EP0338062A1 - Durch sprühen verabreichtes arzneimittel auf basis einer kombination aus polymixin b, tobramycin und amphotericin b - Google Patents

Durch sprühen verabreichtes arzneimittel auf basis einer kombination aus polymixin b, tobramycin und amphotericin b

Info

Publication number
EP0338062A1
EP0338062A1 EP19880909559 EP88909559A EP0338062A1 EP 0338062 A1 EP0338062 A1 EP 0338062A1 EP 19880909559 EP19880909559 EP 19880909559 EP 88909559 A EP88909559 A EP 88909559A EP 0338062 A1 EP0338062 A1 EP 0338062A1
Authority
EP
European Patent Office
Prior art keywords
administered
precise
amphotericin
polymyxin
tobramycin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
EP19880909559
Other languages
English (en)
French (fr)
Inventor
Louis Lefevre-Utile
Xavier Labayle
Nicole Tenaillon
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
MEDIPRO Sarl
Original Assignee
MEDIPRO Sarl
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by MEDIPRO Sarl filed Critical MEDIPRO Sarl
Publication of EP0338062A1 publication Critical patent/EP0338062A1/de
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin

Definitions

  • the present invention relates to a spray medication intended to prevent the risks of infection in patients at risk by decontaminating the nasal and oropharyngeal cavities.
  • Gram-negative bacillus infections and yeast infections are common in at-risk patients. They cause significant morbidity, they are one of the main causes of the death of these patients, they increase health expenditure by increasing the length of hospital stay.
  • the present invention overcomes this drawback. It includes the combination of three antibiotics administered by spraying into the nasal and oropharyngeal cavities.
  • the three antibiotics associated in the preparation are polymyxin B, tobramycin and amphotericin B.
  • the preparation must adhere to the nasal and oral mucous membranes, slowly release the antibiotics and have a surface tension allowing maximum spreading on the mucous membranes nasal and oropharyngeal.
  • the preparation is administered by precise spraying either in the form of a pressurized aerosol dispensed by a continuous or metering valve or in the form of a nebulization dispensed by a precise pump.
  • Two pushers are supplied with each bottle: one with a long and fine cannula allowing the introduction through the nostrils and the vaporization of the nasal passages, the other with a cannula allowing a broad vaporization of the oropharyngeal cavity .
  • the doses dispensed by the valves or pumps will be very precise. They are of course a function of the concentration of antibiotics in the preparation.
  • the frequency of applications also depends on the concentration of these products.
  • valve or pump must be adapted to deliver 0.5 ml each time it is pressed.
  • 400 mg of polymyxin B, 360 mg of tobramycin and 2000 mg of amphotericin B are administered daily.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
EP19880909559 1987-10-19 1988-10-19 Durch sprühen verabreichtes arzneimittel auf basis einer kombination aus polymixin b, tobramycin und amphotericin b Ceased EP0338062A1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR8714345A FR2621817B1 (fr) 1987-10-19 1987-10-19 Medicament comprenant l'association de polymyxine b, de tobramycine et d'amphotericine b administre par vaporisation
FR8714345 1987-10-19

Publications (1)

Publication Number Publication Date
EP0338062A1 true EP0338062A1 (de) 1989-10-25

Family

ID=9355910

Family Applications (1)

Application Number Title Priority Date Filing Date
EP19880909559 Ceased EP0338062A1 (de) 1987-10-19 1988-10-19 Durch sprühen verabreichtes arzneimittel auf basis einer kombination aus polymixin b, tobramycin und amphotericin b

Country Status (4)

Country Link
EP (1) EP0338062A1 (de)
AU (1) AU2614088A (de)
FR (1) FR2621817B1 (de)
WO (1) WO1989003673A1 (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2290708A (en) * 1994-06-28 1996-01-10 Georgi Stankov Pharmaceutical uses of polyene macrolides
GB2290707A (en) * 1994-06-28 1996-01-10 Georgi Stankov Pharmaceutical uses of Amphotericin B
EP2077132A1 (de) 2008-01-02 2009-07-08 Boehringer Ingelheim Pharma GmbH & Co. KG Abgabevorrichtung, Aufbewahrungsvorrichtung und Verfahren zur Abgabe einer Formulierung
WO2010112358A2 (de) 2009-03-31 2010-10-07 Boehringer Ingelheim International Gmbh Verfahren zur beschichtung einer oberfläche eines bauteils
JP5763053B2 (ja) 2009-05-18 2015-08-12 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング アダプタ、吸入器具及びアトマイザ
EA026241B1 (ru) 2009-11-25 2017-03-31 Бёрингер Ингельхайм Интернациональ Гмбх Распылитель
JP5658268B2 (ja) 2009-11-25 2015-01-21 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング ネブライザ
US10016568B2 (en) 2009-11-25 2018-07-10 Boehringer Ingelheim International Gmbh Nebulizer
JP5874724B2 (ja) 2010-06-24 2016-03-02 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング ネブライザ
WO2012130757A1 (de) 2011-04-01 2012-10-04 Boehringer Ingelheim International Gmbh Medizinisches gerät mit behälter
US9827384B2 (en) 2011-05-23 2017-11-28 Boehringer Ingelheim International Gmbh Nebulizer
WO2013152894A1 (de) 2012-04-13 2013-10-17 Boehringer Ingelheim International Gmbh Zerstäuber mit kodiermitteln
EP2835146B1 (de) 2013-08-09 2020-09-30 Boehringer Ingelheim International GmbH Zerstäuber
US9744313B2 (en) 2013-08-09 2017-08-29 Boehringer Ingelheim International Gmbh Nebulizer
NZ724449A (en) 2014-05-07 2022-01-28 Boehringer Ingelheim Int Nebulizer and container
DK3139979T3 (da) 2014-05-07 2023-10-09 Boehringer Ingelheim Int Enhed, forstøver og fremgangsmåde
EP3139984B1 (de) 2014-05-07 2021-04-28 Boehringer Ingelheim International GmbH Zerstäuber

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL121455C (de) * 1900-01-01
BE629985A (de) * 1962-11-29
AU539563B2 (en) * 1981-01-21 1984-10-04 Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Primycin, doxycyline and sisomicin composition

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See references of WO8903673A1 *

Also Published As

Publication number Publication date
FR2621817B1 (fr) 1990-12-14
FR2621817A1 (fr) 1989-04-21
WO1989003673A1 (fr) 1989-05-05
AU2614088A (en) 1989-05-23

Similar Documents

Publication Publication Date Title
EP0338062A1 (de) Durch sprühen verabreichtes arzneimittel auf basis einer kombination aus polymixin b, tobramycin und amphotericin b
WO1989003672A1 (fr) Medicament comprenant l'association de polymyxine b, de netilmicine et d'amphotericine b administre par vaporisation
EP0390832A1 (de) Arzneimittel mit einem gehalt an einer mischung von colistin, tobramycin und amphotericin b zur verabreichung durch verdampfung
ES2104522T3 (es) Nuevo sistema de administracion de medicamento.
ATE261301T1 (de) Arzneizubereitungen enthaltend nicht-steroidale entzündungshemmende arzneimittel
PT984762E (pt) Configuracoes de controlador de debito para um dispositivo de administracao de agente activo
DK0998916T3 (da) Lægemidler til administration til slimhinden
GEP20043260B (en) Aerosolized Active Agent Delivery and Device for Realization Thereof
CA2039456A1 (en) Osmotic dosage system for liquid drug delivery
NO912001L (no) Buccal tablett med hurtig utlevering.
KR880002502A (ko) 산에 민감한 유익한 약제의 투여용 제형(劑形)
US4876283A (en) Antisnoring agent
WO2002007810A3 (en) Catheter for target specific drug delivery
CA1223210A (en) Antisnoring agent
CA2433833A1 (en) Use of flumazenil in developing a drug for the treatment of alcohol dependence
KR970032872A (ko) 아세틸살리실산을 함유하는 피부 손상 처치용 약물
CA2296231C (en) Composition and method for treating common viral infections
JP2002068963A (ja) 液剤及び容器
FR2624017A1 (fr) Medicament comprenant l'association de colistine, d'amikacine et d'amphotericine b administre par vaporisation
FR2622113A1 (fr) Medicament comprenant l'association de polymyxine b, d'amikacine et d'amphotericine b administre par vaporisation
FR2624739A1 (fr) Medicament comprenant l'association de colistine, de neomycine et d'amphotericine b administre par vaporisation
FR2624738A1 (fr) Medicament comprenant l'association de colistine, de sisomicine et d'amphotericine b administre par vaporisation
FR2624740A1 (fr) Medicament comprenant l'association de colistine, de dibekacine et d'amphotericine b administre par vaporisation
FR2622111A1 (fr) Medicament comprenant l'association de polymyxine b, de dibekacine et d'amphotericine b administre par vaporisation
FR2622112A1 (fr) Medicament comprenant l'association de polymyxine b, de neomycine et d'amphotericine b administre par vaporisation

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AT BE CH DE GB IT LI LU NL SE

17P Request for examination filed

Effective date: 19890911

17Q First examination report despatched

Effective date: 19910404

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION HAS BEEN REFUSED

18R Application refused

Effective date: 19910922