0282958A1 (de) | 1987-03-19 | 1988-03-15 | Verfahren und Vorrichtung zur Dosierung von Pulvern |
Country Status (12)
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9911770D0 (en) | 1999-05-21 | 1999-07-21 | Glaxo Group Ltd | Powder loading method |
| DE3834339A1 (de) * | 1988-10-08 | 1990-04-12 | Ulrich Reissmann | Vorrichtung zum entladen von behaeltern |
| FR2664694A1 (fr) * | 1990-07-12 | 1992-01-17 | Sedepro | Dispositif doseur de produits en grains ou pulverulents. |
| DE4228229C1 (de) * | 1992-08-25 | 1993-12-09 | Dieter Jossner | Verfahren und Vorrichtung zur Erzeugung von Nebeln |
| KR100244690B1 (ko) * | 1993-05-12 | 2000-02-15 | 야스이 쇼사꾸 | 분말상 약제 멀티도스 시약장치 |
| GB9409851D0 (en) * | 1994-05-17 | 1994-07-06 | Cambridge Consultants | Improvements in and relating to containers of particulate material |
| DE19548826C2 (de) * | 1995-12-27 | 1999-10-28 | Guenther Schmidt | Elektrisches Schnellauftaugerät und Verfahren zum raschen Auftauen von gefrorenen Flüssigkeiten |
| EP1237605A4 (en) * | 1999-11-18 | 2003-10-22 | Transpharma Ltd | powder inhaler |
| GB0025749D0 (en) * | 2000-10-20 | 2000-12-06 | Glaxo Group Ltd | Inhaler |
| GB0207769D0 (en) | 2002-04-04 | 2002-05-15 | Glaxo Group Ltd | Method and apparatus for loading a container with a product |
| US7677411B2 (en) | 2002-05-10 | 2010-03-16 | Oriel Therapeutics, Inc. | Apparatus, systems and related methods for processing, dispensing and/or evaluatingl dry powders |
| SI1535349T1 (sl) * | 2002-06-27 | 2014-10-30 | Oriel Therapeutics, Inc. | Naprave, sistemi in ustrezni postopki za predelavo, izdajo in/ali vrednotenje nefarmacevtskih suhih praškov |
| EP1953088A1 (en) * | 2007-02-02 | 2008-08-06 | Mettler-Toledo Flexilab SAS | Powder-metering apparatus with an impact device |
| JP5342458B2 (ja) | 2007-02-02 | 2013-11-13 | メトラー−トレド アクチェンゲゼルシャフト | 衝撃デバイスを備えた粉体計量装置 |
| GB2472817A (en) | 2009-08-19 | 2011-02-23 | Queen Mary & Westfield College | Powder dispenser with permanently-open linear-taper nozzle operated by vibration |
| GB201300828D0 (en) | 2013-01-17 | 2013-03-06 | Varydose Ltd | Apparatus and method for dispensing powders |
| GB201508320D0 (en) * | 2015-05-15 | 2015-06-24 | 3P Innovation Ltd | Filling assembly |
| CN106742108B (zh) * | 2017-01-19 | 2019-06-07 | 杭州畅溪制药有限公司 | 一种机械振动式粉体微量灌装喷头 |
| CN106628282B (zh) * | 2017-01-19 | 2019-06-07 | 杭州畅溪制药有限公司 | 一种超声振动式粉体微量灌装喷头 |
| CN106697344B (zh) * | 2017-01-19 | 2019-06-07 | 杭州畅溪制药有限公司 | 一种超声振动式粉体微量灌装喷头 |
| CN106828991B (zh) * | 2017-01-19 | 2019-06-14 | 杭州畅溪制药有限公司 | 一种药剂粉体微量灌装机 |
| CN106628283B (zh) * | 2017-01-19 | 2019-06-04 | 杭州畅溪制药有限公司 | 一种粉体微量灌装流道 |
| CN112960149A (zh) * | 2021-01-31 | 2021-06-15 | 发泰（天津）科技有限公司 | 一种丸剂数粒喂料装置 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR1303147A (fr) * | 1961-07-27 | 1962-09-07 | Bonduwe Ets De | Distributeur doseur à alvéoles pour produits pulvérulents |
| GB1401446A (en) * | 1972-06-21 | 1975-07-16 | Carver Inc Fred S | Apparatus and method for the vibratory feeding of pulverulent and granular materials |
| FR2419235A1 (fr) * | 1978-03-08 | 1979-10-05 | Cit Alcatel | Reservoir de poudre |
| US4583660A (en) * | 1982-09-27 | 1986-04-22 | Hewlett-Packard Company | Vibratory toner dispensing system |
| US4472091A (en) * | 1983-04-25 | 1984-09-18 | Pennwalt Corporation | Dry powder metering apparatus |
-
1987
- 1987-03-19 DE DE19873708933 patent/DE3708933A1/de active Granted
-
1988
- 1988-03-15 BR BR888807413A patent/BR8807413A/pt unknown
- 1988-03-15 EP EP88902461A patent/EP0349560A1/de not_active Withdrawn
- 1988-03-15 HU HU882156A patent/HUT54922A/hu unknown
- 1988-03-15 WO PCT/EP1988/000202 patent/WO1988006915A1/de not_active Application Discontinuation
- 1988-03-15 DE DE8890048U patent/DE8890048U1/de not_active Expired
- 1988-03-15 AU AU14886/88A patent/AU1488688A/en not_active Abandoned
- 1988-03-15 EP EP88104041A patent/EP0282958A1/de not_active Withdrawn
- 1988-03-15 FI FI894421A patent/FI894421L/fi not_active IP Right Cessation
- 1988-03-15 JP JP63502554A patent/JPH02502525A/ja active Pending
- 1988-03-17 DD DD88313751A patent/DD280945A5/de not_active IP Right Cessation
- 1988-03-17 IL IL85769A patent/IL85769A0/xx unknown
- 1988-03-18 ZA ZA881938A patent/ZA881938B/xx unknown
- 1988-11-18 KR KR1019880701488A patent/KR890700393A/ko not_active Withdrawn
Non-Patent Citations (1)
| Title |
|---|
| See references of WO8806915A1 * |
Also Published As
| Publication number | Publication date |
|---|---|
| DE3708933A1 (de) | 1988-09-29 |
| HUT54922A (en) | 1991-04-29 |
| AU1488688A (en) | 1988-10-10 |
| DE3708933C2 (enrdf_load_stackoverflow) | 1990-06-28 |
| DD280945A5 (de) | 1990-07-25 |
| IL85769A0 (en) | 1988-09-30 |
| ZA881938B (en) | 1989-11-29 |
| JPH02502525A (ja) | 1990-08-16 |
| EP0282958A1 (de) | 1988-09-21 |
| DE8890048U1 (de) | 1989-09-14 |
| FI894421A7 (fi) | 1989-09-19 |
| FI894421A0 (fi) | 1989-09-19 |
| WO1988006915A1 (fr) | 1988-09-22 |
| BR8807413A (pt) | 1990-05-15 |
| KR890700393A (ko) | 1989-04-24 |
| FI894421L (fi) | 1989-09-19 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
| 17P | Request for examination filed |
Effective date: 19890916 |
|
| AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AT BE CH DE FR GB IT LI LU NL SE |
|
| 17Q | First examination report despatched |
Effective date: 19900601 |
|
| STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
|
| 18D | Application deemed to be withdrawn |
Effective date: 19910808 |